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  1. Article ; Online: Imaging the Governing Step of Metastasis in Gelfoam

    Hoffman, Robert M / Chishima, Takashi

    Methods in molecular biology (Clifton, N.J.)

    2018  Volume 1760, Page(s) 215–220

    Abstract: Distant organ colonization by cancer cells is the governing step of metastasis. We review in this chapter the modeling and imaging of organ colonization by cancer cells in ... ...

    Abstract Distant organ colonization by cancer cells is the governing step of metastasis. We review in this chapter the modeling and imaging of organ colonization by cancer cells in Gelfoam
    MeSH term(s) Cell Culture Techniques ; Cell Line, Tumor ; Gelatin Sponge, Absorbable ; Genes, Reporter ; Humans ; Lung Neoplasms/pathology ; Molecular Imaging/methods ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Tissue Culture Techniques ; Tumor Cells, Cultured ; Tumor Stem Cell Assay
    Language English
    Publishing date 2018-03-23
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-7745-1_20
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  2. Article: Can magnetic resonance imaging obviate the need for biopsy for microcalcifications?

    Yamamoto, Shinya / Chishima, Takashi

    Gland surgery

    2017  Volume 6, Issue 4, Page(s) 302–307

    Abstract: Background: Although microcalcifications detected with mammography (MG) are usually biopsied, biopsies cannot be performed in all cases. We sought to determine if magnetic resonance imaging (MRI) findings could indicate whether stereotactic vacuum- ... ...

    Abstract Background: Although microcalcifications detected with mammography (MG) are usually biopsied, biopsies cannot be performed in all cases. We sought to determine if magnetic resonance imaging (MRI) findings could indicate whether stereotactic vacuum-assisted biopsy (SVAB) is necessary.
    Methods: Patients with mammographically detected Breast Imaging-Reporting and Data System (BI-RADS) 3, 4, and 5 microcalcifications were analyzed from April 2012 to September 2014. All patients underwent MRI. All patients with enhancing lesions in the region of the microcalcifications underwent SVAB. Non-enhancing lesions were followed or biopsied, depending on the patient's preferences. MRI findings were classified as either malignant-suspicious or benign-suspicious ("none" or "nonspecific"), and we evaluated the positive predictive value (PPV) and negative predictive value (NPV) of these classifications for predicting malignancy.
    Results: A total of 87 patients underwent both MRI and SVAB. The NPV of MRI was 100% in the group with no enhancement. In BI-RADS category 3, there were 57 benign-suspicious lesions on MRI, of which eight were malignant (NPV of MRI: 85.0%).
    Conclusions: It may be possible to omit SVAB for microcalcifications if there is no enhancement on MRI; however, any kind of enhancement indicates the need for biopsy in cases of BI-RADS 3 calcifications on MG.
    Language English
    Publishing date 2017-08-18
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 3016969-0
    ISSN 2227-8575 ; 2227-684X
    ISSN (online) 2227-8575
    ISSN 2227-684X
    DOI 10.21037/gs.2017.03.14
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  3. Article ; Online: Correlation between postoperative treatment selection and prognosis determined using the Oncotype DX® test data: a retrospective multicenter study in Japan.

    Tsuchida, Yasue / Niikura, Naoki / Chishima, Takashi / Mizuno, Mari / Kawate, Takahiko / Fuchikami, Hiromi / Miyoshi, Yasuo / Sakai, Takehiko / Kotani, Haruru / Kondo, Naoto / Hayashi, Naoki

    Breast cancer (Tokyo, Japan)

    2024  Volume 31, Issue 3, Page(s) 401–408

    Abstract: Purpose: Oncotype DX® is a frequently used multigene assay for hormone receptor-positive breast cancers. However, limited evidence is available regarding its application in Japan owing to the lack of insurance coverage. Therefore, we conducted this ... ...

