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  1. AU="Chiricozzi, Andrea"
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  1. Article: Shedding Light on Novel Pathogenic and Therapeutic Aspects Related to Immune-Mediated Skin Diseases.

    Chiricozzi, Andrea / Girolomoni, Giampiero

    Vaccines

    2023  Volume 11, Issue 4

    Abstract: Great advances in the understanding of the pathogenic mechanisms characterizing various immune-mediated skin diseases have been achieved [ ... ]. ...

    Abstract Great advances in the understanding of the pathogenic mechanisms characterizing various immune-mediated skin diseases have been achieved [...].
    Language English
    Publishing date 2023-03-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11040761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Secukinumab in the therapy of psoriasis and psoriatic arthritis: a safe choice in clinical practice.

    Chiricozzi, Andrea

    The Journal of dermatological treatment

    2018  Volume 29, Issue sup2, Page(s) 1–2

    Language English
    Publishing date 2018-12-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2018.1557875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2627: Show issues Location:
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  3. Article ; Online: [No title information]

    Chiricozzi, Andrea / Costanzo, Antonio / Levi, Anna / Parretta, Federica / Ravasio, Roberto

    Global & regional health technology assessment

    2024  Volume 11, Page(s) 38–50

    Title translation Costo per NNT di upadacitinib nel trattamento dei pazienti con dermatite atopica da moderata a severa in Italia.
    Language Italian
    Publishing date 2024-02-16
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2963961-X
    ISSN 2283-5733 ; 2284-2403
    ISSN (online) 2283-5733
    ISSN 2284-2403
    DOI 10.33393/grhta.2024.2728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Efficacy and safety of a combined pharmacological and surgical approach in patients affected by hidradenitis suppurativa: data from a retrospective real-world clinical study.

    Malvaso, Dalma / Chiricozzi, Andrea / Fossati, Barbara / Antonelli, Flaminia / Peris, Ketty

    Italian journal of dermatology and venereology

    2024  Volume 159, Issue 2, Page(s) 190–195

    Abstract: Background: Hidradenitis suppurativa (HS) is a debilitating chronic skin disease; its therapeutic approach often requires combined medical and surgical treatment.: Methods: The aim of this study was to assess the efficacy and safety of the surgical ... ...

    Abstract Background: Hidradenitis suppurativa (HS) is a debilitating chronic skin disease; its therapeutic approach often requires combined medical and surgical treatment.
    Methods: The aim of this study was to assess the efficacy and safety of the surgical approach combined with different pharmacological treatments, evaluating the proportion of patients achieving the hidradenitis suppurativa clinical response (HiSCR), along with the incidence of postoperative complications, and local recurrence. A retrospective study of HS patients (Hurley I-III) presenting at least one skin lesion requiring surgery was performed. Demographic and clinical data were collected (kind and anatomical location of lesion excised, type of surgical procedure). Further data included: Hurley stage and IHS4 at baseline and week 16, HiSCR at week 16 after surgery, ongoing therapy at the time of surgery (topical, systemic antibiotic, biologics), postoperative complications and local recurrence at week 16.
    Results: Forty-two patients with female predominance (66.7%, 28/42), with a mean age of 30.3 (SD±10.5) years, were enrolled. At week 16, 53% of patients achieved HiSCR, with baseline Hurley III inversely related to HiSCR achievement (P<0.05). No increased incidence of postoperative complications was detected. Three cases of local recurrence were reported at week 16.
    Conclusions: The results support the efficacy and safety of the combined therapy in the management of HS; no increased risk of complications emerged among patients concomitantly treated with biologics, compared to those on conventional systemic therapy or exclusively treated with surgery.
    MeSH term(s) Humans ; Hidradenitis Suppurativa/surgery ; Hidradenitis Suppurativa/drug therapy ; Male ; Retrospective Studies ; Female ; Adult ; Combined Modality Therapy ; Recurrence ; Postoperative Complications/epidemiology ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/adverse effects ; Treatment Outcome ; Young Adult ; Biological Products/therapeutic use ; Biological Products/adverse effects ; Middle Aged
    Chemical Substances Anti-Bacterial Agents ; Biological Products
    Language English
    Publishing date 2024-04-23
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.24.07620-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 119: Show issues Location:
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  5. Article ; Online: Editorial: The immunobiology of the skin in response to the environment.

    Donetti, Elena / Sommariva, Michele / Chiricozzi, Andrea / Prignano, Francesca

    Frontiers in immunology

    2023  Volume 14, Page(s) 1220335

    MeSH term(s) Humans ; Skin ; Psoriasis
    Language English
    Publishing date 2023-05-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1220335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Brodalumab in the Treatment of Plaque Psoriasis Localized in Difficult-to-Treat Areas: A Narrative Review.

    Cannizzaro, Maria Vittoria / Coscarella, Giulia / Chiricozzi, Andrea

    Dermatology practical & conceptual

    2023  Volume 13, Issue 3

    Abstract: Introduction: Psoriasis is a common chronic, immune-mediated, inflammatory skin disease that in certain localization results difficult to treat. Psoriatic lesions in difficult-to-treat areas might be hardly managed as no standardized therapeutic ... ...

