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Article ; Online: Current endodontic practice and use of newer technologies in Australia and New Zealand.

Cheung, M C / Parashos, P

2023 Volume 68, Issue 3, Page(s) 186–196

Abstract: Background: This study investigated endodontic clinical preferences, adoption of newer technologies and information sources among dentists and endodontists.: Methods: Dental and endodontic society members in Australia and New Zealand were surveyed ... ...

Abstract	Background: This study investigated endodontic clinical preferences, adoption of newer technologies and information sources among dentists and endodontists. Methods: Dental and endodontic society members in Australia and New Zealand were surveyed online regarding their endodontic treatment preferences, armamentarium, information sources and continuing professional education (CPE) attendance. Results: Complete responses were received from 71 endodontic specialists or postgraduates (Group E) and 139 general dentists (Group D). Most of Group E used dental operating microscopes (95.8%), endodontic cone-beam computed tomography (CBCT; 98.6%) and calcium silicate-based materials (CSBMs; 97.2%), significantly more (P < 0.001) than Group D (86.3% used loupes, <32% used CBCT for endodontics or CSBMs). Most respondents used dental dam always for endodontics (94.3%), electronic apex locators (EAL; 81.0%) and engine-driven nickel-titanium (NiTi) instruments (91.4%); Group E had more experience with engine-driven NiTi (P < 0.001). Endodontic CPE attendance was highest at dental association programs (P < 0.001) while hands-on NiTi training attendance was highest via commercial companies (P < 0.05). Online information sources were commonly used (38.8% of Group D, 59.2% of Group E). Conclusion: Dental dam, EAL and engine-driven NiTi were almost universally used. The endodontic group reported high adoption of newer endodontic technologies. Endodontic CPE and information sources should be further surveyed as online engagement evolves. © 2023 Australian Dental Association.
MeSH term(s)	Humans ; New Zealand ; General Practice, Dental ; Australia ; Practice Patterns, Dentists' ; Endodontics/education ; Surveys and Questionnaires
Chemical Substances	nitinol (2EWL73IJ7F) ; titanium nickelide (12035-60-8)
Language	English
Publishing date	2023-06-29
Publishing country	Australia
Document type	Journal Article
ZDB-ID	603965-0
ISSN	1834-7819 ; 0045-0421
ISSN (online)	1834-7819
ISSN	0045-0421
DOI	10.1111/adj.12967
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Article ; Online: Dentists' preferences in implant maintenance and hygiene instruction.

Cheung, M C / Hopcraft, M S / Darby, I B

Australian dental journal

2021 Volume 66, Issue 3, Page(s) 278–288

Abstract: Background: This study investigated the preferences of dentists in Australia in providing professional implant maintenance and implant-specific oral hygiene instructions (OHI).: Methods: General dentists were surveyed online about their preferences ... ...

Abstract	Background: This study investigated the preferences of dentists in Australia in providing professional implant maintenance and implant-specific oral hygiene instructions (OHI). Methods: General dentists were surveyed online about their preferences in peri-implant diagnostics, maintenance provision, armamentarium used, and implant OHI techniques and frequency. Results: Most of the 303 respondents (96%) provided maintenance services; 87.6% reviewed implants regularly while 10.7% only performed diagnostics after detecting clinical signs/symptoms. Supragingival prosthesis cleaning was performed by 77.9% of respondents, 35.0% performed subgingival debridement, 41.9% treated peri-implant mucositis and 18.2% treated peri-implantitis. About 15% did not treat nor refer peri-implant disease, including significantly more non-implant providers and dentists without implant training. Maintenance armamentarium commonly included floss (76.3%), prophylaxis (73.9%), plastic curettes (43.3%) and stainless-steel ultrasonics (38.0%). Brushing (86.5%), flossing (73.9%) and interdental brush use (68.3%) were most commonly recommended. Implant OHI was repeated routinely by 57.4% of dentists who provided it. Dentists with greater implant training and experience were more likely to perform reviews and complex maintenance procedures. Conclusions: Peri-implant diagnostics performed, treatments provided and armamentarium varied among dentists. Implant providers and those with higher levels of training had more preventative approaches to implant OHI. Possible shortcomings in disease management and OHI reinforcement were identified.
MeSH term(s)	Dental Implants ; Dentists ; Humans ; Hygiene ; Peri-Implantitis/diagnosis ; Peri-Implantitis/prevention & control ; Toothbrushing
Chemical Substances	Dental Implants
Language	English
Publishing date	2021-03-03
Publishing country	Australia
Document type	Journal Article
ZDB-ID	603965-0
ISSN	1834-7819 ; 0045-0421
ISSN (online)	1834-7819
ISSN	0045-0421
DOI	10.1111/adj.12831
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Book ; Online: Machine learning in solar physics

