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Article ; Online: Global Pediatric Research Investigator: Mohammod Jobayer Chisti.

Chisti, Mohammod Jobayer

2020 Volume 88, Issue 5, Page(s) 689

MeSH term(s)	Biomedical Research/education ; Biomedical Research/history ; Career Choice ; History, 20th Century ; History, 21st Century ; Humans ; Pediatrics/education ; Pediatrics/history ; Research Personnel/education ; Research Personnel/history
Keywords	covid19
Language	English
Publishing date	2020-07-25
Publishing country	United States
Document type	Autobiography ; Historical Article ; Journal Article ; Portrait
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-020-1087-z
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Article ; Online: Cooked Green Banana in Hospitalized Children With Acute Watery Diarrhea Without Dehydration.

Chisti, Mohammod Jobayer / Sarmin, Monira

Indian pediatrics

2020 Volume 57, Issue 12, Page(s) 1108–1109

MeSH term(s)	Child ; Child, Hospitalized ; Dehydration ; Diarrhea ; Humans ; Musa
Language	English
Publishing date	2020-11-17
Publishing country	India
Document type	Editorial ; Comment
ZDB-ID	402594-5
ISSN	0974-7559 ; 0019-6061
ISSN (online)	0974-7559
ISSN	0019-6061
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Article ; Online: Prognostic accuracy of early warning scores for predicting serious illness and in-hospital mortality in patients with COVID-19.

Kamal, Mehnaz / Hasan, S M Tafsir / Sarmin, Monira / Das, Subhasish / Shahrin, Lubaba / Faruque, A S G / Chisti, Mohammod Jobayer / Ahmed, Tahmeed

PLOS global public health

2024 Volume 4, Issue 3, Page(s) e0002438

Abstract: A simple bedside triage tool is essential to stratify COVID-19 patients in the emergency department (ED). This study aimed to identify an early warning score (EWS) that could best predict the clinical outcomes in COVID-19 patients. Data were obtained ... ...

Abstract	A simple bedside triage tool is essential to stratify COVID-19 patients in the emergency department (ED). This study aimed to identify an early warning score (EWS) that could best predict the clinical outcomes in COVID-19 patients. Data were obtained from medical records of 219 laboratory-confirmed COVID-19 positive patients. We calculated 13 EWSs based on the admission characteristics of the patients. Receiver operating characteristic (ROC) curve analysis was used to assess the performance of the scores in predicting serious illness and in-hospital mortality. The median patient age was 51 (38, 60) years, and 25 (11.4%) patients died. Among patients admitted with mild to moderate illness (n = 175), 61 (34.9%) developed serious illness. Modified National Early Warning Score (m-NEWS) (AUROC 0.766; 95% CI: 0.693, 0.839) and Rapid Emergency Medicine Score (REMS) (AUROC 0.890; 95% CI: 0.818, 0.962) demonstrated the highest AUROC point estimates in predicting serious illness and in-hospital mortality, respectively. Both m-NEWS and REMS demonstrated good accuracy in predicting both the outcomes. However, no significant difference was found between m-NEWS (p = 0.983) and REMS (p = 0.428) as well as some other EWSs regarding the AUROCs in predicting serious illness and in-hospital mortality. We propose m-NEWS could be used as a triage score to identify COVID-19 patients at risk of disease progression and death especially in resource-poor settings because it has been explicitly developed for risk stratification of COVID-19 patients in some countries like China and Italy. However, this tool needs to be validated by further large-scale prospective studies.
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ISSN	2767-3375
ISSN (online)	2767-3375
DOI	10.1371/journal.pgph.0002438
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Article: Diagnostic, Management, and Research Considerations for Pediatric Acute Respiratory Distress Syndrome in Resource-Limited Settings: From the Second Pediatric Acute Lung Injury Consensus Conference.