    Abstract Purpose: Oncotype DX® is a frequently used multigene assay for hormone receptor-positive breast cancers. However, limited evidence is available regarding its application in Japan owing to the lack of insurance coverage. Therefore, we conducted this large-scale, retrospective study by collecting data from nine Japanese institutes and assessed postoperative treatment choice and prognosis by using Oncotype DX®.
    Methods: Six hundred thirty-two patients who underwent breast surgery and whose recurrence score (RS) data were available were included. They were divided into RS 0-25 and RS ≥ 26 groups. The groups were compared in terms of clinicopathological factors, treatment options, and prognosis.
    Results: After the median follow-up period of 10.1 years, the disease-free survival (DFS) rates were significantly better in the RS 0-25 group (p = 0.02). Per the recurrent event type, there was no significant intergroup difference in locoregional recurrence (p = 0.139). However, a trend toward better distant DFS was observed in the RS 0-25 group (p = 0.08). Overall survival was also significantly better in this group (p = 0.027). Considering chemotherapy use, DFS worsened among chemotherapy-treated patients with an RS of 0-25 and those with an RS ≥ 26 who did not receive chemotherapy (p < 0.001). Seven (1.35%) chemotherapy-treated patients with an RS of 0-25 showed disease recurrence.
    Conclusions: This study presents the largest database-derived prognostic data in Japanese patients, utilizing the Oncotype DX® treatment selection. Further studies are needed to determine the impact on treatment choice, considering the clinical risk, and the need for additional postoperative treatment.
    MeSH term(s) Humans ; Female ; Middle Aged ; Retrospective Studies ; Japan/epidemiology ; Breast Neoplasms/surgery ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Breast Neoplasms/mortality ; Breast Neoplasms/drug therapy ; Breast Neoplasms/therapy ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology ; Aged ; Adult ; Prognosis ; Disease-Free Survival ; Mastectomy ; Chemotherapy, Adjuvant/methods ; Follow-Up Studies ; Receptors, Estrogen/metabolism ; Receptors, Estrogen/analysis ; Gene Expression Profiling/methods ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Receptor, ErbB-2/metabolism ; Receptors, Progesterone/metabolism
    Chemical Substances Receptors, Estrogen ; Biomarkers, Tumor ; Receptor, ErbB-2 (EC 2.7.10.1) ; Receptors, Progesterone
    Language English
    Publishing date 2024-03-07
    Publishing country Japan
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2052429-8
    ISSN 1880-4233 ; 1340-6868
    ISSN (online) 1880-4233
    ISSN 1340-6868
    DOI 10.1007/s12282-024-01548-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5536: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Breast cancer suspected to originate from familial hereditary tumors: A case report.

    Yamamoto, Shinya / Chishima, Takashi / Sugae, Sadatoshi / Shibata, Yukako / Yamada, Akimitsu

    Clinical case reports

    2020  Volume 8, Issue 4, Page(s) 648–652

    Abstract: If familial hereditary tumor is suspected, diagnosis and treatment should always be performed considering the presence of familial hereditary tumors irrespective of whether genetic testing is performed. ...

    Abstract If familial hereditary tumor is suspected, diagnosis and treatment should always be performed considering the presence of familial hereditary tumors irrespective of whether genetic testing is performed.
    Language English
    Publishing date 2020-02-08
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.2698
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  5. Article ; Online: Stratification of Prognosis by Biological Features Following Neoadjuvant Chemotherapy in Luminal Breast Cancer.

    Yamamoto, Shinya / Chishima, Takashi / Shibata, Yukako / Inoue, Shiori / Harada, Fumi / Takeuchi, Hideki / Yamada, Akimitsu / Narui, Kazutaka / Endo, Itaru

    In vivo (Athens, Greece)

    2022  Volume 36, Issue 2, Page(s) 859–864

    Abstract: Background/aim: There are few models predicting breast cancer prognosis among patients receiving neoadjuvant chemotherapy (NAC) for estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative (luminal) breast cancer. We ... ...

