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Article ; Online: Physical reservoirs based on MoS

Li, Lingqi / Xiang, Heng / Zheng, Haofei / Chien, Yu-Chieh / Duong, Ngoc Thanh / Gao, Jing / Ang, Kah-Wee

Nanoscale horizons

2024 Volume 9, Issue 5, Page(s) 752–763

Abstract: Reservoir computing (RC), a variant of recurrent neural networks (RNNs), is well-known for its reduced energy consumption through exclusive focus on training the output weight and its superior performance in handling spatiotemporal information. ... ...

Abstract	Reservoir computing (RC), a variant of recurrent neural networks (RNNs), is well-known for its reduced energy consumption through exclusive focus on training the output weight and its superior performance in handling spatiotemporal information. Implementing these networks in hardware requires devices with superior fading memory behavior. Unlike filament-based two-terminal devices, those relying on ferroelectric switching demonstrate improved voltage reliability, while three-terminal transistors provide additional active control. HfO
Language	English
Publishing date	2024-04-29
Publishing country	England
Document type	Journal Article
ISSN	2055-6764
ISSN (online)	2055-6764
DOI	10.1039/d3nh00524k
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Article ; Online: Attack Resilient True Random Number Generators Using Ferroelectric-Enhanced Stochasticity in 2D Transistor.

Chien, Yu-Chieh / Xiang, Heng / Wang, Jianze / Shi, Yufei / Fong, Xuanyao / Ang, Kah-Wee

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 19, Issue 38, Page(s) e2302842

Abstract: By harnessing the physically unclonable properties, true random number generators (TRNGs) offer significant promises to alleviate security concerns by generating random bitstreams that are cryptographically secured. However, fundamental challenges remain ...

Abstract	By harnessing the physically unclonable properties, true random number generators (TRNGs) offer significant promises to alleviate security concerns by generating random bitstreams that are cryptographically secured. However, fundamental challenges remain as conventional hardware often requires complex circuitry design, showing a predictable pattern that is susceptible to machine learning attacks. Here, a low-power self-corrected TRNG is presented by exploiting the stochastic ferroelectric switching and charge trapping in molybdenum disulfide (MoS
Language	English
Publishing date	2023-05-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202302842
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Article ; Online: A MoS

Chien, Yu-Chieh / Xiang, Heng / Shi, Yufei / Duong, Ngoc Thanh / Li, Sifan / Ang, Kah-Wee

Advanced materials (Deerfield Beach, Fla.)

2022 , Page(s) e2204949

Abstract: Spiking neural network (SNN), where the information is evaluated recurrently through spikes, has manifested significant promises to minimize the energy expenditure in data-intensive machine learning and artificial intelligence. Among these applications, ... ...

Abstract	Spiking neural network (SNN), where the information is evaluated recurrently through spikes, has manifested significant promises to minimize the energy expenditure in data-intensive machine learning and artificial intelligence. Among these applications, the artificial neural encoders are essential to convert the external stimuli to a spiking format that can be subsequently fed to the neural network. Here, a molybdenum disulfide (MoS
Language	English
Publishing date	2022-11-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202204949
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Article ; Online: Coupled Ferroelectric-Photonic Memory in a Retinomorphic Hardware for In-Sensor Computing.

Duong, Ngoc Thanh / Shi, Yufei / Li, Sifan / Chien, Yu-Chieh / Xiang, Heng / Zheng, Haofei / Li, Peiyang / Li, Lingqi / Wu, Yangwu / Ang, Kah-Wee

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 Volume 11, Issue 12, Page(s) e2303447

Abstract: The development of all-in-one devices for artificial visual systems offers an attractive solution in terms of energy efficiency and real-time processing speed. In recent years, the proliferation of smart sensors in the growth of Internet-of-Things (IoT) ... ...

Abstract	The development of all-in-one devices for artificial visual systems offers an attractive solution in terms of energy efficiency and real-time processing speed. In recent years, the proliferation of smart sensors in the growth of Internet-of-Things (IoT) has led to the increasing importance of in-sensor computing technology, which places computational power at the edge of the data-flow architecture. In this study, a prototype visual sensor inspired by the human retina is proposed, which integrates ferroelectricity and photosensitivity in two-dimensional (2D) α-In
Language	English
Publishing date	2024-01-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202303447
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Article ; Online: Interface-Modulated Resistive Switching in Mo-Irradiated ReS

Pam, Mei Er / Li, Sifan / Su, Tong / Chien, Yu-Chieh / Li, Yesheng / Ang, Yee Sin / Ang, Kah-Wee

Advanced materials (Deerfield Beach, Fla.)

