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  1. Article ; Online: Reply on "Identification of people with high risk of osteoporosis in Asia".

    Cheung, Ching-Lung

    Osteoporosis and sarcopenia

    2023  Volume 9, Issue 3, Page(s) 113–114

    Language English
    Publishing date 2023-09-07
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2405-5263
    ISSN (online) 2405-5263
    DOI 10.1016/j.afos.2023.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: More research and education of osteoporosis should be focused on the oldest old and men.

    Cheung, Ching-Lung

    Osteoporosis and sarcopenia

    2019  Volume 5, Issue 3, Page(s) 63–64

    Language English
    Publishing date 2019-10-04
    Publishing country Netherlands
    Document type Editorial
    ISSN 2405-5263
    ISSN (online) 2405-5263
    DOI 10.1016/j.afos.2019.09.004
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  3. Article ; Online: FRAX-based intervention thresholds in Asia: Now and future.

    Cheung, Ching-Lung

    Osteoporosis and sarcopenia

    2019  Volume 5, Issue 4, Page(s) 103

    Language English
    Publishing date 2019-12-20
    Publishing country Netherlands
    Document type Editorial
    ISSN 2405-5263
    ISSN (online) 2405-5263
    DOI 10.1016/j.afos.2019.12.003
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  4. Article ; Online: COVID-19 and cognitive performance: a Mendelian randomization study.

    Tang, Ching-Man / Li, Gloria Hoi-Yee / Cheung, Ching-Lung

    Frontiers in public health

    2023  Volume 11, Page(s) 1185957

    Abstract: Background: A substantial proportion of individuals with COVID-19 experienced cognitive impairment after resolution of SARS-CoV-2 infection. We aimed to evaluate whether genetic liability to SARS-CoV-2 infection : Methods: We firstly performed ... ...

    Abstract Background: A substantial proportion of individuals with COVID-19 experienced cognitive impairment after resolution of SARS-CoV-2 infection. We aimed to evaluate whether genetic liability to SARS-CoV-2 infection
    Methods: We firstly performed univariable Mendelian randomization (MR) analysis to examine whether genetic liability to SARS-CoV-2 infection, hospitalized and severe COVID-19 is causally associated with cognitive performance. To dissect the causal pathway, multivariable MR (MVMR) analysis was conducted by adjusting for five inflammatory markers [C-reactive protein, interleukin (IL)-1β, IL-6, IL-8, and tumour necrosis factor α, as proxies of systemic inflammation].
    Results: In univariable MR analysis, host genetic liability to SARS-CoV-2 infection was associated with lower cognitive performance [inverse variance weighted (IVW) analysis, estimate: -0.023; 95% Confidence Interval (CI): -0.038 to -0.009]. Such causal association was attenuated in MVMR analysis when we adjusted for the five correlated inflammatory markers in one analysis (IVW analysis, estimate: -0.022; 95% CI: -0.049 to 0.004). There was insufficient evidence of association for genetic liability to hospitalized and severe COVID-19 with cognitive performance.
    Conclusion: The causal effect of host genetic liability to SARS-CoV-2 infection on reduced cognitive performance may be mediated by systemic inflammation. Future studies examining whether anti-inflammatory agents could alleviate cognitive impairment in SARS-CoV-2-infected individuals are warranted.
    MeSH term(s) Humans ; COVID-19/epidemiology ; SARS-CoV-2 ; Mendelian Randomization Analysis ; Inflammation ; Cognition
    Language English
    Publishing date 2023-08-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1185957
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  5. Article ; Online: Causal association of genetically determined caffeine intake from tea or coffee with bone health: a two-sample Mendelian randomization study.

    Li, Gloria Hoi-Yee / Tang, Ching-Man / Wu, Suet-Man / Cheung, Ching-Lung

    Postgraduate medical journal

    2024  

    Abstract: Background: Relationship of caffeine intake and consumption of caffeinated beverages, such as tea and coffee, with bone health remains controversial. This study aimed to evaluate whether genetically determined caffeine intake from tea or coffee has ... ...

