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  1. Book: Hypertension

    Cheriyan, Joseph / McEniery, Carmel M. / Wilkinson, Ian

    (Oxford specialist handbooks)

    2010  

    Title variant Oxford specialist handbooks hypertension ; Specialist handbooks hypertension
    Author's details Joseph Cheriya ; Carmel M. McEniery ; Ian B. Wilkinson
    Series title Oxford specialist handbooks
    Keywords Hypertension
    Subject code 616.132
    Language English
    Size XXII, 313 S., [4] Bl. : Ill., graph. Darst., 18 cm
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016168068
    ISBN 978-0-19-922955-0 ; 0-19-922955-4
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Non-invasive measurements of arterial function: What? When? Why should we use them?

    Sun, Zoe Dong Yang / Cheriyan, Joseph

    Heart (British Cardiac Society)

    2019  Volume 105, Issue 15, Page(s) 1203–1211

    MeSH term(s) Diagnostic Techniques, Cardiovascular ; Humans ; Patient Selection ; Risk Factors ; Vascular Diseases/diagnosis ; Vascular Diseases/etiology ; Vascular Diseases/physiopathology
    Language English
    Publishing date 2019-03-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2018-312970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Approximation Algorithms for Flexible Graph Connectivity

    Boyd, Sylvia / Cheriyan, Joseph / Haddadan, Arash / Ibrahimpur, Sharat

    2022  

    Abstract: We present approximation algorithms for several network design problems in the model of Flexible Graph Connectivity (Adjiashvili, Hommelsheim and M\"uhlenthaler, "Flexible Graph Connectivity", Math. Program. pp. 1-33 (2021), and IPCO 2020: pp. 13-26). ... ...

    Abstract We present approximation algorithms for several network design problems in the model of Flexible Graph Connectivity (Adjiashvili, Hommelsheim and M\"uhlenthaler, "Flexible Graph Connectivity", Math. Program. pp. 1-33 (2021), and IPCO 2020: pp. 13-26). Let $k\geq 1$, $p\geq 1$ and $q\geq 0$ be integers. In an instance of the $(p,q)$-Flexible Graph Connectivity problem, denoted $(p,q)$-FGC, we have an undirected connected graph $G = (V,E)$, a partition of $E$ into a set of safe edges $S$ and a set of unsafe edges $U$, and nonnegative costs $c: E\to\Re$ on the edges. A subset $F \subseteq E$ of edges is feasible for the $(p,q)$-FGC problem if for any subset $F'$ of unsafe edges with $|F'|\leq q$, the subgraph $(V, F \setminus F')$ is $p$-edge connected. The algorithmic goal is to find a feasible solution $F$ that minimizes $c(F) = \sum_{e \in F} c_e$. We present a simple $2$-approximation algorithm for the $(1,1)$-FGC problem via a reduction to the minimum-cost rooted $2$-arborescence problem. This improves on the $2.527$-approximation algorithm of Adjiashvili et al. Our $2$-approximation algorithm for the $(1,1)$-FGC problem extends to a $(k+1)$-approximation algorithm for the $(1,k)$-FGC problem. We present a $4$-approximation algorithm for the $(p,1)$-FGC problem, and an $O(q\log|V|)$-approximation algorithm for the $(p,q)$-FGC problem. Finally, we improve on the result of Adjiashvili et al. for the unweighted $(1,1)$-FGC problem by presenting a $16/11$-approximation algorithm. The $(p,q)$-FGC problem is related to the well-known Capacitated $k$-Connected Subgraph problem (denoted Cap-k-ECSS) that arises in the area of Capacitated Network Design. We give a $\min(k,2 u_{max})$-approximation algorithm for the Cap-k-ECSS problem, where $u_{max}$ denotes the maximum capacity of an edge.