2022 Volume 34, Issue 30, Page(s) e2202722

Abstract: Coupling charge impurity scattering effects and charge-carrier modulation by doping can offer intriguing opportunities for atomic-level control of resistive switching (RS). Nonetheless, such effects have remained unexplored for memristive applications ... ...

Abstract	Coupling charge impurity scattering effects and charge-carrier modulation by doping can offer intriguing opportunities for atomic-level control of resistive switching (RS). Nonetheless, such effects have remained unexplored for memristive applications based on 2D materials. Here a facile approach is reported to transform an RS-inactive rhenium disulfide (ReS
Language	English
Publishing date	2022-06-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202202722
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Article ; Online: Wafer-Scale 2D Hafnium Diselenide Based Memristor Crossbar Array for Energy-Efficient Neural Network Hardware.

Li, Sifan / Pam, Mei-Er / Li, Yesheng / Chen, Li / Chien, Yu-Chieh / Fong, Xuanyao / Chi, Dongzhi / Ang, Kah-Wee

Advanced materials (Deerfield Beach, Fla.)

2021 Volume 34, Issue 25, Page(s) e2103376

Abstract: Memristor crossbar with programmable conductance could overcome the energy consumption and speed limitations of neural networks when executing core computing tasks in image processing. However, the implementation of crossbar array (CBA) based on ... ...

Abstract	Memristor crossbar with programmable conductance could overcome the energy consumption and speed limitations of neural networks when executing core computing tasks in image processing. However, the implementation of crossbar array (CBA) based on ultrathin 2D materials is hindered by challenges associated with large-scale material synthesis and device integration. Here, a memristor CBA is demonstrated using wafer-scale (2-inch) polycrystalline hafnium diselenide (HfSe
MeSH term(s)	Computers ; Hafnium ; Neural Networks, Computer ; Physical Phenomena
Chemical Substances	Hafnium (X71938L1DO)
Language	English
Publishing date	2021-09-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202103376
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Article ; Online: An electro-photo-sensitive synaptic transistor for edge neuromorphic visual systems.

Duan, Nian / Li, Yi / Chiang, Hsiao-Cheng / Chen, Jia / Pan, Wen-Qian / Zhou, Ya-Xiong / Chien, Yu-Chieh / He, Yu-Hui / Xue, Kan-Hao / Liu, Gang / Chang, Ting-Chang / Miao, Xiang-Shui

Nanoscale

2019 Volume 11, Issue 38, Page(s) 17590–17599

Abstract: The practical application of optoelectronic artificial synapses in neuromorphic visual systems is still hindered by their limited functionality, reliability and the challenge of mass production. Here, an electro-photo-sensitive synapse based on a highly ... ...

Abstract	The practical application of optoelectronic artificial synapses in neuromorphic visual systems is still hindered by their limited functionality, reliability and the challenge of mass production. Here, an electro-photo-sensitive synapse based on a highly reliable amorphous InGaZnO thin-film transistor is demonstrated. Not only does the synapse respond to electrical voltage spikes due to charge trapping/detrapping, but also the weight is modified directly by persistent photocurrent effects under UV-light stimulation. Representative forms of synaptic plasticity, including inhibitory and excitatory postsynaptic currents, frequency-dependent characteristics, short-term to long-term plasticity transitions, and summation effects, are successfully demonstrated. In particular, optoelectronic synergetic modulation leads to reconfigurable excitatory and inhibitory synaptic behaviors, which provides a promising way to achieve the homeostatic regulation of synaptic weights. Moreover, the analogue channel conductance with 100 states is used as the weight update rule to perform MNIST handwritten digit recognition, using system-level LeNet-5 convolutional neural network simulations. The network shows a high recognition accuracy of 95.99% and good tolerance to noisy input patterns. This study highlights the commercial potential of mature optoelectronic InGaZnO transistor technology in edge neuromorphic systems.
Language	English
Publishing date	2019-08-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/c9nr04195h
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Article ; Online: Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation.

Lin, Yu-Min / Sun, Hung-Yu / Chiu, Wen-Tai / Su, Hui-Chen / Chien, Yu-Chieh / Chang, Heng-Ai / Chong, Lee-Won / Chang, Hung-Chuen / Young, Kung-Chia / Bai, Chyi-Huey / Tsao, Chiung-Wen

BioMed research international

2019 Volume 2019, Page(s) 3102414

Abstract: Etifoxine, an 18 kDa translocator protein (TSPO) agonist for the treatment of anxiety disorders in clinic, may be able to cause acute liver injury or cytolytic hepatitis. TSPO has been demonstrated to participate in inflammatory responses in infective ... ...

