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Article ; Online: Ten circumstances and solutions for finding the sample mean and standard deviation for meta-analysis.

Chi, Kuan-Yu / Li, Man-Yun / Chen, Chiehfeng / Kang, Enoch

2023 Volume 12, Issue 1, Page(s) 62

Abstract: A common problem in meta-analyses is the unavailability of mean and standard deviation (SD). Unfortunately, only having values of the median, interquartile range (IQR), or range cannot be directly utilized for meta-analysis. Although some estimation and ... ...

Abstract	A common problem in meta-analyses is the unavailability of mean and standard deviation (SD). Unfortunately, only having values of the median, interquartile range (IQR), or range cannot be directly utilized for meta-analysis. Although some estimation and conversion methods have been proposed in the past two decades, there were no published and user-friendly tools developed based on multiple scenarios of missing SD. Therefore, this study aimed to provide a collection of possible circumstances of missing sample means or SD with solutions for teaching and research. A total of 10 common circumstances of missing SD or mean could have available statistics of p value, t value, z score, confidence interval, standard error, median, IQR, and range. Teachers and investigators can use relevant formulas for finding the sample mean and SD according to the available circumstance. Due to the complicated computations, our team provides a free available spreadsheet. With ever-evolving statistical methods, some formulas may be further improved in the future; therefore, it is recommended to involve statisticians in evidence-based practice or systematic reviews.
Language	English
Publishing date	2023-04-01
Publishing country	England
Document type	Letter
ZDB-ID	2662257-9
ISSN	2046-4053 ; 2046-4053
ISSN (online)	2046-4053
ISSN	2046-4053
DOI	10.1186/s13643-023-02217-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Remimazolam

Chang, Yu / Huang, Yun-Ting / Chi, Kuan-Yu / Huang, Yen-Ta

PeerJ

2023 Volume 11, Page(s) e15495

Abstract: Background: To improve patient tolerability and satisfaction as well as minimize complications, procedural sedation has been widely used. Propofol is the most widely used agent for induction of anesthesia and sedation by anesthesiologists. With a ... ...

Abstract	Background: To improve patient tolerability and satisfaction as well as minimize complications, procedural sedation has been widely used. Propofol is the most widely used agent for induction of anesthesia and sedation by anesthesiologists. With a different mechanism compared to propofol, remimazolam is a new short-acting GABA-A receptor agonist. It is an ester-based benzodiazepine. This meta-analysis aims to clarify the efficacy and safety of remimazolam versus propofol for procedure sedation. Methods: Electronic databases were searched for randomized controlled trials (RCTs) comparing efficacy or safety of remimazolam versus propofol. Meta-analysis were conducted using RStudio with "metafor" package with random-effects model. Results: A total of twelve RCTs were included in the meta-analysis. The pooled results demonstrated that patients with remimazolam for procedural sedation had lower risk of bradycardia (OR 0.28, 95% CI [0.14-0.57]), hypotension (OR 0.26, 95% CI [0.22-0.32]), and respiratory depression (OR 0.22, 95% CI [0.14-0.36]). There was no difference in the risk of developing postoperative nausea and vomiting (PONV) (OR 0.65, 95% CI [0.15-2.79]) and dizziness (OR 0.93, 95% CI [0.53-1.61]) between the remimazolam and propofol groups. Using remimazolam for procedural sedation is significantly associated with less injection pain compared to propofol (OR 0.06, 95% CI [0.03-0.13]). Regarding the sedation efficacy, there was no difference in sedation success rate or time to loss of consciousness, recover and discharge between the remimazolam and the propofol groups. Conclusions: Based on our meta-analysis, patients receiving procedural sedation with remimazolam had lower risk of bradycardia, hypotension, respiratory depression and injection pain compared with propofol. On the other hand, there was no difference in sedation success rate, risk of PONV, dizziness, time to LOC, recovery and discharge between these two sedatives. Prospero registration number: CRD42022362950.
MeSH term(s)	Humans ; Propofol/adverse effects ; Postoperative Nausea and Vomiting ; Dizziness ; Bradycardia ; Conscious Sedation/methods ; Randomized Controlled Trials as Topic ; Benzodiazepines/adverse effects ; Pain ; Anesthesia ; Hypotension/chemically induced ; Respiratory Insufficiency
Chemical Substances	Propofol (YI7VU623SF) ; remimazolam (7V4A8U16MB) ; Benzodiazepines (12794-10-4)
Language	English
Publishing date	2023-06-12
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.15495
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Article ; Online: Valve positions upon which cardiac surgeons operate should be taken into consideration.

