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  1. Article: Decoding Applications of Artificial Intelligence in Rheumatology.

    Chinnadurai, Saranya / Mahadevan, Sabarinath / Navaneethakrishnan, Balakrishnan / Mamadapur, Mahabaleshwar

    Cureus

    2023  Volume 15, Issue 9, Page(s) e46164

    Abstract: Artificial intelligence (AI) is not a newcomer in medicine. It has been employed for image analysis, disease diagnosis, drug discovery, and improving overall patient care. ChatGPT (Chat Generative Pre-trained Transformer, Inc., Delaware) has renewed ... ...

    Abstract Artificial intelligence (AI) is not a newcomer in medicine. It has been employed for image analysis, disease diagnosis, drug discovery, and improving overall patient care. ChatGPT (Chat Generative Pre-trained Transformer, Inc., Delaware) has renewed interest and enthusiasm in artificial intelligence. Algorithms, machine learning, deep learning, and data analysis are some of the complex terminologies often encountered when health professionals try to learn AI. In this article, we try to review the practical applications of artificial intelligence in vernacular language in the fields of medicine and rheumatology in particular. From the standpoint of the everyday physician, we have endeavored to encapsulate the influence of AI on the cutting edge of medical practice and the potential revolutionary shift in the realm of rheumatology.
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.46164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A Retrospective Study on Antinuclear Antibody Patterns in Systemic Lupus Erythematosus Patients and Its Correlation With Serological Markers.

    Ramachandran, Aishwarya / Kumar, Kennedy / Sankaralingam, Rajeswari / Chinnadurai, Saranya / Chilukuri, Balaji

    Cureus

    2023  Volume 15, Issue 12, Page(s) e50049

    Abstract: Introduction: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Detection of antinuclear antibodies (ANAs) aids in the diagnosis of SLE. The indirect immunofluorescence (IIF) assay is often used a routine screening test for the ... ...

    Abstract Introduction: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Detection of antinuclear antibodies (ANAs) aids in the diagnosis of SLE. The indirect immunofluorescence (IIF) assay is often used a routine screening test for the detection of ANA. The pathogenic role and significance of various patterns produced in IIF is yet to be explored.
    Aim: This study aimed to detect ANA patterns generated by IIF and correlate these patterns with specific antibodies detected by line immunoassay. We also investigated the significance of each ANA pattern and its association with specific serological SLE markers, such as complement molecules, anti-dsDNA, antiphospholipid antibody, and C-reactive protein (CRP), along with associations with direct Coombs test (DCT).
    Materials and methods: We conducted a retrospective study that included 204 patients newly diagnosed with SLE according to the European Alliance of Associations for Rheumatology/American College of Rheumatology (EULAR/ACR) criteria. The detection and pattern determination of ANA was performed by IIF using HEp-20-10. Furthermore, line immunoassay was performed, and the antibody profile of each sample was obtained. Other immunodiagnostic markers were analyzed, including C3, C4, anti-dsDNA, antiphospholipid antibodies (anti-cardiolipin antibodies, anti-beta-2-glycoprotein I, and lupus anticoagulant), CRP, and DCT.
    Results: Of the 204 samples, the most frequent ANA pattern observed was nucleus speckled (52.9%), followed by nucleus homogenous (27.5%), mixed (13.7%), and cytoplasm speckled (5.9%). The nucleus homogenous pattern showed the most pathogenic immune profile due to its close association with markers of disease activity, namely, high anti-dsDNA titer, low C3 level, and DCT positivity.  Conclusion: This study showed that the most common pattern associated with SLE is nucleus speckled, followed by the nucleus homogenous pattern. Based on associations with specific serological markers, the nucleus homogenous pattern may be linked to a high disease activity in SLE.
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.50049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Diffuse subcutaneous calcification with leg ulcers in a child with lupus.

    Janarthanan, Mahesh / Chinnadurai, Saranya / Balaji, Chilukuri / Rajeswari, Sankaralingam

    The Lancet. Rheumatology

    2021  Volume 3, Issue 3, Page(s) e234

    Language English
    Publishing date 2021-02-24
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(20)30338-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Eyebrow rashes and discolouration of ears: beware of the wolf.

    Janarthanan, Mahesh / Balaji, Chilukuri / Chinnadurai, Saranya / Sankaralingam, Rajeswari

    Archives of disease in childhood

    2020  Volume 106, Issue 9, Page(s) 920

    Language English
    Publishing date 2020-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2020-320678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Clinical profile of osteonecrosis in systemic lupus erythematosus - Experience from a tertiary care centre in South India.

    Chinnadurai, Saranya / Chilukuri, Balaji / Mahendran, Bhuvanesh / Mantharam, Vignesh / Selvakumar, Balameena / Sankaralingam, Rajeswari

    Journal of family medicine and primary care

    2020  Volume 9, Issue 8, Page(s) 4363–4367

    Abstract: Introduction: Osteonecrosis or Avascular necrosis of bone (AVN) is a well recognized complication of systemic lupus erythematosus (SLE) leading to significant morbidity.: Methods: We did a cross sectional descriptive study in cohort of SLE patients, ... ...

    Abstract Introduction: Osteonecrosis or Avascular necrosis of bone (AVN) is a well recognized complication of systemic lupus erythematosus (SLE) leading to significant morbidity.
    Methods: We did a cross sectional descriptive study in cohort of SLE patients, on regular follow-up at our Rheumatology OPD over a period of 5 years from 2012 to 2017.
    Results: Of the total 415 SLE, 5.1% (
    Conclusion: This study described the prevalence and epidemiology of osteonecrosis in our cohort of SLE patients.
    Language English
    Publishing date 2020-08-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_1234_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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