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  1. Article ; Online: Correction to Tailored Three-Dimensionally Printed Triply Periodic Calcium Phosphate Implants: A Preclinical Study for Craniofacial Bone Repair.

    Paré, Arnaud / Charbonnier, Baptiste / Tournier, Pierre / Vignes, Caroline / Veziers, Joëlle / Lesoeur, Julie / Laure, Boris / Bertin, Hélios / De Pinieux, Gonzague / Cherrier, Grégory / Guicheux, Jérome / Gauthier, Olivier / Corre, Pierre / Marchat, David / Weiss, Pierre

    ACS biomaterials science & engineering

    2020  Volume 6, Issue 3, Page(s) 1821

    Language English
    Publishing date 2020-02-20
    Publishing country United States
    Document type Published Erratum
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.0c00167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Tailored Three-Dimensionally Printed Triply Periodic Calcium Phosphate Implants: A Preclinical Study for Craniofacial Bone Repair.

    Paré, Arnaud / Charbonnier, Baptiste / Tournier, Pierre / Vignes, Caroline / Veziers, Joëlle / Lesoeur, Julie / Laure, Boris / Bertin, Hélios / De Pinieux, Gonzague / Cherrier, Grégory / Guicheux, Jérome / Gauthier, Olivier / Corre, Pierre / Marchat, David / Weiss, Pierre

    ACS biomaterials science & engineering

    2019  Volume 6, Issue 1, Page(s) 553–563

    Abstract: Finding alternative strategies for the regeneration of craniofacial bone defects (CSD), such as combining a synthetic ephemeral calcium phosphate (CaP) implant and/or active substances and cells, would contribute to solving this reconstructive roadblock. ...

    Abstract Finding alternative strategies for the regeneration of craniofacial bone defects (CSD), such as combining a synthetic ephemeral calcium phosphate (CaP) implant and/or active substances and cells, would contribute to solving this reconstructive roadblock. However, CaP's architectural features (i.e., architecture and composition) still need to be tailored, and the use of processed stem cells and synthetic active substances (e.g., recombinant human bone morphogenetic protein 2) drastically limits the clinical application of such approaches. Focusing on solutions that are directly transposable to the clinical setting, biphasic calcium phosphate (BCP) and carbonated hydroxyapatite (CHA) 3D-printed disks with a triply periodic minimal structure (TPMS) were implanted in calvarial critical-sized defects (rat model) with or without addition of total bone marrow (TBM). Bone regeneration within the defect was evaluated, and the outcomes were compared to a standard-care procedure based on BCP granules soaked with TBM (positive control). After 7 weeks, de novo bone formation was significantly greater in the CHA disks + TBM group than in the positive controls (3.33 mm
    MeSH term(s) Animals ; Bone Regeneration ; Bone and Bones ; Calcium Phosphates ; Osteogenesis ; Printing, Three-Dimensional ; Rats
    Chemical Substances Calcium Phosphates
    Language English
    Publishing date 2019-11-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-9878
    ISSN 2373-9878
    DOI 10.1021/acsbiomaterials.9b01241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Management and outcomes of adolescent and young adult sarcoma patients: results from the French nationwide database NETSARC.

    Kubicek, Pierre / Cesne, Axel Le / Lervat, Cyril / Toulmonde, Maud / Chevreau, Christine / Duffaud, Florence / Le Nail, Louis-Romée / Morelle, Magali / Gaspar, Nathalie / Vérité, Cécile / Castex, Marie-Pierre / Penel, Nicolas / Saada, Esma / Causeret, Sylvain / Bertucci, François / Perrin, Christophe / Bompas, Emmanuelle / Orbach, Daniel / Laurence, Valérie /
    Piperno-Neumann, Sophie / Anract, Philippe / Rios, Maria / Gentet, Jean-Claude / Mascard, Éric / Pannier, Stéphanie / Blouin, Pascale / Carrère, Sébastien / Chaigneau, Loïc / Soibinet-Oudot, Pauline / Corradini, Nadège / Boudou-Rouquette, Pascaline / Ruzic, Jean-Christophe / Lebrun-Ly, Valérie / Dubray-Longeras, Pascale / Varatharajah, Sharmini / Lebbe, Céleste / Ropars, Mickaël / Kurtz, Jean-Emmanuel / Guillemet, Cécile / Lotz, Jean-Pierre / Berchoud, Juliane / Cherrier, Grégory / Ducimetière, Françoise / Chemin, Claire / Italiano, Antoine / Honoré, Charles / Desandes, Emmanuel / Blay, Jean-Yves / Gouin, François / Marec-Bérard, Perrine

    BMC cancer

    2023  Volume 23, Issue 1, Page(s) 69

    Abstract: Background: The initial management of patients with sarcoma is a critical issue. We used the nationwide French National Cancer Institute-funded prospective sarcoma database NETSARC to report the management and oncologic outcomes in adolescents and young ...

    Abstract Background: The initial management of patients with sarcoma is a critical issue. We used the nationwide French National Cancer Institute-funded prospective sarcoma database NETSARC to report the management and oncologic outcomes in adolescents and young adults (AYAs) patients with sarcoma at the national level.
    Patients and methods: NETSARC database gathers regularly monitored and updated data from patients with sarcoma. NETSARC was queried for patients (15-30 years) with sarcoma diagnosed from 2010 to 2017 for whom tumor resection had been performed. We reported management, locoregional recurrence-free survival (LRFS), progression-free survival (PFS), and overall survival (OS) in AYA treated in French reference sarcoma centers (RSC) and outside RSC (non-RSC) and conducted multivariable survival analyses adjusted for classical prognostic factors.
    Results: Among 3,227 patients aged 15-30 years with sarcoma diagnosed between 2010 and 2017, the study included 2,227 patients with surgery data available, among whom 1,290 AYAs had been operated in RSC, and 937 AYAs in non-RSC. Significant differences in compliance to guidelines were observed including pre-treatment biopsy (RSC: 85.9%; non-RSC 48.1%), pre-treatment imaging (RSC: 86.8%; non-RSC: 56.5%) and R0 margins (RSC 57.6%; non-RSC: 20.2%) (p < 0.001). 3y-OS rates were 81.1% (95%CI 78.3-83.6) in AYA in RSC and 82.7% (95%CI 79.4-85.5) in AYA in non-RSC, respectively. Whereas no significant differences in OS was observed in AYAs treated in RSC and in non-RSC, LRFS and PFS were improved in AYAs treated in RSC compared to AYAs treated in non-RSC (Hazard Ratios (HR): 0.58 and 0.83, respectively).
    Conclusions: This study highlights the importance for AYA patients with sarcoma to be managed in national sarcoma reference centers involving multidisciplinary medical teams with paediatric and adult oncologists.
    MeSH term(s) Humans ; Adolescent ; Young Adult ; Child ; Prospective Studies ; Sarcoma/diagnosis ; Sarcoma/surgery ; Soft Tissue Neoplasms/surgery ; Databases, Factual ; Progression-Free Survival
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-10556-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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