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  1. AU="Chhavarath Dary"
  2. AU=Kimberley Fiona C
  3. AU="Solís, José Gabriel"
  4. AU="Becker, Maximilian R"
  5. AU="Alasonati, Enrica"
  6. AU="Arribas, Silvia Magdalena"
  7. AU=Edry Efrat
  8. AU="James B. McCauley"
  9. AU="Offringa, Ite A"
  10. AU="Sakso, Salima Ahriz"
  11. AU="Huang, Zexiang"
  12. AU="Feleke, Sindew M"
  13. AU="van der Velden, Janielle"
  14. AU="Carmen Gonzalez"
  15. AU="Cheah, Jaime H"
  16. AU="Forte, Florence"
  17. AU="Anika Nier"
  18. AU="Bar, Adi"
  19. AU="Alvarado Pinedo, María F."
  20. AU="Scarlett, Garry"
  21. AU="Carlos G. Vanoye"
  22. AU=Lohrmann Jens
  23. AU="Petersen, Moritz"
  24. AU="Giovanni, L."
  25. AU="Liu, Xingzheng"
  26. AU="Głód, Mateusz"
  27. AU=Teo Kelvin Yi Chong
  28. AU="Khatmi, Aysan"
  29. AU="Erculiani, M"
  30. AU="Olivier Lortholary"
  31. AU="Lisnic, Vanda Juranic"
  32. AU="Seabloom, Eric W"
  33. AU="Odvina, Clarita V"
  34. AU="Singh, Inderbir"
  35. AU="Wonoh Lee"
  36. AU="Nelson, Warrick"
  37. AU="Douglas, David N"
  38. AU="King, Gary"
  39. AU="Barbera, Lauren"
  40. AU="Carlino, Antonio"
  41. AU="Shan, Qing-Hua"
  42. AU="Starko, S"
  43. AU="Lievre, Loïc"
  44. AU=Cammack N
  45. AU="Xia, Qin"
  46. AU="Ong, Ju Lynn"
  47. AU="Cullin, Christophe"
  48. AU="Georg K.S. Andersson"
  49. AU="Jeannel, Gaël-François"
  50. AU="Stuart Woods"
  51. AU="Shchegolev, A."
  52. AU="Nadeau, Pierre-Louis"
  53. AU="Gordon, David E A"
  54. AU="Shahid Mahmood"
  55. AU="Rosenblatt, Karin"
  56. AU="Dasgupta, Suvankar"
  57. AU=Nguyen Sylvain AU=Nguyen Sylvain

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  1. Artikel ; Online: Whole-genome sequencing of Mycobacterium tuberculosis from Cambodia

    Konstantin Edokimov / Yoshiyuki Yamada / Chhavarath Dary / Qing Hao Miow / Li-Yang Hsu / Rick Twee-Hee Ong / Vonthanak Saphonn

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Band 8

    Abstract: Abstract Cambodia has one of the highest tuberculosis (TB) incidence rates in the WHO Western Pacific region. Remarkably though, the prevalence of multidrug-resistant TB (MDR-TB) remains low. We explored the genetic diversity of Mycobacterium ... ...

    Abstract Abstract Cambodia has one of the highest tuberculosis (TB) incidence rates in the WHO Western Pacific region. Remarkably though, the prevalence of multidrug-resistant TB (MDR-TB) remains low. We explored the genetic diversity of Mycobacterium tuberculosis (MTB) circulating in this unique setting using whole-genome sequencing (WGS). From October 2017 until January 2018, we collected one hundred sputum specimens from consenting adults older than 21 years of age, newly diagnosed with bacteriologically confirmed TB in 3 districts of Phnom Penh and Takeo provinces of Cambodia before they commence on their TB treatment, where eighty MTB isolates were successfully cultured and sequenced. Majority of the isolates belonged to Lineage 1 (Indo-Oceanic) (69/80, 86.25%), followed by Lineage 2 (East Asian) (10/80, 12.5%) and Lineage 4 (Euro-American) (1/80, 1.25%). Phenotypic resistance to both streptomycin and isoniazid was found in 3 isolates (3/80, 3.75%), while mono-resistance to streptomycin and isoniazid was identical at 2.5% (N = 2 each). None of the isolates tested was resistant to either rifampicin or ethambutol. The specificities of genotypic prediction for resistance to all drugs tested were 100%, while the sensitivities of genotypic resistance predictions to isoniazid and streptomycin were lower at 40% (2/5) and 80% (4/5) respectively. We identified 8 clusters each comprising of two to five individuals all residing in the Takeo province, making up half (28/56, 50%) of all individuals sampled in the province, indicating the presence of multiple ongoing transmission events. All clustered isolates were of Lineage 1 and none are resistant to any of the drugs tested. This study while demonstrating the relevance and utility of WGS in predicting drug resistance and inference of disease transmission, highlights the need to increase the representation of genotype–phenotype TB data from low and middle income countries in Asia and Africa to improve the accuracies for prediction of drug resistance.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: i-MoMCARE

    Chan Hang Saing / Mengieng Ung / Sovanthida Suy / Sreymom Oy / Chhavarath Dary / Esabelle Lo Yan Yam / Sophea Chhorn / Michiko Nagashima-Hayashi / Dyna Khuon / Sovatha Mam / Rattana Kim / Vonthanak Saphonn / Siyan Yi

    Trials, Vol 24, Iss 1, Pp 1-

    Innovative Mobile Technology for Maternal and Child Health Care in Cambodia—study protocol of a cluster randomized controlled trial

    2023  Band 19

    Abstract: Abstract Background The Government of Cambodia established the village health support groups (VHSGs) in 2003 to facilitate primary healthcare activities, including maternal and child health (MCH) services. However, VHSGs face several challenges that ... ...

    Abstract Abstract Background The Government of Cambodia established the village health support groups (VHSGs) in 2003 to facilitate primary healthcare activities, including maternal and child health (MCH) services. However, VHSGs face several challenges that hinder them from performing optimally, including a lack of regular structured training and remuneration and limited and inconsistent support and supervision from the health centers (HCs). This implementation research aims to develop, implement, and evaluate a digital health intervention to improve the performance of VHSGs through better support and supervision and increase the MCH service coverage in rural Cambodia. Methods i-MoMCARE, a two-arm cluster randomized controlled trial, will be conducted between 2022 and 2025. Five operational districts (ODs) have been randomized to an intervention arm and the other five ODs to the control arm. The intervention will last for 24 months. Around 200 VHSGs in the intervention arm will be equipped with a mobile application as a job aid and 20 HC staff with a web interface to improve support and supervision of VHSGs. The potential beneficiaries will include pregnant women, mothers, and children under 2 years old. We will measure the outcomes at baseline and endline. The primary outcomes will consist of a composite MCH index constructed from maternal and newborn care indicators, child immunization, and treatment of under-two children. Secondary outcomes will include coverage of selected MCH services. We will conduct the intention-to-treat and per-protocol analyses. We will conduct qualitative interviews with selected beneficiaries and stakeholders to evaluate the intervention’s acceptability, feasibility, and scalability. We will also conduct a cost-effective analysis using decision-analytic modeling incorporating a societal perspective that explores different time horizons, intervention effects, and when scaled up to the national level. Discussion i-MoMCARE is expected to increase MCH service access and coverage in rural ...
    Schlagwörter Community health workers ; Digital health intervention ; Maternal and child health ; Implementation research ; Low- and middle-income country ; Asia ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2023-10-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

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