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  1. Article ; Online: Comment on

    Tartaglia, D / Coccolini, F / Chiarugi, M

    SARS-Cov-2 in peritoneal fluid: an important finding in the Covid-19 pandemic

    2020  

    Keywords covid19
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Intra-operative enteroscopy for the identification of obscure bleeding source caused by gastrointestinal angiodysplasias: through a balloon-tip trocar is better.

    Tartaglia, D / Mazzoni, A / Puglisi, A G / Coccolini, F / Chiarugi, M

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2020  Volume 22, Issue 12, Page(s) 2326–2329

    Abstract: Aim: Intra-operative enteroscopy (IE) is a valid diagnostic tool which can be adopted in order to identify the precise location of bleeding gastrointestinal angiodysplasias (GIADs) of the small bowel. We describe a novel IE technique that may increase ... ...

    Abstract Aim: Intra-operative enteroscopy (IE) is a valid diagnostic tool which can be adopted in order to identify the precise location of bleeding gastrointestinal angiodysplasias (GIADs) of the small bowel. We describe a novel IE technique that may increase the diagnostic yield by maintaining a steady distension of the bowel and that prevents microtrauma to the intestinal mucosa and spillage of enteric content into the operative field.
    Methods: After laparotomy, a centimetric transverse enterotomy is performed approximately at the middle of the small bowel. A 12-mm trocar with balloon is then introduced and insufflated. The small bowel is gently distended by carbon dioxide insufflation. Through the trocar, a paediatric colonscope is then inserted and the enteroscopy is performed either retrogradely to the duodenum or anterogradely to the caecum. Once located, surgery is tailored to the precise site of bleeding, with a consequent sparing of intestinal resection.
    Results: IE with 12-mm trocar with balloon was adopted in four elderly patients undergoing surgery for bleeding GIADs. The length of small bowel resection ranged from 10 to 200 cm, depending on the number of GIADs. Operating time ranged from 210 to 275 min. Intra-operative blood loss was nil. No patient developed organ-space or wound infections. There was no recurrence of bleeding from the midgut.
    Conclusion: Performing IE through a balloon trocar may increase the diagnostic accuracy of the procedure with the benefit of reducing the risk of traumatic injury to the bowel and the risk of surgical site infection.
    MeSH term(s) Aged ; Angiodysplasia ; Child ; Double-Balloon Enteroscopy ; Endoscopy, Gastrointestinal ; Gastrointestinal Hemorrhage/etiology ; Humans ; Intestine, Small/surgery ; Surgical Instruments
    Language English
    Publishing date 2020-09-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.15348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comment on: SARS-Cov-2 in peritoneal fluid: an important finding in the Covid-19 pandemic.

    Tartaglia, Dario / Coccolini, Federico / Chiarugi, Massimo

    The British journal of surgery

    2020  Volume 107, Issue 13, Page(s) e667

    MeSH term(s) Ascitic Fluid ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-10-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.12049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Intraperitoneal chemotherapy for ovarian cancer with peritoneal metastases, systematic review of the literature and focused personal experience.

    Coccolini, Federico / Fugazzola, Paola / Montori, Giulia / Ansaloni, Luca / Chiarugi, Massimo

    Journal of gastrointestinal oncology

    2021  Volume 12, Issue Suppl 1, Page(s) S144–S181

    Abstract: Epithelial ovarian cancer (EOC) causes 60% of ovarian cancer cases and is the fourth most common cause of death from cancer in women. The standard of care for EOC includes a combination of surgery followed by intravenous chemotherapy. Intraperitoneal (IP) ...

