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Book: Prävention kardiovaskulärer Erkrankungen und Atherosklerose

Kuhlmann, Inga / Chin, Dawn / Rimbach, Gerald

(essentials)

2014

Author's details	Inga Kuhlmann ; Dawn Chin ; Gerald Rimbach
Series title	essentials
Keywords	Apolipoprotein E ; Nahrungsfaktoren für die Gefäßgesundheit ; Risikofaktoren ; Herz-Kreislauf-Erkrankungen ; Stickstoffmonoxid-Synthasen
Language	German
Size	VIII, 32 S. : graph. Darst.
Publisher	Springer
Publishing place	Wiesbaden
Publishing country	Germany
Document type	Book
HBZ-ID	HT018610463
ISBN	978-3-658-08359-5 ; 978-3-658-08358-8 ; 3-658-08358-1 ; 3-658-08359-X
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2015 A 3238	available for loan (reading room)	Lesesaal EG

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Article ; Online: Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of D. melanogaster.

Lüersen, Kai / Jöckel, Tobias / Chin, Dawn / Demetrowitsch, Tobias / Schwarz, Karin / Rimbach, Gerald

BioFactors (Oxford, England)

2023 Volume 50, Issue 1, Page(s) 161–180

Abstract: Recent reports indicated that the phytochemical curcumin possesses iron-chelating activity. Here, by employing the fruit fly Drosophila melanogaster, we conducted feeding studies supplementing curcumin or, as a control, the iron chelator ... ...

Abstract	Recent reports indicated that the phytochemical curcumin possesses iron-chelating activity. Here, by employing the fruit fly Drosophila melanogaster, we conducted feeding studies supplementing curcumin or, as a control, the iron chelator bathophenanthroline (BPA). First, the absorption and further metabolization of dietary curcuminoids were proved by metabolomics analyses. Next, we found that 0.2% dietary curcumin, similar to BPA, lowered the iron but also the cobalt content, and to a lesser extent affected the manganese and zinc status. Supplementation during larval stages was required and sufficient for both compounds to elicit these alterations in adult animals. However, curcumin-induced retarded larval development was not attributable to the changed trace metal status. In addition, a reduction in the iron content of up to 70% by curcumin or BPA supplementation did not reduce heme-dependent catalase activity and tolerance toward H
MeSH term(s)	Mice ; Animals ; Drosophila melanogaster/genetics ; Curcumin/pharmacology ; Cobalt ; Polyamines ; Iron ; Oxidative Stress ; Chelating Agents ; Antioxidants ; Dietary Supplements
Chemical Substances	Curcumin (IT942ZTH98) ; Cobalt (3G0H8C9362) ; Polyamines ; Iron (E1UOL152H7) ; Chelating Agents ; Antioxidants
Language	English
Publishing date	2023-08-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	59230-4
ISSN	1872-8081 ; 0951-6433
ISSN (online)	1872-8081
ISSN	0951-6433
DOI	10.1002/biof.2000
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In Contrast to Dietary Restriction, Application of Resveratrol in Mice Does not Alter Mouse Major Urinary Protein Expression.

Pallauf, Kathrin / Günther, Ilka / Chin, Dawn / Rimbach, Gerald

Nutrients

2020 Volume 12, Issue 3

Abstract: Resveratrol (RSV) supplementation in mice has been discussed as partly mimicking the beneficial effects of dietary restriction (DR). However, data on putative benefits from resveratrol application in mice and other model organisms including humans is ... ...

