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  1. Article ; Online: Cross-protection induced by highly conserved human B, CD4

    Prakash, Swayam / Dhanushkodi, Nisha R / Zayou, Latifa / Ibraim, Izabela Coimbra / Quadiri, Afshana / Coulon, Pierre Gregoire / Tifrea, Delia F / Suzer, Berfin / Shaik, Amin Mohammed / Chilukuri, Amruth / Edwards, Robert A / Singer, Mahmoud / Vahed, Hawa / Nesburn, Anthony B / Kuppermann, Baruch D / Ulmer, Jeffrey B / Gil, Daniel / Jones, Trevor M / BenMohamed, Lbachir

    Frontiers in immunology

    2024  Volume 15, Page(s) 1328905

    Abstract: Background: The coronavirus disease 2019 (COVID-19) pandemic has created one of the largest global health crises in almost a century. Although the current rate of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections has decreased ... ...

    Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic has created one of the largest global health crises in almost a century. Although the current rate of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections has decreased significantly, the long-term outlook of COVID-19 remains a serious cause of morbidity and mortality worldwide, with the mortality rate still substantially surpassing even that recorded for influenza viruses. The continued emergence of SARS-CoV-2 variants of concern (VOCs), including multiple heavily mutated Omicron sub-variants, has prolonged the COVID-19 pandemic and underscores the urgent need for a next-generation vaccine that will protect from multiple SARS-CoV-2 VOCs.
    Methods: We designed a multi-epitope-based coronavirus vaccine that incorporated B, CD4
    Results: The pan-variant SARS-CoV-2 vaccine (i) is safe , (ii) induces high frequencies of lung-resident functional CD8
    Conclusion: A multi-epitope pan-variant SARS-CoV-2 vaccine bearing conserved human B- and T- cell epitopes from structural and non-structural SARS-CoV-2 antigens induced cross-protective immunity that facilitated virus clearance, and reduced morbidity, COVID-19-related lung pathology, and death caused by multiple SARS-CoV-2 VOCs.
    MeSH term(s) Animals ; Humans ; Mice ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Epitopes, T-Lymphocyte/genetics ; Pandemics ; SARS-CoV-2/genetics ; Cross Protection
    Chemical Substances COVID-19 Vaccines ; Epitopes, T-Lymphocyte
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1328905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cross-Protection Induced by Highly Conserved Human B, CD4

    Prakash, Swayam / Dhanushkodi, Nisha R / Zayou, Latifa / Ibraim, Izabela Coimbra / Quadiri, Afshana / Coulon, Pierre Gregoire / Tifrea, Delia F / Suzler, Berfin / Amin, Mohamed / Chilukuri, Amruth / Edwards, Robert A / Vahed, Hawa / Nesburn, Anthony B / Kuppermann, Baruch D / Ulmer, Jeffrey B / Gil, Daniel / Jones, Trevor M / BenMohamed, Lbachir

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Background: The Coronavirus disease 2019 (COVID-19) pandemic has created one of the largest global health crises in almost a century. Although the current rate of SARS-CoV-2 infections has decreased significantly; the long-term outlook of COVID-19 ... ...

    Abstract Background: The Coronavirus disease 2019 (COVID-19) pandemic has created one of the largest global health crises in almost a century. Although the current rate of SARS-CoV-2 infections has decreased significantly; the long-term outlook of COVID-19 remains a serious cause of high death worldwide; with the mortality rate still surpassing even the worst mortality rates recorded for the influenza viruses. The continuous emergence of SARS-CoV-2 variants of concern (VOCs), including multiple heavily mutated Omicron sub-variants, have prolonged the COVID-19 pandemic and outlines the urgent need for a next-generation vaccine that will protect from multiple SARS-CoV-2 VOCs.
    Methods: In the present study, we designed a multi-epitope-based Coronavirus vaccine that incorporated B, CD4
    Results: The Pan-Coronavirus vaccine: (
    Conclusions: A multi-epitope pan-Coronavirus vaccine bearing conserved human B and T cell epitopes from structural and non-structural SARS-CoV-2 antigens induced cross-protective immunity that cleared the virus, and reduced COVID-19-related lung pathology and death caused by multiple SARS-CoV-2 VOCs.
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.24.541850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A multi-epitope/CXCL11 prime/pull coronavirus mucosal vaccine boosts the frequency and the function of lung-resident memory CD4