    Abstract Epithelial ovarian cancer (EOC) causes 60% of ovarian cancer cases and is the fourth most common cause of death from cancer in women. The standard of care for EOC includes a combination of surgery followed by intravenous chemotherapy. Intraperitoneal (IP) chemotherapy (CT) has been introduced into the therapeutic algorithm of EOC with positive results. To explore existing results regarding intraperitoneal chemotherapy a systematic review of the literature and an analysis of our own institutional prospective database of patients treated with cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC) for EOC at different stages were conducted. The focused report concerning our personal experience with advanced EOC treated with cytoreductive surgery and HIPEC produced the following results: In 57 patients cisplatin + paclitaxel as HIPEC was the only significant factor improving overall survival (OS) at multivariate analysis (OR 6.54, 95% CI: 1.24-34.47, P=0.027). Patients treated with HIPEC cisplatin + paclitaxel showed a median OS of 46 months (SD 6.4, 95% CI: 33.4-58.6), while patients treated with other HIPEC regimens showed a median OS of 12 months (SD 3.1, 95% CI: 6.0-18.0). The 2y-OS was 72% and 3y-OS was 68% for cisplatin + paclitaxel as HIPEC, while the 2y- and 3y-OS was 0% for other HIPEC regimens. Patients treated with HIPEC cisplatin + paclitaxel showed a median disease-free survival (DFS) of 13 months (SD 1.6, 95% CI: 9.9-16.1), while patients treated with other HIPEC regimens showed a median DFS of 8 months (SD 3.1, 95% CI: 1.9-14.1). In conclusion, HIPEC cisplatin + paclitaxel in ovarian cancer showed positive results that may be considered semi-definitive according to the level of evidence and should be considered a starting point for further investigations. At present HIPEC cisplatin + paclitaxel should be proposed to patients with advanced ovarian cancer as standard treatment at almost all stages of disease. Platinum + taxane-based intraperitoneal regimens demonstrated superior results compared to other regimens.
    Language English
    Publishing date 2021-05-01
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2594644-4
    ISSN 2219-679X ; 2078-6891
    ISSN (online) 2219-679X
    ISSN 2078-6891
    DOI 10.21037/jgo-2020-06
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Raw veganism severe complication.

    Coccolini, Federico / Tartaglia, Dario / Cremonini, Camilla / Cicuttin, Enrico / Chiarugi, Massimo

    ANZ journal of surgery

    2021  Volume 91, Issue 12, Page(s) E757

    MeSH term(s) Diet, Vegan ; Humans
    Language English
    Publishing date 2021-04-22
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.16877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Positive peritoneal swab in SARS-CoV-2 patients undergoing abdominal emergency surgery: effect or cause?

    Tartaglia, Dario / Barberis, Andrea / Coccolini, Federico / Pistello, Mauro / Rutigliani, Mariangela / Chiarugi, Massimo

    Infection

    2022  Volume 50, Issue 4, Page(s) 989–993

    Abstract: Purpose: The presence of the SARS-CoV-2 in the peritoneal fluid is a matter of debate in the COVID-19 literature. The study aimed to report the prevalence of SARS-CoV-2 in the peritoneal fluid of patients with nasopharyngeal swab tested positive for ... ...

    Abstract Purpose: The presence of the SARS-CoV-2 in the peritoneal fluid is a matter of debate in the COVID-19 literature. The study aimed to report the prevalence of SARS-CoV-2 in the peritoneal fluid of patients with nasopharyngeal swab tested positive for SARS-CoV-2 undergoing emergency surgery and review the literature.
    Methods: The present study was conducted between March 2020 and June 2021. Diagnosis of SARS-CoV-2 positivity was confirmed by preoperative real-time reverse transcriptase-polymerase chain reaction (RT-PCR).
    Results: Eighteen patients with positive nasopharyngeal swabs were operated in emergency in two third-level Italian hospitals. In 13 of these patients (72%), a peritoneal swab was analyzed: SARS-CoV-2 RNA was found in the abdominal fluid of two patients (15%). Neither of them had visceral perforation and one patient died. In ten patients with negative peritoneal swabs, visceral perforation and mortality rates were 30% and 20%, respectively.
    Conclusion: SARS-CoV-2 peritoneal positivity is rare. Abdominal surgery can, therefore, be safely performed in patients with COVID-19 using standard precautions. The correlation with a visceral perforation is not evaluable. The clinical outcomes seem uninfluenced by the viral colonization of the peritoneum. Assessment in large series to provide definitive answers about the involvement of the SARS-CoV-2 in the peritoneum will be challenging to coordinate.
    MeSH term(s) COVID-19/diagnosis ; COVID-19 Testing ; Humans ; RNA, Viral/genetics ; Real-Time Polymerase Chain Reaction ; SARS-CoV-2/genetics
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2022-03-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-022-01785-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Adhesive small bowel obstruction: predictive factors of laparoscopic failure.

