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  1. Article ; Online: Cost-effectiveness of detection of peri-operative myocardial injury: Beat to the punch or jumping the gun?

    Chew, Michelle S / Longrois, Dan

    European journal of anaesthesiology

    2023  Volume 40, Issue 12, Page(s) 886–887

    MeSH term(s) Humans ; Cost-Benefit Analysis ; Myocardium ; Cost-Effectiveness Analysis
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 605770-6
    ISSN 1365-2346 ; 0265-0215
    ISSN (online) 1365-2346
    ISSN 0265-0215
    DOI 10.1097/EJA.0000000000001852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comments on 'Cardiac arrest during the perioperative period': A consensus guideline for identification, treatment and prevention from the European Society of Anaesthesiology and Intensive Care and the European Society of Trauma and Emergency Surgery.

    Longrois, Dan / Chew, Michelle S

    European journal of anaesthesiology

    2023  Volume 40, Issue 10, Page(s) 719–720

    MeSH term(s) Humans ; Anesthesiology ; Perioperative Period ; Critical Care ; Heart Arrest/diagnosis ; Heart Arrest/etiology ; Heart Arrest/prevention & control
    Language English
    Publishing date 2023-09-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 605770-6
    ISSN 1365-2346 ; 0265-0215
    ISSN (online) 1365-2346
    ISSN 0265-0215
    DOI 10.1097/EJA.0000000000001820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A global perspective on acute kidney injury after major surgery: much needed insights and sobering results.

    Saugel, Bernd / Hoste, Eric / Chew, Michelle S

    Intensive care medicine

    2023  Volume 49, Issue 12, Page(s) 1508–1510

    MeSH term(s) Humans ; Risk Factors ; Postoperative Complications/etiology ; Acute Kidney Injury/etiology ; Retrospective Studies
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Editorial
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07250-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Echocardiography in shock.

    Chew, Michelle S / Aissaoui, Nadia / Balik, Martin

    Current opinion in critical care

    2023  Volume 29, Issue 3, Page(s) 252–258

    Abstract: Purpose of review: The aim of this study was to illustrate the varying roles of echocardiography in all phases of shock ranging from a rapid, diagnostic tool at the bedside, to a tool for monitoring the adequacy and effects of shock treatment and ... ...

    Abstract Purpose of review: The aim of this study was to illustrate the varying roles of echocardiography in all phases of shock ranging from a rapid, diagnostic tool at the bedside, to a tool for monitoring the adequacy and effects of shock treatment and finally for identification of patients suitable for de-escalation of therapy.
    Recent findings: Echocardiography has become an indispensable tool for establishing diagnosis in patients with shock. It is also important for assessing the adequacy of treatment such as fluid resuscitation, vasopressors and inotropes by providing integrated information on cardiac contractility and systemic flow conditions, particularly when used in conjunction with other methods of advanced haemodynamic monitoring. Apart from a traditional, diagnostic role, it may be used as an advanced, albeit intermittent, monitoring tool. Examples include the assessment of heart-lung interactions in mechanically ventilated patients, fluid responsiveness, vasopressor adequacy, preload dependence in ventilator-induced pulmonary oedema and indications for and monitoring during extracorporeal life support. Emerging studies also illustrate the role of echocardiography in de-escalation of shock treatment.
    Summary: This study provides the reader with a structured review on the uses of echocardiography in all phases of shock treatment.
    MeSH term(s) Humans ; Echocardiography ; Shock/diagnostic imaging ; Shock/therapy ; Heart ; Fluid Therapy ; Vasoconstrictor Agents/therapeutic use ; Hemodynamics
    Chemical Substances Vasoconstrictor Agents
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Myocardial injury after noncardiac surgery: facts, fallacies and how to approach clinically.

    Chew, Michelle S / Puelacher, Christian

    Current opinion in critical care

    2021  Volume 27, Issue 6, Page(s) 670–675

    Abstract: Purpose of review: Acute myocardial injury occurs commonly during perioperative care. There is still considerable confusion regarding its diagnosis and definition, and a lack of consensus on who and how to screen, exacerbated by a lack of studies ... ...

