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  1. Article ; Online: Bilateral radial keratoneuritis resulting from acanthamoeba keratitis

    Po‐Yu Lee / Chia‐Ching Lin / Li‐Yi Chiu / Po‐Yen Lee

    Kaohsiung Journal of Medical Sciences, Vol 38, Iss 1, Pp 79-

    2022  Volume 80

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The Adverse Effects of Air Pollution on the Eye

    Chia-Ching Lin / Chien-Chih Chiu / Po-Yen Lee / Kuo-Jen Chen / Chen-Xi He / Sheng-Kai Hsu / Kai-Chun Cheng

    International Journal of Environmental Research and Public Health, Vol 19, Iss 1186, p

    A Review

    2022  Volume 1186

    Abstract: Air pollution is inevitably the result of human civilization, industrialization, and globalization. It is composed of a mixture of gases and particles at harmful levels. Particulate matter (PM), nitrogen oxides (NOx), and carbon dioxides (CO 2 ) are ... ...

    Abstract Air pollution is inevitably the result of human civilization, industrialization, and globalization. It is composed of a mixture of gases and particles at harmful levels. Particulate matter (PM), nitrogen oxides (NOx), and carbon dioxides (CO 2 ) are mainly generated from vehicle emissions and fuel consumption and are the main materials causing outdoor air pollution. Exposure to polluted outdoor air has been proven to be harmful to human eyes. On the other hand, indoor air pollution from environmental tobacco smoking, heating, cooking, or poor indoor ventilation is also related to several eye diseases, including conjunctivitis, glaucoma, cataracts, and age-related macular degeneration (AMD). In the past 30 years, no updated review has provided an overview of the impact of air pollution on the eye. We reviewed reports on air pollution and eye diseases in the last three decades in the PubMed database, Medline databases, and Google Scholar and discussed the effect of various outdoor and indoor pollutants on human eyes.
    Keywords air pollution ; eye diseases ; ocular surface diseases ; glaucoma ; cataract ; retinal diseases ; Medicine ; R
    Subject code 333
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Predicting financial trouble using call data-On social capital, phone logs, and financial trouble.

    Rishav Raj Agarwal / Chia-Ching Lin / Kuan-Ta Chen / Vivek Kumar Singh

    PLoS ONE, Vol 13, Iss 2, p e

    2018  Volume 0191863

    Abstract: An ability to understand and predict financial wellbeing for individuals is of interest to economists, policy designers, financial institutions, and the individuals themselves. According to the Nilson reports, there were more than 3 billion credit cards ... ...

    Abstract An ability to understand and predict financial wellbeing for individuals is of interest to economists, policy designers, financial institutions, and the individuals themselves. According to the Nilson reports, there were more than 3 billion credit cards in use in 2013, accounting for purchases exceeding US$ 2.2 trillion, and according to the Federal Reserve report, 39% of American households were carrying credit card debt from month to month. Prior literature has connected individual financial wellbeing with social capital. However, as yet, there is limited empirical evidence connecting social interaction behavior with financial outcomes. This work reports results from one of the largest known studies connecting financial outcomes and phone-based social behavior (180,000 individuals; 2 years' time frame; 82.2 million monthly bills, and 350 million call logs). Our methodology tackles highly imbalanced dataset, which is a pertinent problem with modelling credit risk behavior, and offers a novel hybrid method that yields improvements over, both, a traditional transaction data only approach, and an approach that uses only call data. The results pave way for better financial modelling of billions of unbanked and underbanked customers using non-traditional metrics like phone-based credit scoring.
    Keywords Medicine ; R ; Science ; Q
    Subject code 332
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Exchange Rate Movements, Foreign Direct Investment, and Domestic R&D

    Kun-Ming Chen / Chia-Ching Lin / Shu-Fei Yang

    Research in World Economy, Vol 6, Iss

    2015  Volume 1

    Abstract: This paper develops a game-theoretical model to investigate heterogeneous firms’ entry mode choice of international expansion. The distinct feature of this paper is that exchange rate, R&D competition, and intra-industry firm heterogeneity are ... ...

    Abstract This paper develops a game-theoretical model to investigate heterogeneous firms’ entry mode choice of international expansion. The distinct feature of this paper is that exchange rate, R&D competition, and intra-industry firm heterogeneity are incorporated into the theoretical framework. The possible impact of a firm’s outward foreign direct investment (OFDI) on its R&D spending and other non-OFDI firms’ R&D spending is also examined. Our analytical results indicate that, if host country has lower labor costs, when facing rising domestic labor costs or appreciation of home currency, a firm with lower productivity in production or R&D activity will choose OFDI, whereas the firms with higher productivity will produce at home and export. In addition, our results demonstrate that the impact of OFDI on R&D spending is ambiguous, depending on firm heterogeneity as well as the wage gap between home country and host country.
    Keywords Economic history and conditions ; HC10-1085 ; Social Sciences ; H
    Subject code 337
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Sciedu Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A Transdermal Measurement Platform Based on Microfluidics

    Wen-Ying Huang / Jung-Ping Huang / Chia-Ching Lin / Yung-Sheng Lin

    Journal of Chemistry, Vol

    2017  Volume 2017

    Abstract: The Franz diffusion cell is one of the most widely used devices to evaluate transdermal drug delivery. However, this static and nonflowing system has some limitations, such as a relatively large solution volume and skin area and the development of gas ... ...

