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  1. Article: In Vivo Validation of Folkloric Use of

    Bhuyan, Biman / Chetia, Dipak

    Indian journal of clinical biochemistry : IJCB

    2019  Volume 35, Issue 2, Page(s) 225–231

    Abstract: ... Costus ... ...

    Abstract Costus pictus
    Language English
    Publishing date 2019-03-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-019-00819-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: In vitro

    Gogoi, Neelutpal / Rudrapal, Mithun / Celik, Ismail / Kaishap, Partha Pratim / Chetia, Dipak

    Journal of biomolecular structure & dynamics

    2023  , Page(s) 1–12

    Abstract: As a part of our continuous effort to find new therapeutic agents from natural sources, the hydroalcoholic (1:1) extract ... ...

    Abstract As a part of our continuous effort to find new therapeutic agents from natural sources, the hydroalcoholic (1:1) extract of
    Language English
    Publishing date 2023-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2283154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Revelation of potential drug targets of luteolin in

    Zothantluanga, James H / Umar, Abd Kakhar / Aswin, Keerthic / Rajkhowa, Sanchaita / Chetia, Dipak

    Journal of biomolecular structure & dynamics

    2023  , Page(s) 1–17

    Abstract: ... In- ... ...

    Abstract In-silico
    Language English
    Publishing date 2023-09-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2263875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: In Vivo and in Silico Based Evaluation of Antidiabetic Potential of an Isolated Flavonoid from Allium hookeri in Type 2 Diabetic Rat Model.

    Singh, Khumanthem Deepak / Chetia, Dipak / Gogoi, Neelutpal / Gogoi, Bhaskarjyoti / Rudrapal, Mithun

    Chemistry & biodiversity

    2023  Volume 21, Issue 1, Page(s) e202301299

    Abstract: Allium hookeri (F: Liliaceae), an indigenous plant of Manipur, India, is traditionally used to treat various diseases and disorders like diabetes, hypertension, and stomach ache. In our previous study, the methanol extract of the plant showed significant ...

    Abstract Allium hookeri (F: Liliaceae), an indigenous plant of Manipur, India, is traditionally used to treat various diseases and disorders like diabetes, hypertension, and stomach ache. In our previous study, the methanol extract of the plant showed significant antidiabetic potential in rats. In the present study, we evaluated the antidiabetic potential of a flavonoid compound named MEA isolated from the methanolic leaf extract of A. Hookeri in rats. Additionally, we assessed the compound's mode of action through the molecular docking study. The MEA reduced the blood glucose level from 317±12.8 to 99.4±6.67 mg/dl after 21 days of treatment. Besides, MEA also restored the body weights and other biochemical parameters including lipid profile significantly compared to the diabetic group (p<0.001). The histoarchitecture of the pancreatic tissues of the MEA treated group was also improved compared to the diabetic group. In the docking study, the compound showed good binding affinity in the active binding site of the two structures of pancreatic beta-cell SUR1 (Sulfonylurea Receptor 1) subunit with CDocker energy -31.556 kcal/mol and -39.703 kcal/mol, respectively. The compound MEA was found to be drug-like with non-carcinogenic, non-mutagenic and non-irritant properties. These findings indicate the antidiabetic potential of MEA, which might act by modulating the pancreatic beta-cell SUR1 subunit present in the K
    MeSH term(s) Rats ; Animals ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Allium/chemistry ; Plant Extracts ; Flavonoids/pharmacology ; Flavonoids/therapeutic use ; Molecular Docking Simulation ; Diabetes Mellitus, Experimental/metabolism ; India ; Methanol ; Diabetes Mellitus, Type 2/drug therapy
    Chemical Substances Hypoglycemic Agents ; Plant Extracts ; Flavonoids ; Methanol (Y4S76JWI15)
    Language English
    Publishing date 2023-12-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202301299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Integrated computational approach towards repurposing of antimalarial drug against SARS-CoV-2 main protease.

    Gogoi, Neelutpal / Chowdhury, Purvita / Goswami, Ashis Kumar / Das, Aparoop / Chetia, Dipak / Gogoi, Bhaskarjyoti

    Structural chemistry

    2022  Volume 33, Issue 5, Page(s) 1409–1422

    Abstract: Huge vaccination drives are underway around the world for the ongoing COVID-19 pandemic. However, the search for antiviral drugs is equally crucial. As new drug discovery is a time-consuming process, repurposing of existing drugs or developing drug ... ...

