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  1. Article: Increased healing of the disrupted wound--a myth or simply enhanced angiogenesis following wounding? Personal discussions with Tom Hunt from the 1960s to the present.

    Cherry, George W / Hughes, Margaret

    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

    2003  Volume 11, Issue 6, Page(s) 401–404

    MeSH term(s) Fibroblast Growth Factors/physiology ; Growth Substances/physiology ; History, 20th Century ; History, 21st Century ; Humans ; Neovascularization, Physiologic ; Platelet-Derived Growth Factor/physiology ; Vascular Endothelial Growth Factor A/physiology ; Wound Healing/physiology
    Chemical Substances Growth Substances ; Platelet-Derived Growth Factor ; Vascular Endothelial Growth Factor A ; Fibroblast Growth Factors (62031-54-3)
    Language English
    Publishing date 2003-11-04
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 1174873-4
    ISSN 1524-475X ; 1067-1927
    ISSN (online) 1524-475X
    ISSN 1067-1927
    DOI 10.1046/j.1524-475x.2003.11603.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effect of Traumacel P on the growth of human dermal fibroblasts in vitro.

    Hughes, M A / Yang, Y / Cherry, George W

    Journal of wound care

    2002  Volume 11, Issue 4, Page(s) 149–154

    Abstract: Objective: It has been postulated that Traumacel P, a haemostatic powder, might assist the wound-healing process. This in vitro study investigated the effect of the powder on human dermal fibroblasts.: Method: Experiments using fibroblasts from a 50- ... ...

    Abstract Objective: It has been postulated that Traumacel P, a haemostatic powder, might assist the wound-healing process. This in vitro study investigated the effect of the powder on human dermal fibroblasts.
    Method: Experiments using fibroblasts from a 50-year-old donor were carried out using suspensions of Traumacel P ranging from 0.1 to 10.0 mg/ml. Dulbecco's Modified Eagle Medium with 10% or 0.4% foetal calf serum (FCS) and 5.5 mM or 25 mM glucose was used. The powder was either placed in contact with the cells or separated from them by a porous membrane. The response of the fibroblasts was assessed using the MTT assay.
    Results: Concentrations of 0.5 mg/ml and 1.0 mg/ml stimulated the metabolic activity of the fibroblasts in both high and low glucose medium with 10% FCS, regardless of whether the powder was in contact with or separated from the cells. The greatest stimulation, to 174% of the controls, was produced by 0.5 mg/ml Traumacel P in low glucose/10% FCS with the powder in contact with the cells (p < 0.0001). Traumacel concentrations ranging from 0.5 to 5.0 mg/ml in 0.4% FCS significantly stimulated the metabolic activity of fibroblasts in low glucose medium, but not in the high glucose medium.
    Conclusion: These studies indicate that direct stimulation of fibroblast proliferation may be one of the ways in which Traumacel P aids the healing of ulcers observed in the clinic.
    MeSH term(s) Cells, Cultured ; Female ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Hemostatics/pharmacology ; Hemostatics/therapeutic use ; Humans ; Middle Aged ; Uronic Acids/pharmacology ; Uronic Acids/therapeutic use ; Wound Healing/drug effects
    Chemical Substances Hemostatics ; Uronic Acids ; traumacel
    Language English
    Publishing date 2002-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1353951-6
    ISSN 0969-0700
    ISSN 0969-0700
    DOI 10.12968/jowc.2002.11.4.26392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Software construction with object-oriented pictures

    Cherry, George W

    specifying reactive and interactive systems

    1990  

    Author's details George W. Cherry
    Language English
    Size XII, 191 S, graph. Darst
    Publisher Thought**Tools
    Publishing place Canandaigua, NY
    Document type Book
    Note Literaturverz. S. 180 - 182
    ISBN 0962500305 ; 9780962500305
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Book ; Conference proceedings: Wound bed preparation

    Cherry, George W / Harding, K. G / Ryan, Terence J

    proceedings of a symposium sponsored by the European Tissue Repair Society through an educational grant from Smith & Nephew, and held at St. Anne's College & Green College, University of Oxford, UK 24-25 November 2000