    Abstract The Franz diffusion cell is one of the most widely used devices to evaluate transdermal drug delivery. However, this static and nonflowing system has some limitations, such as a relatively large solution volume and skin area and the development of gas bubbles during sampling. To overcome these disadvantages, this study provides a proof of concept for miniaturizing models of transdermal delivery by using a microfluidic chip combined with a diffusion cell. The proposed diffusion microchip system requires only 80 μL of sample solution and provides flow circulation. Two model compounds, Coomassie Brilliant Blue G-250 and potassium ferricyanide, were successfully tested for transdermal delivery experiments. The diffusion rate is high for a high sample concentration or a large membrane pore size. The developed diffusion microchip system, which is feasible, can be applied for transdermal measurement in the future.
    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Gain of CXCR7 function with mesenchymal stem cell therapy ameliorates experimental arthritis via enhancing tissue regeneration and immunomodulation

    Sung-Tai Wei / Yen-Chih Huang / Jung-Ying Chiang / Chia-Ching Lin / Yu-Jung Lin / Woei-Cherng Shyu / Hui-Chen Chen / Chia-Hung Hsieh

    Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-

    2021  Volume 19

    Abstract: Abstract Background The major barriers to mesenchymal stem cell (MSC) therapy in rheumatoid arthritis (RA) are a low extent of tissue regeneration and insufficient immunomodulation after cell transplantation. In addition, the role of C-X-C chemokine ... ...

    Abstract Abstract Background The major barriers to mesenchymal stem cell (MSC) therapy in rheumatoid arthritis (RA) are a low extent of tissue regeneration and insufficient immunomodulation after cell transplantation. In addition, the role of C-X-C chemokine receptor type 7 (CXCR7) and its mechanism of action in MSC-mediated osteogenic or chondrogenic differentiation and immunomodulation are unclear. Methods Gain of CXCR7 function on human MSCs was carried out by lentiviral vector-mediated CXCR7 overexpression or CXCR7 agonist, TC14012. These cells were determined the role and potential mechanisms for CXCR7-regulated MSC differentiation and immunomodulation using cellular and molecular assays. The therapeutic benefits in RA were investigated in rats with collagen-induced arthritis (CIA). Results CXCR7 was upregulated in MSCs during the induction of osteogenic or chondrogenic differentiation. Blockage of CXCR7 function inhibited osteogenic or chondrogenic differentiation of MSCs whereas gain of CXCR7 function had the opposite effects. Besides, MSCs with CXCR7 gain-of-function facilitated macrophage apoptosis and regulatory T cell differentiation in a co-culture system. Gain of CXCR7 function also promoted the production of anti-inflammatory soluble factors. A gene expression profiling assay and signaling reporter assays revealed that CXCR7 could regulate several candidate genes related to the PPAR, WNT, Hedgehog or Notch pathways, and their signaling activities, which are known to control cell differentiation and immunomodulation. Finally, MSCs with CXCR7 gain-of-function significantly reduced the articular index scores, ankle circumference, radiographic scores, histologic scores, and inflammation in rats with CIA compared with control MSCs. Conclusions CXCR7 promotes the osteogenic and chondrogenic differentiation of MSCs and MSC-mediated immunomodulation by regulating several signaling pathways and anti-inflammatory soluble factors. MSCs with CXCR7 gain-of-function significantly ameliorate arthritic symptoms in a CIA ...
    Keywords Mesenchymal stem cells ; CXC chemokine receptor 7 ; rheumatoid arthritis ; differentiation ; immunomodulation ; Medicine (General) ; R5-920 ; Biochemistry ; QD415-436
    Subject code 571
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Kinetics Investigation on Mushroom Tyrosinase Inhibition of Proso Millet

    Wen-Ying Huang / Hui-Ju Chen / Chia-Ching Lin / Chin-Shuh Chen / Yung-Sheng Lin

    Journal of Chemistry, Vol

    2018  Volume 2018

    Abstract: Proso millet (Panicum miliaceum) is rich in nutritive components and is widely used as a human food, feed and forage for animals, and fuel. This study investigated the effect of a proso millet extract on the inhibition of tyrosinase, a key enzyme in ... ...

