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  1. Article: A rare presentation of ectopic thyroid gland at right axilla.

    Chin, Y H / Yap, Y L / Chin, H H / Sarina, S

    The Medical journal of Malaysia

    2021  Volume 76, Issue 4, Page(s) 600–602

    Abstract: The thyroid gland and its hormones play important roles in organ development and in the homeostatic control of physiological mechanisms in human beings. As a result of embryogenic descent of thyroid gland, it commonly resides along the midline - from ... ...

    Abstract The thyroid gland and its hormones play important roles in organ development and in the homeostatic control of physiological mechanisms in human beings. As a result of embryogenic descent of thyroid gland, it commonly resides along the midline - from tongue to mediastinum (90%). Ectopic thyroid gland is a rare occurrence, with extra-lingual ectopic thyroid gland being even rarer. Thus, there is a concern for malignant metastasis. Madam H, a 56-year-old healthy woman presented to the Hospital Sultanah Nora Ismail, Johor, Malaysia in April 2020 with an increasing size of right axilla mass and history of weight loss. She was having right axilla mass for the previous 7 years but only noticed the increase in size about 1 year ago. She has no other constitutional symptoms. A tru-cut biopsy performed demonstrated a benign ectopic thyroid tissue. Thyroid function test showed primary hypothyroidism. Serum Chromogranin A and other thyroid antibodies were within the normal value. Further radiological imaging showed the normal thyroid gland at neck, with no signs of distant malignancy. There was no other axillary, mediastinal or hilar lymph node enlargement. She was started on regular T. L Thyroxine 100mcg daily and given regular follow-up in endocrine clinic. Benign ectopic thyroid gland is an unusual finding. As such, follow up is needed with possibility of carcinomatous transformation such as papillary carcinoma should be considered.
    MeSH term(s) Axilla ; Carcinoma, Papillary ; Female ; Humans ; Middle Aged ; Thyroid Dysgenesis/diagnostic imaging ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/surgery
    Language English
    Publishing date 2021-07-23
    Publishing country Malaysia
    Document type Case Reports ; Journal Article
    ZDB-ID 604286-7
    ISSN 0300-5283
    ISSN 0300-5283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Hypothalamic-pituitary fungal infection causing panhypopituitarism.

    Chin, Y H / Yap, Y L / Chin, H H / Lau, B K

    The Medical journal of Malaysia

    2021  Volume 76, Issue 4, Page(s) 606–609

    Abstract: Madam LPS, a 69 years old lady complained of left eye blurring of vision since January 2017. It was associated with left orbital swelling with chemosis, eye redness, epiphora, several episodes of self-limiting epistaxis and bilateral ophthalmoplegia. ... ...

    Abstract Madam LPS, a 69 years old lady complained of left eye blurring of vision since January 2017. It was associated with left orbital swelling with chemosis, eye redness, epiphora, several episodes of self-limiting epistaxis and bilateral ophthalmoplegia. Other neurological examinations and cerebellar systems were intact. Magnetic Resonance Imaging (MRI) Brain and Orbit were performed, depicting a sellar mass with suprasellar extension with blood investigations results showed panhypopituitarism. She underwent bilateral orbital decompression. Trans-nasal endoscopic biopsy showed suppurative granulomatous lesion, which cultured Candida Albicans and Candida Galbrata. She was started on antifungal and hormonal replacement therapy for panhypopituitarism. Unfortunately, she did not respond well to treatment as repeated MRI Brain on December 2018 showed increase in size of sellar mass causing obstructive hydrocephalus and increasing size of left orbital lesion. She was counselled for another debulking surgery with a ventriculoperitoneal (VP) shunt. HPE taken were reported as chronic inflammatory process in favour to fungal infection. Pituitary infections may mimic pituitary mass. Some may exhibit symptoms of panhypopituitarism as well. Thus, physical examination, MRI brain imaging as well as HPE of biopsy are important aids to achieve diagnosis. Optimal treatment of fungal pituitary abscess includes transsphenoidal surgery combined with antifungal therapy.
    MeSH term(s) Aged ; Female ; Humans ; Hypopituitarism/diagnosis ; Hypopituitarism/etiology ; Hypopituitarism/therapy ; Magnetic Resonance Imaging ; Mycoses ; Pituitary Diseases ; Pituitary Gland
    Language English
    Publishing date 2021-05-11
    Publishing country Malaysia
    Document type Case Reports ; Journal Article
    ZDB-ID 604286-7
    ISSN 0300-5283
    ISSN 0300-5283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A retrospective cross-sectional study on the risk factors and survival outcome of End Stage Kidney Disease patients receiving regular maintenance haemodialysis with COVID-19 infection in Hospital Enche' Besar Hajjah Khalsom, Kluang.