    Abstract Background/aim: There are few models predicting breast cancer prognosis among patients receiving neoadjuvant chemotherapy (NAC) for estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative (luminal) breast cancer. We examined whether biological features (BFs) of residual tumors are prognostic factors following NAC.
    Patients and methods: We enrolled patients with remnant tumors following NAC for luminal breast cancer and evaluated clinical stage, pathological stage, BFs prior to NAC, and BFs following NAC as prognostic factors. BFs were divided into high and low risk using the previously reported YR-IHC4 model calculated according to ER, progesterone receptor (PgR), HER2, and the proliferation marker Ki-67.
    Results: A total of 57 patients were enrolled in the current study. We observed a statistically significant difference in relapse-free survival (RFS) between the BF risk categories via YR-IHC4 predictions following NAC (p=0.044). The 5-year RFS rates of the BF low- and high-risk groups following NAC were 84.2% and 52.5%, respectively.
    Conclusion: BFs of residual tumors following NAC may be important prognostic factors in luminal breast cancer.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Breast Neoplasms/pathology ; Female ; Humans ; Neoadjuvant Therapy ; Neoplasm Recurrence, Local/drug therapy ; Prognosis ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism
    Chemical Substances Receptors, Estrogen ; Receptors, Progesterone ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2022-03-03
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.12774
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    Zs.A 2288: Show issues Location:
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  6. Article: Accelerated glycolysis in tumor microenvironment is associated with worse survival in triple-negative but not consistently with ER+/HER2- breast cancer.

    Oshi, Masanori / Roy, Arya Mariam / Yan, Li / Sasamoto, Mahato / Tokumaru, Yoshihisa / Wu, Rongrong / Yamada, Akimitsu / Yamamoto, Shinya / Chishima, Takashi / Narui, Kazutaka / Endo, Itaru / Takabe, Kazuaki

    American journal of cancer research

    2023  Volume 13, Issue 7, Page(s) 3041–3054

    Abstract: Metabolic reprogramming to sustain immortality is a hallmark of cancer and glycolysis is an important way to attain this. Thus, we investigate the association of glycolysis and associated pathways in the survival of breast cancer. A total of 5,176 breast ...

    Abstract Metabolic reprogramming to sustain immortality is a hallmark of cancer and glycolysis is an important way to attain this. Thus, we investigate the association of glycolysis and associated pathways in the survival of breast cancer. A total of 5,176 breast cancer patients from multiple independent cohorts were analyzed. We determined the glycolytic signaling score by the degree of enrichment by Gene Set Variant Analysis and the median was used to divide each cohort into high vs low score groups. Glycolysis high breast cancer significantly enriched the hallmark cell proliferation-related gene sets (E2F targets, G2M checkpoint, and MYC targets v1 and v2) and was associated with high
    Language English
    Publishing date 2023-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
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  7. Article ; Online: Clinical Impact of a Novel Model Predictive of Oncotype DX Recurrence Score in Breast Cancer.

    Yamamoto, Shinya / Chishima, Takashi / Shibata, Yukako / Harada, Fumi / Takeuchi, Hideki / Yamada, Akimitsu / Narui, Kazutaka / Misumi, Toshihiro / Ishikawa, Takashi / Endo, Itaru

    In vivo (Athens, Greece)

    2021  Volume 35, Issue 4, Page(s) 2439–2444

    Abstract: Background/aim: Oncotype DX recurrence score (RS) for breast cancer is a useful tool for determining chemotherapy indication but it is expensive and time-consuming. We determined whether four immuno-histochemical markers, namely human epidermal growth ... ...