Ramos, A. Asensio / Cheung, M. C. M. / Chifu, I. / Gafeira, R.

2023

Abstract: The application of machine learning in solar physics has the potential to greatly enhance our understanding of the complex processes that take place in the atmosphere of the Sun. By using techniques such as deep learning, we are now in the position to ... ...

Abstract	The application of machine learning in solar physics has the potential to greatly enhance our understanding of the complex processes that take place in the atmosphere of the Sun. By using techniques such as deep learning, we are now in the position to analyze large amounts of data from solar observations and identify patterns and trends that may not have been apparent using traditional methods. This can help us improve our understanding of explosive events like solar flares, which can have a strong effect on the Earth environment. Predicting hazardous events on Earth becomes crucial for our technological society. Machine learning can also improve our understanding of the inner workings of the sun itself by allowing us to go deeper into the data and to propose more complex models to explain them. Additionally, the use of machine learning can help to automate the analysis of solar data, reducing the need for manual labor and increasing the efficiency of research in this field. Comment: 100 pages, 13 figures, 286 references, accepted for publication as a Living Review in Solar Physics (LRSP)
Keywords	Astrophysics - Solar and Stellar Astrophysics ; Astrophysics - Instrumentation and Methods for Astrophysics ; Computer Science - Computer Vision and Pattern Recognition
Subject code	006
Publishing date	2023-06-27
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Implant education patterns and clinical practice of general dentists in Australia.

Cheung, M C / Hopcraft, M S / Darby, I B

Australian dental journal

2019 Volume 64, Issue 3, Page(s) 273–281

Abstract: Background: This study aimed to understand trends in dentists' implant training attendance and correlation to treatment provision. Implant-specific oral hygiene instruction coverage in training programs was investigated.: Methods: A cross-sectional ... ...

Abstract	Background: This study aimed to understand trends in dentists' implant training attendance and correlation to treatment provision. Implant-specific oral hygiene instruction coverage in training programs was investigated. Methods: A cross-sectional web-survey of dentists registered in Australia was conducted. Respondents were asked about their background, implant training history and treatment provision. Results were analysed by implant provision characteristics and graduation decade. Results: Three hundred and three responses from general dental practitioners (GDPs) were received and analysed. The highest implant training levels attained post-graduation were postgraduate non-specialist qualification (7.9% of respondents), continuing professional development (CPD) (73.6%) versus none (18.5%), with differences between implant providers and non-providers (P < 0.001), different graduation decades (P < 0.001) and those restoring implants or performing surgery as well (P < 0.001). University-based CPD was attended less than dental association/society or implant company CPD. Non-providers were significantly less likely to recall implant oral hygiene instruction sources (P < 0.001). Most GDPs (74.9%) provided implant services, with younger GDPs beginning earlier after graduation. About 16% of respondents did not provide implants once established career-wise. Conclusions: Dentists might be providing implant treatments increasingly earlier in their careers. Respondents with more training were significantly more likely to perform more complex procedures, while implant training attendance trends varied by graduation decade.
MeSH term(s)	Attitude of Health Personnel ; Australia ; Cross-Sectional Studies ; Dental Implants ; Dentists ; Endodontics/education ; General Practice, Dental ; Humans ; Practice Patterns, Dentists' ; Surveys and Questionnaires
Chemical Substances	Dental Implants
Language	English
Publishing date	2019-08-02
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603965-0
ISSN	1834-7819 ; 0045-0421
ISSN (online)	1834-7819
ISSN	0045-0421
DOI	10.1111/adj.12708
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Book ; Online: Solar wind prediction using deep learning