Morrow, Brenda M / Agulnik, Asya / Brunow de Carvalho, Werther / Chisti, Mohammod Jobayer / Lee, Jan Hau

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2023 Volume 24, Issue 12 Suppl 2, Page(s) S148–S159

Abstract: Objectives: Diagnosis of pediatric acute respiratory distress syndrome (PARDS) in resource-limited settings (RLS) is challenging and remains poorly described. We conducted a review of the literature to optimize recognition of PARDS in RLS and to provide ...

Abstract	Objectives: Diagnosis of pediatric acute respiratory distress syndrome (PARDS) in resource-limited settings (RLS) is challenging and remains poorly described. We conducted a review of the literature to optimize recognition of PARDS in RLS and to provide recommendations/statements for clinical practice and future research in these settings as part of the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2). Data sources: MEDLINE (Ovid), Embase (Elsevier), and CINAHL Complete (EBSCOhost). Study selection: We included studies related to precipitating factors for PARDS, mechanical ventilation (MV), pulmonary and nonpulmonary ancillary treatments, and long-term outcomes in children who survive PARDS in RLS. Data extraction: Title/abstract review, full-text review, and data extraction using a standardized data collection form. Data synthesis: The Grading of Recommendations Assessment, Development, and Evaluation approach was used to identify and summarize evidence and develop recommendations. Seventy-seven studies were identified for full-text extraction. We were unable to identify any literature on which to base recommendations. We gained consensus on six clinical statements (good practice, definition, and policy) and five research statements. Clinicians should be aware of diseases and comorbidities, uncommon in most high-income settings, that predispose to the development of PARDS in RLS. Because of difficulties in recognizing PARDS and to avoid underdiagnosis, the PALICC-2 possible PARDS definition allows exclusion of imaging criteria when all other criteria are met, including noninvasive metrics of hypoxemia. The availability of MV support, regular MV training and education, as well as accessibility and costs of pulmonary and nonpulmonary ancillary therapies are other concerns related to management of PARDS in RLS. Data on long-term outcomes and feasibility of follow-up in PARDS survivors from RLS are also lacking. Conclusions: To date, PARDS remains poorly described in RLS. Clinicians working in these settings should be aware of common precipitating factors for PARDS in their patients. Future studies utilizing the PALICC-2 definitions are urgently needed to describe the epidemiology, management, and outcomes of PARDS in RLS.
MeSH term(s)	Child ; Humans ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/therapy ; Lung ; Respiration, Artificial/methods ; Acute Lung Injury ; Consensus
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000003166
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Article ; Online: Inpatient Morbidity and Mortality of Severely Underweight Children Was Comparable to That of Severely Wasted Children in Dhaka, Bangladesh.

Islam, Md Ridwan / Nuzhat, Sharika / Alam, Jinat / Huq, Sayeeda / Chisti, Mohammod Jobayer / Ahmed, Tahmeed

The American journal of tropical medicine and hygiene

2023 Volume 109, Issue 3, Page(s) 698–703

Abstract: Both wasting and undernutrition are responsible for multiple morbidities and increased mortality in younger children hospitalized for acute illnesses. The question of whether children who are suffering from severe underweight are as vulnerable as ... ...