    Zayou, Latifa / Prakash, Swayam / Dhanushkodi, Nisha Rajeswari / Quadiri, Afshana / Ibraim, Izabela Coimbra / Singer, Mahmoud / Salem, Amirah / Shaik, Amin Mohammed / Suzer, Berfin / Chilukuri, Amruth / Tran, Jennifer / Nguyen, Pauline Chau / Sun, Miyo / Hormi-Carver, Kathy K / Belmouden, Ahmed / Vahed, Hawa / Gil, Daniel / Ulmer, Jeffrey B / BenMohamed, Lbachir

    Journal of virology

    2023  Volume 97, Issue 12, Page(s) e0109623

    Abstract: Importance: Although the current rate of SARS-CoV-2 infections has decreased significantly, COVID-19 still ranks very high as a cause of death worldwide. As of October 2023, the weekly mortality rate is still at 600 deaths in the United States alone, ... ...

    Abstract Importance: Although the current rate of SARS-CoV-2 infections has decreased significantly, COVID-19 still ranks very high as a cause of death worldwide. As of October 2023, the weekly mortality rate is still at 600 deaths in the United States alone, which surpasses even the worst mortality rates recorded for influenza. Thus, the long-term outlook of COVID-19 is still a serious concern outlining the need for the next-generation vaccine. This study found that a prime/pull coronavirus vaccine strategy increased the frequency of functional SARS-CoV-2-specific CD4
    MeSH term(s) Animals ; Humans ; Mice ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Chemokine CXCL11/immunology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Epitopes ; Lung/immunology ; Lung/virology ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus ; Disease Models, Animal
    Chemical Substances Chemokine CXCL11 ; COVID-19 Vaccines ; CXCL11 protein, human ; Epitopes ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.01096-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Multi-Epitope/CXCL11 Prime/Pull Coronavirus Mucosal Vaccine Boosts the Frequency and the Function of Lung-Resident CD4+ and CD8+ Memory T Cells and Protects Against COVID-19-like Symptoms and Death Caused by SARS-CoV-2 infection

    Zayou, Latifa / Prakash, Swayam / Dhanushkodi, Nisha R / Quadiri, Afshana / Ibraim, Izabela Coimbra / Singer, Mahmoud / Salem, Amirah / Shaik, Amin Mohammed / Suzer, Berfin / Chilukuri, Amruth / Tran, Jennifer / Nguyen, Pauline Chau / Sun, Miyo / Hormi-Carver, Kathy K / Belmouden, Ahmed / Vahed, Hawa / Ulmer, Jeffrey B / BENMOHAMED, LBACHIR

    bioRxiv

    Abstract: The pandemic of the coronavirus disease 2019 (COVID-19) has created the largest global health crisis in almost a century. Following exposure to SARS-CoV-2, the virus particles replicate in the lungs, induce a cytokine storm and potentially cause life- ... ...

    Abstract The pandemic of the coronavirus disease 2019 (COVID-19) has created the largest global health crisis in almost a century. Following exposure to SARS-CoV-2, the virus particles replicate in the lungs, induce a cytokine storm and potentially cause life-threatening inflammatory disease. Low frequencies of function SARS-CoV-2-specific CD4+ and CD8+ T cells in the lungs of COVID-19 patients were associated with severe cases of COVID-19. The apparent low level of T cell-attracting CXCL9, CXCL10, and CXCL11 chemokines in infected lungs may not be sufficient enough to assure the sequestration and/or homing of CD4+ and CD8+ T cells from the circulation into infected lungs. We hypothesize that a Coronavirus vaccine strategy that boosts the frequencies of functional SARS-CoV-2-specific CD4+ and CD8+ T cells in the lungs would lead to better protection against SARS-CoV-2 infection, COVID19-like symptoms, and death. In the present study, we designed and pre-clinically tested the safety, immunogenicity, and protective efficacy of a novel multi-epitope//CXCL11 prime/pull mucosal Coronavirus vaccine. This prime/pull vaccine strategy consists of intranasal delivery of a lung-tropic adeno-associated virus type 9 (AAV-9) vector that incorporates highly conserved human B, CD4+ CD8+ cell epitopes of SARS-CoV-2 (prime) and pulling the primed B and T cells into the lungs using the T cell attracting chemokine, CXCL-11 (pull). We demonstrated that immunization of HLA-DR*0101/HLA-A*0201/hACE2 triple transgenic mice with this multi-epitope//CXCL11 prime/pull Coronavirus mucosal vaccine: (i) Increased the frequencies of CD4+ and CD8+ TEM, TCM, and TRM cells in the lungs; and (ii) reduced COVID19-like symptoms, lowered virus replication, and prevented deaths following challenge with SARS-CoV-2. These findings discuss the importance of bolstering the number and function of lung-resident memory CD4+ and CD8+ T cells for better protection against SARS-CoV-2 infection, COVID-19-like symptoms, and death.
    Keywords covid19
    Language English
    Publishing date 2023-05-26
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2023.05.23.542024
    Database COVID19

