Article ; Online: Post-translational lipid modifications in Plasmodium parasites.
Current opinion in microbiology
2022 Volume 69, Page(s) 102196
Abstract: Most eukaryotic proteins undergo post-translational modifications (PTMs) that significantly alter protein properties, regulate diverse cellular processes and increase proteome complexity. Among these PTMs, lipidation plays a unique and key role in ... ...
| Abstract | Most eukaryotic proteins undergo post-translational modifications (PTMs) that significantly alter protein properties, regulate diverse cellular processes and increase proteome complexity. Among these PTMs, lipidation plays a unique and key role in subcellular trafficking, signalling and membrane association of proteins through altering substrate function, and hydrophobicity via the addition and removal of lipid groups. Three prevalent classes of lipid modifications in Plasmodium parasites include prenylation, myristoylation, and palmitoylation that are important for regulating parasite-specific molecular processes. The enzymes that catalyse these lipid attachments have also been explored as potential drug targets for antimalarial development. In this review, we discuss these lipidation processes in Plasmodium spp. and the methodologies that have been used to identify these modifications in the deadliest species of malaria parasite, Plasmodium falciparum. We also discuss the development status of inhibitors that block these pathways. |
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| MeSH term(s) | Animals ; Lipids ; Parasites ; Plasmodium/genetics ; Plasmodium/metabolism ; Plasmodium falciparum/genetics ; Plasmodium falciparum/metabolism ; Protein Processing, Post-Translational ; Protozoan Proteins/metabolism |
| Chemical Substances | Lipids ; Protozoan Proteins |
| Language | English |
| Publishing date | 2022-08-26 |
| Publishing country | England |
| Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1418474-6 |
| ISSN | 1879-0364 ; 1369-5274 |
| ISSN (online) | 1879-0364 |
| ISSN | 1369-5274 |
| DOI | 10.1016/j.mib.2022.102196 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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