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  1. Article ; Online: Accidental finding of 2 giant coronary button aneurysms 23 years after composite graft replacement.

    Schmiady, Martin O / Alkadhi, Hatem / Chiodini, Alessandra / Ouda, Ahmed

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2021  Volume 60, Issue 4, Page(s) 1000

    MeSH term(s) Aortic Valve ; Blood Vessel Prosthesis/adverse effects ; Coronary Aneurysm/diagnostic imaging ; Coronary Aneurysm/etiology ; Coronary Aneurysm/surgery ; Humans ; Replantation
    Language English
    Publishing date 2021-02-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezab240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2303: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Menstrual Pain and Elasticity of Uterine Cervix.

    Xholli, Anjeza / Simoncini, Gianluca / Vujosevic, Sonja / Trombetta, Giulia / Chiodini, Alessandra / Ferraro, Mattia Francesco / Cagnacci, Angelo

    Journal of clinical medicine

    2021  Volume 10, Issue 5

    Abstract: Menstrual pain is consequent to intense uterine contraction aimed to expel menstrual flow through downstream uterine cervix. Herein it was evaluated whether characteristics of uterine cervix are associated with intensity of menstrual pain. Ultrasound ... ...

    Abstract Menstrual pain is consequent to intense uterine contraction aimed to expel menstrual flow through downstream uterine cervix. Herein it was evaluated whether characteristics of uterine cervix are associated with intensity of menstrual pain. Ultrasound elastography was used to analyze cervix elasticity of 75 consecutive outpatient women. Elasticity was related to intensity of menstrual pain defined by a Visual Analogue Scale (VAS). Four regions of interest (ROI) were considered: internal uterine orifice (IUO), anterior (ACC) and posterior cervical (PCC) compartment and middle cervical canal (MCC). Tissue elasticity, evaluated by color score (from 0.5 = blue/violet (low elasticity) to 3.0 = red (high elasticity), and percent tissue deformation was analyzed. Elasticity of IUO was lower (
    Language English
    Publishing date 2021-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10051110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Differentiating hereditary arrhythmogenic right ventricular cardiomyopathy from cardiac sarcoidosis fulfilling 2010 ARVC Task Force Criteria.

    Gasperetti, Alessio / Rossi, Valentina A / Chiodini, Alessandra / Casella, Michela / Costa, Sarah / Akdis, Deniz / Büchel, Ronny / Deliniere, Antoine / Pruvot, Etienne / Gruner, Christiane / Carbucicchio, Corrado / Manka, Robert / Dello Russo, Antonio / Tondo, Claudio / Brunckhorst, Corinna / Tanner, Felix / Duru, Firat / Saguner, Ardan M

    Heart rhythm

    2020  Volume 18, Issue 2, Page(s) 231–238

    Abstract: Background: The clinical presentation of cardiac sarcoidosis (CS) may resemble that of arrhythmogenic right ventricular cardiomyopathy (ARVC).: Objective: The purpose of this study was to identify clinical variables to better discriminate between ... ...

