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  1. Article ; Online: Association of Psoriasis With Hearing Loss: A Systematic Review and Meta-Analysis.

    Ger, Tzong-Yun / Lien, Kuang-Hsu / Chi, Ching-Chi

    Journal of cutaneous medicine and surgery

    2023  Volume 27, Issue 4, Page(s) 330–339

    Abstract: Background: The relation between psoriasis and hearing loss has been unclear.: Objective: To investigate the association of psoriasis with hearing loss.: Methods: We searched MEDLINE and Embase on 12th November 2022 for studies on the association ... ...

    Abstract Background: The relation between psoriasis and hearing loss has been unclear.
    Objective: To investigate the association of psoriasis with hearing loss.
    Methods: We searched MEDLINE and Embase on 12th November 2022 for studies on the association between psoriasis and hearing loss. We conducted a random-effects model meta-analysis to calculate pooled mean difference (MD) in the pure tone thresholds, pooled odds ratio for sensorineural hearing loss, and pooled hazard ratio for sudden sensorineural hearing loss related to psoriasis.
    Results: We included 12 case-control/cross-sectional and 3 cohort studies with 202,683 subjects. Psoriasis was associated with hearing loss at 500 Hz (pooled MD 2.21, 95% CI (CI) 0.13 to 4.29), 1000 Hz (pooled MD 2.97, 95% CI 1.01 to 4.93), 2000 Hz (pooled MD 5.13, 95% CI 2.45 to 7.82), 4000 Hz (pooled MD 9.3, 95% CI 5.1 to 13.51), and 6000 Hz (pooled MD 11.04, 95% CI 5.05 to 17.03). Patients with psoriasis had increased odds for sensorineural hearing loss (pooled odds ratio 3.85, 95% CI 1.07-13.9) and risk for sudden sensorineural hearing loss (pooled hazard ratio 1.45; 95% CI 1.22-1.71).
    Conclusion: Psoriasis is associated with hearing loss, especially at high frequencies.
    MeSH term(s) Humans ; Cross-Sectional Studies ; Hearing Loss, Sensorineural/epidemiology ; Cohort Studies ; Psoriasis/complications ; Psoriasis/epidemiology
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 1361720-5
    ISSN 1615-7109 ; 1203-4754
    ISSN (online) 1615-7109
    ISSN 1203-4754
    DOI 10.1177/12034754231177613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effects of Preoperative Chronic Steroid Use on Postoperative Outcomes in Orthopedic Surgery: A Systematic Review and Meta-Analysis.

    Hung, Yu-Ting / Hung, Wei-Kai / Chi, Ching-Chi

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 9

    Abstract: Higher rates of postoperative complications have been found in preoperative chronic steroid users. However, the effects of preoperative chronic steroid use on outcomes in orthopedic surgery were unclear. We performed a systematic review of cohort studies ...

    Abstract Higher rates of postoperative complications have been found in preoperative chronic steroid users. However, the effects of preoperative chronic steroid use on outcomes in orthopedic surgery were unclear. We performed a systematic review of cohort studies examining the effects of chronic steroid use on postoperative outcomes following orthopedic surgery and searched PubMed, Embase, and CENTRAL through 29 April 2023. We included 17 studies with 1,546,562 patients. No increase in 30-day mortality (adjusted odds ratio (aOR) 1.40, 95% confidence interval (CI) 0.64-3.09) and composite thromboembolic events (aOR 1.61, 95% CI 0.99-2.63) but increases in 30-day overall complications (aOR 1.42, 95% CI 1.16-1.75), wound dehiscence (aOR 2.91, 95% CI 1.49-5.66), infectious complications (any infection (aOR 1.61, 95% CI 1.44-1.80), sepsis (aOR 2.07, 95% CI 1.34-3.21), superficial surgical site infection (SSI) (aOR 1.73, 95% CI 1.03-2.89) and deep SSI (aOR 1.96, 95% CI 1.26-3.05)), re-admission (aOR 1.62, 95% CI 1.48-1.77), both 30-day (aOR 1.28, 95% CI 1.03-1.59) and 1-year re-operation (aOR 1.78, 95% CI 1.09-2.92), pulmonary embolism (aOR 5.94, 95% CI 1.52-23.29), and deep vein thrombosis (aOR 2.07, 95% CI 1.24-3.46) were detected in preoperative steroid users. An increased risk of adverse outcomes following orthopedic surgery in chronic steroid users was found.
    Language English
    Publishing date 2023-09-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16091328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Association of Alopecia Areata with Sensorineural Hearing Loss: A Systematic Review and Meta-analysis.