    Abstract Background: Relationship of caffeine intake and consumption of caffeinated beverages, such as tea and coffee, with bone health remains controversial. This study aimed to evaluate whether genetically determined caffeine intake from tea or coffee has causal effects on overall total body bone mineral density (TB-BMD) and fracture. We also assessed the association with TB-BMD in five age strata.
    Methods: Using two-sample Mendelian randomization approach, summary statistics were retrieved from genome-wide association studies (GWAS)/GWAS meta-analyses of caffeine intake from tea (n = 395 866)/coffee (n = 373 522), TB-BMD (n = 66 628), and fracture (n = 426 795). Inverse variance weighted method was adopted as the main univariable analysis. Multivariable analysis was conducted to evaluate whether the causal effect is independent.
    Results: In univariable analysis, genetically determined caffeine intake from tea had positive association with overall TB-BMD (per SD increase in genetically determined caffeine intake, beta of TB-BMD [in SD]: 0.166; 95% confidence interval (CI): 0.006-0.326) and inverse association with fracture (OR = 0.79; 95% CI: 0.654-0.954). Genetically determined caffeine intake from coffee was also positively associated with overall TB-BMD (beta = 0.231; 95% CI: 0.093-0.369). The association remained significant after adjustment for smoking in multivariable analysis. Genetically determined caffeine intake from tea or coffee was both positively associated with TB-BMD in the age strata of 45-60 years, but we lacked evidence of association in other strata.
    Conclusions: Genetically, caffeine intake from tea or coffee may be beneficial to bone health. Due to the ascertainment method of caffeine intake from tea, our study also implied genetically higher tea consumption may improve TB-BMD and lower fracture risk.
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1093/postmj/qgae051
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.340: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Metabolomics of Osteoporosis in Humans: A Systematic Review.

    Lau, Kat-Tik / Krishnamoorthy, Suhas / Sing, Chor-Wing / Cheung, Ching Lung

    Current osteoporosis reports

    2023  Volume 21, Issue 3, Page(s) 278–288

    Abstract: Purpose of review: To systematically review recent studies investigating the association between metabolites and bone mineral density (BMD) in humans.: Methods: Using predefined keywords, we searched literature published from Jan 1, 2019 to Feb 20, ... ...

    Abstract Purpose of review: To systematically review recent studies investigating the association between metabolites and bone mineral density (BMD) in humans.
    Methods: Using predefined keywords, we searched literature published from Jan 1, 2019 to Feb 20, 2022 in PubMed, Web of Science, Embase, and Scopus. Studies that met the predefined exclusion criteria were excluded. Among the included studies, we identified metabolites that were reported to be associated with BMD by at least three independent studies.
    Recent findings: A total of 170 studies were retrieved from the databases. After excluding studies that did not meet our predefined inclusion criteria, 16 articles were used in this review. More than 400 unique metabolites in blood were shown to be significantly associated with BMD. Of these, three metabolites were reported by ≥ 3 studies, namely valine, leucine and glycine. Glycine was consistently shown to be inversely associated with BMD, while valine was consistently observed to be positively associated with BMD. Inconsistent associations with BMD was observed for leucine. With advances in metabolomics technology, an increasing number of metabolites associated with BMD have been identified. Two of these metabolites, namely valine and glycine, were consistently associated with BMD, highlighting their potential for clinical application in osteoporosis. International collaboration with a larger population to conduct clinical studies on these metabolites is warranted. On the other hand, given that metabolomics could be affected by genetics and environmental factors, whether the inconsistent association of the metabolites with BMD is due to the interaction between metabolites and genes and/or lifestyle warrants further study.
    MeSH term(s) Humans ; Leucine ; Osteoporosis/epidemiology ; Bone Density
    Chemical Substances Leucine (GMW67QNF9C)
    Language English
    Publishing date 2023-04-15
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2186581-4
    ISSN 1544-2241 ; 1544-1873
    ISSN (online) 1544-2241
    ISSN 1544-1873
    DOI 10.1007/s11914-023-00785-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6146: Show issues Location:
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  7. Article ; Online: Transcriptome-wide summary data-based Mendelian randomization analysis reveals 38 novel genes associated with severe COVID-19.

    Krishnamoorthy, Suhas / Li, Gloria H-Y / Cheung, Ching-Lung

    Journal of medical virology

    2022  Volume 95, Issue 1, Page(s) e28162

    Abstract: Severe COVID-19 has a poor prognosis, while the genetic mechanism underlying severe COVID-19 remains largely unknown. We aimed to identify genes that are potentially causally associated with severe COVID-19. We conducted a summary data-based Mendelian ... ...