    Abstract Background: The clinical presentation of cardiac sarcoidosis (CS) may resemble that of arrhythmogenic right ventricular cardiomyopathy (ARVC).
    Objective: The purpose of this study was to identify clinical variables to better discriminate between patients with genetically determined ARVC and those with CS fulfilling definite 2010 ARVC Task Force Criteria (TFC).
    Methods: In this multicenter study, 10 patients with CS fulfilling definite 2010 ARVC TFC were age and gender matched with 10 genetically proven ARVC patients. A cardiac
    Results: The 2010 ARVC TFC did not reliably differentiate between the 2 diseases. CS patients presented with longer PR intervals, advanced atrioventricular block (AVB), and longer QRS duration (P <.001 and P = .009, respectively), whereas T-wave inversions (TWIs) in the peripheral leads were more common in ARVC patients (P = .009). CS patients presented with more extensive left ventricular involvement and lower left ventricular ejection fraction (LVEF), whereas ARVC patients had a larger right ventricular outflow tract (RVOT) (P = .044). PET scan positivity was only present in CS patients (90% vs 0%).
    Conclusion: The 2010 ARVC TFC do not reliably differentiate between CS patients fulfilling 2010 ARVC TFC and those with hereditary ARVC. Prolonged PR interval, advanced AVB, longer QRS duration, right ventricular apical involvement, reduced LVEF, and positive
    MeSH term(s) Arrhythmogenic Right Ventricular Dysplasia/diagnosis ; Arrhythmogenic Right Ventricular Dysplasia/physiopathology ; Cardiomyopathies/diagnosis ; Cardiomyopathies/physiopathology ; Diagnosis, Differential ; Electrocardiography/methods ; Electrocardiography, Ambulatory/methods ; Female ; Heart Conduction System/physiopathology ; Heart Rate/physiology ; Humans ; Male ; Middle Aged ; Positron-Emission Tomography/methods ; Retrospective Studies ; Sarcoidosis/diagnosis ; Sarcoidosis/physiopathology ; Ventricular Function, Left/physiology
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2020.09.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6278: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: High rate of subcutaneous implantable cardioverter-defibrillator sensing screening failure in patients with Brugada syndrome: a comparison with other inherited primary arrhythmia syndromes.

    Conte, Giulio / Kawabata, Mihoko / de Asmundis, Carlo / Taravelli, Erika / Petracca, Francesco / Ruggiero, Diego / Caputo, Maria Luce / Regoli, François / Chierchia, Gian-Battista / Chiodini, Alessandra / Del Bufalo, Alessandro / Moccetti, Tiziano / Goya, Masahiko / Hirao, Kenzo / Vicentini, Alessandro / De Ferrari, Gaetano M / Brugada, Pedro / Auricchio, Angelo

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2017  Volume 20, Issue 7, Page(s) 1188–1193

    Abstract: Aims: Subcutaneous implantable cardioverter-defibrillator (S-ICD) can avoid important complications associated with transvenous leads in patients with inherited primary arrhythmia syndromes, who do not need pacing therapy. Few data are available on the ... ...

    Abstract Aims: Subcutaneous implantable cardioverter-defibrillator (S-ICD) can avoid important complications associated with transvenous leads in patients with inherited primary arrhythmia syndromes, who do not need pacing therapy. Few data are available on the percentage of patients with inherited arrhythmia syndromes eligible for S-ICD implantation. Aim of this study was to analyse the eligibility for S-ICD in a series of patients with Brugada syndrome (BrS), and to compare it with patients with other channelopathies.
    Methods and results: Patients presenting with BrS, long-QT syndrome (LQTS), early repolarization syndrome (ERS), and idiopathic ventricular fibrillation (IVF) were considered eligible for this study. ECG screening was performed by analysis of QRS complex and T wave morphology recorded in standing and supine position. Eligibility was defined when ≥1 sense vector was acceptable in both supine and standing position. A total of 100 patients (72 males; mean age: 46 ± 17 years) underwent S-ICD sensing screening. Sixty-one patients presented with BrS, 21 with LQTS, 14 with IVF, and 4 with ERS. Thirty-four patients with BrS (56%) presented with spontaneous type 1 ECG. In the other 27 patients (44%), type 1 ECG was unmasked by ajmaline. Overall, rate of screening failure was 13%. Patients with BrS had a higher rate of inappropriate morphology analysis as compared with other channelopathies (18% vs. 5%, P = 0.07) and had a lower number of suitable sensing vectors (49.6% vs. 84.7% vs. P < 0.001). Ajmaline challenge unmasked sensing failure in 14.8% of drug-induced BrS patients previously considered eligible. In all patients, the reason for sensing inappropriateness was due to the presence of high T wave voltages.
    Conclusion: S-ICD screening failure occurs in up to 13% of patients with inherited primary arrhythmia syndromes. Patients with BrS present a higher rate of screening failure as compared with other cardiac channelopathies.
    MeSH term(s) Adult ; Brugada Syndrome/diagnosis ; Brugada Syndrome/genetics ; Brugada Syndrome/physiopathology ; Brugada Syndrome/surgery ; Clinical Decision-Making ; Defibrillators, Implantable ; Electric Countershock/instrumentation ; Electrocardiography ; Eligibility Determination ; Europe ; Female ; Genetic Predisposition to Disease ; Heredity ; Humans ; Male ; Middle Aged ; Patient Selection ; Phenotype ; Predictive Value of Tests ; Tokyo ; Vectorcardiography
    Language English
    Publishing date 2017-10-16
    Publishing country England
    Document type Comparative Study ; Journal Article ; Multicenter Study
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/eux009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5434: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Heme induces heme oxygenase 1 via Nrf2: role in the homeostatic macrophage response to intraplaque hemorrhage.

