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  1. Article: Clinical outcome of bacterial endogenous endophthalmitis in 15 patients.

    Goenadi, Catherina J / Chew, Kean Lee / Gopal, Lingam / Chen, David Z

    Annals of the Academy of Medicine, Singapore

    2023  Volume 52, Issue 1, Page(s) 44–47

    MeSH term(s) Humans ; Endophthalmitis/drug therapy ; Endophthalmitis/microbiology ; Eye Infections, Bacterial/drug therapy ; Eye Infections, Bacterial/microbiology ; Anti-Bacterial Agents/therapeutic use ; Retrospective Studies
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-02-01
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 604527-3
    ISSN 0304-4602
    ISSN 0304-4602
    DOI 10.47102/annals-acadmedsg.2022407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2420: Show issues Location:
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  2. Article ; Online: Acinetobacter ursingii masquerading as Gram-positive cocci.

    Chew, Ka Lip / Chew, Kean Lee

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2018  Volume 24, Issue 8, Page(s) 856–857

    MeSH term(s) Acinetobacter/classification ; Acinetobacter Infections/diagnosis ; Acinetobacter Infections/etiology ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Gentian Violet ; Gram-Positive Cocci/classification ; Humans ; Leukemia, Myeloid, Acute/complications ; Leukemia, Myeloid, Acute/drug therapy ; Middle Aged ; Phenazines
    Chemical Substances Gram's stain ; Phenazines ; Gentian Violet (J4Z741D6O5)
    Language English
    Publishing date 2018-04-24
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2018.04.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4541: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 284: Show issues

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  3. Article ; Online: Muyocopron laterale: invasive human infection of a plant pathogen in an immunocompromised host.

    Lye, Priscillia / Cheng, Janet / Lum, Lionel / Chew, Kean Lee / Teo, Jeanette / Chew, Ka Lip

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2022  Volume 28, Issue 10, Page(s) 1351–1352

    MeSH term(s) Ascomycota ; Humans ; Immunocompromised Host
    Language English
    Publishing date 2022-01-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2022.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4541: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 284: Show issues

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  4. Article ; Online: Sensititre broth microdilution plates variation in colistin quality control minimum inhibitory concentration results.

    Chew, Ka Lip / Low, Clayton / Achik, Rosemini / Jureen, Roland / Chew, Kean Lee

    Pathology

    2021  Volume 54, Issue 5, Page(s) 662–664

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Colistin/pharmacology ; Humans ; Microbial Sensitivity Tests ; Quality Control
    Chemical Substances Anti-Bacterial Agents ; Colistin (Z67X93HJG1)
    Language English
    Publishing date 2021-11-22
    Publishing country England
    Document type Letter
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2021.08.016
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 723: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Volvariella volvacea brain Abscess in an immunocompromised host-An emerging fungal pathogen in Asia.

    Alagha, Rawan / Tham, Sai Meng / Chew, Kean Lee / Cheng, Janet Weng Sze / Lian, Derrick WenQuan / Vathsala, Anantharaman / Lum, Lionel Hon Wai

    Journal de mycologie medicale

    2022  Volume 32, Issue 3, Page(s) 101272

    Abstract: Volvariella volvacea is a fungus found in tropical regions, commonly associated with straw mushrooms. This is a 50-year-old Singaporean female post living donor renal transplant who presented with fever, cough and headache. She was diagnosed to have ... ...

    Abstract Volvariella volvacea is a fungus found in tropical regions, commonly associated with straw mushrooms. This is a 50-year-old Singaporean female post living donor renal transplant who presented with fever, cough and headache. She was diagnosed to have Volvariella volvacea brain abscess. She was treated with combination anti-fungal therapy without surgical debridement and remains stable. The pathogenicity of this rare fungus in immunocompromised hosts is demonstrated here and is of significance particularly in Asia where ingestion of straw mushrooms may be a risk factor for invasive fungal disease.
    MeSH term(s) Agaricales ; Brain Abscess/drug therapy ; Female ; Humans ; Immunocompromised Host ; Middle Aged ; Volvariella
    Language English
    Publishing date 2022-03-04
    Publishing country France
    Document type Case Reports
    ZDB-ID 1067006-3
    ISSN 1773-0449 ; 1156-5233
    ISSN (online) 1773-0449
    ISSN 1156-5233
    DOI 10.1016/j.mycmed.2022.101272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Non-Tuberculous Mycobacterial Cervicofacial Lymphadenitis in Children-10-Year Experience in a Tertiary Pediatric Center.

    Leow, Olivia / Aoyama, Rie / Loh, Woei Shyang / Shih, E'Ching / Tay, Sok Yan / Chew, Ka Lip / Chew, Kean Lee / Shen, Liang / Chan, Si Min

    Journal of the Pediatric Infectious Diseases Society

    2023  Volume 12, Issue 7, Page(s) 406–412

    Abstract: Background: Lymphadenitis is the most common manifestation of non-tuberculous mycobacteria (NTM) infection in children. We describe the epidemiology and clinical characteristics of NTM lymphadenitis, determine diagnostic yield from tissue sampling, and ... ...