    Chin, H H / Chin, Y H / Yap, Y L / Tan, P S / Tiong, X T / Noor Hidayah, Y / Chin, P W

    The Medical journal of Malaysia

    2021  Volume 76, Issue 6, Page(s) 845–852

    Abstract: Introduction: COVID-19 pandemic has affected healthcare services around the globe as hospitals were turned into designated hospitals to accommodate high risk groups of patients with COVID-19 infection including end stage kidney disease (ESKD) patients. ... ...

    Abstract Introduction: COVID-19 pandemic has affected healthcare services around the globe as hospitals were turned into designated hospitals to accommodate high risk groups of patients with COVID-19 infection including end stage kidney disease (ESKD) patients. In Malaysia, there was insufficient data on COVID-19 infection among ESKD patients. This study aims to determine factors and survival outcomes associated with COVID-19 infection among ESKD patients in a designated COVID-19 hospital in Malaysia.
    Methods and materials: A retrospective cross-sectional study involving 80 haemodialysis (HD) patients recruited from March 2020 till March 2021. Patients' information and results was retrieved and evaluated. Risk factors affecting the COVID-19 mortality were analysed using a one-way analysis of variance (ANOVA) and binary logistic regression.
    Results: The mean age of the patients was 54 years who were predominantly Malays (87.5%) and living in rural areas. Majority of them had comorbidities such as diabetes mellitus (71%) and hypertension (90%). The most common presentations were fever (46%) and cough (54%) with chest radiographs showing bilateral lower zone ground glass opacities (45%). A quarter of the study population were admitted to the intensive care unit, necessitating mechanical ventilation. This study found that 51% of the patients were given steroids and 45% required oxygen supplementation. The COVID-19 infection mortality among the study population was 12.5%. Simple logistic regression analysis showed that albumin, Odd Ratio, OR=0.85 (95% Confidence Interval, 95%CI: 0.73, 0.98)) and absolute lymphocyte count OR=0.08 (95%CI: 0.11, 0.56) have inverse association with COVID-19 mortality. C-reactive protein OR=1.02 (95%CI: 1.01, 1.04), lactate dehydrogenase OR=1.01 (95%CI: 1.00, 1.01), mechanical ventilation OR=17.21 (95%CI: 3.03, 97.67) and high dose steroids OR=15.71 (95%CI: 1.80, 137.42) were directly associated with COVID-19 mortality.
    Conclusion: The high mortality rate among ESKD patients receiving HD was alarming. This warrants additional infection control measures to prevent the spread of COVID- 19 infection among this vulnerable group of patients. Expediting vaccination efforts in this group of patients should be advocated to reduce the incidence of complications from COVID-19 infection.
    MeSH term(s) COVID-19 ; Cross-Sectional Studies ; Hospitals ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Middle Aged ; Pandemics ; Renal Dialysis ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
    Language English
    Publishing date 2021-11-26
    Publishing country Malaysia
    Document type Journal Article
    ZDB-ID 604286-7
    ISSN 0300-5283
    ISSN 0300-5283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Incidence of SARS-CoV-2 infection in inflammatory bowel disease.

    Lee, M H / Ng, C H / Chin, Y H / Muthiah, M / Foo, F J / Chong, C S

    Journal of gastroenterology and hepatology

    2020  Volume 35, Issue 11, Page(s) 2021–2022

    MeSH term(s) Biological Products/therapeutic use ; COVID-19/epidemiology ; Humans ; Incidence ; Inflammatory Bowel Diseases/drug therapy ; SARS-CoV-2
    Chemical Substances Biological Products
    Keywords covid19
    Language English
    Publishing date 2020-08-03
    Publishing country Australia
    Document type Letter ; Meta-Analysis ; Systematic Review
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.15191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Colorectal resection via natural orifice specimen extraction versus conventional laparoscopic extraction: a meta-analysis with meta-regression.

    Chin, Y H / Decruz, G M / Ng, C H / Tan, H Q M / Lim, F / Foo, F J / Tai, C H / Chong, C S

    Techniques in coloproctology

    2020  Volume 25, Issue 1, Page(s) 35–48

    Abstract: Background: Studies have shown differences in postoperative outcomes between two minimally invasive extraction methods for colorectal lesions-natural orifice specimen extraction surgery (NOSES) and conventional laparoscopic surgery (CLS). The aim of ... ...