Wang, Tsu-Hsien / Kang, Yi-No / Lin, Wan-Ying / Chi, Kuan-Yu

Canadian journal of surgery. Journal canadien de chirurgie

2023 Volume 66, Issue 5, Page(s) E472–E473

MeSH term(s)	Humans ; Surgeons ; Cardiac Surgical Procedures ; Heart Valves/surgery
Language	English
Publishing date	2023-09-06
Publishing country	Canada
Document type	Letter
ZDB-ID	410651-9
ISSN	1488-2310 ; 0008-428X
ISSN (online)	1488-2310
ISSN	0008-428X
DOI	10.1503/cjs.010122-l
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Article ; Online: Extranodal Natural Killer T-Cell Lymphoma.

Chi, Kuan-Yu / Shen, Hsiu-Nien

The New England journal of medicine

2020 Volume 382, Issue 6, Page(s) 562

MeSH term(s)	Blood Cell Count ; Epstein-Barr Virus Infections/complications ; Fluorodeoxyglucose F18/metabolism ; Herpesvirus 4, Human/isolation & purification ; Humans ; Lymphoma, Extranodal NK-T-Cell/diagnosis ; Lymphoma, Extranodal NK-T-Cell/virology ; Male ; Middle Aged ; Positron-Emission Tomography ; Viral Load
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2020-02-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMicm1910000
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Article ; Online: Association between statin use and risk of gallstone disease and cholecystectomy: a meta-analysis of 590,086 patients.

Chang, Yu / Lin, Hong-Min / Chi, Kuan-Yu / Lin, Wan-Ying / Chou, Tsung-Ching

PeerJ

2023 Volume 11, Page(s) e15149

Abstract: Background: Statins have been reported to reduce the risk of gallstone disease. However, the impacts of different durations of statin use on gallstone disease have not been clarified. The aim of this study is toperform a systematic review with meta- ... ...

Abstract	Background: Statins have been reported to reduce the risk of gallstone disease. However, the impacts of different durations of statin use on gallstone disease have not been clarified. The aim of this study is toperform a systematic review with meta-analysis to update and to elucidate the association between statin use and the risk of gallstone disease and cholecystectomy. Methods: Medline, Embase and Cochrane Library were searched from the inception until August 2022 for relevant articles investigating the difference in the risk of gallstone disease between statin users and non-users (PROSPERO, ID: CRD42020182445). Meta-analyses were conducted using odds ratios (ORs) with corresponding 95% confidence intervals (CIs) to compare the risk of gallstone disease and cholecystectomy between statin user and nonusers. Results: Eight studies enrolling 590,086 patients were included. Overall, the use of statins was associated with a marginally significant lower risk of gallstone disease than nonusers (OR, 0.91; 95% CI [0.82-1.00]). Further subgroup analysis showed that short-term users, medium-term users, and long-term users were associated with a significantly higher risk (OR, 1.18; 95% CI [1.11-1.25]), comparable risk (OR, 0.93; 95% CI [0.83-1.04]), and significantly lower risk of gallstone diseases (OR, 0.78; 95% CI [0.68-0.90]) respectively, compared to nonusers. Conclusions: Patients with medium-term or long-term use of statins without discontinuation are at a lower risk of gallstone disease or cholecystectomy.
MeSH term(s)	Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Cholelithiasis ; Cholecystectomy/adverse effects ; Risk ; Odds Ratio
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2023-04-07
Publishing country	United States
Document type	Systematic Review ; Meta-Analysis ; Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.15149
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Article ; Online: Decompressive Craniectomy versus Craniotomy for Acute Subdural Hematoma: Updated meta-analysis of real-world clinical outcome after RESCUE-ASDH trial.