    Abstract Background: Lymphadenitis is the most common manifestation of non-tuberculous mycobacteria (NTM) infection in children. We describe the epidemiology and clinical characteristics of NTM lymphadenitis, determine diagnostic yield from tissue sampling, and review management and outcomes.
    Methods: This was a 10-year retrospective review of children aged 0-16 years diagnosed with NTM cervicofacial lymphadenitis who were seen in a pediatric infectious disease clinic in a tertiary public hospital. Data relating to patient demographics, clinical features, surgical and antimicrobial treatment, complications, and outcomes were retrieved from patients' electronic medical records and analyzed.
    Results: There were 48 episodes of NTM cervicofacial lymphadenitis in 45 children (17 males and 28 females). Of these episodes, 43.7% manifested as a unilateral single node, mostly parotid (39.6%) and submandibular (29.2%). All patients underwent diagnostic fine-needle aspiration or surgery. Surgical excision more frequently yielded positive histological findings (P = .016). NTM was identified in 22/48 episodes (45.8%) via culture or molecular sequencing. Mycobacterium abscessus was most commonly found (47.8%). Thirty-eight children (79.2%) received antibiotics. Outcomes in 43 episodes revealed full resolution in 69.8%, while 25.6% had de novo disease and 4.6% experienced recurrence at the same site. Overlying skin changes and multiple or bilateral nodal diseases were significantly associated with de novo disease or recurrence (P = .034 and .084, respectively). Complications occurred in 11/70 (15.7%) procedures. Antibiotic-associated adverse effects occurred in 14/38 (36.8%) episodes.
    Conclusions: NTM lymphadenitis remains a challenging condition. More aggressive management with surgical excision and antibiotics is recommended for those with overlying skin changes and extensive nodal disease.
    MeSH term(s) Male ; Female ; Child ; Humans ; Infant ; Nontuberculous Mycobacteria ; Mycobacterium Infections, Nontuberculous/diagnosis ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/epidemiology ; Neck ; Lymphadenitis/epidemiology ; Lymphadenitis/drug therapy ; Lymphadenitis/microbiology ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piad043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: High-Throughput Mutagenesis and Cross-Complementation Experiments Reveal Substrate Preference and Critical Residues of the Capsule Transporters in

    Chua, Wan-Zhen / Maiwald, Matthias / Chew, Kean Lee / Lin, Raymond Tzer-Pin / Zheng, Sanduo / Sham, Lok-To

    mBio

    2021  Volume 12, Issue 6, Page(s) e0261521

    Abstract: MOP (Multidrug/Oligosaccharidyl-lipid/Polysaccharide) family transporters are found in almost all life forms. They are responsible for transporting lipid-linked precursors across the cell membrane to support the synthesis of various glycoconjugates. ... ...

    Abstract MOP (Multidrug/Oligosaccharidyl-lipid/Polysaccharide) family transporters are found in almost all life forms. They are responsible for transporting lipid-linked precursors across the cell membrane to support the synthesis of various glycoconjugates. While significant progress has been made in elucidating their transport mechanism, how these transporters select their substrates remains unclear. Here, we systematically tested the MOP transporters in the Streptococcus pneumoniae capsule pathway for their ability to translocate noncognate capsule precursors. Sequence similarity cannot predict whether these transporters are interchangeable. We showed that subtle changes in the central aqueous cavity of the transporter are sufficient to accommodate a different cargo. These changes can occur naturally, suggesting a potential mechanism of expanding substrate selectivity. A directed evolution experiment was performed to identify gain-of-function variants that translocate a noncognate cargo. Coupled with a high-throughput mutagenesis and sequencing (Mut-seq) experiment, residues that are functionally important for the capsule transporter were revealed. Lastly, we showed that the expression of a flippase that can transport unfinished precursors resulted in an increased susceptibility to bacitracin and mild cell shape defects, which may be a driving force to maintain transporter specificity.
    MeSH term(s) Amino Acid Motifs ; Bacterial Capsules/genetics ; Bacterial Capsules/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Genetic Complementation Test ; High-Throughput Nucleotide Sequencing ; Membrane Transport Proteins/chemistry ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Mutagenesis ; Streptococcus pneumoniae/chemistry ; Streptococcus pneumoniae/genetics ; Streptococcus pneumoniae/metabolism
    Chemical Substances Bacterial Proteins ; Membrane Transport Proteins
    Language English
    Publishing date 2021-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.02615-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Whole Genome Sequencing Shows Genetic Diversity, as Well as Clonal Complex and Gene Polymorphisms Associated with Fluconazole Non-Susceptible Isolates of

    Keighley, Caitlin / Gall, Mailie / van Hal, Sebastiaan J / Halliday, Catriona L / Chai, Louis Yi Ann / Chew, Kean Lee / Biswas, Chayanika / Slavin, Monica A / Meyer, Wieland / Sintchenko, Vitali / Chen, Sharon C A

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 9

    Abstract: Resistance to azoles in Candida tropicalis is increasing and may be mediated by genetic characteristics. Using whole genome sequencing (WGS), we examined the genetic diversity of 82 bloodstream C. tropicalis isolates from two countries and one ATCC ... ...