    Abstract Background: Studies have shown differences in postoperative outcomes between two minimally invasive extraction methods for colorectal lesions-natural orifice specimen extraction surgery (NOSES) and conventional laparoscopic surgery (CLS). The aim of this study was to discover the major differences in NOSES and CLS to refine current practice.
    Methods: Electronic databases were searched for articles comparing NOSES and CLS from inception till March 2020. Weighted mean differences (WMD) and odds ratio (OR) were estimated for continuous and dichotomous outcomes, respectively. Summary statistics were calculated using the DerSimonian and Laird random effects.
    Results: Twenty-one studies (15 on malignant disease, 4 on benign disease, 2 on both) were included in this meta-analysis, totalling 2378 patients (1079 NOSE, 1299 CLS). NOSE was associated with decreased: intraoperative bleeding (WMD: - 10.652 ml; 95% CI: - 18.818 ml to - 2.482 ml; p < 0.001), pain score (WMD: - 1.520; 95% CI - 1.965 to - 1.076; p < 0.001), time to flatus (WMD: - 0.306 days; 95% CI: - 0.526 to - 0.085 days; p < 0.001), length of hospital stay (WMD: - 1.048 days; 95% CI: - 1.488 to - 0.609 days; p < 0.001), and total morbidity (OR: 0.548; 95% CI: 0.387 to 0.777; p = 0.001). Subgroup analyses showed significant differences between malignant and benign lesions for intraoperative bleeding (p = 0.011) and pain score (p = 0.010). Meta-regression analyses showed an association between the American Society of Anaesthesiologists (ASA) physical status classification III with pain (p = 0.03) and ASA III with time to flatus (p = 0.04).
    Conclusions: This meta-analysis and meta-regression demonstrated that NOSES had better postoperative outcomes compared to CLS. More comprehensive reviews should be conducted on the long-term outcomes specific to the extraction site to better inform clinical practice.
    MeSH term(s) Colorectal Neoplasms/surgery ; Digestive System Surgical Procedures ; Humans ; Laparoscopy ; Length of Stay ; Treatment Outcome
    Language English
    Publishing date 2020-08-26
    Publishing country Italy
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-020-02330-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: X-band ppm klystron development for JLC

    Chin, Y. H

    (KEK Preprint ; 2001,46)

    2001  

    Author's details Y. H. Chin
    Series title KEK Preprint ; 2001,46
    Language English
    Size 3 S, Ill., graph. Darst
    Publisher High Energy Accelerator Research Organization (KEK)
    Publishing place Tsukuba
    Document type Book
    Note Presented at the 2001 Particle Accelerator Conference (PAC 2001), Chicago, U.S.A., June 18 - 22, 2001
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Book: Status of the x-band RF power source development for JLC

    Chin, Y. H

    (KEK Preprint ; 2000,70)

    2000  

    Author's details Y. H. Chin
    Series title KEK Preprint ; 2000,70
    Language English
    Size 3 S, Ill., graph. Darst
    Publisher High Energy Accelerator Research Organization (KEK)
    Publishing place Tsukuba
    Document type Book
    Note Submitted to the 7th European Particle Accelerator Conference (EPAC 2000), Vienna, Austria, June 26 - 30, 2000
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book ; Conference proceedings: Proceedings of the First Asian Particle Accelerator Conference

    Chin, Y. H

    KEK, Tsukuba, Japan, 23 - 27 March, 1998

    (KEK proceedings ; 98-10)

    1998  

    Institution Asian Particle Accelerator Conference
    Kō-Enerugī-Kasokuki-Kenkyū-Kikō
    Event/congress APAC 98 (1, 1998.03.23-27, Tsukuba) ; Asian Particle Accelerator Conference (1, 1998.03.23-27, Tsukuba)
    Author's details ed. board: Y. H. Chin
    Series title KEK proceedings ; 98-10
    Language English
    Size XV, 903 S., S. XVII-XL, 6 S. Abb
    Publisher High Energy Accelerator Research Organization
    Publishing place Tsukuba-shi
    Document type Book ; Conference proceedings
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Book: The 120 MW X-band klystron development at KEK

    Chin, Y. H

    (KEK Preprint ; 98-118)

    1998  

    Author's details Y. H. Chin
    Series title KEK Preprint ; 98-118
    Language English
    Size 3 S, graph. Darst
    Publisher High Energy Accelerator Research Organization (KEK)
    Publishing place Tsukuba
    Document type Book
    Note Submitted to Sixth European Particle Accelerator Conference, (EPAC98) Stockholm, 22 - 26 June 1998
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Book: JLC R & D status

    Chin, Y. H

    (KEK Preprint ; 2001,47)

    2001  

    Author's details Y. H. Chin
    Series title KEK Preprint ; 2001,47
    Language English
    Size 3 S, graph. Darst
    Publisher High Energy Accelerator Research Organization (KEK)
    Publishing place Tsukuba
    Document type Book
    Note Contributed talk presented at the 2001 Particle Accelerator Conference (PAC 2001), Chicago, U.S.A., June 18 - 22, 2001
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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