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  5. Article ; Online: Cross-Protection Induced by Highly Conserved Human B, CD4+, and CD8+ T Cell Epitopes-Based Coronavirus Vaccine Against Severe Infection, Disease, and Death Caused by Multiple SARS-CoV-2 Variants of Concern

    Prakash, Swayam / Dhanushkodi, Nisha R. / Zayou, Latifa / Ibraim, Izabela Coimbra / Quadiri, Afshana / Coulon, Pierre Gregoire / Tifrea, Delia F / Suzler, Berfin / Amin, Mohamed / Chilukuri, Amruth / Edwards, Robert A / Vahed, Hawa / Nesburn, Anthony B / Kuppermann, Baruch D / Ulmer, Jeffrey B. / Gil, Daniel / Jones, Trevor M. / BenMohamed, Lbachir

    bioRxiv

    Abstract: Background: The Coronavirus disease 2019 (COVID-19) pandemic has created one of the largest global health crises in almost a century. Although the current rate of SARS-CoV-2 infections has decreased significantly; the long-term outlook of COVID-19 ... ...

    Abstract Background: The Coronavirus disease 2019 (COVID-19) pandemic has created one of the largest global health crises in almost a century. Although the current rate of SARS-CoV-2 infections has decreased significantly; the long-term outlook of COVID-19 remains a serious cause of high death worldwide; with the mortality rate still surpassing even the worst mortality rates recorded for the influenza viruses. The continuous emergence of SARS-CoV-2 variants of concern (VOCs), including multiple heavily mutated Omicron sub-variants, have prolonged the COVID-19 pandemic and outlines the urgent need for a next-generation vaccine that will protect from multiple SARS-CoV-2 VOCs. Methods: In the present study, we designed a multi-epitope-based Coronavirus vaccine that incorporated B, CD4+, and CD8+ T cell epitopes conserved among all known SARS-CoV-2 VOCs and selectively recognized by CD8+ and CD4+ T-cells from asymptomatic COVID-19 patients irrespective of VOC infection. The safety, immunogenicity, and cross-protective immunity of this pan-Coronavirus vaccine were studied against six VOCs using an innovative triple transgenic h-ACE-2-HLA-A2/DR mouse model. Results: The Pan-Coronavirus vaccine: (i) is safe; (ii) induces high frequencies of lung-resident functional CD8+ and CD4+ TEM and TRM cells; and (iii) provides robust protection against virus replication and COVID-19-related lung pathology and death caused by six SARS-CoV-2 VOCs: Alpha (B.1.1.7), Beta (B.1.351), Gamma or P1 (B.1.1.28.1), Delta (lineage B.1.617.2) and Omicron (B.1.1.529). Conclusions: A multi-epitope pan-Coronavirus vaccine bearing conserved human B and T cell epitopes from structural and non-structural SARS-CoV-2 antigens induced cross-protective immunity that cleared the virus, and reduced COVID-19-related lung pathology and death caused by multiple SARS-CoV-2 VOCs.
    Keywords covid19
    Language English
    Publishing date 2023-05-24
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2023.05.24.541850
    Database COVID19

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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