Upendran, Vishal / Cheung, M. C. M / Hanasoge, Shravan / Krishnamurthi, Ganapathi

2020

Abstract: Emanating from the base of the Sun's corona, the solar wind fills the interplanetary medium with a magnetized stream of charged particles whose interaction with the Earth's magnetosphere has space-weather consequences such as geomagnetic storms. ... ...

Abstract	Emanating from the base of the Sun's corona, the solar wind fills the interplanetary medium with a magnetized stream of charged particles whose interaction with the Earth's magnetosphere has space-weather consequences such as geomagnetic storms. Accurately predicting the solar wind through measurements of the spatio-temporally evolving conditions in the solar atmosphere is important but remains an unsolved problem in heliophysics and space-weather research. In this work, we use deep learning for prediction of solar wind (SW) properties. We use Extreme Ultraviolet images of the solar corona from space based observations to predict the SW speed from the NASA OMNIWEB dataset, measured at Lagragian point 1. We evaluate our model against autoregressive and naive models, and find that our model outperforms the benchmark models, obtaining a best-fit correlation of 0.55 $\pm$ 0.03 with the observed data. Upon visualization and investigation of how the model uses data to make predictions, we find higher activation at the coronal holes for fast wind prediction ($\approx$ 3 to 4 days prior to prediction), and at the active regions for slow wind prediction. These trends bear an uncanny similarity to the influence of regions potentially being the sources of fast and slow wind, as reported in literature. This suggests that our model was able to learn some of the salient associations between coronal and solar wind structure without built-in physics knowledge. Such an approach may help us discover hitherto unknown relationships in heliophysics datasets. Comment: 29 pages, 12 figures, accepted for publication in AGU: Spaceweather
Keywords	Astrophysics - Solar and Stellar Astrophysics
Subject code	551
Publishing date	2020-06-10
Publishing country	us
Document type	Book ; Online
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Article ; Online: Reimbursement recommendations for cancer drugs supported by phase II evidence in Canada.

Li, Y Y R / Mai, H / Trudeau, M E / Mittmann, N / Chiasson, K / Chan, K K W / Cheung, M C

Current oncology (Toronto, Ont.)

2020 Volume 27, Issue 5, Page(s) e495–e500

Abstract: Background: Phase ii data are increasingly being used as primary evidence for public reimbursement for oncologic drugs. We compared the frequency of reimbursement recommendations for phase ii and phase iii submissions and assessed for variables ... ...

Abstract	Background: Phase ii data are increasingly being used as primary evidence for public reimbursement for oncologic drugs. We compared the frequency of reimbursement recommendations for phase ii and phase iii submissions and assessed for variables associated with a positive or conditional recommendation. Methods: We identified submissions made to the pan-Canadian Oncology Drug Review's Expert Review Committee (perc), of the Canadian Agency for Drugs and Technologies in Health, July 2011 to July 2019, that were supported only by phase ii data. We identified variables within the perc's deliberative framework, including clinical and economic factors, associated with the final reimbursement recommendation. We conducted a multivariable analysis with logistic regression for these variables: feasibility of phase iii study, hematologic indication, and unmet need. Results: We identified 139 submissions with a perc final recommendation. In 27 instances (19%), the submission had only phase ii evidence, and a positive recommendation was issued for 63% of them (the positive recommendation rate was 82% for submissions with phase iii evidence). Clinical benefit ( Conclusions: Although more than half the oncologic submissions with phase ii data were recommended for public reimbursement, compared with submissions having phase iii data, they were less likely to be recommended. A positive or conditional recommendation was more likely if clinical benefit and alignment with patient values was demonstrated. The perc was less likely to recommend reimbursement for submissions with phase ii evidence if a phase iii trial was deemed possible.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Canada ; Clinical Trials, Phase II as Topic ; Cost-Benefit Analysis ; Drug Costs ; Humans ; Insurance, Health, Reimbursement ; Logistic Models ; Medical Oncology ; Neoplasms/drug therapy
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2020-10-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3747/co.27.6489
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Article ; Online: Conditional approval of cancer drugs in Canada: accountability and impact on public funding.