    Abstract Proso millet (Panicum miliaceum) is rich in nutritive components and is widely used as a human food, feed and forage for animals, and fuel. This study investigated the effect of a proso millet extract on the inhibition of tyrosinase, a key enzyme in melanogenesis. High performance liquid chromatography analysis indicated that the proso millet extract contained phenolic tyrosinase inhibitors, such as syringic acid, p-coumaric acid, and ferulic acid. The extract had an IC50 for inhibition of tyrosinase activity of 14.02 mg/mL. A Lineweaver-Burk double reciprocal plot showed that the proso millet extract functioned as a mixed competitive and noncompetitive inhibitor. Proso millet has potential as a tyrosinase inhibitor that may have applications in the cosmetics industry.
    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation

    Chia-Ching Lin / Yi-Ru Shen / Chi-Chih Chang / Xiang-Yi Guo / Yun-Yun Young / Ting-Yu Lai / I-Shing Yu / Chih-Yuan Lee / Tsung-Hsien Chuang / Hsin-Yue Tsai / Li-Chung Hsu

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 16

    Abstract: Terminal uridyltransferase 7 (TUT7) adds U-tails on diverse RNAs to promote degradation. Here the authors show that TUT7 is induced upon LPS treatment in macrophages and promotes decay of Regnase-1, thereby regulating the expression of a subset of ... ...

    Abstract Terminal uridyltransferase 7 (TUT7) adds U-tails on diverse RNAs to promote degradation. Here the authors show that TUT7 is induced upon LPS treatment in macrophages and promotes decay of Regnase-1, thereby regulating the expression of a subset of cytokines, including IL-6.
    Keywords Science ; Q
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Toxicity of amantadine hydrochloride on cultured bovine cornea endothelial cells

    Po-Yen Lee / Yu-Hung Lai / Po-Len Liu / Ching-Chih Liu / Chia-Cheng Su / Fang-Yen Chiu / Wei-Chung Cheng / Shiuh-Liang Hsu / Kai-Chun Cheng / Li-Yi Chiu / Tzu-En Kao / Chia-Ching Lin / Yo-Chen Chang / Shu-Chi Wang / Chia-Yang Li

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 11

    Abstract: Abstract Amantadine hydrochloride (HCl) is commonly prescribed for treating influenza A virus infection and Parkinson’s disease. Recently, several studies have indicated that the use of amantadine HCl is associated with corneal edema; however, the ... ...

    Abstract Abstract Amantadine hydrochloride (HCl) is commonly prescribed for treating influenza A virus infection and Parkinson’s disease. Recently, several studies have indicated that the use of amantadine HCl is associated with corneal edema; however, the cytotoxic effect of amantadine HCl has not been investigated. In the present study, the effects of amantadine HCl on cell growth, proliferation, and apoptosis in bovine cornea endothelial cells, and in vitro endothelial permeability were examined. Results showed that lower doses of amantadine HCl do not affect cell growth (≤ 20 μΜ), whereas higher doses of amantadine HCl inhibits cell growth (≥ 50 μΜ), induces apoptosis (2000 μΜ), increases sub-G1 phase growth arrest (2000 μΜ), causes DNA damage (≥ 1000 μΜ), and induces endothelial hyperpermeability (≥ 1000 μΜ) in bovine cornea endothelial cells; additionally, we also found that amantadine HCl attenuates the proliferation (≥ 200 μΜ) and arrests cell cycle at G1 phase (≥ 200 μΜ) in bovine cornea endothelial cells. In the present study, we measured the cytotoxic doses of amantadine HCl on cornea endothelial cells, which might be applied in evaluating the association of corneal edema.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: pH Control in Fog and Rain in East Asia

    Otto Klemm / Wei-Ti Tseng / Chia-Ching Lin / Kerstin I. Klemm / Neng-Huei (George) Lin

    Atmosphere, Vol 6, Iss 11, Pp 1785-

    Temporal Advection of Clean Air Masses to Mt. Bamboo, Taiwan

    2015  Volume 1800

    Abstract: Fog and rain was collected during an 18-day period in January 2011 at Mt. Bamboo, northern Taiwan. Almost 300 hourly fog samples and 16 daily rain samples were taken. One single fog sample (pH 3.17) was influenced by local volcanic activity, otherwise ... ...

    Abstract Fog and rain was collected during an 18-day period in January 2011 at Mt. Bamboo, northern Taiwan. Almost 300 hourly fog samples and 16 daily rain samples were taken. One single fog sample (pH 3.17) was influenced by local volcanic activity, otherwise the pH ranged from 3.23 to 6.41 in fog and from 3.59 to 6.31 in rain. All the respective air masses arrived from the northeast, but exhibited two distinct groups: Group_1 had high concentrations of all ions (median interquartile range of total ion concentrations 3200–6200 µeq.·L−1) and low pHs (median 3.52), the respective air masses had travelled over densely populated and industrialized regions of mainland China. Group_2 was from air masses with long travel times over the ocean and relatively low total ion concentrations (80–570 µeq.·L−1) and higher pHs (median 4.80). The cleanest samples are among the cleanest reported in the literature of worldwide fog and rain. In both groups, the pH was governed by the balance of sulfate, nitrate, ammonium, and, in some cases, calcium. The variability of these ions was higher than the variability of 10−pH, which shows that the pH is a rather robust parameter in contrast to its drivers such as non-sea-salt sulfate.
    Keywords fog chemistry ; acid rain ; East Asia ; air pollution ; pH ; Meteorology. Climatology ; QC851-999
    Subject code 551
    Language English
    Publishing date 2015-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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