    Abstract Huge vaccination drives are underway around the world for the ongoing COVID-19 pandemic. However, the search for antiviral drugs is equally crucial. As new drug discovery is a time-consuming process, repurposing of existing drugs or developing drug candidates against SARS-CoV-2 will make the process faster. Considering this, 63 approved and developing antimalarial compounds were selected to screen against main protease (M
    Supplementary information: The online version contains supplementary material available at 10.1007/s11224-022-01916-0.
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2018832-8
    ISSN 1572-9001 ; 1040-0400
    ISSN (online) 1572-9001
    ISSN 1040-0400
    DOI 10.1007/s11224-022-01916-0
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  6. Article ; Online: Multi-target molecular dynamic simulations reveal glutathione-S-transferase as the most favorable drug target of knipholone in

    Sarma, Malita / Abdalla, Mohnad / Zothantluanga, James H / Abdullah Thagfan, Felwa / Umar, Abd Kakhar / Chetia, Dipak / Almanaa, Taghreed N / Al-Shouli, Samia T

    Journal of biomolecular structure & dynamics

    2023  Volume 41, Issue 22, Page(s) 12808–12824

    Abstract: Knipholone is an antiplasmodial phytocompound obtained from the roots ... ...

    Abstract Knipholone is an antiplasmodial phytocompound obtained from the roots of
    MeSH term(s) Humans ; Plasmodium falciparum ; Molecular Dynamics Simulation ; Glutathione Transferase/metabolism ; Ligands ; Malaria, Falciparum ; Glutathione/metabolism ; Molecular Docking Simulation
    Chemical Substances knipholone ; Glutathione Transferase (EC 2.5.1.18) ; Ligands ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2175378
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Multiple-targets Directed Screening of Flavonoid Compounds from

    Gogoi, Neelutpal / Chetia, Dipak / Gogoi, Bhaskarjyoti / Das, Aparoop

    Current computer-aided drug design

    2019  Volume 17, Issue 1, Page(s) 69–82

    Abstract: Background: Development of resistance by the malaria parasite Plasmodium falciparum has created challenges in the eradication of this deadly infectious disease. Hence newer strategies are adopted to combat this disease and simultaneously, new lead/hit ... ...

    Abstract Background: Development of resistance by the malaria parasite Plasmodium falciparum has created challenges in the eradication of this deadly infectious disease. Hence newer strategies are adopted to combat this disease and simultaneously, new lead/hit identification is going on worldwide to develop new chemotherapeutic agents against malaria.
    Objective: In this study, 44 flavonoids found mainly in the fruit juice of Citrus species having traditional use in malaria-associated fever were selected for in silico multiple-target directed screening against three vital targets of the parasite namely dihydroorotate dehydrogenase (PfDHODH), dihydrofolate reductase thymidine synthase (PfDHFR-TS) and plasma membrane P-type cation translocating ATPase (PfATP4) to find out new lead molecule(s).
    Methods: The in silico screening was carried out using different protocols of the Biovia Discovery Studio 2018 software and Network analyzer plugin of Cytoscape 3.6.0 followed by in vitro screening of the best lead.
    Results: After screening, CF8 or luteolin was found to have good binding affinity against PfDHODH and PfATP4 with -CDocker energy 42.2719 and 33.1447 with respect to their cocrystal ligands. These findings were also supported by structure-based pharmacophore, DFT (Density Functional Theory) study and finally by in vitro screening of the lead with IC50 values of 8.23 μm and 12.41 μm against 3D7 (chloroquine-sensitive) and RKL-9 (chloroquine-resistant) strain of P. falciparum, respectively.
    Conclusion: Our study found a moderately active lead molecule with the predicted mode of action which can be utilized to design some new derivatives with more safety and efficacy by targeting the two enzymes.
    MeSH term(s) Antimalarials/isolation & purification ; Antimalarials/pharmacology ; Chloroquine/pharmacology ; Citrus/chemistry ; Computer Simulation ; Density Functional Theory ; Drug Resistance ; Flavonoids/administration & dosage ; Flavonoids/isolation & purification ; Flavonoids/pharmacology ; Inhibitory Concentration 50 ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/parasitology ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/enzymology
    Chemical Substances Antimalarials ; Flavonoids ; Chloroquine (886U3H6UFF)
    Language English
    Publishing date 2019-12-26
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1875-6697
    ISSN (online) 1875-6697
    DOI 10.2174/1573409916666191226103000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Design, Synthesis, Antimalarial Activity and Docking Study of 7-Chloro-4- (2-(substituted benzylidene)hydrazineyl)quinolines.