Andersen, S K / Penner, N / Chambers, A / Trudeau, M E / Chan, K K W / Cheung, M C

Current oncology (Toronto, Ont.)

2019 Volume 26, Issue 1, Page(s) e100–e105

Abstract: Background: We examined how conditional market approval of cancer pharmaceuticals by Health Canada (hc) affects public funding recommendations by the pan-Canadian Oncology Review (pcodr). We were also interested to see how often hc conditions are ... ...

Abstract	Background: We examined how conditional market approval of cancer pharmaceuticals by Health Canada (hc) affects public funding recommendations by the pan-Canadian Oncology Review (pcodr). We were also interested to see how often hc conditions are enforced. Methods: Health Canada and pcodr databases for 2010-2017 were analyzed for patterns in hc conditional authorization and post-authorization reviews of cancer drugs and for correlation with pcodr reimbursement recommendations. Results: Between 2010 and 2017, pcodr reviewed 105 unique drug-indication pairings; 21% ( Conclusions: One fifth of the cancer drugs reviewed for public reimbursement in Canada were conditionally authorized by hc based on preliminary data. Conditional authorization was associated with a recommendation against public funding by pcodr. No drugs had their conditional market authorization revoked for failure to meet conditions, suggesting that a more robust hc reappraisal framework is needed.
MeSH term(s)	Antineoplastic Agents/economics ; Canada ; Cost-Benefit Analysis/methods ; Humans ; Medical Oncology/economics ; Neoplasms/drug therapy ; Neoplasms/economics ; Social Responsibility
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2019-02-01
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3747/co.26.4397
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Article ; Online: Amino acid substitution L232F in non-structural protein 6 identified as a possible human-adaptive mutation in clade B MERS coronaviruses.

So, Ray T Y / Chu, Daniel K W / Hui, Kenrie P Y / Mok, Chris K P / Shum, Marcus H H / Sanyal, Sumana / Nicholls, John M / Ho, John C W / Cheung, Man-Chun / Ng, Ka-Chun / Yeung, Hin-Wo / Chan, Michael C W / Poon, Leo L M / Zhao, Jincun / Lam, Tommy T Y / Peiris, Malik

Journal of virology

2023 Volume 97, Issue 12, Page(s) e0136923

Abstract: Importance: Viral host adaptation plays an important role in inter-species transmission of coronaviruses and influenza viruses. Multiple human-adaptive mutations have been identified in influenza viruses but not so far in MERS-CoV that circulates widely ...

Abstract	Importance: Viral host adaptation plays an important role in inter-species transmission of coronaviruses and influenza viruses. Multiple human-adaptive mutations have been identified in influenza viruses but not so far in MERS-CoV that circulates widely in dromedary camels in the Arabian Peninsula leading to zoonotic transmission. Here, we analyzed clade B MERS-CoV sequences and identified an amino acid substitution L232F in nsp6 that repeatedly occurs in human MERS-CoV. Using a loss-of-function reverse genetics approach, we found the nsp6 L232F conferred increased viral replication competence
MeSH term(s)	Animals ; Humans ; Mice ; Amino Acid Substitution ; Camelus ; Coronavirus Infections/virology ; Middle East Respiratory Syndrome Coronavirus/genetics ; Mutation ; Viral Nonstructural Proteins/genetics
Chemical Substances	Viral Nonstructural Proteins
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01369-23
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Article: The experiences of cancer survivors while transitioning from tertiary to primary care.

Franco, B B / Dharmakulaseelan, L / McAndrew, A / Bae, S / Cheung, M C / Singh, S

Current oncology (Toronto, Ont.)