    Lien, Kuang-Hsu / Ger, Tzong-Yun / Chi, Ching-Chi

    Dermatology (Basel, Switzerland)

    2023  Volume 239, Issue 4, Page(s) 523–532

    Abstract: Background: Immune-mediated melanocyte-related pathogenesis in alopecia areata (AA) may cause sensorineural hearing loss (SNHL). However, the relation between AA and SNHL has been unclear. Therefore, we aimed to investigate this association between AA ... ...

    Abstract Background: Immune-mediated melanocyte-related pathogenesis in alopecia areata (AA) may cause sensorineural hearing loss (SNHL). However, the relation between AA and SNHL has been unclear. Therefore, we aimed to investigate this association between AA and SNHL.
    Methods: We performed a systematic review and searched MEDLINE and Embase on July 25, 2022, for cross-sectional, case-control, or cohort studies that examined the association of AA with SNHL. The Newcastle-Ottawa Scale was used to evaluate their risk of bias. A random-effects model meta-analysis was performed to obtain the mean differences in frequency-specific hearing thresholds between AA patients and age-matched healthy controls and the pooled odds ratio for SNHL in relation to AA.
    Results: We included 5 case-control studies and 1 cohort study, with none of them rated with high risk of biases. The meta-analysis showed AA patients had significantly higher mean differences in pure-tone hearing thresholds at 4,000 Hz and 12,000-12,500 Hz. The meta-analysis also found increased odds for SNHL among patients with AA (OR: 3.18; 95% CI: 2.06-4.89; I2 = 0%).
    Conclusions: AA is associated with an increase of SNHL, especially at high frequencies. Otologic consultation may be indicated if AA patients present with hearing loss or tinnitus.
    MeSH term(s) Humans ; Alopecia Areata/complications ; Cohort Studies ; Cross-Sectional Studies ; Hearing Loss, Sensorineural/complications
    Language English
    Publishing date 2023-04-24
    Publishing country Switzerland
    Document type Systematic Review ; Meta-Analysis
    ZDB-ID 1099692-8
    ISSN 1421-9832 ; 1018-8665
    ISSN (online) 1421-9832
    ISSN 1018-8665
    DOI 10.1159/000530784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bidirektionale Assoziationen zwischen Psoriasis und Migräne: Eine systematische Übersicht und Metaanalyse.

    Huang, I-Hsin / Hung, Wei-Kai / Chi, Ching-Chi

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21, Issue 5, Page(s) 493–503

    Language German
    Publishing date 2023-05-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14994_g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Bidirectional associations between psoriasis and migraine: A systematic review and meta-analysis.

    Huang, I-Hsin / Hung, Wei-Kai / Chi, Ching-Chi

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21, Issue 5, Page(s) 493–502

    Abstract: Background and objectives: To evaluate the association between psoriasis and migraine.: Patients and methods: MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched for relevant observational studies from their ... ...