    Boyle, Joseph J / Johns, Michael / Lo, Jonathan / Chiodini, Alessandra / Ambrose, Nicola / Evans, Paul C / Mason, Justin C / Haskard, Dorian O

    Arteriosclerosis, thrombosis, and vascular biology

    2011  Volume 31, Issue 11, Page(s) 2685–2691

    Abstract: Objective: Intraplaque hemorrhage (IPH) is an important progression event in advanced atherosclerosis, in large part because of the delivery of prooxidant hemoglobin in erythrocytes. We have previously defined a novel macrophage phenotype (hemorrhage- ... ...

    Abstract Objective: Intraplaque hemorrhage (IPH) is an important progression event in advanced atherosclerosis, in large part because of the delivery of prooxidant hemoglobin in erythrocytes. We have previously defined a novel macrophage phenotype (hemorrhage-associated-mac) in human advanced plaques with IPH. These may be atheroprotective in view of raised heme oxygenase 1 (HO-1), CD163, and interleukin-10 expression and suppressed oxidative stress.
    Methods and results: We have used a combination of small interfering RNA and pharmacological reagents, protein analysis, and oxidative stress measurements to dissect the pathway leading to the development of this phenotype. We found that erythrocytes, hemoglobin, or purified heme similarly induced CD163 and suppressed human leukocyte antigen and reactive oxygen species. HO-1 was required for the development of each of these features. Challenge of macrophages with purified heme provoked nuclear translocation of Nrf2, and Nrf2 small interfering RNA resulted in significant inhibition of the ability of heme to induce HO-1 protein. Furthermore, tert-butyl-hydroquinone, which activates Nrf2, upregulated CD163, suppressed human leukocyte antigen, and induced interleukin-10, further supporting a role for Nrf2-mediated signaling. However, an inducible protein transactivator is also probably necessary, as heme-induced HO-1 mRNA expression was fully inhibited by the protein synthesis inhibitor cycloheximide.
    Conclusion: Our experiments define an Nrf2-mediated pathway by which heme induces a homeostatic macrophage response following IPH.
    MeSH term(s) Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism ; Cells, Cultured ; Erythrocytes/pathology ; Heme/metabolism ; Heme Oxygenase-1/metabolism ; Hemorrhage/pathology ; Hemorrhage/physiopathology ; Homeostasis/physiology ; Humans ; Interleukin-10/metabolism ; Macrophages/drug effects ; Macrophages/pathology ; Macrophages/physiology ; Monocytes/pathology ; NF-E2-Related Factor 2/metabolism ; Plaque, Atherosclerotic/pathology ; Plaque, Atherosclerotic/physiopathology ; RNA, Small Interfering/pharmacology ; Receptors, Cell Surface/metabolism ; Signal Transduction/physiology
    Chemical Substances Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; CD163 antigen ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; RNA, Small Interfering ; Receptors, Cell Surface ; Interleukin-10 (130068-27-8) ; Heme (42VZT0U6YR) ; Heme Oxygenase-1 (EC 1.14.14.18)
    Language English
    Publishing date 2011-08-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.111.225813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1705: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Heart failure in COVID-19: the multicentre, multinational PCHF-COVICAV registry.