    Comment: 23 pages, 1 figure, preliminary version in the Proceedings of the 41st IARCS Annual Conference on Foundations of Software Technology and Theoretical Computer Science (FSTTCS 2021), December 15-17, (LIPIcs, Volume 213, Article No. 9, pp. 9:1-9:14), see https://doi.org/10.4230/LIPIcs.FSTTCS.2021.9. Related manuscript: arXiv:2102.03304
    Keywords Computer Science - Data Structures and Algorithms ; 68W25 (Primary) 90C17 ; 90C27 ; 90C59 ; 05C40 (Secondary)
    Subject code 518
    Publishing date 2022-02-27
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Online: Unconstrained Traveling Tournament Problem is APX-complete

    Bendayan, Salomon / Cheriyan, Joseph / Cheung, Kevin K. H.

    2022  

    Abstract: We show that the Unconstrained Traveling Tournament Problem (UTTP) is APX-complete by presenting an L-reduction from a version of metric (1,2)-TSP to UTTP. Keywords: Traveling Tournament Problem, APX-complete, Approximation algorithms, Traveling Salesman ...

    Abstract We show that the Unconstrained Traveling Tournament Problem (UTTP) is APX-complete by presenting an L-reduction from a version of metric (1,2)-TSP to UTTP. Keywords: Traveling Tournament Problem, APX-complete, Approximation algorithms, Traveling Salesman Problem

    Comment: The results of this paper appear in preliminary form in the thesis of the first author "The Traveling Tournament Problem'', Master's thesis, University of Waterloo, 2022. See: https://uwspace.uwaterloo.ca/handle/10012/18553
    Keywords Computer Science - Data Structures and Algorithms ; Mathematics - Combinatorics
    Publishing date 2022-12-18
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Online: Improved Approximation Algorithms by Generalizing the Primal-Dual Method Beyond Uncrossable Functions

    Bansal, Ishan / Cheriyan, Joseph / Grout, Logan / Ibrahimpur, Sharat

    2022  

    Abstract: We address long-standing open questions raised by Williamson, Goemans, Vazirani and Mihail pertaining to the design of approximation algorithms for problems in network design via the primal-dual method (Combinatorica 15(3):435-454, 1995). Williamson et ... ...

    Abstract We address long-standing open questions raised by Williamson, Goemans, Vazirani and Mihail pertaining to the design of approximation algorithms for problems in network design via the primal-dual method (Combinatorica 15(3):435-454, 1995). Williamson et al. prove an approximation guarantee of two for connectivity augmentation problems where the connectivity requirements can be specified by so-called uncrossable functions. They state: ``Extending our algorithm to handle non-uncrossable functions remains a challenging open problem. The key feature of uncrossable functions is that there exists an optimal dual solution which is laminar. This property characterizes uncrossable functions\dots\ A larger open issue is to explore further the power of the primal-dual approach for obtaining approximation algorithms for other combinatorial optimization problems.'' Our main result proves that the primal-dual algorithm of Williamson et al. achieves an approximation ratio of 16 for a class of functions that generalizes the notion of an uncrossable function. There exist instances that can be handled by our methods where none of the optimal dual solutions has a laminar support. We present three applications of our main result. (1) A 16-approximation algorithm for augmenting a family of small cuts of a graph $G$. (2) A $16 \cdot {\lceil k/u_{min} \rceil}$-approximation algorithm for the Cap-$k$-ECSS problem which is as follows: Given an undirected graph $G = (V,E)$ with edge costs $c \in \mathbb{Q}_{\geq 0}^E$ and edge capacities $u \in \mathbb{Z}_{\geq 0}^E$, find a minimum-cost subset of the edges $F\subseteq E$ such that the capacity of any cut in $(V,F)$ is at least $k$; we use $u_{min}$ to denote the minimum capacity of an edge in $E$. (3) An $O(1)$-approximation algorithm for the model of $(p,2)$-Flexible Graph Connectivity.

    Comment: updated v3, improved exposition at a few points, results and proofs are the same
    Keywords Computer Science - Data Structures and Algorithms
    Subject code 518
    Publishing date 2022-09-22
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Association for Human Pharmacology in the Pharmaceutical Industry conference 2022: impending change, innovations and future challenges.

