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  1. Book ; Online ; E-Book: Rare sarcomas

    Chevreau, Christine / Italiano, Antoine

    2020  

    Author's details Christine Chevreau, Antoine Italiano editors
    Keywords Oncology   ; Pathology
    Language English
    Size 1 Online-Ressource(V, 164 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020479280
    ISBN 978-3-030-24697-6 ; 9783030246969 ; 3-030-24697-3 ; 3030246965
    DOI 10.1007/978-3-030-24697-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Brain metastases from germ cell tumor: time to reconsider radiotherapy?

    Khalifa, Jonathan / Fléchon, Aude / Chevreau, Christine

    Critical reviews in oncology/hematology

    2020  Volume 150, Page(s) 102946

    Abstract: The presence of brain metastases (BMs) from germ cell tumor (GCT) remains a rare situation. BMs predominantly occur among patients with testis primary tumor site, and are almost exclusively associated with non-seminomatous (NS) histologies. Two ... ...

    Abstract The presence of brain metastases (BMs) from germ cell tumor (GCT) remains a rare situation. BMs predominantly occur among patients with testis primary tumor site, and are almost exclusively associated with non-seminomatous (NS) histologies. Two situations must be distinguished, which differ in terms of clinical presentation, overall prognostic and management. At diagnosis, BMs are almost systematically associated with extra-cerebral metastases and the cornerstone of treatment is chemotherapy, while the role of local treatment remains controversial. In the metachronous setting, BMs more frequently constitute an isolated site of relapse, the outcome is poorer, and the role of local treatment is more consensual. However, all these data widely come from old reports, with outdated radiation techniques. The recent advances in radiation oncology, especially the rising use of stereotactic radiotherapy, could lead to the reconsideration of ancient dogmas regarding the "radiosensitivity" of (NS)GCT and the role of radiotherapy among patients with BMs.
    MeSH term(s) Brain Neoplasms/pathology ; Brain Neoplasms/surgery ; Humans ; Male ; Neoplasm Recurrence, Local ; Neoplasms, Germ Cell and Embryonal/pathology ; Neoplasms, Germ Cell and Embryonal/surgery ; Radiosurgery ; Retrospective Studies ; Testicular Neoplasms/pathology ; Testicular Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2020-04-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2020.102946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Management of tumor volume changes during preoperative radiotherapy for extremity soft tissue sarcoma

    De Lamarliere Marion Geneau / Lusque Amélie / Khalifa Justine Attal / Esteyrie Vincent / Chevreau Christine / Valentin Thibaud / Gangloff Dimitri / Meresse Thomas / Courtot Louis / Rochaix Philippe / Boulet Bérénice / Graulieres Eliane / Ducassou Anne

    Radiology and Oncology, Vol 57, Iss 4, Pp 507-

    a new strategy of adaptive radiotherapy

    2023  Volume 515

    Abstract: Using adaptive radiotherapy (ART), to determine objective clinical criteria that identify extremity soft tissue sarcoma (ESTS) patients requiring adaptation of their preoperative radiotherapy (RT) plan. ...

    Abstract Using adaptive radiotherapy (ART), to determine objective clinical criteria that identify extremity soft tissue sarcoma (ESTS) patients requiring adaptation of their preoperative radiotherapy (RT) plan.
    Keywords soft tissue sarcoma ; preoperative radiotherapy ; adaptive radiotherapy ; image guided radiotherapy ; volumes changes ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: EBUS-TBNA for the diagnosis of primary pulmonary artery sarcoma.

    Villeneuve, Thomas / Chevreau, Christine / Pontier, Sandrine / Prévot, Grégoire / Rochaix, Philippe / Courtade-Saidi, Monique / Guibert, Nicolas

    Respiratory medicine and research

    2022  Volume 83, Page(s) 100974

    MeSH term(s) Humans ; Pulmonary Artery/diagnostic imaging ; Lung Neoplasms/diagnostic imaging ; Endoscopic Ultrasound-Guided Fine Needle Aspiration ; Sarcoma/diagnostic imaging
    Language English
    Publishing date 2022-11-17
    Publishing country France
    Document type Letter
    ISSN 2590-0412
    ISSN (online) 2590-0412
    DOI 10.1016/j.resmer.2022.100974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Elbow flexion reconstruction after arm-sparing excision for high-grade triton sarcoma: a case report.

    Lupon, Elise / Chevreau, Christine / Lellouch, Alexandre Gaston / Gangloff, Dimitry / Meresse, Thomas

    Journal of medical case reports

    2020  Volume 14, Issue 1, Page(s) 103

    Abstract: Background: Soft tissue sarcomas affecting the root of an upper extremity raise the question of limb amputation depending on their location, size, and malignancy. Malignant triton tumors are a rare subtype of neurofibrosarcomas that have been poorly ... ...