Abstract	Resveratrol (RSV) supplementation in mice has been discussed as partly mimicking the beneficial effects of dietary restriction (DR). However, data on putative benefits from resveratrol application in mice and other model organisms including humans is contradictory. Mouse major urinary proteins (MUPs) are a family of proteins that are expressed in rodent liver and secreted via urine. Impacting (mating) behavior and pheromone communication, they are severely down-regulated upon DR. We carried out two studies in C57BL/6Rj mice where RSV was either supplemented via diet or injected intraperitoneally for 8 weeks. Contrary to -40% DR, RSV did not decrease total MUP protein expression or
MeSH term(s)	Animals ; Caloric Restriction ; Eating ; Gene Expression ; Gene Expression Regulation/drug effects ; Male ; Mice ; Proteins/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Glucocorticoid/genetics ; Receptors, Glucocorticoid/metabolism ; Resveratrol/pharmacology
Chemical Substances	Proteins ; RNA, Messenger ; Receptors, Glucocorticoid ; major urinary proteins ; Resveratrol (Q369O8926L)
Language	English
Publishing date	2020-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12030815
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: In Contrast to Dietary Restriction, Application of Resveratrol in Mice Does not Alter Mouse Major Urinary Protein Expression

Pallauf, Kathrin / Günther, Ilka / Chin, Dawn / Rimbach, Gerald

Nutrients. 2020 Mar. 19, v. 12, no. 3

2020

Abstract	Resveratrol (RSV) supplementation in mice has been discussed as partly mimicking the beneficial effects of dietary restriction (DR). However, data on putative benefits from resveratrol application in mice and other model organisms including humans is contradictory. Mouse major urinary proteins (MUPs) are a family of proteins that are expressed in rodent liver and secreted via urine. Impacting (mating) behavior and pheromone communication, they are severely down-regulated upon DR. We carried out two studies in C57BL/6Rj mice where RSV was either supplemented via diet or injected intraperitoneally for 8 weeks. Contrary to -40% DR, RSV did not decrease total MUP protein expression or Mup (amongst others Mup3, Mup5, Mup6, Mup15, and Mup20) mRNA levels in mouse liver when compared to ad-libitum (AL)-fed controls. Since inhibitory glucocorticoid response elements can be found in Mup promoters, we also measured glucocorticoid receptor (GR) levels in nuclear hepatic extracts. Consistent with differential MUP expression, we observed more nuclear GR in DR mice than in RSV-supplemented and AL control mice with no difference between RSV and AL. These findings point to the notion that, in mice, RSV does not mimic DR in terms of differential MUP expression.
Keywords	alpha-globulins ; diet ; dietary restriction ; extracts ; glucocorticoid receptors ; glucocorticoids ; humans ; liver ; mice ; models ; nutrients ; pheromones ; protein synthesis ; response elements ; resveratrol ; urine
Language	English
Dates of publication	2020-0319
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12030815
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Innovationen für den Ernährungssektor: Innovative Strategien zur Steigerung der biologischen Aktivität von sekundären Pflanzenstoffen mit geringer oraler Bioverfügbarkeit und deren Anwendung in funktionellen Lebensmitteln zum optimalen Schutz des Gehirns während des Alterns, Teilprojekt 3: Curcumin und Neuroinflammation: Bedeutung des Apolipoprotein E-Genotyps

Chin, Dawn / Rimbach, Gerald

Abschlussbericht ; Laufzeit des Vorhabens: 01.08.2010 - 31.07.2013

2013

Title variant	Novel strategies for the enhancement of the potency of nutraceuticals with low oral bioavailability and their application in novel functional foods for optimum protection of the aging brain, WP 3: Curcumin, neuroinflammation, and the role of apolipoprotein E genotype
Author's details	Autoren: Chin, Dawn; Rimbach, Gerald
Language	German ; English
Size	Online-Ressource (PDF-Datei: 21 S., 233 KB), graph. Darst.
Publisher	Techn. Informationsbibl. und Univ.-Bibl ; Christian-Albrechts-Univ. zu Kiel, Inst. für Humanernährung und Lebensmittelkunde, Abt. Lebensmittelwiss
Publishing place	Hannover ; Kiel
Document type	Book ; Online
Note	Text engl. - Zsfassung in engl. u. dt. Sprache ; Förderkennzeichen BMBF 01EA1334C [neu] - 0315679C [alt]. - Verbund-Nr. 01075926. - Engl. Berichtsbl. u.d.T.: Novel strategies for the enhancement of the potency of nutraceuticals with low oral bioavailability and their application in novel functional foods for optimum protection of the aging brain, WP 3: Curcumin, neuroinflammation, and the role of apolipoprotein E genotype ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: The Potential of Resveratrol to Act as a Caloric Restriction Mimetic Appears to Be Limited: Insights from Studies in Mice