Abstract	Etifoxine, an 18 kDa translocator protein (TSPO) agonist for the treatment of anxiety disorders in clinic, may be able to cause acute liver injury or cytolytic hepatitis. TSPO has been demonstrated to participate in inflammatory responses in infective diseases as well as to modulate glucose and lipid homeostasis. Hepatitis C virus (HCV) infection disrupts glucose and lipid homoeostasis, leading to insulin resistance (IR). Whether TSPO affects the HCV-induced IR remains unclear. Here, we found that the administration of etifoxine increased the TSPO protein expression and recovered the HCV-mediated lower mitochondrial membrane potential (MMP) without affecting HCV infection. Moreover, etifoxine reversed the HCV-induced lipid accumulation by modulating the expressions of sterol regulatory element-binding protein-1 and apolipoprotein J. On the other hand, in infected cells pretreated with etifoxine, the insulin-mediated insulin receptor substrate-1/Akt signals, forkhead box protein O1 translocation, and glucose uptake were blocked. Taken together, our results pointed out that etifoxine relieved the HCV-retarded MMP and reduced the lipid accumulation but deteriorated the HCV-induced IR by interfering with insulin signal molecules.
MeSH term(s)	Cell Line ; Cell Survival/drug effects ; Forkhead Box Protein O1/genetics ; Gene Expression Regulation/drug effects ; Glucose/metabolism ; Hepatitis C/drug therapy ; Hepatitis C/genetics ; Hepatitis C/pathology ; Hepatitis C/virology ; Humans ; Inflammation/drug therapy ; Inflammation/genetics ; Inflammation/pathology ; Inflammation/virology ; Insulin Receptor Substrate Proteins/genetics ; Insulin Resistance/genetics ; Lipid Metabolism/drug effects ; Lipids/genetics ; Membrane Potential, Mitochondrial/drug effects ; Oxazines/administration & dosage ; Proto-Oncogene Proteins c-akt/genetics ; Receptors, GABA/genetics
Chemical Substances	Forkhead Box Protein O1 ; Insulin Receptor Substrate Proteins ; Lipids ; Oxazines ; Receptors, GABA ; TSPO protein, human ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Glucose (IY9XDZ35W2) ; etifoxine (X24X82MX4X)
Language	English
Publishing date	2019-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2019/3102414
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Article ; Online: Calcitriol Inhibits HCV Infection via Blockade of Activation of PPAR and Interference with Endoplasmic Reticulum-Associated Degradation.

Lin, Yu-Min / Sun, Hung-Yu / Chiu, Wen-Tai / Su, Hui-Chen / Chien, Yu-Chieh / Chong, Lee-Won / Chang, Hung-Chuen / Bai, Chyi-Huey / Young, Kung-Chia / Tsao, Chiung-Wen

Viruses

2018 Volume 10, Issue 2

Abstract: Vitamin D has been identified as an innate anti-hepatitis C virus (HCV) agent but the possible mechanisms for this issue remain unclear. Here, we clarified the mechanisms of calcitriol-mediated inhibition of HCV infection. Calcitriol partially inhibited ... ...