    Morelli, Marta / Strambi, Silvia / Cremonini, Camilla / Musetti, Serena / Tonerini, Michele / Coccolini, Federico / Chiarugi, Massimo / Tartaglia, Dario

    Updates in surgery

    2023  Volume 76, Issue 2, Page(s) 705–712

    Abstract: The adoption of laparoscopy for the management of adhesive small bowel obstruction (ASBO) patients is debated. The laparoscopic approach has been associated with a considerable conversion-to-open rate. Nonetheless, reliable predictors of conversion are ... ...

    Abstract The adoption of laparoscopy for the management of adhesive small bowel obstruction (ASBO) patients is debated. The laparoscopic approach has been associated with a considerable conversion-to-open rate. Nonetheless, reliable predictors of conversion are still unclear. The present study aimed to identify factors associated with conversion to open in ASBO patients who underwent laparoscopic surgery. Patients who underwent laparoscopic surgery for ASBO and were admitted to our unit between December 2014 and October 2022 were retrospectively evaluated. The patients were categorized into two groups: patients who underwent complete laparoscopy approach (Group 1) and patients converted to open technique (Group 2). Demographic, clinical, and radiological features, intraoperative findings, and postoperative outcomes were compared. A total of 168 patients were enrolled: 100 patients (59.5%) were included in Group 1, and 68 patients (40.5%) were included in Group 2. The rate of ischemia (p = 0.023), surgical complications (p = 0.001), operative time (p < 0.0001), days of nasogastric tube maintenance (p < 0.0001), time to canalization (p < 0.0001), and length of hospital stay (p < 0.0001) were significantly higher in Group 2 than Group 1. Following univariate analysis, the presence of feces signs (p = 0.044) and high mean radiodensity of intraperitoneal free fluid (p = 0.031) were significantly associated with Group 2 compared with Group 1. Following multivariate analysis, the feces sign was a significant predictive factor of conversion (OR 1.965 [IC 95%]; p = 0.046). Laparoscopic treatment is a safe and effective approach in patients affected by ASBO. The feces sign may be a predictive factor of conversion and could guide the surgeon in selecting the appropriate management of patients affected by ASBO.
    MeSH term(s) Humans ; Tissue Adhesions/complications ; Tissue Adhesions/surgery ; Retrospective Studies ; Postoperative Complications/epidemiology ; Postoperative Complications/surgery ; Intestinal Obstruction/diagnostic imaging ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Laparoscopy/methods ; Treatment Outcome
    Language English
    Publishing date 2023-12-27
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-023-01725-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Reed bed systems for sludge treatment: case studies in Italy.

    Masciandaro, G / Iannelli, R / Chiarugi, M / Peruzzi, E

    Water science and technology : a journal of the International Association on Water Pollution Research

    2015  Volume 72, Issue 7, Page(s) 1043–1050

    Abstract: In recent years, reed bed systems (RBSs) have been widely considered as a valid technology for sludge treatment. In this study are presented results about sludge stabilization occurring within beds in four RBSs, situated in Tuscany (Italy). The results ... ...