    (International congress and symposium series, ; 250)

    2001  

    Institution European Tissue Repair Society
    Author's details edited by G.W. Cherry, K.G. Harding, T.J. Ryan
    Series title International congress and symposium series, ; 250
    MeSH term(s) Wound Healing ; Wounds and Injuries/therapy
    Language English
    Size vi, 124 p. :, ill.
    Publisher Royal Society of Medicine Press
    Publishing place London, UK ; Lake Forest, IL
    Document type Book ; Conference proceedings
    ISBN 9781853154959 ; 1853154954
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Book ; Conference proceedings: Warming and wound healing

    Ryan, Terence J / Cherry, George W / Harding, K. G

    Warm-Up active wound therapy : proceedings of a symposium on thermal regulation in wound care held at St. Anne's College, the University of Oxford, on 19-20 February 1999, and sponsored by an educational grant from Augustine Medical Inc

    (International congress and symposium series, ; 237)

    2000  

    Author's details edited by T.J. Ryan, G.W. Cherry, K.G. Harding
    Series title International congress and symposium series, ; 237
    MeSH term(s) Wound Healing ; Hot Temperature/therapeutic use ; Hyperthermia, Induced/instrumentation ; Wounds and Injuries/therapy
    Language English
    Size vi, 92 p. :, ill. ;, 24 cm.
    Publisher Royal Society of Medicine Press
    Publishing place London ; Lake Forest, IL
    Document type Book ; Conference proceedings
    ISBN 9781853154478 ; 1853154474
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Article: Evidence of oxidative stress in chronic venous ulcers.

    James, Tim J / Hughes, Margaret A / Cherry, George W / Taylor, Richard P

    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

    2003  Volume 11, Issue 3, Page(s) 172–176

    Abstract: Reactive oxygen species have been implicated in the impaired healing of chronic leg ulcers but little direct evidence is available. We have observed a significant (p < 0.01) elevation of the allantoin : uric acid percentage ratio, a marker of oxidative ... ...

    Abstract Reactive oxygen species have been implicated in the impaired healing of chronic leg ulcers but little direct evidence is available. We have observed a significant (p < 0.01) elevation of the allantoin : uric acid percentage ratio, a marker of oxidative stress, in wound fluid from chronic leg ulcers (median 17, range 8-860) compared to both paired plasma (median 2, range 1-8) and acute surgical wound fluid (median 4, range 3-7). However, the allantoin : uric acid percentage ratio did not differ significantly between chronic wounds that healed and those that failed to heal. Neutrophil elastase was elevated 30- to 1300-fold in chronic wound fluid compared to plasma and there was a correlation (r(2) = 0.742) between wound fluid elastase and the allantoin : uric acid percentage ratio. Total antioxidant capacity of wound fluid, as measured with a chemiluminescence assay, did not show a correlation (r(2) = 0.03) with the observed oxidative stress. These observations suggest that conditions of localized oxidative stress, possibly related to neutrophil-associated production of reactive oxygen species, are present in chronic leg ulcers. It is possible that future therapeutic strategies aimed at reducing oxidative stress, in addition to good standard care, could improve healing rates of chronic wounds.
    MeSH term(s) Aged ; Aged, 80 and over ; Allantoin/metabolism ; Antioxidants/metabolism ; Chromatography, High Pressure Liquid ; Chronic Disease ; Enzyme-Linked Immunosorbent Assay ; Exudates and Transudates/chemistry ; Female ; Humans ; Leg Ulcer/metabolism ; Leg Ulcer/physiopathology ; Leukocyte Elastase/metabolism ; Male ; Middle Aged ; Oxidative Stress ; Statistics, Nonparametric ; Uric Acid/metabolism ; Wound Healing/physiology
    Chemical Substances Antioxidants ; Uric Acid (268B43MJ25) ; Allantoin (344S277G0Z) ; Leukocyte Elastase (EC 3.4.21.37)
    Language English
    Publishing date 2003-03-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1174873-4
    ISSN 1524-475X ; 1067-1927
    ISSN (online) 1524-475X
    ISSN 1067-1927
    DOI 10.1046/j.1524-475x.2003.11304.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Initial healing rates of venous ulcers: are they useful as predictors of healing?