    Abstract Background and objectives: To evaluate the association between psoriasis and migraine.
    Patients and methods: MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched for relevant observational studies from their respective inception to May 1, 2022. A random-effects model meta-analysis was performed to calculate the risk estimates quantifying the associations between psoriasis and migraine. We also performed a sensitivity analysis by including only studies with adjusted risk estimates and a subgroup analysis according to the severity of psoriasis.
    Results: We included 9 studies with 6,742,075 participants. The meta-analysis illustrated increased odds for prevalent migraine among patients with psoriasis (pooled OR: 1.69, 95% CI: 1.26-2.28) and increased odds for prevalent psoriasis among those with migraine (OR: 1.88, 95% CI: 1.32-3.67). A subgroup analysis of cohort studies demonstrated an increasingly higher risk of incident migraine in patients with mild psoriasis and severe psoriasis (IRR being 1.37 (95% CI 1.30-1.44) and 1.55 (95% CI 1.29-1.86), respectively).
    Conclusions: This meta-analysis revealed significant bidirectional associations between migraine and psoriasis. Greater severity of psoriasis appears to be associated with a higher risk of developing migraine. Clinicians should evaluate symptoms of migraine in patients with psoriasis and provide proper treatments.
    MeSH term(s) Humans ; Migraine Disorders/epidemiology ; Migraine Disorders/complications ; Psoriasis/epidemiology ; Psoriasis/complications ; Cohort Studies
    Language English
    Publishing date 2023-04-17
    Publishing country Germany
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Rosacea, Germs, and Bowels: A Review on Gastrointestinal Comorbidities and Gut-Skin Axis of Rosacea.

    Wang, Fang-Ying / Chi, Ching-Chi

    Advances in therapy

    2021  Volume 38, Issue 3, Page(s) 1415–1424

    Abstract: Rosacea is a chronic inflammatory disease with complicated pathophysiology that involves genetic and environmental elements and dysregulation of innate and adaptive immunity, neurovascular responses, microbiome colonization or infection, resulting in ... ...

    Abstract Rosacea is a chronic inflammatory disease with complicated pathophysiology that involves genetic and environmental elements and dysregulation of innate and adaptive immunity, neurovascular responses, microbiome colonization or infection, resulting in recurrent inflammation. Rosacea has been reported associated with various gastrointestinal diseases including inflammatory bowel disease, celiac disease, irritable bowel syndrome, gastroesophageal reflux disease, Helicobacter pylori (HP) infection, and small intestine bacterial overgrowth (SIBO). The link may involve common predisposing genetic, microbiota, and immunological factors, comprising the theory of the gut-skin axis. Although the evidence is still controversial, interestingly, medications for eradicating SIBO and HP provided an effective and prolonged therapeutic response in rosacea, and conventional therapy for which is usually disappointing because of frequent relapses. In this article, we review the current evidence and discuss probable mechanisms of the association between rosacea and gastrointestinal comorbidities.
    MeSH term(s) Comorbidity ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Microbiome ; Helicobacter Infections/complications ; Helicobacter Infections/drug therapy ; Helicobacter Infections/epidemiology ; Humans ; Rosacea/drug therapy ; Rosacea/epidemiology
    Language English
    Publishing date 2021-01-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-021-01624-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Steroid bursts associated with severe adverse events.

    Shao, Shih-Chieh / Chi, Ching-Chi

    The Journal of pediatrics

    2021  Volume 236, Page(s) 325–328

    Language English
    Publishing date 2021-08-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2021.06.053
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  8. Article ; Online: Risk of breast cancer among patients with psoriasis: a systematic review and meta-analysis.

    Tung, Tao-Hsin / Jiesisibieke, Zhu Liduzi / Cheng, Yu-Hsien / Chi, Ching-Chi

    Archives of dermatological research

    2023  Volume 316, Issue 1, Page(s) 12

    Abstract: Relevant evidence regarding the risk of incident breast cancer in patients with psoriasis is lacking. Hence, this systematic review and meta-analysis aimed to assess the risk of breast cancer in patients with psoriasis. We searched the PubMed, Cochrane ... ...