    Abstract Purpose of review: Acute myocardial injury occurs commonly during perioperative care. There is still considerable confusion regarding its diagnosis and definition, and a lack of consensus on who and how to screen, exacerbated by a lack of studies addressing how to manage patients with detected myocardial injury.
    Recent findings: Far from a benign biochemical anomaly, myocardial injury occurring perioperatively is largely a silent disease and is not necessarily because of ischaemia. Preoperative, postoperative, and perioperative changes in cardiac troponins (cTns) are independently associated with increased mortality and adverse cardiovascular outcomes. Routine screening with cTns is required for reliable detection of myocardial injury. Measurement of changes (from preoperative to postoperative) will detect acute events as well as identify patients with chronic troponin increases.
    Summary: This review aims to bring together current literature regarding myocardial injury that is detected perioperatively, identifies knowledge gaps for future research and provides suggestions for management.
    MeSH term(s) Biomarkers ; Humans ; Myocardial Ischemia/etiology ; Perioperative Care ; Postoperative Complications/etiology ; Postoperative Period ; Troponin
    Chemical Substances Biomarkers ; Troponin
    Language English
    Publishing date 2021-09-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Notes from afar: reflections from two Australian intensivists in Sweden during the COVID-19 pandemic.

    Chew, Michelle S / Halliday, Thomas

    The Medical journal of Australia

    2021  Volume 214, Issue 5, Page(s) 235–235.e1

    MeSH term(s) Australia ; COVID-19 ; Communicable Disease Control/organization & administration ; Critical Care/organization & administration ; Cross Infection/prevention & control ; Disease Management ; Epidemiological Monitoring ; Humans ; Infection Control/organization & administration ; Interprofessional Relations ; Risk Assessment ; Sweden
    Language English
    Publishing date 2021-02-19
    Publishing country Australia
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.50949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Outcomes following perioperative red blood cell transfusion in patients undergoing elective major abdominal surgery: a systematic review and meta-analysis.

    Morris, Fraser J D / Fung, Yoke-Lin / Craswell, Alison / Chew, Michelle S

    British journal of anaesthesia

    2023  Volume 131, Issue 6, Page(s) 1002–1013

    Abstract: Background: Perioperative red blood cell transfusion is a double-edged sword for surgical patients. While transfusion of red cells can increase oxygen delivery by increasing haemoglobin levels, its impact on short- and long-term postoperative outcomes, ... ...

    Abstract Background: Perioperative red blood cell transfusion is a double-edged sword for surgical patients. While transfusion of red cells can increase oxygen delivery by increasing haemoglobin levels, its impact on short- and long-term postoperative outcomes, particularly in patients undergoing elective major abdominal surgery, is unclear.
    Methods: We conducted a systematic review and meta-analysis on the effect of perioperative blood transfusions on postoperative outcomes in elective major abdominal surgery. PubMed, Cochrane, and Scopus databases were searched for studies with data collected between January 1, 2000 and June 6, 2020. The primary outcome was short-term mortality, including all-cause 30-day or in-hospital mortality. Secondary outcomes included long-term all-cause mortality, any morbidity, infectious complications, overall survival, and recurrence-free survival. No randomised controlled trials were found. Thirty-nine observational studies were identified, of which 37 were included in the meta-analysis.
    Results: Perioperative blood transfusion was associated with short-term all-cause mortality (odds ratio [OR] 2.72, 95% confidence interval [CI] 1.89-3.91, P<0.001), long-term all-cause mortality (hazard ratio 1.35, 95% CI 1.09-1.67, P=0.007), any morbidity (OR 2.18, 95% CI 1.81-2.64, P<0.001), and infectious complications (OR 1.90, 95% CI 1.60-2.26, P<0.001). Perioperative blood transfusion remained associated with short-term mortality in the sensitivity analysis after excluding studies that did not control for preoperative anaemia (OR 2.27, 95% CI 1.59-3.24, P<0.001).
    Conclusions: Perioperative blood transfusion in patients undergoing elective major abdominal surgery is associated with poorer short- and long-term postoperative outcomes. This highlights the need to implement patient blood management strategies to manage and preserve the patient's own blood and reduce the need for red blood cell transfusion.
    Trial registration: PROSPERO (CRD42021254360).
    MeSH term(s) Humans ; Erythrocyte Transfusion/adverse effects ; Anemia ; Blood Transfusion ; Elective Surgical Procedures ; Hospital Mortality
    Language English
    Publishing date 2023-09-21
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2023.08.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Discrimination in an "equal country"-a survey amongst Swedish final-year medical students.

    Velin, Lotta / Chew, Michelle S / Pompermaier, Laura

    BMC medical education

    2022  Volume 22, Issue 1, Page(s) 503

    Abstract: Background: Discrimination due to gender and ethnicity has been found to be widespread in medicine and healthcare. Swedish and European legislation list seven discrimination grounds (age, sex, ethnicity, religion, sexuality, non-binary gender identity, ... ...