Abstract	Both wasting and undernutrition are responsible for multiple morbidities and increased mortality in younger children hospitalized for acute illnesses. The question of whether children who are suffering from severe underweight are as vulnerable as children suffering from severe wasting needs to be researched further. We aimed to compare the morbidity and mortality of severely underweight but not severely wasted (SU-nSW) children with that of severely wasted (SW) children admitted to inpatient wards of a hospital. Data from 12,894 children aged < 5 years were collected using cross-sectional methods from Dhaka Hospital, International Centre for Diarrhoeal Disease Research, Bangladesh between March 2019 and December 2021. After exclusion of non-desired populations (N = 8,834), comparisons between SU-nSW (N = 1,876) and SW (N = 2,184) children were observed. The risk of morbidities and mortality among SU-nSW and SW children was analyzed after adjusting for age and sex. Inpatient morbidities were mostly similar among children with sepsis (adjusted odds ratio [aOR]: 0.90; 95% CI: 0.69, 1.19; P = 0.472) and convulsions (aOR: 0.84; 95% CI: 0.51, 1.37; P = 0.475). Dehydration (aOR: 0.71; 95% CI: 0.62, 0.81; P < 0.001) and hypokalemia (aOR: 0.58; 95% CI: 0.42, 0.79; P = 0.001) were more likely associated with SW children than with SU-nSW children. Pneumonia/severe pneumonia was more likely to affect SU-nSW children (aOR: 1.24; 95% CI: 1.02, 1.48; P = 0.018). Death was comparable between the two groups (aOR: 1.32; 95% CI: 0.70, 2.49; P = 0.386). This study underscores the importance of implementing present treatment guidelines for severe acute malnutrition in the facility-based management of severely underweight children as well.
MeSH term(s)	Humans ; Child ; Infant ; Thinness/epidemiology ; Bangladesh/epidemiology ; Cross-Sectional Studies ; Inpatients ; Malnutrition/complications ; Malnutrition/epidemiology ; Morbidity ; Pneumonia/epidemiology
Language	English
Publishing date	2023-08-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.23-0137
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Article ; Online: Prolonged diarrhea among under-five children in Bangladesh: Burden and risk factors.

Hossain, Md Iqbal / Faruque, A S G / Sarmin, Monira / Chisti, Mohammod Jobayer / Ahmed, Tahmeed

PloS one

2022 Volume 17, Issue 10, Page(s) e0273148

Abstract: Introduction & background: Prolonged (duration >7 to 13 days) diarrhea (ProD) in under-five children is a universal health problem including Bangladesh. Data on epidemiology and associated or risk factors of ProD are limited, particularly in Bangladesh ... ...

Abstract	Introduction & background: Prolonged (duration >7 to 13 days) diarrhea (ProD) in under-five children is a universal health problem including Bangladesh. Data on epidemiology and associated or risk factors of ProD are limited, particularly in Bangladesh where a high burden of ProD is reported. This study intended to assess the case load of ProD and its associated or risk factors compared to acute diarrhea (AD, duration ≤7 days). Methods: We analyzed the data collected between 1996-2014 from a hospital-based Diarrheal-Disease-Surveillance-System (DDSS) in the 'Dhaka Hospital' of International Centre for Diarrhoeal Diseases, Bangladesh (icddr,b). The DDSS enrolled a 2% systematic sample, regardless of age, sex, and diarrhea severity. The data included information on socio-demographic factors, environmental history, clinical characteristics, nutritional status, and diarrhea-pathogens. After cleaning of data, relevant information of 21,566 under-five children were available who reported with ≤13 days diarrhea (including AD and ProD), and their data were analyzed. Variables found significantly associated with ProD compared to AD in bi-variate analysis were used in logistic regression model after checking the multicollinearity between independent variables. Results: The mean±SD age of the children was 14.9±11.7 months and 40.4% were female; 7.6% had ProD and 92.4% had AD. Age <12 months, mucoid- or bloody-stool, warmer months (April-September), drug used at home before seeking care from hospital, and history of diarrhea within last one month were found associated with ProD (p<0.05); however, rotavirus infection was less common in children with ProD (p<0.05). ProD children more often needed inpatient admission than AD children (14.4 vs. 6.3, p<0.001). Case fatality rate of ProD vs. AD was 0.3% (n = 5) vs. 0.1% (n- = 22) respectively (p = 0.051). Conclusion: A considerable proportion (7.6%) of under-five children reporting to icddr,b hospital suffered from ProD. Understanding the above-mentioned associated or risk factors is likely to help policy makers formulating appropriate strategies for alleviating the burden and effectively managing ProD in under-five children.
MeSH term(s)	Bangladesh/epidemiology ; Child, Preschool ; Diarrhea/epidemiology ; Diarrhea/virology ; Female ; Humans ; Infant ; Male ; Risk Factors ; Rotavirus Infections/complications ; Rotavirus Infections/epidemiology
Language	English
Publishing date	2022-10-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0273148
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Article ; Online: Maternal Underweight and Its Association with Composite Index of Anthropometric Failure among Children under Two Years of Age with Diarrhea in Bangladesh.