    Abstract Background/aim: Oncotype DX recurrence score (RS) for breast cancer is a useful tool for determining chemotherapy indication but it is expensive and time-consuming. We determined whether four immuno-histochemical markers, namely human epidermal growth factor 2 (HER2), estrogen receptor (ER), progesterone receptor (PgR), and Ki-67, are predictive of an RS ≥26 in Japanese patients.
    Patients and methods: The study included 95 Japanese patients evaluated for RS. A predictive model was created using logistic regression analysis.
    Results: The discriminant function was calculated as follows: p=1/{1+exp [-(4.611+1.2342×HER2-0.0813×ER- 0.0489 ×PgR+0.0857×Ki67)]}. Using a probability of 0.5 as the cutoff, the accuracy, sensitivity, specificity, positive predictive and negative predictive values were 90.5%, 72.2%, 94.8%, 76.4% and 93.5%, respectively.
    Conclusion: The model had a high negative predictive value in predicting RS ≥26 in Japanese patients, indicating that Oncotype DX testing may be omitted in patients with a negative result according to the predictive model.
    MeSH term(s) Biomarkers, Tumor/genetics ; Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Epidermal Growth Factor ; Female ; Gene Expression Profiling ; Humans ; Neoplasm Recurrence, Local/genetics ; Prognosis ; Receptor, ErbB-2/genetics ; Receptors, Estrogen/genetics
    Chemical Substances Biomarkers, Tumor ; Receptors, Estrogen ; Epidermal Growth Factor (62229-50-9) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2021-06-26
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.12522
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    Zs.A 2288: Show issues Location:
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  8. Article ; Online: Evaluation of aesthetic outcomes of breast-conserving surgery by the surgeon, nurse, and patients.

    Yamamoto, Shinya / Chishima, Takashi / Sugae, Sadatoshi / Yamagishi, Shigeru / Yamada, Akimitsu / Narui, Kazutaka / Misumi, Toshihiro / Ishikawa, Takashi / Endo, Itaru

    Asian journal of surgery

    2021  Volume 45, Issue 1, Page(s) 131–136

    Abstract: Background: Evaluation of the cosmetic outcome after breast-conserving surgery (BCS) differs depending on the evaluator. We performed a clinical trial to examine the differences between assessments of cosmetic outcomes performed by a surgeon, patients, ... ...

    Abstract Background: Evaluation of the cosmetic outcome after breast-conserving surgery (BCS) differs depending on the evaluator. We performed a clinical trial to examine the differences between assessments of cosmetic outcomes performed by a surgeon, patients, and a nurse as a third party after BCS; the evaluation was performed two times (at 3 months and 9 months after surgery). Similarly, we identified factors most significantly affecting the overall cosmetic outcomes.
    Methods: Sixty-eight patients with primary breast cancer who had undergone BCS between September 2017 and December 2018 were consecutively enrolled in the study. Breast shape, symmetry, hardness, scarring, and overall outcomes were evaluated by a surgeon, patients, and a nurse via a questionnaire.
    Results: Intraclass correlation coefficients (ICCs) for the 3- to 9-month comparisons of the surgeon, patients, and nurse were 0.73, 0.64, and 0.29, respectively. The ICCs for the surgeon-patient, nurse-patient, and surgeon-nurse comparisons (3 months/9 months) were 0.49/0.44, 0.34/0.10, and 0.41/0.51, respectively. The partial regression coefficient for shape was 0.45 (p = 0.003)/0.61 (p = 0.001), 0.37 (p = 0.005)/0.50 (p < 0.001), and -0.08 (p = 0.48)/0.58 (p < 0.001) for evaluations performed by the surgeon, patients, and nurse, 3 months and 9 months, respectively.
    Conclusion: With reproducibility, only moderate agreement was observed between the surgeon and the patients. Breast shape was identified as the most important factor affecting cosmetic outcomes.
    MeSH term(s) Breast Neoplasms/surgery ; Esthetics ; Female ; Humans ; Mastectomy, Segmental ; Reproducibility of Results ; Surgeons
    Language English
    Publishing date 2021-04-18
    Publishing country China
    Document type Clinical Trial ; Journal Article
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2021.03.034
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    Zs.B 2831: Show issues Location:
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  9. Article ; Online: Clinicopathological Characteristics and Prognosis of Triple-Negative Apocrine Carcinoma: A Case-Control Study.