    Abstract Background: Discrimination due to gender and ethnicity has been found to be widespread in medicine and healthcare. Swedish and European legislation list seven discrimination grounds (age, sex, ethnicity, religion, sexuality, non-binary gender identity, and disability) which may intersect with each other; yet these have only been sparsely researched. The aim of this study was to assess the extent of discrimination, based on these seven discrimination grounds, amongst final-year medical students in Sweden.
    Methods: A web-based survey, based on the CHERRIES-checklist, was disseminated to course coordinators and program directors in charge of final year medical students at all seven medical schools in Sweden. Quantitative data were analyzed using descriptive statistics, Fisher's exact test, and logistic regression. Free-text answers were analyzed thematically using the "Master Suppression techniques" conceptual framework.
    Results: Of the 1298 medical students contacted, 247 (19%) took part in the survey. Almost half (n = 103, 42%) had experienced some form of discrimination, and this difference was statistically significant by gender (p = 0.012), self-perceived ethnicity (p < 0.001), country of birth other than Scandinavia (p < 0.001) and visible religious signs (p = 0.037). The most common type of discrimination was gender-based (in 83% of students who had experienced discrimination), followed by age (48%), and ethnicity (42%). In the logistic regression, women/non-binary gender (p = 0.001, OR 2.44 [95% CI 1.41-4.22]), country of birth not in Scandinavia (p < 0.001, OR 8.05 [2.69-24.03]), non-Caucasian ethnicity (p = 0.04, OR 2.70 [1.39-5.27]), and disability (p = 0.02, OR 13.8 [1.58-12040]) were independently associated with discrimination. Half of those who had experienced religion-based discrimination and nearly one-third of victims of ethnicity-based discrimination reported "large" or "extreme" impact of this. Clinical staff or supervisors were the most common offenders (34%), closely followed by patients and their relatives (30%), with non-Caucasian respondents significantly more likely to experience discrimination by patients (p < 0.001).
    Conclusions: Discrimination appears to be frequent in medical school, even in one of the world's "most equal countries". Discrimination is most commonly gender- or ethnicity-based, with ethnicity- and religion-based discrimination appearing to have the largest impact. Future research should continue to evaluate discrimination from an intersectional perspective, adapted for local contexts and legislations.
    MeSH term(s) Ethnicity ; Female ; Gender Identity ; Humans ; Male ; Schools, Medical ; Sexism ; Social Discrimination/psychology ; Stereotyping ; Students, Medical/psychology ; Surveys and Questionnaires ; Sweden
    Language English
    Publishing date 2022-06-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2044473-4
    ISSN 1472-6920 ; 1472-6920
    ISSN (online) 1472-6920
    ISSN 1472-6920
    DOI 10.1186/s12909-022-03558-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Perioperative troponin surveillance in major noncardiac surgery: a narrative review.

    Chew, Michelle S / Saugel, Bernd / Lurati-Buse, Giovanna

    British journal of anaesthesia

    2022  

    Abstract: Myocardial injury is now an acknowledged complication in patients undergoing noncardiac surgery. Heterogeneity in the definitions of myocardial injury contributes to difficulty in evaluating the value of cardiac troponins (cTns) measurement in ... ...

    Abstract Myocardial injury is now an acknowledged complication in patients undergoing noncardiac surgery. Heterogeneity in the definitions of myocardial injury contributes to difficulty in evaluating the value of cardiac troponins (cTns) measurement in perioperative care. Pre-, post-, and peri-operatively increased cTns are encompassed by the umbrella term 'myocardial injury' and are likely to reflect different pathophysiological mechanisms. Increased cTns are independently associated with cardiovascular and non-cardiovascular complications, poor short-term and long-term cardiovascular outcomes, and increased mortality. Preoperative measurement of cTns aids preoperative risk stratification beyond the Revised Cardiac Risk Index. Systematic measurement detects acute perioperative increases and allows early identification of acute myocardial injury. Common definitions and standards for reporting are a prerequisite for designing impactful future trials and perioperative management strategies.
    Language English
    Publishing date 2022-12-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2022.08.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cardiac Biomarkers to Assess Perioperative Myocardial Injury in Noncardiac Surgery Patients: Tools or Toys?

    Foëx, Pierre / Chew, Michelle S / De Hert, Stefan

    Anesthesia and analgesia

    2022  Volume 134, Issue 2, Page(s) 253–256

    MeSH term(s) Biomarkers ; Humans ; Myocardial Ischemia ; Myocardium
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-01-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000005788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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