    Mundy, Charles / Bush, James / Cheriyan, Joseph / Lorch, Ulrike / Stringer, Steffan / Taubel, Jörg / Wydenbach, Kirsty / Hardman, Timothy C

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1219591

    Abstract: The Association for Human Pharmacology in the Pharmaceutical Industry's annual meeting focused on current and impending challenges facing the United Kingdom's (UK) pharmaceutical industry and how these opportunities can inspire innovation and best ... ...

    Abstract The Association for Human Pharmacology in the Pharmaceutical Industry's annual meeting focused on current and impending challenges facing the United Kingdom's (UK) pharmaceutical industry and how these opportunities can inspire innovation and best practice. The UK pharmaceutical landscape is still evolving following Brexit and learnings from the coronavirus disease 2019 (COVID-19) pandemic. As such, the UK's clinical community is in a unique position to steer innovation in a meaningful direction. With the continuation of remote forms of working, further opportunities have arisen to support novel practices away from the clinic. The keynote speaker reflected on clinical development over the past 40 years and how the industry must continue to concentrate on patient welfare. The future of drug development was discussed regarding challenges associated with developing translational gene therapies, and the status of investment markets analyzed from a business strategy and consulting perspective. The patient viewpoint was a core theme throughout the conference with patient-centric blood sampling and decentralized clinical trials providing suggestions for how the industry can save costs and increase efficiency. Moreover, the patient perspective was central to a debate over whether ethics requirements should be the same for oncology patients taking part in first-in-human studies as those for healthy subjects. Discussions continued around the changing roles of the Qualified Person and Principal Investigators which underpins how sponsors may want to run future trials in the UK. Lessons learned from conducting challenge trials in healthy volunteers and patients were discussed following a presentation from the serving Chair of the COVID-19 challenge ethics committee. The current state of interactions with the Medicines and Healthcare products Regulatory Agency were also explored. It was considered how the immediate future for the UK clinical trials community is inevitably still linked with Europe; the newly implemented European Medicines Agency Clinical Trials Information System has been met with lukewarm responses, providing a promising opportunity to ensure UK Phase I units continue to play a vital role in global research.
    Language English
    Publishing date 2023-11-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1219591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: A simple proof of the Moore-Hodgson Algorithm for minimizing the number of late jobs

    Cheriyan, Joseph / Ravi, R. / Skutella, Martin

    2021  

    Abstract: The Moore-Hodgson Algorithm minimizes the number of late jobs on a single machine. That is, it finds an optimal schedule for the classical problem $1~|\;|~\sum{U_j}$. Several proofs of the correctness of this algorithm have been published. We present a ... ...

    Abstract The Moore-Hodgson Algorithm minimizes the number of late jobs on a single machine. That is, it finds an optimal schedule for the classical problem $1~|\;|~\sum{U_j}$. Several proofs of the correctness of this algorithm have been published. We present a new short proof.

    Comment: 3 pages
    Keywords Computer Science - Data Structures and Algorithms ; Computer Science - Performance ; Mathematics - Combinatorics ; 90B35 ; 68W40 ; F.2.2
    Publishing date 2021-04-13
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online: A $2$-Approximation Algorithm for Flexible Graph Connectivity

    Boyd, Sylvia / Cheriyan, Joseph / Haddadan, Arash / Ibrahimpur, Sharat

    2021  

    Abstract: We present a $2$-approximation algorithm for the Flexible Graph Connectivity problem [AHM20] via a reduction to the minimum cost $r$-out $2$-arborescence problem. ... Comment: 2 ... ...

    Abstract We present a $2$-approximation algorithm for the Flexible Graph Connectivity problem [AHM20] via a reduction to the minimum cost $r$-out $2$-arborescence problem.

    Comment: 2 pages
    Keywords Computer Science - Data Structures and Algorithms ; Computer Science - Discrete Mathematics ; F.2.2 ; G.1.6 ; G.2.2
    Publishing date 2021-02-05
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Niclosamide-A promising treatment for COVID-19.