    Hill, D P / Poore, S / Wilson, J / Robson, M C / Cherry, George W

    American journal of surgery

    2004  Volume 188, Issue 1A Suppl, Page(s) 22–25

    Abstract: Clinical trials that follow venous ulcers to complete healing can be costly because of the prolonged healing time involved. Initial healing rates in venous ulcers are calculated by 2 methods, which are based on a metric using wound area and perimeter. It ...

    Abstract Clinical trials that follow venous ulcers to complete healing can be costly because of the prolonged healing time involved. Initial healing rates in venous ulcers are calculated by 2 methods, which are based on a metric using wound area and perimeter. It has been proposed that these rates allow the prediction of complete healing and that they may be useful as surrogate end points for clinical trials. The objective of this study was to compare the 2 proposed methods for calculating initial healing rates and determine their usefulness in predicting the healing of venous ulcers. Venous leg ulcers from patients enrolled in a randomized, double-blind, placebo-controlled study were measured weekly for up to 12 weeks. Their healing status was determined for up to 24 weeks. Initial healing rates were calculated using the 2 proposed methods. The ability of these rates to predict time to complete healing was assessed. Information from 17 patients was available. The initial healing rates, calculated by either method, were quite similar; both methods produced the same median value of 0.046 cm/week in our patients. Five of the patients had negative initial healing rates, which do not allow any prediction of a healing time. Three of 7 patients predicted to heal within 24 weeks failed to do so. One of the 5 patients was predicted to heal at some time after 24 weeks but actually healed within 24 weeks. None of the 5 patients with negative initial healing rates healed within 24 weeks. Initial healing rates, as calculated by either method, have limited utility in describing healing curves and predicting a healing time. This poor predictive ability argues against using these initial healing rates as surrogate end points for clinical trials. The great variability observed in venous ulcer healing curves may limit the development of useful predictive models in this patient population.
    MeSH term(s) Aged ; Aged, 80 and over ; Biomarkers ; Clinical Trials as Topic/statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Regression Analysis ; Retrospective Studies ; Varicose Ulcer/diagnosis ; Varicose Ulcer/drug therapy ; Wound Healing
    Chemical Substances Biomarkers
    Language English
    Publishing date 2004-07
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/S0002-9610(03)00287-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Vascular birthmarks

    Ryan, Terence J / Cherry, George W

    pathogenesis and management

    (Oxford medical publications)

    1987  

    Author's details edited by Terence J. Ryan and George W. Cherry
    Series title Oxford medical publications
    MeSH term(s) Child ; Infant ; Hemangioma ; Hemangioma/therapy
    Language English
    Size xiii, 203 p. :, ill.
    Publisher Oxford University Press
    Publishing place Oxford ; New York
    Document type Book
    ISBN 9780192616289 ; 0192616285
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article: The serendipity of the fully functioning manager

    Cherry, George W

    Sloan management review Vol. 17, No. 3 , p. 69-82

    1976  Volume 17, Issue 3, Page(s) 69–82

    Author's details George W. Cherry
    Keywords Betriebsleiter
    Publisher Alfred P. Sloan School of Management
    Publishing place Cambridge, Mass.
    Document type Article
    Note Condenced version of the author's S. M. thesis at the Alfred P. Sloan School of Management, Massachusetts Institute of Technology ; mit bibliogr. Angaben
    ZDB-ID 241848-4
    Database ECONomics Information System

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  10. Book: Personal PASCAL

    Cortesi, David E / Cherry, George W

    compiled PASCAL for the IBM personal computer

    1984  

    Title variant Cortesi/Cherry
    Author's details D. E. Cortesi; G. W. Cherry
    Language Undetermined
    Size 420 S, graph. Darst
    Publishing place Reston, Va
    Document type Book
    ISBN 0835955222 ; 0835955230 ; 9780835955225 ; 9780835955232
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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