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  1. Article ; Online: De novo exon 18 G724S point mutation may be sensitive to Gefitinib

    Tai‐Huang Lee / Chih‐Jen Yang

    Kaohsiung Journal of Medical Sciences, Vol 37, Iss 10, Pp 918-

    2021  Volume 919

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A Study of the Relationship between Phthalate Exposure and the Occurrence of Adult Asthma in Taiwan

    Tsai-Hui Duh / Chih-Jen Yang / Chien-Hung Lee / Ying-Chin Ko

    Molecules, Vol 28, Iss 5230, p

    2023  Volume 5230

    Abstract: Although phthalate esters contribute to airway remodeling by increasing bronchial cells’ migration and proliferation, the relationship between human exposure to phthalates and asthma is not understood. We measured phthalate exposure in the human body and ...

    Abstract Although phthalate esters contribute to airway remodeling by increasing bronchial cells’ migration and proliferation, the relationship between human exposure to phthalates and asthma is not understood. We measured phthalate exposure in the human body and evaluated its effect on asthma. Asthma ( n = 123) and asthma-free ( n = 139) participants were, respectively, recruited from an asthma clinic and the community in Taiwan. The urine levels of six phthalate metabolites were determined by liquid chromatography tandem mass spectrometry. Compared with the controls, male asthma patients had higher means of mono-(2-ethylhexyl) phthalate (MEHP) (116.3 nmol/g), monobutyl phthalate (MBP) (850.3 nmol/g) and monoethyl phthalate (MEP) (965.8 nmol/g), and female patients had greater MBP (2902.4 nmol/g). Each 10-fold increase in the level of these phthalate metabolites was correspondingly associated with a 5.0-, 5.8-, 4.2- and 5.3-fold risk of contracting asthma. Male asthma patients were identified to have a higher proportion of MEHP exposure (32.5%) than the controls (25.3%). In asthma patients, an increase in urine MEHP levels and the total phthalate metabolite concentration were notably linked to increased risks of emergency room visits and being hospitalized. For the occurrence and acute clinical events of adult asthma, phthalate exposures and MEHP retention may contribute to higher risks of contracting this respiratory disorder.
    Keywords adult asthma ; phthalate exposure ; phthalate metabolites ; Organic chemistry ; QD241-441
    Subject code 610
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: EGFR‐TKI plus antiangiogenic agent combination therapy may reduce the incidence of EGFR‐TKI–associated interstitial lung disease in Asian

    Tai‐Huang Lee / Hsiao‐Ling Chen / Ming‐Ju Tsai / Chih‐Jen Yang

    Kaohsiung Journal of Medical Sciences, Vol 38, Iss 11, Pp 1133-

    2022  Volume 1134

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The preventive strategies of community hospital in the battle of fighting pandemic COVID-19 in Taiwan

    Chih-Jen Yang / Tun-Chieh Chen / Yen-Hsu Chen

    Journal of Microbiology, Immunology and Infection, Vol 53, Iss 3, Pp 381-

    2020  Volume 383

    Keywords COVID-19 ; Preventive strategies ; Community hospital ; Microbiology ; QR1-502 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Emergent bronchoscopic cryotherapy may safely cease invasive lung cancer induced massive endobronchial hemorrhaging in patients with high oxygen supply

    Feng‐Ching Shen / Cheng‐Hao Chuang / Ying‐Ming Tsai / Chih‐Jen Yang

    Kaohsiung Journal of Medical Sciences, Vol 37, Iss 9, Pp 833-

    2021  Volume 834

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: FAK in Cancer

    Hsiang-Hao Chuang / Yen-Yi Zhen / Yu-Chen Tsai / Cheng-Hao Chuang / Michael Hsiao / Ming-Shyan Huang / Chih-Jen Yang

    International Journal of Molecular Sciences, Vol 23, Iss 1726, p

    From Mechanisms to Therapeutic Strategies

    2022  Volume 1726

    Abstract: Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and activated in many cancer types. FAK regulates diverse cellular processes, including growth factor signaling, cell cycle progression, cell survival, cell motility, ... ...

    Abstract Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and activated in many cancer types. FAK regulates diverse cellular processes, including growth factor signaling, cell cycle progression, cell survival, cell motility, angiogenesis, and the establishment of immunosuppressive tumor microenvironments through kinase-dependent and kinase-independent scaffolding functions in the cytoplasm and nucleus. Mounting evidence has indicated that targeting FAK, either alone or in combination with other agents, may represent a promising therapeutic strategy for various cancers. In this review, we summarize the mechanisms underlying FAK-mediated signaling networks during tumor development. We also summarize the recent progress of FAK-targeted small-molecule compounds for anticancer activity from preclinical and clinical evidence.
    Keywords focal adhesion kinase ; metastasis ; drug resistance ; combination therapy ; tumor microenvironment ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: FAK Executes Anti-Senescence via Regulating EZH2 Signaling in Non-Small Cell Lung Cancer Cells

    Hsiang-Hao Chuang / Ming-Shyan Huang / Yen-Yi Zhen / Cheng-Hao Chuang / Ying-Ray Lee / Michael Hsiao / Chih-Jen Yang

    Biomedicines, Vol 10, Iss 8, p

    2022  Volume 1937

    Abstract: Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase overexpressed in various cancer types that plays a critical role in tumor progression. Accumulating evidence suggests that targeting FAK, either alone or in combination with other agents, may ... ...