    Singh, Shivani / Weiss, Anne / Goodman, James / Fisk, Marie / Kulkarni, Spoorthy / Lu, Ing / Gray, Joanna / Smith, Rona / Sommer, Morten / Cheriyan, Joseph

    British journal of pharmacology

    2022  Volume 179, Issue 13, Page(s) 3250–3267

    Abstract: Vaccines have reduced the transmission and severity of COVID-19, but there remains a paucity of efficacious treatment for drug-resistant strains and more susceptible individuals, particularly those who mount a suboptimal vaccine response, either due to ... ...

    Abstract Vaccines have reduced the transmission and severity of COVID-19, but there remains a paucity of efficacious treatment for drug-resistant strains and more susceptible individuals, particularly those who mount a suboptimal vaccine response, either due to underlying health conditions or concomitant therapies. Repurposing existing drugs is a timely, safe and scientifically robust method for treating pandemics, such as COVID-19. Here, we review the pharmacology and scientific rationale for repurposing niclosamide, an anti-helminth already in human use as a treatment for COVID-19. In addition, its potent antiviral activity, niclosamide has shown pleiotropic anti-inflammatory, antibacterial, bronchodilatory and anticancer effects in numerous preclinical and early clinical studies. The advantages and rationale for nebulized and intranasal formulations of niclosamide, which target the site of the primary infection in COVID-19, are reviewed. Finally, we give an overview of ongoing clinical trials investigating niclosamide as a promising candidate against SARS-CoV-2.
    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Drug Repositioning/methods ; Humans ; Niclosamide/pharmacology ; Niclosamide/therapeutic use ; Pandemics ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Niclosamide (8KK8CQ2K8G)
    Language English
    Publishing date 2022-04-11
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Advances in PET to assess pulmonary inflammation: A systematic review.

    Vass, Laurence / Fisk, Marie / Lee, Sarah / Wilson, Frederick J / Cheriyan, Joseph / Wilkinson, Ian

    European journal of radiology

    2020  Volume 130, Page(s) 109182

    Abstract: Background: Respiratory diseases are one of the leading causes of death worldwide, yet effective treatment options remain limited. Although inflammation is thought to be a key driver in the pathogenesis and progression of several lung diseases, the ... ...

    Abstract Background: Respiratory diseases are one of the leading causes of death worldwide, yet effective treatment options remain limited. Although inflammation is thought to be a key driver in the pathogenesis and progression of several lung diseases, the underlying molecular mechanisms of lung dysfunction remain poorly understood. Imaging techniques may help to further our understanding of the pathophysiology and facilitate the translation of novel therapies. Positron Emission Tomography (PET) is a functional imaging technique which has the potential to interrogate the underlying inflammatory response. We present a systematic review of the literature summarising the emerging PET radiotracers developed to quantify pulmonary inflammation.
    Method: We performed a systematic review using the following databases: Medline, Embase, Scopus, PubMed, Web of Science and Cochrane. We included articles between 1995 and 2019 for all studies using PET radiotracers to evaluate inflammatory response in the lung. From a total of 911 articles covering both animal and human studies, two reviewers selected papers based on the inclusion/exclusion criteria and extracted data from 68 articles selected.
    Results: 53 out of 68 papers, including both human and animal studies, were eligible for synthesis. Heterogenous study populations and differences in study design, image acquisition and analysis made data pooling unfeasible; instead, we provide a narrative synthesis.
    Conclusions: Currently, very few novel radiotracers targeting lung inflammation have crossed the translational gap from animal models to human studies. Nevertheless, our results highlight a handful of promising tracers which warrant further evaluation in humans.
    MeSH term(s) Animals ; Disease Progression ; Fluorodeoxyglucose F18/administration & dosage ; Forecasting ; Humans ; Pneumonia/diagnostic imaging ; Pneumonia/therapy ; Positron-Emission Tomography/methods ; Positron-Emission Tomography/trends ; Radiopharmaceuticals/administration & dosage ; Treatment Outcome
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2020-07-12
    Publishing country Ireland
    Document type Journal Article ; Systematic Review
    ZDB-ID 138815-0
    ISSN 1872-7727 ; 0720-048X
    ISSN (online) 1872-7727
    ISSN 0720-048X
    DOI 10.1016/j.ejrad.2020.109182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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