    Abstract In recent years, reed bed systems (RBSs) have been widely considered as a valid technology for sludge treatment. In this study are presented results about sludge stabilization occurring within beds in four RBSs, situated in Tuscany (Italy). The results showed that stabilization of the sludge over time occurred in all RBSs, as shown by the low content of water-soluble carbon and dehydrogenase activity, which measures indirectly the overall microbial metabolism, and by the re-synthesis of humic-like matter highlighted by the pyrolytic indices of mineralization and humification. Results about heavy metal fractionation, an appropriate technique to estimate the heavy metal bioavailability and sludge biotoxicity, showed that the process of sludge stabilization occurring in RBSs retains metals in fractions related to the stabilized organic matter, making metals less bioavailable. Moreover, the concentrations of various toxic organic compounds were below the limit of concentration suggested by the European Union's Working Document on Sludge, for land application. The effectiveness of the stabilization processes in RBs was hence clearly proven by the results that measured mineralization and humification processes, and by the low levels of bioavailable heavy metals and toxic organic compounds in stabilized sludges.
    MeSH term(s) Biodegradation, Environmental ; Environmental Monitoring/methods ; Humic Substances/analysis ; Italy ; Metals, Heavy/isolation & purification ; Poaceae/growth & development ; Seasons ; Sewage/chemistry ; Sewage/microbiology ; Waste Disposal, Fluid/methods ; Water Pollutants, Chemical/isolation & purification ; Wetlands
    Chemical Substances Humic Substances ; Metals, Heavy ; Sewage ; Water Pollutants, Chemical
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 764273-8
    ISSN 1996-9732 ; 0273-1223
    ISSN (online) 1996-9732
    ISSN 0273-1223
    DOI 10.2166/wst.2015.309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Diagnostic pathways in acute appendicitis: Clinical score plus ultrasound outperform CT scan or upfront surgery, especially in doubtful cases.

    Coccolini, Federico / Martinez-Perez, Aleix / Licitra, Gabriella / De Angelis, Nicola / Cremonini, Camilla / Strambi, Silvia / Zocco, Giuseppe / Puglisi, Adolfo / Tartaglia, Dario / Chiarugi, Massimo

    World journal of surgery

    2024  

    Abstract: Background: Controversies remain on the diagnostic strategy in suspected AA, considering the different settings worldwide.: Material and methods: A prospective observational international multicentric study including patients operated for suspected ... ...

    Abstract Background: Controversies remain on the diagnostic strategy in suspected AA, considering the different settings worldwide.
    Material and methods: A prospective observational international multicentric study including patients operated for suspected AA with a definitive histopathological analysis was conducted. Three groups were analyzed: (1) No radiology; (2) Ultrasound, and (3) Computed tomography. The aim was to analyze the performance of three diagnostic schemes.
    Results: Three thousand and one hundred twenty three patients were enrolled; 899 in the no radiology group, 1490 in the US group, and 734 in the CT group. The sex ratio was in favor of males (p < 0.001). The mean age was lower in the no radiology group (24 years) compared to 28 and 38 years in US and CT-scan groups, respectively (p < 0.001). Overall, the negative appendectomy rate 3.8%: no radiology group (5.1%) versus US (2.9%) and CT-scan (4.1%) (p < 0.001). The sensitivity and specificity analysis showed the best balance in clinical evaluation + score + US. These data reach the best results in those patients with an equivocal Alvarado score (4-6). Inverse probability weighting (IPW), showed as the use of ultrasound, is significantly associated with an increased probability of formulating the correct diagnosis (p 0.004). In the case of a CT scan, this association appears weaker (p 0.08).
    Conclusion: The association of clinical scores and ultrasound seems the best strategy to reach a correct preoperative diagnosis in patients with clinical suspicion of AA, even in those population subgroups where the clinical score may have an equivocal result. This strategy can be especially useful in low-resource settings worldwide. CT-scan association may improve the detection of patients who may potentially be submitted to conservative treatment.
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1002/wjs.12160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Abdominal compartment syndrome as unusual presentation of a fast-growing solid tumor.

    Tartaglia, Dario / Arces, Francesco / Morelli, Marta / Coccolini, Federico / Chiarugi, Massimo

    The journal of trauma and acute care surgery

    2020  Volume 89, Issue 4, Page(s) e125–e127

    MeSH term(s) Abdominal Cavity/diagnostic imaging ; Abdominal Cavity/pathology ; Abdominal Neoplasms/diagnostic imaging ; Abdominal Neoplasms/pathology ; Abdominal Neoplasms/surgery ; Adult ; Compartment Syndromes/etiology ; Humans ; Male ; Neurofibrosarcoma/diagnostic imaging ; Neurofibrosarcoma/pathology ; Neurofibrosarcoma/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    DOI 10.1097/TA.0000000000002883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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