Pallauf, Kathrin / Günther, Ilka / Kühn, Gianna / Chin, Dawn / de Pascual-Teresa, Sonia / Rimbach, Gerald

Advances in nutrition. 2020 Dec. 03, v. 12, no. 3

2020

Abstract: Caloric restriction (CR) has been shown repeatedly to prolong the lifespan in laboratory animals, with its benefits dependent on molecular targets forming part of the nutrient signaling network, including the NAD-dependent deacetylase silent mating type ... ...

Abstract	Caloric restriction (CR) has been shown repeatedly to prolong the lifespan in laboratory animals, with its benefits dependent on molecular targets forming part of the nutrient signaling network, including the NAD-dependent deacetylase silent mating type information regulation 2 homologue 1 (SIRT1). It has been hypothesized that the stilbene resveratrol (RSV) may counteract age- and obesity-related diseases similarly to CR. In yeast and worms, RSV-promoted longevity also depended on SIRT1. While it remains unclear whether RSV can prolong lifespans in mammals, some studies in rodents supplemented with RSV have reported lowered body weight (BW) and fat mass, improved insulin sensitivity, lowered cholesterol levels, increased fitness, and mitochondrial biogenesis. Molecular mechanisms possibly leading to such changes include altered gene transcription and activation of SIRT1, AMP-activated kinase (AMPK), and peroxisome proliferator–activated receptor gamma coactivator 1-alpha (PPARGC1A). However, some mouse models did not benefit from RSV treatment to the same extent as others. We conducted a literature search on PubMed (15 April, 2020) for trials directly comparing RSV application to CR feeding in mice. In most studies retrieved by this systematic PubMed search, mice supplemented with RSV did not show significant reductions of BW, glucose, or insulin. Moreover, in some of these studies, RSV and CR treatments affected molecular targets differently and/or findings on RSV and CR impacts varied between trials. We discuss those RSV-induced changes in gene transcription hypothesized to partly counteract age-related alterations. Although there may be a moderate effect of RSV supplementation on parameters such as insulin sensitivity toward a more CR-like profile in mice, data are inconsistent. Likewise, RSV supplementation trials in humans report controversial findings. While we consider that RSV may, under certain circumstances, moderately mimic some aspects of CR, current evidence does not fully support its use to prevent or treat age- or obesity-related diseases.
Keywords	biogenesis ; body weight ; cholesterol ; glucose ; insulin ; insulin resistance ; longevity ; low calorie diet ; mice ; mitochondria ; peroxisome proliferator-activated receptor gamma ; resveratrol ; transcription (genetics) ; yeasts
Language	English
Dates of publication	2020-1203
Size	p. 995-1005.
Publishing place	Oxford University Press
Document type	Article
ZDB-ID	2583634-1
ISSN	2156-5376
ISSN	2156-5376
DOI	10.1093/advances/nmaa148
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Potential of Resveratrol to Act as a Caloric Restriction Mimetic Appears to Be Limited: Insights from Studies in Mice.

Pallauf, Kathrin / Günther, Ilka / Kühn, Gianna / Chin, Dawn / de Pascual-Teresa, Sonia / Rimbach, Gerald

Advances in nutrition (Bethesda, Md.)