    Abstract Severe COVID-19 has a poor prognosis, while the genetic mechanism underlying severe COVID-19 remains largely unknown. We aimed to identify genes that are potentially causally associated with severe COVID-19. We conducted a summary data-based Mendelian randomization (SMR) analysis using expression quantitative trait loci (eQTL) data from 49 different tissues as the exposure and three COVID-19-phenotypes (very severe respiratory confirmed COVID-19 [severe COVID-19], hospitalized COVID-19, and SARS-CoV-2 infection) as the outcomes. SMR using multiple SNPs was used as a sensitivity analysis to reduce false positive rate. Multiple testing was corrected using the false discovery rate (FDR) q-value. We identified 309 significant gene-trait associations (FDR q value < 0.05) across 46 tissues for severe COVID-19, which mapped to 64 genes, of which 38 are novel. The top five most associated protein-coding genes were Interferon Alpha and Beta Receptor Subunit 2 (IFNAR2), 2'-5'-Oligoadenylate Synthetase 3 (OAS3), mucin 1 (MUC1), Interleukin 10 Receptor Subunit Beta (IL10RB), and Napsin A Aspartic Peptidase (NAPSA). The potential causal genes were enriched in biological processes related to type I interferons, interferon-gamma inducible protein 10 production, and chemokine (C-X-C motif) ligand 2 production. In addition, we further identified 23 genes and 5 biological processes which are unique to hospitalized COVID-19, as well as 13 genes that are unique to SARS-CoV-2 infection. We identified several genes that are potentially causally associated with severe COVID-19. These findings improve our limited understanding of the mechanism of COVID-19 and shed light on the development of therapeutic agents for treating severe COVID-19.
    MeSH term(s) Humans ; COVID-19/genetics ; Transcriptome ; Mendelian Randomization Analysis ; SARS-CoV-2/genetics ; Genome-Wide Association Study
    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28162
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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  8. Article ; Online: COVID-19 and Thyroid Function: A Bi-Directional Two-Sample Mendelian Randomization Study.

    Li, Gloria Hoi-Yee / Tang, Ching-Man / Cheung, Ching-Lung

    Thyroid : official journal of the American Thyroid Association

    2022  Volume 32, Issue 9, Page(s) 1037–1050

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) COVID-19/epidemiology ; COVID-19/genetics ; Genetic Predisposition to Disease ; Genome-Wide Association Study/methods ; Humans ; Hyperthyroidism/epidemiology ; Hyperthyroidism/genetics ; Hypothyroidism/epidemiology ; Hypothyroidism/genetics ; Mendelian Randomization Analysis/methods ; Polymorphism, Single Nucleotide ; SARS-CoV-2 ; Thyrotropin/genetics ; Thyroxine
    Chemical Substances Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1086044-7
    ISSN 1557-9077 ; 1050-7256
    ISSN (online) 1557-9077
    ISSN 1050-7256
    DOI 10.1089/thy.2022.0243
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    Zs.A 3307: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 106: Show issues

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  9. Article: Validation of Diagnostic Coding for Asthma in an Electronic Health Record System in Hong Kong.

    Kwok, Wang Chun / Tam, Terence Chi Chun / Sing, Chor Wing / Chan, Esther Wai Yin / Cheung, Ching-Lung

    Journal of asthma and allergy

    2023  Volume 16, Page(s) 315–321

    Abstract: Background: Electronic health record (EHR) databases can facilitate epidemiology research into various diseases including asthma. Given the diagnostic challenges of asthma, the validity of the coding in EHR requires clarification. We aimed to assess the ...

    Abstract Background: Electronic health record (EHR) databases can facilitate epidemiology research into various diseases including asthma. Given the diagnostic challenges of asthma, the validity of the coding in EHR requires clarification. We aimed to assess the validity of International Classification of Diseases, 9th Revision (ICD-9) code algorithms for identifying asthma in the territory-wide electronic medical health record system of the Clinical Data Analysis and Reporting System (CDARS) in Hong Kong.
    Methods: Adult patients who had the diagnosis of asthma input from all public hospitals in Hong Kong and those from Queen Mary Hospital in 2011-2020 were identified using the ICD-9 code of 493 (493.0, 493.1, 493.2, and 493.9) by CDARS. Patients' clinical record and spirometry were reviewed by two respiratory specialists to confirm the presence of asthma in the randomly selected cases.
    Results: There were 43,454 patients who had the diagnostic code of asthma among all public hospitals in Hong Kong and 1852 in Queen Mary Hospital in the same period. A total of 200 cases were randomly selected and validated using medical record and spirometry review by a respiratory specialist. The overall positive predictive value (PPV) was 85.0% (95% CI 80.1-89.9%).
    Conclusion: This was the first ICD-9 code validation for CDARS (EHR) in Hong Kong on asthma. Our study demonstrated that using ICD-9 code (493.0, 493.1, 493.2 and 493.9) to identify asthma can result in a PPV that was reliable to support the utility of the CDARS database for further research on asthma among the Hong Kong population.
    Language English
    Publishing date 2023-03-27
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494877-9
    ISSN 1178-6965
    ISSN 1178-6965
    DOI 10.2147/JAA.S405297
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  10. Article ; Online: Summary of the special issue of the meta-analyses of lean mass with mortality in multiple perspectives.

    Cheung, Ching-Lung / Li, Gloria Hoi-Yee

    Osteoporosis and sarcopenia

    2021  Volume 7, Issue Suppl 1, Page(s) S1–S2

    Language English
    Publishing date 2021-03-23
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2405-5263
    ISSN (online) 2405-5263
    DOI 10.1016/j.afos.2021.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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