Das, Rina / Kabir, Md Farhad / Ashorn, Per / Simon, Jonathon / Chisti, Mohammod Jobayer / Ahmed, Tahmeed

Nutrients

2022 Volume 14, Issue 9

Abstract: Malnutrition in women has been a long-standing public health concern, with serious effects on child survival and development. Maternal body mass index (BMI) is an important maternal nutritional indicator. There are few published studies although child ... ...

Abstract	Malnutrition in women has been a long-standing public health concern, with serious effects on child survival and development. Maternal body mass index (BMI) is an important maternal nutritional indicator. There are few published studies although child anthropometric failures do not occur in isolation and identifying children with single versus several co-occurring failures can better capture cases of growth failure in combination: stunting, wasting, and underweight. In the context of multiple anthropometric failures, traditional markers used to assess children's nutritional status tend to underestimate overall undernutrition. Using the composite index of anthropometric failure (CIAF), we aimed to assess the association between maternal undernutrition and child undernutrition among children with diarrhea under the age of two and to investigate the correlates. Using 1431 mother-child dyads from the Antibiotic for Children with Diarrhea (ABCD) trial, we extracted children's data at enrollment and on day 90 and day 180 follow-ups. ABCD was a randomized, multi-country, multi-site, double-blind, placebo-controlled clinical trial. The Bangladesh site collected data from July 2017 to July 2019. The outcome variable, CIAF, allows combinations of height-for-age, height-for-weight, and weight-for-age to determine the overall prevalence of undernutrition. The generalized estimating equation was used to explore the correlates of CIAF. After adjusting all the potential covariates, maternal undernutrition status was found to be strongly associated with child undernutrition using the CIAF [aOR: 1.4 (95% CI: 1.0, 1.9),
MeSH term(s)	Bangladesh/epidemiology ; Child Nutrition Disorders/epidemiology ; Child, Preschool ; Cross-Sectional Studies ; Diarrhea/epidemiology ; Female ; Growth Disorders/epidemiology ; Humans ; Infant ; Malnutrition/epidemiology ; Nutritional Status ; Prevalence ; Thinness/epidemiology
Language	English
Publishing date	2022-05-05
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14091935
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Article ; Online: Is Fibersol-2 efficacious in reducing duration of watery diarrhea and stool output in children 1-3 years old? A randomized, parallel, double-blinded, placebo-controlled, two arm clinical trial.

Shahid, Abu Sadat Mohammad Sayeem Bin / Ahmed, Shahnawaz / Dash, Sampa / Kishimoto, Yuka / Kanahori, Sumiko / Ahmed, Tahmeed / Faruque, Abu Syed Golam / Chisti, Mohammod Jobayer

PloS one

2023 Volume 18, Issue 1, Page(s) e0280934

Abstract: Background: Fibersol-2 has innumerable beneficial effects on human health. It is a fermentable, non-viscous, water-soluble, indigestible dextrin containing 90% dietary fiber produced from corn starch. We aimed to evaluate whether additional intake of ... ...