    Sokolski, Mateusz / Trenson, Sander / Sokolska, Justyna M / D'Amario, Domenico / Meyer, Philippe / Poku, Nana K / Biering-Sørensen, Tor / Højbjerg Lassen, Mats C / Skaarup, Kristoffer G / Barge-Caballero, Eduardo / Pouleur, Anne-Catherine / Stolfo, Davide / Sinagra, Gianfranco / Ablasser, Klemens / Muster, Viktoria / Rainer, Peter P / Wallner, Markus / Chiodini, Alessandra / Heiniger, Pascal S /
    Mikulicic, Fran / Schwaiger, Judith / Winnik, Stephan / Cakmak, Huseyin A / Gaudenzi, Margherita / Mapelli, Massimo / Mattavelli, Irene / Paul, Matthias / Cabac-Pogorevici, Irina / Bouleti, Claire / Lilliu, Marzia / Minoia, Chiara / Dauw, Jeroen / Costa, Jérôme / Celik, Ahmet / Mewton, Nathan / Montenegro, Carlos E L / Matsue, Yuya / Loncar, Goran / Marchel, Michal / Bechlioulis, Aris / Michalis, Lampros / Dörr, Marcus / Prihadi, Edgard / Schoenrath, Felix / Messroghli, Daniel R / Mullens, Wilfried / Lund, Lars H / Rosano, Giuseppe M C / Ponikowski, Piotr / Ruschitzka, Frank / Flammer, Andreas J

    ESC heart failure

    2021  Volume 8, Issue 6, Page(s) 4955–4967

    Abstract: Aims: We assessed the outcome of hospitalized coronavirus disease 2019 (COVID-19) patients with heart failure (HF) compared with patients with other cardiovascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia). We ... ...

    Abstract Aims: We assessed the outcome of hospitalized coronavirus disease 2019 (COVID-19) patients with heart failure (HF) compared with patients with other cardiovascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia). We further wanted to determine the incidence of HF events and its consequences in these patient populations.
    Methods and results: International retrospective Postgraduate Course in Heart Failure registry for patients hospitalized with COVID-19 and CArdioVascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia) was performed in 28 centres from 15 countries (PCHF-COVICAV). The primary endpoint was in-hospital mortality. Of 1974 patients hospitalized with COVID-19, 1282 had cardiovascular disease and/or risk factors (median age: 72 [interquartile range: 62-81] years, 58% male), with HF being present in 256 [20%] patients. Overall in-hospital mortality was 25% (n = 323/1282 deaths). In-hospital mortality was higher in patients with a history of HF (36%, n = 92) compared with non-HF patients (23%, n = 231, odds ratio [OR] 1.93 [95% confidence interval: 1.44-2.59], P < 0.001). After adjusting, HF remained associated with in-hospital mortality (OR 1.45 [95% confidence interval: 1.01-2.06], P = 0.041). Importantly, 186 of 1282 [15%] patients had an acute HF event during hospitalization (76 [40%] with de novo HF), which was associated with higher in-hospital mortality (89 [48%] vs. 220 [23%]) than in patients without HF event (OR 3.10 [2.24-4.29], P < 0.001).
    Conclusions: Hospitalized COVID-19 patients with HF are at increased risk for in-hospital death. In-hospital worsening of HF or acute HF de novo are common and associated with a further increase in in-hospital mortality.
    MeSH term(s) Aged ; COVID-19 ; Female ; Heart Failure/epidemiology ; Hospital Mortality ; Humans ; Male ; Registries ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-09-17
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.13549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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