    Abstract Background: Soft tissue sarcomas affecting the root of an upper extremity raise the question of limb amputation depending on their location, size, and malignancy. Malignant triton tumors are a rare subtype of neurofibrosarcomas that have been poorly reported in the literature. We report the case of a challenging reconstruction of the upper extremity using a pedicled latissimus dorsal flap.
    Case presentation: A 25-year-old Occidental man was referred to our sarcoma unit for the management of a large, high-grade malignant peripheral nerve sheath tumor with no regional or distant extension and very fast progression. He was treated first by concomitant neoadjuvant radiotherapy and chemotherapy. Carcinologic excision was performed "en bloc" including the skin, the tumor, and the flexor muscles of our patient's elbow. Coverage of the skin defect and elbow flexion restoration were achieved by using a homolateral pedicled musculocutaneous latissimus dorsi flap. Histological analysis showed an R0 resection. The reconstruction process recovered a complete bending of his elbow. He is still in remission at 26 months follow-up.
    Conclusions: A malignant triton tumor is a rare, aggressive, and high-grade sarcoma. It was successfully treated and this case report describes an effective treatment modality. Reconstructive surgery, allowing large, complete tumor removal, is indispensable after neoadjuvant chemotherapy and radiotherapy.
    MeSH term(s) Adult ; Elbow Joint/surgery ; Humans ; Limb Salvage/methods ; Male ; Nerve Sheath Neoplasms/surgery ; Sarcoma/therapy ; Superficial Back Muscles ; Surgical Flaps/transplantation
    Language English
    Publishing date 2020-07-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-020-02384-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Correction to: Elbow flexion reconstruction after arm-sparing excision for high-grade triton sarcoma: a case report.

    Lupon, Elise / Chevreau, Christine / Lellouch, Alexandre Gaston / Gangloff, Dimitry / Meresse, Thomas

    Journal of medical case reports

    2020  Volume 14, Issue 1, Page(s) 125

    Abstract: An amendment to this paper has been published and can be accessed via the original article. ...

    Abstract An amendment to this paper has been published and can be accessed via the original article.
    Language English
    Publishing date 2020-08-07
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-020-02477-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Refining the Characterization and Outcome of Pathological Complete Responders after Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer: Lessons from the Randomized Phase III VESPER (GETUG-AFU V05) Trial.

    Culine, Stéphane / Harter, Valentin / Krucker, Clémentine / Gravis, Gwenaelle / Fléchon, Aude / Chevreau, Christine / Mahammedi, Hakim / Laguerre, Brigitte / Guillot, Aline / Joly, Florence / Fontugne, Jacqueline / Allory, Yves / Pfister, Christian

    Cancers

    2023  Volume 15, Issue 6

    Abstract: Neoadjuvant cisplatin-based chemotherapy (NAC) followed by radical cystectomy and pelvic lymph node dissection is the optimal treatment for patients with muscle-invasive bladder cancer. In recent years, the VESPER trial showed a statistically significant ...

    Abstract Neoadjuvant cisplatin-based chemotherapy (NAC) followed by radical cystectomy and pelvic lymph node dissection is the optimal treatment for patients with muscle-invasive bladder cancer. In recent years, the VESPER trial showed a statistically significant higher progression-free survival with dd-MVAC (dose dense methotrexate, vinblastine, doxorubicin, and cisplatin) compared to GC (gemcitabine and cisplatin). In the present report, we refine the characterization and outcome of patients whose cystectomy specimens were pathologically free of cancer (pathological complete response, pCR). We confirm that these patients portend a better outcome as compared to patients with invasive disease (≥pT1N0) at cystectomy. Nested variant and lymphovascular invasion were identified as adverse predictive factors of pCR. Progression-free survival probability three years after pCR on cystectomy was about 85%, regardless of the NAC regimen. A lower creatinine clearance and the delivery of less than four cycles were associated with a higher risk of relapse. Predicting the efficacy of NAC remains a major challenge. The planned analysis of molecular subtypes in the VESPER trial could help predict which patients may achieve complete response and better outcome.
    Language English
    Publishing date 2023-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15061742
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  8. Article: Consolidative Radiotherapy for Metastatic Urothelial Bladder Cancer Patients with No Progression and with No More than Five Residual Metastatic Lesions Following First-Line Systemic Therapy: A Retrospective Analysis.

    Aboudaram, Amélie / Chaltiel, Léonor / Pouessel, Damien / Graff-Cailleaud, Pierre / Benziane-Ouaritini, Nicolas / Sargos, Paul / Schick, Ulrike / Créhange, Gilles / Cohen-Jonathan Moyal, Elizabeth / Chevreau, Christine / Khalifa, Jonathan

    Cancers

    2023  Volume 15, Issue 4

    Abstract: Local consolidative radiotherapy in the treatment of metastatic malignancies has shown promising results in several types of tumors. The objective of this study was to assess consolidative radiotherapy to the bladder and to residual metastases in ... ...