    Abstract Relevant evidence regarding the risk of incident breast cancer in patients with psoriasis is lacking. Hence, this systematic review and meta-analysis aimed to assess the risk of breast cancer in patients with psoriasis. We searched the PubMed, Cochrane Library, and Embase databases from inception to December 31, 2021, for relevant cohort studies without language limitations. The Newcastle-Ottawa Scale was used to determine the quality of the selected papers. A random-effects model meta-analysis was performed to obtain the pooled hazard ratio (HR) with a 95% confidence interval (CI) for breast cancer in relation to psoriasis. We also performed a subgroup analysis of patients with mild-to-moderate-to-severe psoriasis. We included seven cohort studies, all of which were considered high quality, and three of them provided data for meta-analysis. The risk for breast cancer did not increase among patients with psoriasis (pooled HR: 1.11, 95% CI 0.97-1.27; I
    MeSH term(s) Humans ; Female ; Breast Neoplasms/epidemiology ; Psoriasis/complications ; Psoriasis/epidemiology ; Patients
    Language English
    Publishing date 2023-12-01
    Publishing country Germany
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 130131-7
    ISSN 1432-069X ; 0340-3696
    ISSN (online) 1432-069X
    ISSN 0340-3696
    DOI 10.1007/s00403-023-02753-9
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  9. Article ; Online: Nannizzia polymorpha as Rare Cause of Skin Dermatophytosis.

    Sun, Pei-Lun / Chi, Ching-Chi / Shih, I-Hsin / Fan, Yun-Chen

    Emerging infectious diseases

    2023  Volume 29, Issue 7, Page(s) 1451–1454

    Abstract: Nannizzia polymorpha is a dermatophyte that rarely infects humans. We describe 2 case-patients from Asia who had an inflammatory type of tinea capitis and tinea manuum caused by infection with this fungus. The diagnosis was confirmed on the basis of the ... ...

    Abstract Nannizzia polymorpha is a dermatophyte that rarely infects humans. We describe 2 case-patients from Asia who had an inflammatory type of tinea capitis and tinea manuum caused by infection with this fungus. The diagnosis was confirmed on the basis of the morphologic and molecular characteristics of the microorganism.
    MeSH term(s) Humans ; Arthrodermataceae ; Tinea/diagnosis ; Tinea/drug therapy ; Tinea/microbiology ; Skin/microbiology ; Asia ; Hand Dermatoses
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2907.230477
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Efficacy and Safety of Topical Mechanistic Target of Rapamycin Inhibitors for Facial Angiofibromas in Patients with Tuberous Sclerosis Complex: A Systematic Review and Network Meta-Analysis.

    Lin, Yu-Ting / Yu, Chia-Ling / Tu, Yu-Kang / Chi, Ching-Chi

    Biomedicines

    2022  Volume 10, Issue 4

    Abstract: Previous studies have suggested that the topical mechanistic target of rapamycin (mTOR) inhibitors may be effective in treating facial angiofibromas in patients with tuberous sclerosis complex (TSC). Various concentrations of topical sirolimus for TSC ... ...

    Abstract Previous studies have suggested that the topical mechanistic target of rapamycin (mTOR) inhibitors may be effective in treating facial angiofibromas in patients with tuberous sclerosis complex (TSC). Various concentrations of topical sirolimus for TSC have been tested, but their comparative efficacy and safety remained unclear. To assess the effects of topical mTOR inhibitors in treating facial angiofibromas, we conducted a systematic review and network meta-analysis (NMA) and searched MEDLINE, Embase, and Cochrane Library for relevant randomized controlled trials on 14 February 2022. The Cochrane Collaboration tool was used to assess the risk of bias of included trials. Our outcomes were clinical improvement and severe adverse events leading to withdrawal. We included three trials on 261 TSC patients with facial angiofibromas. The NMA found when compared with placebo, facial angiofibromas significantly improved following the application of various concentrations of topical sirolimus (risk ratio being 3.87, 2.70, 4.43, and 3.34 for 0.05%, 0.1%, 0.2%, and 1%, respectively). When compared with placebo, all concentrations of topical sirolimus did not differ in severe adverse events leading to withdrawal. The ranking analysis suggested topical sirolimus 0.2% as the most effective drug. In conclusion, topical sirolimus 0.05-1% are effective and safe in treating facial angiofibromas in patients with TSC, with topical sirolimus 0.2% being the most effective.
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10040826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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