Chang, Yu / Wong, Chia-En / Perng, Pang-Shuo / Atwan, Hany / Chi, Kuan-Yu / Lee, Jung-Shun / Wang, Liang-Chao / Huang, Chih-Yuan

The journal of trauma and acute care surgery

2024

Abstract: Introduction: The RESCUE-ASDH trial found that disability and quality-of-life outcomes were similar between craniotomy and decompressive craniectomy for traumatic acute subdural hematoma, contrasting previous literature. This meta-analysis aims to ... ...

Abstract	Introduction: The RESCUE-ASDH trial found that disability and quality-of-life outcomes were similar between craniotomy and decompressive craniectomy for traumatic acute subdural hematoma, contrasting previous literature. This meta-analysis aims to validate the applicability of RESCUE-ASDH results using real-world data in acute subdural hematoma patients. Methods: We searched Chocrane, Embase, and MEDLINE for relevant articles reporting clinical outcomes of craniotomy and decompressive craniectomy. Meta-analysis utilized R software with the restricted maximum likelihood method for random-effects meta-analyses, presenting odds ratios and 95% confidence intervals with Hartung-Knapp-Sidik-Jonkman adjustment for heterogeneity. Results: Besides RESCUE-ASDH, 5 retrospective studies were included, spanning 2006-2016. A total of 961 patients with traumatic ASDH were included in this study (Craniotomy = 467; Decompressive craniotomy = 494). The pooled analysis of retrospective studies showed no significant difference in poor clinical outcomes between the two groups (OR 0.59, 95% CI, 0.32 to 1.10). These findings align with the RESCUE-ASDH trial (OR 0.84, 95% CI, 0.58 to 1.23). Mortality rate was significant higher in patients undergoing craniectomy in pooled result of retrospective studies (OR 0.59, 95% CI, 0.32 to 1.10). In RESCUE-ASDH trial, reoperation rate was higher in the craniotomy group, but the pooled result of retrospective did not show significant difference between the craniotomy and craniectomy group. Conclusions: This real-world evidence confirms the RESCUE-ASDH trial results. Both craniotomy and decompressive craniectomy yielded similar disability and quality-of-life outcomes for traumatic acute subdural hematoma patients. Level of evidence: Level 2, Systematic and meta-analysis.
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2651070-4
ISSN	2163-0763 ; 2163-0755
ISSN (online)	2163-0763
ISSN	2163-0755
DOI	10.1097/TA.0000000000004243
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Article ; Online: Indigenizing and co-producing the ACGME anesthesiology milestone in Taiwan: a Delphi study and subgroup analysis.

Kang, Enoch Yi-No / Chi, Kuan-Yu / Liao, Faith / Liu, Chih-Chung / Lin, Chih-Peng / Chen, Ta-Liang / Tanaka, Pedro / Chen, Chien-Yu

BMC medical education

2024 Volume 24, Issue 1, Page(s) 154

Abstract: Background: To implement the ACGME Anesthesiology Milestone Project in a non-North American context, a process of indigenization is essential. In this study, we aim to explore the differences in perspective toward the anesthesiology competencies among ... ...