    Abstract Local consolidative radiotherapy in the treatment of metastatic malignancies has shown promising results in several types of tumors. The objective of this study was to assess consolidative radiotherapy to the bladder and to residual metastases in metastatic urothelial bladder cancer with no progression following first-line systemic therapy.
    Materials/methods: Patients who received first-line therapy for the treatment of metastatic urothelial bladder cancer (mUBC) and who were progression-free following treatment with no more than five residual metastases were retrospectively identified through the database of four Comprehensive Cancer Centers, between January 2005 and December 2018. Among them, patients who received subsequent definitive radiotherapy (of EQD2Gy > 45Gy) to the bladder and residual metastases were included in the consolidative group (irradiated (IR) group), and the other patients were included in the observation group (NIR group). Progression-free survival (PFS) and overall survival (OS) were determined from the start of the first-line chemotherapy using the Kaplan-Meier method. To prevent immortal time bias, a Cox model with time-dependent covariates and 6-month landmark analyses were performed to examine OS and PFS.
    Results: A total of 91 patients with at least stable disease following first-line therapy and with no more than five residual metastases were analyzed: 51 in the IR group and 40 in the NIR group. Metachronous metastatic disease was more frequent in the NIR group (19% vs. 5%,
    Conclusion: Consolidative radiotherapy for mUBC patients who have not progressed after first-line therapy and with limited residual disease seems to confer both OS and PFS benefits. The role of consolidative radiotherapy in the context of avelumab maintenance should be addressed prospectively.
    Language English
    Publishing date 2023-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15041161
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  9. Article ; Online: Abrupt development of Dupuytren's contractures with the BRAF inhibitor vemurafenib.

    Sibaud, Vincent / Chevreau, Christine

    Joint bone spine

    2014  Volume 81, Issue 4, Page(s) 373–374

    MeSH term(s) Aged ; Antineoplastic Agents/adverse effects ; Dupuytren Contracture/chemically induced ; Humans ; Indoles/adverse effects ; Male ; Melanoma/drug therapy ; Melanoma/genetics ; Mutation ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; Proto-Oncogene Proteins B-raf/genetics ; Skin Neoplasms/drug therapy ; Skin Neoplasms/genetics ; Sulfonamides/adverse effects ; Vemurafenib
    Chemical Substances Antineoplastic Agents ; Indoles ; Sulfonamides ; Vemurafenib (207SMY3FQT) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language English
    Publishing date 2014-01-24
    Publishing country France
    Document type Case Reports ; Letter
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2013.12.009
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    Zs.A 4590: Show issues Location:
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  10. Article ; Online: Special features of sarcomas developed in patients with Lynch syndrome: A systematic review.

    Poumeaud, François / Valentin, Thibaud / Vande Perre, Pierre / Jaffrelot, Marion / Bonnet, Delphine / Chibon, Frédéric / Chevreau, Christine / Selves, Janick / Guimbaud, Rosine / Fares, Nadim

    Critical reviews in oncology/hematology

    2023  Volume 188, Page(s) 104055

    Abstract: Lynch syndrome (LS) is a genetic predisposition leading to colorectal and non-colorectal tumors such as endometrial, upper urinary tract, small intestine, ovarian, gastric, biliary duct cancers and glioblastoma. Though not classically associated with LS, ...

    Abstract Lynch syndrome (LS) is a genetic predisposition leading to colorectal and non-colorectal tumors such as endometrial, upper urinary tract, small intestine, ovarian, gastric, biliary duct cancers and glioblastoma. Though not classically associated with LS, growing literature suggests that sarcomas might develop in patients with LS. This systematic review of literature identified 44 studies (N = 95) of LS patients who developed sarcomas. It seems that most sarcomas developed in patients with a germline mutation of MSH2 (57 %) exhibit a dMMR (81 %) or MSI (77 %) phenotype, as in other LS-tumors. Although undifferentiated pleomorphic sarcoma (UPS), leiomyosarcoma, and liposarcoma remain the most represented histologic subtype, a higher proportion of rhabdomyosarcoma (10 %, especially pleomorphic rhabdomyosarcoma) is reported. Further studies are required to better characterize this sub-population.
    MeSH term(s) Humans ; Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/pathology ; Colorectal Neoplasms/pathology ; Genetic Predisposition to Disease ; Germ-Line Mutation ; Sarcoma/diagnosis ; Sarcoma/epidemiology ; Sarcoma/etiology ; Rhabdomyosarcoma ; DNA Mismatch Repair ; Microsatellite Instability
    Language English
    Publishing date 2023-06-08
    Publishing country Netherlands
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2023.104055
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