    Suzuki, Chiho / Yamada, Akimitsu / Kawashima, Kei / Sasamoto, Mahato / Fujiwara, Yoshie / Adachi, Shoko / Oshi, Masanori / Wada, Tomoko / Yamamoto, Shinya / Shimada, Kazuhiro / Ota, Ikuko / Narui, Kazutaka / Sugae, Sadatoshi / Shimizu, Daisuke / Tanabe, Mikiko / Chishima, Takashi / Ichikawa, Yasushi / Ishikawa, Takashi / Endo, Itaru

    World journal of oncology

    2023  Volume 14, Issue 6, Page(s) 551–557

    Abstract: Background: With a prevalence of only 1% among all breast cancers in Japan, apocrine carcinoma (AC) is a rare type of breast cancer, and its clinicopathological characteristics remain unclear. The aim of this study was to evaluate the characteristics ... ...

    Abstract Background: With a prevalence of only 1% among all breast cancers in Japan, apocrine carcinoma (AC) is a rare type of breast cancer, and its clinicopathological characteristics remain unclear. The aim of this study was to evaluate the characteristics and prognosis of AC, in relation to the presence or absence of androgen receptor (AR).
    Methods: We conducted a retrospective multi-center case-control study (Yokohama Clinical Oncology Group (YCOG): YCOG1701 study) in Japan. A total of 53 patients were registered who were diagnosed with AC between 2000 and 2017 in YCOG-affiliated hospitals.
    Results: The median age of the patients was 67 (43 - 94) years, and the median observation time was 6.1 years. Among the 53 cases, 24 had triple-negative pure AC (TN-PAC; AR-positive), whereas 29 had other types of AC (other-AC; estrogen receptor-positive and/or human epidermal growth factor receptor 2-positive or AR-negative). Tumor size was smaller (1.4 vs. 2.1 cm, P = 0.024) and metastasis occurred in fewer nodes (12.5% vs. 37.9%, P = 0.036) in the TN-PAC group than in the other-AC group. The number of patients who were administered perioperative adjuvant chemotherapy did not significantly differ between the two groups (TN-PAC/other-AC = 50.0%/55.2%, P = 0.525); however, there was no recurrence in the TN-PAC group, compared to five cases with relapse in the other-AC group.
    Conclusions: AR-positive AC patients showed a favorable prognosis without adjuvant chemotherapy, even with the TN subtype. A clinical trial exploring the possibility of treatment de-escalation is anticipated.
    Language English
    Publishing date 2023-11-03
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2548989-6
    ISSN 1920-454X ; 1920-454X
    ISSN (online) 1920-454X
    ISSN 1920-454X
    DOI 10.14740/wjon1694
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  10. Article: A case of synchronous multiple bilateral breast cancer after breast augmentation.

    Yamamoto, Shinya / Chishima, Takashi / Harada, Fumi / Matsubara, Yuka

    SpringerPlus

    2015  Volume 4, Page(s) 805

    Abstract: Breast cancer after breast augmentation is not rare, but cases of bilateral breast cancer after augmentation are not often reported. A 43-year-old woman attended our hospital because of a mass in her left breast. She had undergone breast augmentation by ... ...

    Abstract Breast cancer after breast augmentation is not rare, but cases of bilateral breast cancer after augmentation are not often reported. A 43-year-old woman attended our hospital because of a mass in her left breast. She had undergone breast augmentation by implants 4 years before at a cosmetic surgery clinic. There were operative scars in her bilateral axilla. A detailed examination revealed bilateral breast cancer, and we performed nipple-sparing mastectomy in both breasts. Sentinel lymph node biopsy using dye was performed and it identified stained lymph nodes on both sides. The sentinel lymph node biopsy was negative for metastasis on both sides, so axillary lymph node dissection was not performed.
    Language English
    Publishing date 2015-12-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661116-8
    ISSN 2193-1801
    ISSN 2193-1801
    DOI 10.1186/s40064-015-1615-1
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