Abstract	Vitamin D has been identified as an innate anti-hepatitis C virus (HCV) agent but the possible mechanisms for this issue remain unclear. Here, we clarified the mechanisms of calcitriol-mediated inhibition of HCV infection. Calcitriol partially inhibited HCV infection, nitric oxide (NO) release and lipid accumulation in Huh7.5 human hepatoma cells via the activation of vitamin D receptor (VDR). When cells were pretreated with the activators of peroxisome proliferator-activated receptor (PPAR)-α (Wy14643) and -γ (Ly171883), the calcitriol-mediated HCV suppression was reversed. Otherwise, three individual stimulators of PPAR-α/β/γ blocked the activation of VDR. PPAR-β (linoleic acid) reversed the inhibition of NO release, whereas PPAR-γ (Ly171883) reversed the inhibitions of NO release and lipid accumulation in the presence of calcitriol. The calcitriol-mediated viral suppression, inhibition of NO release and activation of VDR were partially blocked by an inhibitor of endoplasmic reticulum-associated degradation (ERAD), kifunensine. Furthermore, calcitriol blocked the HCV-induced expressions of apolipoprotein J and 78 kDa glucose-regulated protein, which was restored by pretreatment of kifunensine. These results indicated that the calcitriol-mediated HCV suppression was associated with the activation of VDR, interference with ERAD process, as well as blockades of PPAR, lipid accumulation and nitrative stress.
MeSH term(s)	Active Transport, Cell Nucleus/drug effects ; Alkaloids/pharmacology ; Calcitriol/pharmacology ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Clusterin/genetics ; Endoplasmic Reticulum-Associated Degradation/physiology ; Gene Expression Regulation/drug effects ; Heat-Shock Proteins/genetics ; Hepacivirus/drug effects ; Hepacivirus/physiology ; Hepatitis C/metabolism ; Hepatitis C/virology ; Humans ; Lipid Metabolism/drug effects ; Nitric Oxide/secretion ; Peroxisome Proliferator-Activated Receptors/agonists ; Peroxisome Proliferator-Activated Receptors/metabolism ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; Signal Transduction/drug effects ; Viral Core Proteins/genetics
Chemical Substances	Alkaloids ; CLU protein, human ; Clusterin ; Heat-Shock Proteins ; Peroxisome Proliferator-Activated Receptors ; Receptors, Calcitriol ; VDR protein, human ; Viral Core Proteins ; molecular chaperone GRP78 ; nucleocapsid protein, Hepatitis C virus ; kifunensine (0NI8960271) ; Nitric Oxide (31C4KY9ESH) ; Calcitriol (FXC9231JVH)
Language	English
Publishing date	2018-01-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v10020057
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Article ; Online: Fluoxetine regulates cell growth inhibition of interferon-α.

Lin, Yu-Min / Yu, Bu-Chin / Chiu, Wen-Tai / Sun, Hung-Yu / Chien, Yu-Chieh / Su, Hui-Chen / Yen, Shu-Yang / Lai, Hsin-Wen / Bai, Chyi-Huey / Young, Kung-Chia / Tsao, Chiung-Wen

International journal of oncology

2016 Volume 49, Issue 4, Page(s) 1746–1754

Abstract: Fluoxetine, a well-known anti-depression agent, may act as a chemosensitizer to assist and promote cancer therapy. However, how fluoxetine regulates cellular signaling to enhance cellular responses against tumor cell growth remains unclear. In the ... ...

Abstract	Fluoxetine, a well-known anti-depression agent, may act as a chemosensitizer to assist and promote cancer therapy. However, how fluoxetine regulates cellular signaling to enhance cellular responses against tumor cell growth remains unclear. In the present study, addition of fluoxetine promoted growth inhibition of interferon-alpha (IFN-α) in human bladder carcinoma cells but not in normal uroepithelial cells through lessening the IFN-α-induced apoptosis but switching to cause G1 arrest, and maintaining the IFN-α-mediated reduction in G2/M phase. Activations and signal transducer and transactivator (STAT)-1 and peroxisome proliferator-activated receptor alpha (PPAR-α) were involved in this process. Chemical inhibitions of STAT-1 or PPAR-α partially rescued bladder carcinoma cells from IFN-α-mediated growth inhibition via blockades of G1 arrest, cyclin D1 reduction, p53 downregulation and p27 upregulation in the presence of fluoxetine. However, the functions of both proteins were not involved in the control of fluoxetine over apoptosis and maintained the declined G2/M phase of IFN-α. These results indicated that activation of PPAR-α and STAT-1 participated, at least in part, in growth inhibition of IFN-α in the presence of fluoxetine.
MeSH term(s)	Antiviral Agents/pharmacology ; Blotting, Western ; Cell Proliferation/drug effects ; Flow Cytometry ; Fluorescent Antibody Technique, Indirect ; Fluoxetine/pharmacology ; Humans ; Interferon-alpha/pharmacology ; Serotonin Uptake Inhibitors/pharmacology ; Signal Transduction/drug effects ; Tumor Cells, Cultured ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/metabolism ; Urinary Bladder Neoplasms/pathology
Chemical Substances	Antiviral Agents ; Interferon-alpha ; Serotonin Uptake Inhibitors ; Fluoxetine (01K63SUP8D)
Language	English
Publishing date	2016-10
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1154403-x
ISSN	1791-2423 ; 1019-6439
ISSN (online)	1791-2423
ISSN	1019-6439
DOI	10.3892/ijo.2016.3650
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