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  1. Article ; Online: Dante Gabriel Rossetti's Pre-Raphaelites Beginnings

    Chiara Moriconi

    Between, Vol 2, Iss

    “Mary’s Girlhood” e The Girlhood of Mary Virgin

    2012  Volume 4

    Abstract: Right from the beginnings of Dante Gabriel Rossetti’s career, his most striking quality lies in his deep commitment to a continual interrelation between the arts of poetry and of painting. This essay aims at revealing the strategies applied to the ... ...

    Abstract Right from the beginnings of Dante Gabriel Rossetti’s career, his most striking quality lies in his deep commitment to a continual interrelation between the arts of poetry and of painting. This essay aims at revealing the strategies applied to the intersemiotic process taking place between Rossetti’s first Pre-raphaelite canvas, The Girlhood of Mary Virgin, and the two sonnets written to ‘illustrate’ it. To better examine the shift between different media and Rossetti’s own appraisal of such a translating process, reference has been made to some of the great names of the contemporary debate about intersemiotic translation, such as Greimas, Eco and Jakobson. By applying such modern tools of intersemiotic analysis to the artist’s first double work of art it will eventually be clear how Rossetti’s Pre-raphaelite phase is anything but an immature debut in the Victorian artistic scene. Many of the features of his early career are in fact to be found as faithfully maintained in the more complex development of his maturer art. This essay will show how The Girlhood of Mary Virgin and “Mary’s Girlhood” are to be considered as a true manifesto of Rossetti’s entire career and of his appraisal of the relation between the sister arts.
    Keywords Traduzione Intersemiotica ; Rossetti ; Preraffaelliti ; Geography. Anthropology. Recreation ; G ; Language. Linguistic theory. Comparative grammar ; P101-410 ; Translating and interpreting ; P306-310
    Subject code 700
    Language English
    Publishing date 2012-12-01T00:00:00Z
    Publisher Università degli Studi di Cagliari
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: INSIDIA 2.0 High-Throughput Analysis of 3D Cancer Models

    Giordano Perini / Enrico Rosa / Ginevra Friggeri / Lorena Di Pietro / Marta Barba / Ornella Parolini / Gabriele Ciasca / Chiara Moriconi / Massimiliano Papi / Marco De Spirito / Valentina Palmieri

    International Journal of Molecular Sciences, Vol 23, Iss 3217, p

    Multiparametric Quantification of Graphene Quantum Dots Photothermal Therapy for Glioblastoma and Pancreatic Cancer

    2022  Volume 3217

    Abstract: Cancer spheroids are in vitro 3D models that became crucial in nanomaterials science thanks to the possibility of performing high throughput screening of nanoparticles and combined nanoparticle-drug therapies on in vitro models. However, most of the ... ...

    Abstract Cancer spheroids are in vitro 3D models that became crucial in nanomaterials science thanks to the possibility of performing high throughput screening of nanoparticles and combined nanoparticle-drug therapies on in vitro models. However, most of the current spheroid analysis methods involve manual steps. This is a time-consuming process and is extremely liable to the variability of individual operators. For this reason, rapid, user-friendly, ready-to-use, high-throughput image analysis software is necessary. In this work, we report the INSIDIA 2.0 macro, which offers researchers high-throughput and high content quantitative analysis of in vitro 3D cancer cell spheroids and allows advanced parametrization of the expanding and invading cancer cellular mass. INSIDIA has been implemented to provide in-depth morphologic analysis and has been used for the analysis of the effect of graphene quantum dots photothermal therapy on glioblastoma (U87) and pancreatic cancer (PANC-1) spheroids. Thanks to INSIDIA 2.0 analysis, two types of effects have been observed: In U87 spheroids, death is accompanied by a decrease in area of the entire spheroid, with a decrease in entropy due to the generation of a high uniform density spheroid core. On the other hand, PANC-1 spheroids’ death caused by nanoparticle photothermal disruption is accompanied with an overall increase in area and entropy due to the progressive loss of integrity and increase in variability of spheroid texture. We have summarized these effects in a quantitative parameter of spheroid disruption demonstrating that INSIDIA 2.0 multiparametric analysis can be used to quantify cell death in a non-invasive, fast, and high-throughput fashion.
    Keywords quantum dots ; graphene ; photothermal therapy ; cancer spheroids ; image analysis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The Impact of Age and BMI on the VWF/ADAMTS13 Axis and Simultaneous Thrombin and Plasmin Generation in Hospitalized COVID-19 Patients

    Kiruphagaran Thangaraju / Upendra Katneni / Imo J. Akpan / Kenichi Tanaka / Tiffany Thomas / Saini Setua / Julie A. Reisz / Francesca Cendali / Fabia Gamboni / Travis Nemkov / Stacie Kahn / Alexander Z. Wei / Jacob E. Valk / Krystalyn E. Hudson / David J. Roh / Chiara Moriconi / James C. Zimring / Angelo D'Alessandro / Steven L. Spitalnik /
    Richard O. Francis / Paul W. Buehler

    Frontiers in Medicine, Vol

    2022  Volume 8

    Abstract: Aging and obesity independently contribute toward an endothelial dysfunction that results in an imbalanced VWF to ADAMTS13 ratio. In addition, plasma thrombin and plasmin generation are elevated and reduced, respectively, with increasing age and also ... ...

    Abstract Aging and obesity independently contribute toward an endothelial dysfunction that results in an imbalanced VWF to ADAMTS13 ratio. In addition, plasma thrombin and plasmin generation are elevated and reduced, respectively, with increasing age and also with increasing body mass index (BMI). The severity risk of Corona Virus Disease 2019 (COVID-19) increases in adults older than 65 and in individuals with certain pre-existing health conditions, including obesity (>30 kg/m2). The present cross-sectional study focused on an analysis of the VWF/ADAMTS13 axis, including measurements of von Willebrand factor (VWF) antigen (VWF:AG), VWF collagen binding activity (VWF:CBA), Factor VIII antigen, ADAMTS13 antigen, and ADAMTS13 activity, in addition to thrombin and plasmin generation potential, in a demographically diverse population of COVID-19 negative (−) (n = 288) and COVID-19 positive (+) (n = 543) patient plasmas collected at the time of hospital presentation. Data were analyzed as a whole, and then after dividing patients by age (<65 and ≥65) and independently by BMI [<18.5, 18.5–24.9, 25–29.9, >30 (kg/m2)]. These analyses suggest that VWF parameters (i.e., the VWF/ADAMTS13 activity ratio) and thrombin and plasmin generation differed in COVID-19 (+), as compared to COVID-19 (−) patient plasma. Further, age (≥65) more than BMI contributed to aberrant plasma indicators of endothelial coagulopathy. Based on these findings, evaluating both the VWF/ADAMTS13 axis, along with thrombin and plasmin generation, could provide insight into the extent of endothelial dysfunction as well as the plasmatic imbalance in coagulation and fibrinolysis potential, particularly for at-risk patient populations.
    Keywords COVID-19 ; plasmin ; thrombin ; von Willebrand factor ; ADAMTS13 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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