    Abstract Introduction: Psoriasis is a common chronic, immune-mediated, inflammatory skin disease that in certain localization results difficult to treat. Psoriatic lesions in difficult-to-treat areas might be hardly managed as no standardized therapeutic approach and the application of topical treatments might have great limitations. Systemic agents, including biologic therapies, have been proven effective in treating this subgroup of patients. In particular, current evidence has shown beneficial effects with the use of brodalumab, a fully human IgG2 monoclonal antibody antagonizing the IL-17 receptor A subunit (IL-17RA).
    Objectives: The aim of this narrative review was to collect published data about efficacy and safety of brodalumab in the treatment of psoriasis occurring in difficult-to-treat areas.
    Methods: Data on brodalumab effectiveness and safety deriving from both trials and real-world setting that had been published in the last 15 years were collected for this review, together with clinical findings issued during international meetings.
    Results: In phase 3 trials, brodalumab demonstrated to be effective in promoting a rapid response in scalp psoriasis as well as in generalized pustular psoriasis and erythrodermic psoriasis. Nail psoriasis demonstrated marked clinical improvement after treatment with brodalumab. Amelioration of palmoplantar psoriasis was also described in brodalumab-treated patients. Various retrospective real-world studies reported a complete clearance of psoriatic lesions in difficult-to-treat areas, including genitalia, through short-term brodalumab treatment.
    Conclusions: Brodalumab, combining rapid and sustained efficacy with a favorable safety profile, may be a valid therapeutic option for severe variants of psoriasis as well as for psoriasis localized in difficult-to-treat areas.
    Language English
    Publishing date 2023-07-01
    Publishing country Austria
    Document type Journal Article ; Review
    ZDB-ID 2685397-8
    ISSN 2160-9381
    ISSN 2160-9381
    DOI 10.5826/dpc.1303a245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Head and neck atopic dermatitis: still a challenging manifestation in the biologic era.

    Gori, Niccolò / Ippoliti, Elena / Peris, Ketty / Chiricozzi, Andrea

    Expert opinion on biological therapy

    2023  Volume 23, Issue 7, Page(s) 575–577

    MeSH term(s) Humans ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/therapy ; Neck ; Head ; Biological Products/therapeutic use ; Severity of Illness Index
    Chemical Substances Biological Products
    Language English
    Publishing date 2023-06-14
    Publishing country England
    Document type Editorial
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2023.2224499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6094: Show issues Location:
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  8. Article ; Online: Clinical effectiveness of combined dupilumab and baricitinib in a patient with multi-drug resistant severe atopic dermatitis.

    Lugli, Anna Paola / Gori, Niccolò / Chiricozzi, Andrea / Boschetti, Giambattista / Peris, Ketty

    International journal of dermatology

    2024  

    Language English
    Publishing date 2024-05-15
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.17250
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  9. Article ; Online: Atopic Dermatitis in the Elderly Population.

    Maurelli, Martina / Chiricozzi, Andrea / Peris, Ketty / Gisondi, Paolo / Girolomoni, Giampiero

    Acta dermato-venereologica

    2023  Volume 103, Page(s) adv13363

    Abstract: Atopic dermatitis is a common inflammatory disease with a chronic and relapsing course. Although considered a childhood disease, it is now evident that atopic dermatitis is also common in adulthood and in the elderly population. Atopic dermatitis ... ...

    Abstract Atopic dermatitis is a common inflammatory disease with a chronic and relapsing course. Although considered a childhood disease, it is now evident that atopic dermatitis is also common in adulthood and in the elderly population. Atopic dermatitis typically manifests with bilateral and symmetrical eczematous lesions on the face, trunk and skin folds. Itch is invariably present and may be very severe, markedly  affecting daily life and sleep. In older adults, atopic dermatitis may have a high level of impact on quality of life, frequently burdening an already complex comorbid situation. The full assessment of disease burden (localizations, itch severity, sleep alterations, impact on quality of life, disease history, comorbidities) is crucial to identify the most appropriate treatment. In many cases, moderate-to-severe atopic dermatitis in the elderly population can be successfully and safely treated with biological agents inhibiting the interleukin-4/-13 pathway, whereas the use of Janus kinase inhibitors may pose concerns about the safety profile.
    MeSH term(s) Humans ; Aged ; Child ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/epidemiology ; Quality of Life ; Pruritus/diagnosis ; Pruritus/drug therapy ; Pruritus/epidemiology ; Cost of Illness ; Comorbidity ; Severity of Illness Index
    Language English
    Publishing date 2023-12-14
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/actadv.v103.13363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Overview of Atopic Dermatitis in Different Ethnic Groups.

    Chiricozzi, Andrea / Maurelli, Martina / Calabrese, Laura / Peris, Ketty / Girolomoni, Giampiero

    Journal of clinical medicine

    2023  Volume 12, Issue 7

    Abstract: Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a high prevalence worldwide, including countries from Asia, Africa, and Latin America, and in different ethnic groups. In recent years, more attention has been placed on the ... ...

    Abstract Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a high prevalence worldwide, including countries from Asia, Africa, and Latin America, and in different ethnic groups. In recent years, more attention has been placed on the heterogeneity of AD associated with multiple factors, including a patient's ethnic background, resulting in an increasing body of clinical, genetic, epidemiologic, and immune-phenotypic evidence that delineates differences in AD among racial groups. Filaggrin (FLG) mutations, the strongest genetic risk factor for the development of AD, are detected in up to 50% of European and 27% of Asian AD patients, but very rarely in Africans. Th2 hyperactivation is a common attribute of all ethnic groups, though the Asian endotype of AD is also characterized by an increased Th17-mediated signal, whereas African Americans show a strong Th2/Th22 signature and an absence of Th1/Th17 skewing. In addition, the ethnic heterogeneity of AD may hold important therapeutic implications as a patient's genetic predisposition may affect treatment response and, thereby, a tailored strategy that better targets the dominant immunologic pathways in each ethnic subgroup may be envisaged. Nevertheless, white patients with AD represent the largest ethnicity enrolled and tested in clinical trials and the most treated in a real-world setting, limiting investigations about safety and efficacy across different ethnicities. The purpose of this review is to describe the heterogeneity in the pathophysiology of AD across ethnicities and its potential therapeutic implications.
    Language English
    Publishing date 2023-04-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12072701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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