2020 Volume 12, Issue 3, Page(s) 995–1005

Abstract	Caloric restriction (CR) has been shown repeatedly to prolong the lifespan in laboratory animals, with its benefits dependent on molecular targets forming part of the nutrient signaling network, including the NAD-dependent deacetylase silent mating type information regulation 2 homologue 1 (SIRT1). It has been hypothesized that the stilbene resveratrol (RSV) may counteract age- and obesity-related diseases similarly to CR. In yeast and worms, RSV-promoted longevity also depended on SIRT1. While it remains unclear whether RSV can prolong lifespans in mammals, some studies in rodents supplemented with RSV have reported lowered body weight (BW) and fat mass, improved insulin sensitivity, lowered cholesterol levels, increased fitness, and mitochondrial biogenesis. Molecular mechanisms possibly leading to such changes include altered gene transcription and activation of SIRT1, AMP-activated kinase (AMPK), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A). However, some mouse models did not benefit from RSV treatment to the same extent as others. We conducted a literature search on PubMed (15 April, 2020) for trials directly comparing RSV application to CR feeding in mice. In most studies retrieved by this systematic PubMed search, mice supplemented with RSV did not show significant reductions of BW, glucose, or insulin. Moreover, in some of these studies, RSV and CR treatments affected molecular targets differently and/or findings on RSV and CR impacts varied between trials. We discuss those RSV-induced changes in gene transcription hypothesized to partly counteract age-related alterations. Although there may be a moderate effect of RSV supplementation on parameters such as insulin sensitivity toward a more CR-like profile in mice, data are inconsistent. Likewise, RSV supplementation trials in humans report controversial findings. While we consider that RSV may, under certain circumstances, moderately mimic some aspects of CR, current evidence does not fully support its use to prevent or treat age- or obesity-related diseases.
MeSH term(s)	Animals ; Caloric Restriction ; Humans ; Insulin ; Mice ; Resveratrol/pharmacology ; Sirtuin 1 ; Stilbenes/pharmacology
Chemical Substances	Insulin ; Stilbenes ; Sirtuin 1 (EC 3.5.1.-) ; Resveratrol (Q369O8926L)
Language	English
Publishing date	2020-12-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2583634-1
ISSN	2156-5376 ; 2156-5376
ISSN (online)	2156-5376
ISSN	2156-5376
DOI	10.1093/advances/nmaa148
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Innovationen für den Ernährungssektor: Innovative Strategien zur Steigerung der biologischen Aktivität von sekundären Pflanzenstoffen mit geringer oraler Bioverfügbarkeit und deren Anwendung in funktionellen Lebensmitteln zum optimalen Schutz des Gehirns während des Alterns

Chin, Dawn / Rimbach, Gerald

Teilprojekt 3: Curcumin und Neuroinflammation: Bedeutung des Apolipoprotein E-Genotyps ; Abschlussbericht ; Laufzeit des Vorhabens: 01.08.2010 - 31.07.2013

2013

Title variant	Novel strategies for the enhancement of the potency of nutraceuticals with low oral bioavailability and their application in novel functional foods for optimum protection of the aging brain
Author's details	[Autoren: Chin, Dawn; Rimbach, Gerald]
Language	English
Size	19 S., graph. Darst.
Publisher	Univ., Inst. für Humanernährung und Lebensmittelkunde, Abt. Lebensmittelwissenschaft
Publishing place	Kiel
Document type	Book
Note	Text engl. ; Förderkennzeichen BMBF 01EA1334C [neu] - 0315679C [alt]. - Verbund-Nr. 01075926
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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Book ; Online: Prävention kardiovaskulärer Erkrankungen und Atherosklerose

Kuhlmann, Inga / Chin, Dawn / Rimbach, Gerald

(essentials)

2014

Abstract: Inga Kuhlmann, Dawn Chin und Gerald Rimbach geben eine Einführung zu Stickstoffmonoxid-Synthasen und deren Bedeutung in der Prävention und Pathogenese kardiovaskulärer Erkrankungen. Außerdem liefern sie einen Überblick zu Apolipoprotein E und dessen ... ...

