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  1. Article: Clinical risk stratification in COVID-19: the need for a revised approach?

    Cherian, Robin

    Pulmonary circulation

    2021  Volume 11, Issue 1, Page(s) 2045894020988630

    Language English
    Publishing date 2021-01-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2638089-4
    ISSN 2045-8940 ; 2045-8932
    ISSN (online) 2045-8940
    ISSN 2045-8932
    DOI 10.1177/2045894020988630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Time to move away from an oxygen-centric model of pulmonary infarction?

    Cherian, Robin / Chandra, Bharatendu

    The Lancet. Respiratory medicine

    2021  Volume 9, Issue 9, Page(s) e91

    MeSH term(s) Humans ; Oxygen ; Pulmonary Infarction
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-08-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00325-8
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    Zs.A 7041: Show issues Location:
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  3. Article ; Online: Resveratrol as a Promising Nutraceutical: Implications in Gut Microbiota Modulation, Inflammatory Disorders, and Colorectal Cancer.

    Prakash, Vidhya / Bose, Chinchu / Sunilkumar, Damu / Cherian, Robin Mathew / Thomas, Shwetha Susan / Nair, Bipin G

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: Natural products have been a long-standing source for exploring health-beneficial components from time immemorial. Modern science has had a renewed interest in natural-products-based drug discovery. The quest for new potential secondary metabolites or ... ...

    Abstract Natural products have been a long-standing source for exploring health-beneficial components from time immemorial. Modern science has had a renewed interest in natural-products-based drug discovery. The quest for new potential secondary metabolites or exploring enhanced activities for existing molecules remains a pertinent topic for research. Resveratrol belongs to the stilbenoid polyphenols group that encompasses two phenol rings linked by ethylene bonds. Several plant species and foods, including grape skin and seeds, are the primary source of this compound. Resveratrol is known to possess potent anti-inflammatory, antiproliferative, and immunoregulatory properties. Among the notable bioactivities associated with resveratrol, its pivotal role in safeguarding the intestinal barrier is highlighted for its capacity to prevent intestinal inflammation and regulate the gut microbiome. A better understanding of how oxidative stress can be controlled using resveratrol and its capability to protect the intestinal barrier from a gut microbiome perspective can shed more light on associated physiological conditions. Additionally, resveratrol exhibits antitumor activity, proving its potential for cancer treatment and prevention. Moreover, cardioprotective, vasorelaxant, phytoestrogenic, and neuroprotective benefits have also been reported. The pharmaceutical industry continues to encounter difficulties administering resveratrol owing to its inadequate bioavailability and poor solubility, which must be addressed simultaneously. This report summarizes the currently available literature unveiling the pharmacological effects of resveratrol.
    MeSH term(s) Humans ; Resveratrol/pharmacology ; Resveratrol/therapeutic use ; Gastrointestinal Microbiome ; Polyphenols/pharmacology ; Dietary Supplements ; Colorectal Neoplasms/drug therapy
    Chemical Substances Resveratrol (Q369O8926L) ; Polyphenols
    Language English
    Publishing date 2024-03-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063370
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  4. Article ; Online: Severe COVID-19 as a virus-independent immunothrombotic process.

    Cherian, Robin / Tung, Moon Ley / Chandra, Bharatendu

    The Lancet. Rheumatology

    2022  Volume 4, Issue 3, Page(s) e172–e173

    Language English
    Publishing date 2022-02-24
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(22)00033-9
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  5. Article: At the 'heart' of the COVID-19 outbreak: early cardiac implications and mitigating strategies.

    Cherian, Robin / Poh, Kian Keong

    Singapore medical journal

    2020  Volume 61, Issue 7, Page(s) 373–374

    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-03-31
    Publishing country Singapore
    Document type Journal Article ; Comment
    ZDB-ID 604319-7
    ISSN 0037-5675
    ISSN 0037-5675
    DOI 10.11622/smedj.2020042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 589: Show issues Location:
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  7. Article ; Online: Anti-phospholipid syndrome and COVID-19 thrombosis: connecting the dots.

    Tung, Moon Ley / Tan, Bryce / Cherian, Robin / Chandra, Bharatendu

    Rheumatology advances in practice

    2021  Volume 5, Issue 1, Page(s) rkaa081

    Abstract: As the coronavirus disease 2019 (COVID-19) pandemic, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly worldwide, it has emerged as a leading cause of mortality, resulting in >1 million deaths over ... ...

    Abstract As the coronavirus disease 2019 (COVID-19) pandemic, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly worldwide, it has emerged as a leading cause of mortality, resulting in >1 million deaths over the past 10 months. The pathophysiology of COVID-19 remains unclear, posing a great challenge to the medical management of patients. Recent studies have reported an unusually high prevalence of thromboembolic events in COVID-19 patients, although the mechanism remains elusive. Several studies have reported the presence of aPLs in COVID-19 patients. We have noticed similarities between COVID-19 and APS, which is an autoimmune prothrombotic disease that is often associated with an infective aetiology. Molecular mimicry and endothelial dysfunction could plausibly explain the mechanism of thrombogenesis in acquired APS. In this review, we discuss the clinicopathological similarities between COVID-19 and APS, and the potential role of therapeutic targets based on the anti-phospholipid model for COVID-19 disease.
    Language English
    Publishing date 2021-02-04
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2514-1775
    ISSN (online) 2514-1775
    DOI 10.1093/rap/rkaa081
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  8. Article ; Online: COVID-19 conundrum: clinical phenotyping based on pathophysiology as a promising approach to guide therapy in a novel illness.

    Cherian, Robin / Chandra, Bharatendu / Tung, Moon Ley / Vuylsteke, Alain

    The European respiratory journal

    2020  Volume 56, Issue 2

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02135-2020
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    Zs.A 2322: Show issues Location:
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  9. Article ; Online: Positive Bubble Study in Severe COVID-19 Indicates the Development of Anatomical Intrapulmonary Shunts in Response to Microvascular Occlusion.

    Cherian, Robin / Chandra, Bharatendu / Tung, Moon Ley / Vuylsteke, Alain

    American journal of respiratory and critical care medicine

    2020  Volume 203, Issue 2, Page(s) 263–265

    Keywords covid19
    Language English
    Publishing date 2020-09-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202008-3186LE
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  10. Article: Catheter-Based Left Ventricular Assist Device for the Management of Cardiogenic Shock Complicating Acute Myocardial Infarction: A First-in-Singapore Experience.

    Lin, Weiqin / Cherian, Robin / Kang, Giap Swee / Tan, Huay Cheem / Low, Adrian Fh

    Annals of the Academy of Medicine, Singapore

    2020  Volume 49, Issue 9, Page(s) 707–711

    MeSH term(s) Catheters ; Heart-Assist Devices ; Humans ; Myocardial Infarction/complications ; Myocardial Infarction/therapy ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/therapy ; Singapore
    Language English
    Publishing date 2020-06-01
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 604527-3
    ISSN 0304-4602
    ISSN 0304-4602
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