2016 Volume 23, Issue 6, Page(s) 378–385

Abstract: Purpose: In current fiscally constrained health care systems, the transition of cancer survivors to primary care from tertiary care settings is becoming more common and necessary. The purpose of our study was to explore the experiences of survivors who ... ...

Abstract	Purpose: In current fiscally constrained health care systems, the transition of cancer survivors to primary care from tertiary care settings is becoming more common and necessary. The purpose of our study was to explore the experiences of survivors who are transitioning from tertiary to primary care. Methods: One focus group and ten individual telephone interviews were conducted. Data saturation was reached with 13 participants. All sessions were audio-recorded, transcribed verbatim, and analyzed using a qualitative descriptive approach. Results: Eight categories relating to the main content category of transition readiness were identified in the analysis. Several factors affected participant transition readiness: how the transition was introduced, perceived continuity of care, support from health care providers, clarity of the timeline throughout the transition, and desire for a "roadmap." Although all participants spoke about the effect of their relationships with health care providers (tertiary, transition, and primary care), their relationship with the primary care provider had the most influence on their transition readiness. Conclusions: Our study provided insights into survivor experiences during the transition to primary care. Transition readiness of survivors is affected by many factors, with their relationship with the primary care provider being particularly influential. Understanding transition readiness from the survivor perspective could prove useful in ensuring patient-centred care as transitions from tertiary to primary care become commonplace.
Language	English
Publishing date	2016-12
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3747/co.23.3140
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Article ; Online: Granulocyte colony-stimulating factor in secondary prophylaxis for advanced-stage Hodgkin lymphoma treated with ABVD chemotherapy: a cost-effectiveness analysis.

Cheung, M C / Prica, A / Graczyk, J / Buckstein, R / Chan, K K W

Leukemia & lymphoma

2016 Volume 57, Issue 8, Page(s) 1865–1875

Abstract: Granulocyte colony-stimulating factor (G-CSF) is commonly administered to patients with Hodgkin lymphoma (HL) with neutropenia. We constructed a decision-analytic model to compare the cost-effectiveness of secondary prophylaxis with G-CSF to a strategy ... ...

Abstract	Granulocyte colony-stimulating factor (G-CSF) is commonly administered to patients with Hodgkin lymphoma (HL) with neutropenia. We constructed a decision-analytic model to compare the cost-effectiveness of secondary prophylaxis with G-CSF to a strategy of 'no G-CSF' in response to severe neutropenia for adults with advanced-stage HL treated with ABVD. A Canadian public health payer's perspective was considered and costs were presented in 2013 Canadian dollars. The quality-adjusted life years (QALYs) attained with the G-CSF and 'no G-CSF' strategies were 1.403 and 1.416, respectively. Costs for the strategies with and without G-CSF were $38,971 and $33,982, respectively. In the base case analysis, the 'no G-CSF' strategy was associated with cost savings and improved QALYs; therefore, 'no G-CSF' was the dominant approach. For patients with severe neutropenia during ABVD chemotherapy for advanced-stage HL, a strategy without G-CSF support is associated with improved quality-adjusted outcomes, cost savings, and is the preferred approach.
MeSH term(s)	Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bleomycin/therapeutic use ; Canada ; Chemotherapy-Induced Febrile Neutropenia/prevention & control ; Cohort Studies ; Cost-Benefit Analysis/methods ; Dacarbazine/therapeutic use ; Decision Support Systems, Clinical ; Doxorubicin/therapeutic use ; Granulocyte Colony-Stimulating Factor/economics ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Hodgkin Disease/drug therapy ; Hodgkin Disease/pathology ; Humans ; Markov Chains ; Neoplasm Staging ; Quality-Adjusted Life Years ; Secondary Prevention/economics ; Secondary Prevention/methods ; Treatment Outcome ; Vinblastine/therapeutic use
Chemical Substances	Bleomycin (11056-06-7) ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Vinblastine (5V9KLZ54CY) ; Dacarbazine (7GR28W0FJI) ; Doxorubicin (80168379AG)
Language	English
Publishing date	2016-01-12
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.3109/10428194.2015.1117609
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