    Abstract Resistance to azoles in Candida tropicalis is increasing and may be mediated by genetic characteristics. Using whole genome sequencing (WGS), we examined the genetic diversity of 82 bloodstream C. tropicalis isolates from two countries and one ATCC strain in a global context. Multilocus sequence typing (MLST) and single nucleotide polymorphism (SNP)-based phylogenies were generated. Minimum inhibitory concentrations (MIC) for antifungal agents were determined using Sensititre YeastOne YO10. Eleven (13.2%) isolates were fluconazole-resistant and 17 (20.5%) were classified as fluconazole-non susceptible (FNS). Together with four Canadian isolates, the genomes of 12 fluconazole-resistant (18 FNS) and 69 fluconazole-susceptible strains were examined for gene mutations associated with drug resistance. Fluconazole-resistant isolates contained a mean of 56 non-synonymous SNPs per isolate in contrast to 36 SNPs in fluconazole-susceptible isolates (interquartile range [IQR] 46−59 vs. 31−48 respectively; p < 0.001). Ten of 18 FNS isolates contained missense ERG11 mutations (amino acid substitutions S154F, Y132F, Y257H). Two echinocandin-non susceptible isolates had homozygous FKS1 mutations (S30P). MLST identified high genetic diversity with 61 diploid sequence types (DSTs), including 53 new DSTs. All four isolates in DST 773 were fluconazole-resistant within clonal complex 2. WGS showed high genetic variation in invasive C. tropicalis; azole resistance was distributed across different lineages but with DST 773 associated with in vitro fluconazole resistance.
    Language English
    Publishing date 2022-08-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8090896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Shared signatures and divergence in skin microbiomes of children with atopic dermatitis and their caregivers.

    Chia, Minghao / Naim, Ahmad N M / Tay, Angeline S L / Lim, Karmun / Chew, Kean Lee / Yow, See Jie / Chen, John / Common, John E A / Nagarajan, Niranjan / Tham, Elizabeth Huiwen

    The Journal of allergy and clinical immunology

    2022  Volume 150, Issue 4, Page(s) 894–908

    Abstract: Background: Atopic dermatitis (AD) is a common chronic skin condition in children (15-20%) that can significantly impair their quality of life. As a result of its relapsing nature and enrichment of Staphylococcus aureus during flares, clinical ... ...

    Abstract Background: Atopic dermatitis (AD) is a common chronic skin condition in children (15-20%) that can significantly impair their quality of life. As a result of its relapsing nature and enrichment of Staphylococcus aureus during flares, clinical management can include eradicating S aureus from the skin of children; however, this does not extend to their healthy caregivers, who are potential reservoirs.
    Objective: Our aim was to understand skin microbiome sharing and microbial features in children with AD and their healthy adult caregivers.
    Methods: We utilized whole-metagenome profiling at 4 body sites (volar forearm, antecubital fossae, cheeks, and lesions) in combination with sequencing of S aureus isolates to characterize a cohort of children with AD and their healthy caregivers (n = 30 families) compared to matched pairs from control households (n = 30 families).
    Results: Metagenomic analysis revealed distinct microbiome configurations in the nonlesional skin of AD children and their healthy caregivers versus controls, which were sufficient to accurately predict case-control status (area under the receiver operating characteristic curve > 0.8). These differences were accompanied by significant microbiome similarity between children and their caregivers, indicating that microbiome sharing may play a role in recurrent disease flares. Whole-genome comparisons with high-quality S aureus isolate genomes (n = 55) confirmed significant strain sharing between AD children and their caregivers and AD-specific enrichment of strains expressing enterotoxins Q and K/K2.
    Conclusion: Our results highlight the distinctive skin microbiome features of healthy caregivers for children with AD and support their inclusion in strategies for the treatment of recurrent pediatric AD.
    MeSH term(s) Adult ; Caregivers ; Child ; Dermatitis, Atopic/pathology ; Enterotoxins ; Humans ; Microbiota ; Neoplasm Recurrence, Local ; Quality of Life ; Skin/pathology ; Staphylococcus aureus
    Chemical Substances Enterotoxins
    Language English
    Publishing date 2022-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.01.031
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  10. Article ; Online: Author Correction: The higher prevalence of extended spectrum beta-lactamases among Escherichia coli ST131 in Southeast Asia is driven by expansion of a single, locally prevalent subclone.

    Chen, Swaine L / Ding, Ying / Apisarnthanarak, Anucha / Kalimuddin, Shirin / Archuleta, Sophia / Omar, Sharifah Faridah Syed / De, Partha Pratim / Koh, Tse Hsien / Chew, Kean Lee / Atiya, Nadia / Suwantarat, Nuntra / Velayuthan, Rukumani Devi / Wong, Joshua Guo Xian / Lye, David C

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 8563

    Language English
    Publishing date 2021-04-14
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-87312-w
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