    Abstract Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase overexpressed in various cancer types that plays a critical role in tumor progression. Accumulating evidence suggests that targeting FAK, either alone or in combination with other agents, may serve as an effective therapeutic strategy for numerous cancers. In addition to retarding proliferation, metastasis, and angiogenesis, FAK inhibition triggers cellular senescence in lung cancer cells. However, the detailed mechanism remains enigmatic. In the present study, we found that FAK inhibition not only elicits DNA-damage signaling but also downregulates enhancer of zeste homolog 2 (EZH2) expression. The manipulation of FAK expression influences EZH2 expression and corresponding signaling in vitro. Immunohistochemistry shows that active FAK signaling corresponds with the activation of the EZH2-mediated signaling cascade in lung-cancer-cells-derived tumor tissues. We also found that ectopic EZH2 expression attenuates FAK-inhibition-induced cellular senescence in lung cancer cells. Our results identify EZH2 as a critical downstream effector of the FAK-mediated anti-senescence pathway. Targeting FAK-EZH2 axis-induced cellular senescence may represent a promising therapeutic strategy for restraining tumor growth.
    Keywords FAK ; EZH2 ; senescence ; lamin A/C ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Decline in invasive pneumococcus diseases while combating the COVID‐19 pandemic in Taiwan

    Jong‐Rung Tsai / Chih‐Jen Yang / Wei‐Ling Huang / Yen‐Hsu Chen

    Kaohsiung Journal of Medical Sciences, Vol 36, Iss 7, Pp 572-

    2020  Volume 573

    Keywords Medicine (General) ; R5-920 ; covid19
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy

    Hsiang-Hao Chuang / Yen-Yi Zhen / Yu-Chen Tsai / Cheng-Hao Chuang / Ming-Shyan Huang / Michael Hsiao / Chih-Jen Yang

    Biomedicines, Vol 9, Iss 359, p

    2021  Volume 359

    Abstract: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in ...

    Abstract Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in cancers and plays an important role in tumorigenesis. Mounting evidence has revealed that targeting Pin1 is a potential therapeutic approach for various cancers by inhibiting cell proliferation, reducing metastasis, and maintaining genome stability. In this review, we summarize the underlying mechanisms of Pin1-mediated upregulation of oncogenes and downregulation of tumor suppressors in cancer development. Furthermore, we also discuss the multiple roles of Pin1 in cancer hallmarks and examine Pin1 as a desirable pharmaceutical target for cancer therapy. We also summarize the recent progress of Pin1-targeted small-molecule compounds for anticancer activity.
    Keywords Pin1 ; cis - trans isomerization ; tumorigenesis ; cell motility ; metastasis ; cancer therapeutics ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma

    Yi-Hua Jan / Tsung-Ching Lai / Chih-Jen Yang / Ming-Shyan Huang / Michael Hsiao

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Volume 11

    Abstract: Abstract Cancer cells utilize altered bioenergetics to fuel uncontrolled proliferation and progression. At the core of bioenergetics, adenine nucleotides are the building blocks for nucleotide synthesis, energy transfer and diverse metabolic processes. ... ...

    Abstract Abstract Cancer cells utilize altered bioenergetics to fuel uncontrolled proliferation and progression. At the core of bioenergetics, adenine nucleotides are the building blocks for nucleotide synthesis, energy transfer and diverse metabolic processes. Adenylate kinases (AK) are ubiquitous phosphotransferases that catalyze the conversion of adenine nucleotides and regulate the homeostasis of nucleotide ratios within cellular compartments. Recently, different isoforms of AK have been shown to induce metabolic reprograming in cancer and were identified as biomarkers for predicting disease progression. Here we aim to systemically analyze the impact of all AK-associated gene signatures on lung adenocarcinoma patient survival and decipher the value for therapeutic interventions. By analyzing TCGA Lung Adenocarcinoma (LUAD) RNA Seq data, we found gene signatures from AK4 and AK1 have higher percentage of prognostic genes compared to other AK-gene signatures. A 118-gene signature was identified from consensus gene expression in AK1 and AK4 prognostic gene signatures. Immunohistochemistry (IHC) analyses in 140 lung adenocarcinoma patients showed overexpression of AK4 significantly correlated with worse overall survival (P = 0.001) whereas overexpression of AK1 significantly associated with good prognosis (P = 0.009). Furthermore, reduced AK4 expression by shRNA reduced the EGFR protein expression in EGFR mutation cells. The inhibition of AK4-AK1 signal might provide a potential target for synergistic effect in target therapy in lung cancer patients.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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