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  1. Article ; Online: Emerging Therapeutic Strategies in The Fight Against Primary Biliary Cholangitis.

    Medford, Abigail / Childs, Jonathan / Little, Ashleigh / Chakraborty, Sanjukta / Baiocchi, Leonardo / Alpini, Gianfranco / Glaser, Shannon

    Journal of clinical and translational hepatology

    2023  Volume 11, Issue 4, Page(s) 949–957

    Abstract: The liver has a vital role in many metabolic and regulatory processes in the body. Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic cholestatic autoimmune disease of the intrahepatic bile ducts associated ... ...

    Abstract The liver has a vital role in many metabolic and regulatory processes in the body. Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic cholestatic autoimmune disease of the intrahepatic bile ducts associated with loss of tolerance to mitochondrial antigens. At this time there is no definitive cure for PBC; however, ursodeoxycholic acid (UDCA) has been shown to reduce injury when administered as the first line of treatment. Additional therapeutics can be given concurrently or as an alternative to UDCA to manage the symptoms and further curb disease progression. Currently, a liver transplant is the only potentially curative option when the patient has developed end-stage liver disease or intractable pruritus. This review aims to delineate the pathogenesis of primary biliary cholangitis and shed light on current therapeutic strategies in the treatment of PBC.
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3019822-7
    ISSN 2310-8819 ; 2225-0719
    ISSN (online) 2310-8819
    ISSN 2225-0719
    DOI 10.14218/JCTH.2022.00398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Recent Advances in Intrahepatic Biliary Epithelial Heterogeneity.

    Little, Ashleigh / Medford, Abigail / O'Brien, April / Childs, Jonathan / Pan, Sharon / Machado, Jolaine / Chakraborty, Sanjukta / Glaser, Shannon

    Seminars in liver disease

    2022  Volume 43, Issue 1, Page(s) 1–12

    Abstract: Biliary epithelium (i.e., cholangiocytes) is a heterogeneous population of epithelial cells in the liver, which line small and large bile ducts and have individual responses and functions dependent on size and location in the biliary tract. We discuss ... ...

    Abstract Biliary epithelium (i.e., cholangiocytes) is a heterogeneous population of epithelial cells in the liver, which line small and large bile ducts and have individual responses and functions dependent on size and location in the biliary tract. We discuss the recent findings showing that the intrahepatic biliary tree is heterogeneous regarding (1) morphology and function, (2) hormone expression and signaling (3), response to injury, and (4) roles in liver regeneration. This review overviews the significant characteristics and differences of the small and large cholangiocytes. Briefly, it outlines the in vitro and in vivo models used in the heterogeneity evaluation. In conclusion, future studies addressing biliary heterogeneity's role in the pathogenesis of liver diseases characterized by ductular reaction may reveal novel therapeutic approaches.
    MeSH term(s) Humans ; Bile Ducts, Intrahepatic/metabolism ; Epithelium/metabolism ; Epithelium/pathology ; Epithelial Cells ; Liver ; Liver Diseases/metabolism ; Biliary Tract
    Language English
    Publishing date 2022-12-15
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603177-8
    ISSN 1098-8971 ; 0272-8087
    ISSN (online) 1098-8971
    ISSN 0272-8087
    DOI 10.1055/s-0042-1758833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1752: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Recent Advances in Intrahepatic Biliary Epithelial Heterogeneity

    Little, Ashleigh / Medford, Abigail / O'Brien, April / Childs, Jonathan / Pan, Sharon / Machado, Jolaine / Chakraborty, Sanjukta / Glaser, Shannon

    Seminars in Liver Disease

    2022  Volume 43, Issue 01, Page(s) 1–12

    Abstract: Biliary epithelium (i.e., cholangiocytes) is a heterogeneous population of epithelial cells in the liver, which line small and large bile ducts and have individual responses and functions dependent on size and location in the biliary tract. We discuss ... ...

    Abstract Biliary epithelium (i.e., cholangiocytes) is a heterogeneous population of epithelial cells in the liver, which line small and large bile ducts and have individual responses and functions dependent on size and location in the biliary tract. We discuss the recent findings showing that the intrahepatic biliary tree is heterogeneous regarding (1) morphology and function, (2) hormone expression and signaling (3), response to injury, and (4) roles in liver regeneration. This review overviews the significant characteristics and differences of the small and large cholangiocytes. Briefly, it outlines the in vitro and in vivo models used in the heterogeneity evaluation. In conclusion, future studies addressing biliary heterogeneity's role in the pathogenesis of liver diseases characterized by ductular reaction may reveal novel therapeutic approaches.
    Keywords cholangiocyte ; heterogeneity ; senescence ; cell signaling
    Language English
    Publishing date 2022-12-15
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 603177-8
    ISSN 1098-8971 ; 0272-8087
    ISSN (online) 1098-8971
    ISSN 0272-8087
    DOI 10.1055/s-0042-1758833
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1752: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: FGF1 Signaling Modulates Biliary Injury and Liver Fibrosis in the Mdr2

    O'Brien, April / Zhou, Tianhao / White, Tori / Medford, Abigail / Chen, Lixian / Kyritsi, Konstantina / Wu, Nan / Childs, Jonathan / Stiles, Danaleigh / Ceci, Ludovica / Chakraborty, Sanjukta / Ekser, Burcin / Baiocchi, Leonardo / Carpino, Guido / Gaudio, Eugenio / Wu, Chaodong / Kennedy, Lindsey / Francis, Heather / Alpini, Gianfranco /
    Glaser, Shannon

    Hepatology communications

    2022  Volume 6, Issue 7, Page(s) 1574–1588

    Abstract: Fibroblast growth factor 1 (FGF1) belongs to a family of growth factors involved in cellular growth and division. MicroRNA 16 (miR-16) is a regulator of gene expression, which is dysregulated during liver injury and insult. However, the role of FGF1 in ... ...

    Abstract Fibroblast growth factor 1 (FGF1) belongs to a family of growth factors involved in cellular growth and division. MicroRNA 16 (miR-16) is a regulator of gene expression, which is dysregulated during liver injury and insult. However, the role of FGF1 in the progression of biliary proliferation, senescence, fibrosis, inflammation, angiogenesis, and its potential interaction with miR-16, are unknown. In vivo studies were performed in male bile duct-ligated (BDL, 12-week-old) mice, multidrug resistance 2 knockout (Mdr2
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B/metabolism ; Animals ; Cholangitis, Sclerosing/drug therapy ; Disease Models, Animal ; Fibroblast Growth Factor 1/genetics ; Fibrosis ; Humans ; Inflammation ; Liver Cirrhosis/drug therapy ; Male ; Mice ; Mice, Knockout ; MicroRNAs/genetics ; ATP-Binding Cassette Sub-Family B Member 4
    Chemical Substances ATP Binding Cassette Transporter, Subfamily B ; MIRN16 microRNA, human ; MicroRNAs ; Fibroblast Growth Factor 1 (104781-85-3)
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2471-254X
    ISSN (online) 2471-254X
    DOI 10.1002/hep4.1909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The ANTOSTRAT Legacy: Science Collaboration and International Transparency in Potential Marine Mineral Resource Exploitation of Antarctica

    Cooper, Alan / Barker, Peter / Barrett, Peter / Behrendt, John / Brancolini, Giuliano / Childs, Jonathan / Escutia, Carlota / Jokat, Wilfried / Kristoffersen, Yngve / Leitchenkov, German / Stagg, Howard / Tanahashi, Manabu / Wardell, Nigel / Webb, Peter
    Document type Article
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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    Inter-library loan at ZB MED

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