Abstract	Background: To implement the ACGME Anesthesiology Milestone Project in a non-North American context, a process of indigenization is essential. In this study, we aim to explore the differences in perspective toward the anesthesiology competencies among residents and junior and senior visiting staff members and co-produce a preliminary framework for the following nation-wide survey in Taiwan. Methods: The expert committee translation and Delphi technique were adopted to co-construct an indigenized draft of milestones. Descriptive analysis, chi-square testing, Pearson correlation testing, and repeated-measures analysis of variance in the general linear model were employed to calculate the F values and mean differences (MDs). Results: The translation committee included three experts and the consensus panel recruited 37 participants from four hospitals in Taiwan: 9 residents, 13 junior visiting staff members (JVSs), and 15 senior visiting staff members (SVSs). The consensus on the content of the 285 milestones was achieved after 271 minor and 6 major modifications in 3 rounds of the Delphi survey. Moreover, JVSs were more concerned regarding patient care than were both residents (MD = - 0.095, P < 0.001) and SVSs (MD = 0.075, P < 0.001). Residents were more concerned regarding practice-based learning improvement than were JVSs (MD = 0.081; P < 0.01); they also acknowledged professionalism more than JVSs (MD = 0.072; P < 0.05) and SVSs (MD = 0.12; P < 0.01). Finally, SVSs graded interpersonal and communication skills lower than both residents (MD = 0.068; P < 0.05) and JVSs (MD = 0.065; P < 0.05) did. Conclusions: Most ACGME anesthesiology milestones are applicable and feasible in Taiwan. Incorporating residents' perspectives may bring insight and facilitate shared understanding to a new educational implementation. This study helped Taiwan generate a well-informed and indigenized draft of a competency-based framework for the following nation-wide Delphi survey.
MeSH term(s)	Humans ; Anesthesiology/education ; Internship and Residency ; Taiwan ; Delphi Technique ; Clinical Competence ; Education, Medical, Graduate
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-024-05081-2
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Article: The Association between Proton Pump Inhibitors and the Effectiveness of CDK Inhibitors in HR+/HER- Advanced Breast Cancer Patients: A Systematic Review and Meta-Analysis.

Chang, Yu-Cheng / Song, Junmin / Chang, Yu / Huang, Chin-Hsuan / Sudan, Aarushi / Chen, Pei-Chin / Chi, Kuan-Yu

Cancers

2023 Volume 15, Issue 21

Abstract: There have been many clinical questions regarding whether the use of proton pump inhibitors (PPIs) could deteriorate the effects of cyclin-dependent kinase inhibitors (CDKIs) in HR+/HER2- advanced breast cancer patients. We performed a systematic review ... ...

Abstract	There have been many clinical questions regarding whether the use of proton pump inhibitors (PPIs) could deteriorate the effects of cyclin-dependent kinase inhibitors (CDKIs) in HR+/HER2- advanced breast cancer patients. We performed a systematic review and meta-analysis of this clinical question, including studies enrolling HR+/HER2- metastatic breast cancer patients treated with CDKIs (Palbociclib or Ribociclib) and reporting at least one comparative survival outcome, either overall survival (OS) or progression-free survival (PFS), between concomitant PPI users and non-users. Eight studies met the eligibility criteria, with a total of 2584 patients included (PPI users: 830, PPI non-users: 1754), demonstrating that concomitant PPI use was associated with significantly higher risks of all-cause mortality (HR = 2.03; 95% CI, 1.49 to 2.77; I
Language	English
Publishing date	2023-10-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15215133
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Article ; Online: Robot-Assisted Kyphoplasty versus Fluoroscopy-Assisted Kyphoplasty: A Meta-Analysis of Postoperative Outcomes.

Chang, Yu / Chen, Wei-Cheng / Chi, Kuan-Yu / Huang, Abel Po-Hao / Jhang, Shang-Wun / Sun, Li-Wei / Chen, Chien-Min

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 4

Abstract: Osteoporotic vertebral compression fractures are the most common manifestation of osteoporosis. Percutaneous kyphoplasty (PKP) can lead to both pain improvement and correction of kyphosis secondary to collapsed vertebral bodies. Robot-assisted (RA) PKP ... ...