Author's details	Inga Kuhlmann; Dawn Chin; Gerald Rimbach
Series title	essentials
Abstract	Inga Kuhlmann, Dawn Chin und Gerald Rimbach geben eine Einführung zu Stickstoffmonoxid-Synthasen und deren Bedeutung in der Prävention und Pathogenese kardiovaskulärer Erkrankungen. Außerdem liefern sie einen Überblick zu Apolipoprotein E und dessen Bedeutung in der Entwicklung einer Atherosklerose. Die Autoren geben abschließend Empfehlungen für eine gesunde Ernährung zur Prävention von Herz-Kreislauf-Erkrankungen. Der Inhalt Molekulare Mechanismen der Atherosklerose Stickstoffmonoxid-Synthasen (NOS) und deren Bedeutung in der Pathogenese kardiovaskulärer Erkrankungen Risikofaktoren Bedeutung von Nahrungsfaktoren für die Gefäßgesundheit Apolipoprotein E-Genotyp und Gefäßgesundheit Die Zielgruppen Dozenten und Studenten der Ernährungswissenschaften mit den Schwerpunkten Humanernährung und Lebensmittelkunde PraktikerInnen, die sich mit dem Thema Ernährung, kardiovaskuläre Erkrankungen und Atherosklerose befassen Die Autoren Inga Kuhlmann ist Ernährungswissenschaftlerin und derzeit in der Lebensmittelindustrie tätig. Dr. Dawn Chin ist wissenschaftliche Mitarbeiterin am Institut für Humanernährung und Lebensmittelkunde an der Universität Kiel. Prof. Dr. Gerald Rimbach ist Professor für Lebensmittelwissenschaft am Institut für Humanernährung und Lebensmittelkunde an der Universität Kiel
Keywords	Biochemistry ; Human genetics ; Medicine
Language	German
Size	Online-Ressource (VIII, 32 S.)
Publisher	Springer Spektrum
Publishing place	Wiesbaden
Document type	Book ; Online
ISBN	9783658083588 ; 9783658083595 ; 3658083581 ; 365808359X
DOI	10.1007/978-3-658-08359-5
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Online: Prävention kardiovaskulärer Erkrankungen und Atherosklerose

Kuhlmann, Inga / Chin, Dawn / Rimbach, Gerald

(essentials)

2014

Author's details	von Inga Kuhlmann, Dawn Chin, Gerald Rimbach
Series title	essentials
Abstract	Inga Kuhlmann, Dawn Chin und Gerald Rimbach geben eine Einführung zu Stickstoffmonoxid-Synthasen und deren Bedeutung in der Prävention und Pathogenese kardiovaskulärer Erkrankungen. Außerdem liefern sie einen Überblick zu Apolipoprotein E und dessen Bedeutung in der Entwicklung einer Atherosklerose. Die Autoren geben abschließend Empfehlungen für eine gesunde Ernährung zur Prävention von Herz-Kreislauf-Erkrankungen. Der Inhalt Molekulare Mechanismen der Atherosklerose Stickstoffmonoxid-Synthasen (NOS) und deren Bedeutung in der Pathogenese kardiovaskulärer Erkrankungen Risikofaktoren Bedeutung von Nahrungsfaktoren für die Gefäßgesundheit Apolipoprotein E-Genotyp und Gefäßgesundheit Die Zielgruppen Dozenten und Studenten der Ernährungswissenschaften mit den Schwerpunkten Humanernährung und Lebensmittelkunde PraktikerInnen, die sich mit dem Thema Ernährung, kardiovaskuläre Erkrankungen und Atherosklerose befassen Die Autoren Inga Kuhlmann ist Ernährungswissenschaftlerin und derzeit in der Lebensmittelindustrie tätig. Dr. Dawn Chin ist wissenschaftliche Mitarbeiterin am Institut für Humanernährung und Lebensmittelkunde an der Universität Kiel. Prof. Dr. Gerald Rimbach ist Professor für Lebensmittelwissenschaft am Institut für Humanernährung und Lebensmittelkunde an der Universität Kiel
Keywords	Biochemistry ; Human genetics ; Medicine
Language	German
Size	Online-Ressource
Publisher	Springer Spektrum
Publishing place	s.l.
Document type	Book ; Online
ISBN	9783658083588 ; 9783658083595 ; 3658083581 ; 365808359X
DOI	10.1007/978-3-658-08359-5
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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