    Kalita, Jahnabi / Chetia, Dipak / Rudrapal, Mithun

    Medicinal chemistry (Shariqah (United Arab Emirates))

    2019  Volume 16, Issue 7, Page(s) 928–937

    Abstract: Background: Malaria is a growing infectious disease burden due to the increasing emergence of resistant strains of Plasmodium falciparum. Because of the limited therapeutic efficacy of available antimalarial drugs, the development of potent antimalarial ...

    Abstract Background: Malaria is a growing infectious disease burden due to the increasing emergence of resistant strains of Plasmodium falciparum. Because of the limited therapeutic efficacy of available antimalarial drugs, the development of potent antimalarial drug agents is therefore an urgent requirement to fight against resistant malaria.
    Objective: The objective of this work was to develop novel quinoline-baed antimalarial agents that would be active against resistant P. falciparum malaria.
    Methods: Some 7-chloro-4-(2-(substituted benzylidene)hydrazineyl)quinolines were synthesized for the evaluation of their potential as possible antimalarial agents, particularly against resistant malaria. The antimalarial activity of synthesized compounds was evaluated in vitro against bloodstage parasites of P. falciparum. Further, molecular docking and drug-likeness including ADMET (Absorption, Distribution, Metabolism, Elimination and Toxicity) studies were also carried out using in silico tools.
    Results: Results reveal the in vitro antimalarial activity of synthesized 7-chloro-4-(2-(substituted benzylidene)hydrazineyl)quinolines against P. falciparum. The docking study investigates the antimalarial effectiveness of synthesized quinolines as novel plasmepsin 2 inhibitors. Drug-likeness prediction exhibits acceptable drug-likeness and ADMET properties.
    Conclusion: Based upon our findings, it is concluded that the molecular scaffold of 7-chloro-4-(2- (substituted benzylidene)hydrazineyl)quinolines may be used as a lead structure for further modifications in the search of more potent antimalarial drug molecules.
    Language English
    Publishing date 2019-08-05
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1875-6638
    ISSN (online) 1875-6638
    DOI 10.2174/1573406415666190806154722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Endoperoxide antimalarials: development, structural diversity and pharmacodynamic aspects with reference to 1,2,4-trioxane-based structural scaffold.

    Rudrapal, Mithun / Chetia, Dipak

    Drug design, development and therapy

    2016  Volume 10, Page(s) 3575–3590

    Abstract: Malaria disease continues to be a major health problem worldwide due to the emergence of multidrug-resistant strains ... ...

    Abstract Malaria disease continues to be a major health problem worldwide due to the emergence of multidrug-resistant strains of
    MeSH term(s) Animals ; Antimalarials/chemical synthesis ; Antimalarials/pharmacology ; Artemisinins/chemistry ; Artemisinins/pharmacology ; Drug Design ; Drug Resistance ; Heterocyclic Compounds/chemical synthesis ; Heterocyclic Compounds/pharmacology ; Humans ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/parasitology ; Molecular Structure ; Peroxides/chemical synthesis ; Peroxides/pharmacology ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/growth & development ; Plasmodium falciparum/pathogenicity ; Structure-Activity Relationship
    Chemical Substances 1,2,4-trioxane ; Antimalarials ; Artemisinins ; Heterocyclic Compounds ; Peroxides
    Language English
    Publishing date 2016
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S118116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Computational guided identification of potential leads from

    Zothantluanga, James H / Gogoi, Neelutpal / Shakya, Anshul / Chetia, Dipak / Lalthanzara, H

    Future journal of pharmaceutical sciences

    2021  Volume 7, Issue 1, Page(s) 201

    Abstract: Background: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started in 2019 and is still an on-going pandemic. SARS-CoV-2 uses a human protease called furin to aid in cellular entry and its main ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started in 2019 and is still an on-going pandemic. SARS-CoV-2 uses a human protease called furin to aid in cellular entry and its main protease (M
    Results: A total of 29 phytocompounds were reported to be isolated from
    Conclusion: The present study found isovitexin as the most promising phytocompound to potentially inhibit the cellular entry and viral replication of SARS-CoV-2. We also conclude that compounds having oxygen atom at position 18 (C-ring), -OH group at position 19 (A-ring), and 6-C-glucoside attached to the A-ring at position 3 on a C
    Language English
    Publishing date 2021-10-09
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2834845-X
    ISSN 2314-7253 ; 2314-7253
    ISSN (online) 2314-7253
    ISSN 2314-7253
    DOI 10.1186/s43094-021-00348-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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