Abstract	Osteoporotic vertebral compression fractures are the most common manifestation of osteoporosis. Percutaneous kyphoplasty (PKP) can lead to both pain improvement and correction of kyphosis secondary to collapsed vertebral bodies. Robot-assisted (RA) PKP has been reported to provide better vertebral body fracture correction than conventional fluoroscopy-assisted (FA) PKP. The aim of this meta-analysis is to compare clinical outcomes of RA PKP versus FA PKP. The Pubmed, Embase, and MEDLINE electronic databases were searched from January 1900 to December 2022, with no language restrictions for relevant articles. We extracted the preoperative and postoperative mean pain score and standard deviation from the included studies and pooled them using an inverse variance method. Statistical analyses were performed using functions available in the metafor package in R software. The results of this meta-analysis were summarized with weighted mean differences (WMDs). Our search strategy identified 181 references from the Pubmed, Embase, and MEDLINE electronic databases. We excluded duplicates and irrelevant references, after screening titles and abstracts. The remaining 12 studies were retrieved for full-text review, and, finally, we included five retrospective cohort studies from 2015 to 2021, comprising 223 patients undergoing RA PKP and 246 patients undergoing FA PKP. No difference was found in subgroup analysis based on the timing of postoperative pain assessment, despite the overall estimate of postoperative pain indicating a significant difference between the RA PKP and FA PKP groups (WMD, -0.22; 95% CI, -0.39 to -0.05). The long-term pain assessment revealed a significantly lower VAS in the RA PKP group than the FA PKP group at six months postoperatively (WMD, -0.15; 95% CI, -0.30 to -0.01), but no difference between the subgroups at three (WMD, 0.06; 95% CI, -0.41 to -0.54) and twelve months (WMD, -0.10; 95% CI, -0.50 to 0.30) postoperatively. Our meta-analysis revealed no significant difference in postoperative pain between RA PKP and FA PKP. Patients undergoing RA PKP had better pain improvement compared to FA PKP at 6 months postoperatively. However, further studies focusing on long-term outcomes in patients undergoing RA PKP are warranted to clarify its benefit, given the small number of included studies.
MeSH term(s)	Humans ; Kyphoplasty/adverse effects ; Kyphoplasty/methods ; Robotics ; Fractures, Compression/surgery ; Fractures, Compression/etiology ; Retrospective Studies ; Spinal Fractures/complications ; Spinal Fractures/surgery ; Osteoporotic Fractures/etiology ; Osteoporotic Fractures/surgery ; Pain, Postoperative/etiology ; Treatment Outcome
Language	English
Publishing date	2023-03-27
Publishing country	Switzerland
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59040662
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Article ; Online: Timing of Adjuvant Radiotherapy After Keloid Excision: A Systematic Review and Meta-Analysis.

Hsieh, Chin-Ling / Chi, Kuan-Yu / Lin, Wan-Ying / Lee, Leon Tsung-Ju

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2021 Volume 47, Issue 11, Page(s) 1438–1443

Abstract: Background: No consensus exists regarding the appropriate timing of adjuvant radiotherapy administration after surgical excision of keloids.: Objective: This study investigated the appropriate timing of adjuvant radiotherapy.: Materials and methods! ...

Abstract	Background: No consensus exists regarding the appropriate timing of adjuvant radiotherapy administration after surgical excision of keloids. Objective: This study investigated the appropriate timing of adjuvant radiotherapy. Materials and methods: A systematic review and meta-analysis of randomized controlled trials and observational cohort studies was performed. A pooled estimate of the incidence rate was performed using a random-effects model. Subgroup analyses based on different anatomic region, biologically effective dose, keloid length, and radiotherapy regimen were also conducted. Results: Sixteen observational cohort studies (1,908 keloid lesions) met the inclusion criteria. The incidence rate was significantly lower in the group treated with electron beam therapy more than 24 hours after surgery (3.80%; 95% confidence interval [CI], 1.78%-8.13%) than that in the group treated with the same therapy within 24 hours of surgery (37.16%; 95% CI, 20.80%-66.37%; p < .0001), but no significant difference was observed between the groups regarding brachytherapy and x-ray treatments. Conclusion: Immediate adjuvant radiotherapy did not significantly reduce the incidence rate of recurrent keloids.
MeSH term(s)	Humans ; Keloid/radiotherapy ; Keloid/surgery ; Radiotherapy, Adjuvant ; Time Factors
Language	English
Publishing date	2021-08-19
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1097/DSS.0000000000003165
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