Abstract	Background: Fibersol-2 has innumerable beneficial effects on human health. It is a fermentable, non-viscous, water-soluble, indigestible dextrin containing 90% dietary fiber produced from corn starch. We aimed to evaluate whether additional intake of Fibersol-2 along with oral rehydration solution treatment can reduce the duration of watery diarrhea and daily stool output in children 1-3 years as well as recovery of such children within 72 hours, compared to placebo. Methods: This placebo-controlled double-blinded, randomized parallel two arm trial conducted in Kumudini Women's Medical College Hospital in rural Bangladesh between March and October, 2018 used 5 gm of either Fibersol-2 or placebo dissolved in 50-ml drinking water which was given orally to ninety-two children with watery diarrhea on enrollment twice daily for a period of 7 days. Randomization was done using a randomization table. We randomly allocated 45 (49%) and 47 (51%) children in Fibersol-2 and placebo groups, respectively. Outcome measures were duration of resolution of watery diarrhea, daily stool output and the proportion of children recovered within 72 hours. Primary and safety analyses were by intention to treat. This trial was registered at ClinicalTrials.gov, number NCT03565393. Results: There was no significant difference observed in terms of duration of resolution of diarrhea (adjusted mean difference 8.20, 95% CI -2.74 to 19.15, p = 0.14, adjusted effect size 0.03); the daily stool output (adjusted mean difference 73.57, 95% CI -94.17 to 241.32, p = 0.38, adjusted effect size 0.33) and the proportion of children recovered within 72 hours (adjusted odds ratio 0.49, 95% CI = 0.12 to 1.96, p = 0.31, adjusted risk difference -0.06 (95% CI -0.19 to -0.06), after regression analysis between Fibersol-2 and placebo. Conclusion: No beneficial role of Fibersol-2 was observed in diarrheal children aged 1-3 years. Trial registration: This trial is registered at ClinicalTrials.gov, number NCT03565393. The authors confirmed that all ongoing and related trials for this drug/intervention are registered. https://clinicaltrials.gov/ct2/show/NCT03565393.
MeSH term(s)	Humans ; Child ; Female ; Infant ; Child, Preschool ; Double-Blind Method ; Diarrhea/drug therapy ; Outcome Assessment, Health Care ; Bangladesh ; Treatment Outcome
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0280934
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Article ; Online: Comparison of Characteristics of Children with Severe Acute and Chronic Malnutrition Hospitalized with Diarrhea.

Rahman, Abu Sayem Mirza Md Hasibur / Haque, Md Ahshanul / Begum, Fardaus Ara / Kabir, Md Farhad / Alam, Baharul / Chisti, Mohammod Jobayer / Ahmed, Tahmeed / Nuzhat, Sharika

The American journal of tropical medicine and hygiene

2023 Volume 110, Issue 2, Page(s) 331–338

Abstract: Children with malnutrition present with aberrant laboratory parameters. This study aimed to identify high-risk diarrheal children with varied nutritional status. The data were obtained from the electronic database of Dhaka Hospital, International Centre ... ...

Abstract	Children with malnutrition present with aberrant laboratory parameters. This study aimed to identify high-risk diarrheal children with varied nutritional status. The data were obtained from the electronic database of Dhaka Hospital, International Centre for Diarrhoeal Disease Research, Bangladesh from 2019 to 2021. Among 1,068 children under 5 years of age with diarrhea, 177 (14%) had severe acute malnutrition (SAM; weight-for-length/height Z score < -3), 239 children (17%) had severe stunting (SS; length/height-for-age Z score < -3), and 652 did not have malnutrition (weight-for-length/height and weight-for-age and length/height-for-age Z score > -2). We independently assessed the relationship of nutritional profiles with each clinical and laboratory parameter. After adjustment for age and sex in the multiple regression model, hyponatremia (adjusted odds ratio [aOR] = 2.37 [95% CI: 1.52-3.68]; P < 0.001) and dehydration (aOR = 2.42 [95% CI: 1.67-3.52]; P < 0.001) were independently associated with SAM compared with children without malnutrition. In comparison to non-malnutrition, SS was less likely to be associated with acute watery diarrhea (aOR = 0.66 [95% CI: 0.47-0.92]; P = 0.014) but was significantly associated with anemia (aOR = 2.18 [95% CI: 1.57-3.02]; P < 0.001) and thrombocytosis (aOR = 2.43 [95% CI: 1.78-3.32]; P < 0.001). The presence of hypernatremia was substantially lower in children with SAM (aOR = 0.38 [95% CI: 0.22-0.65]; P < 0.001) or SS (aOR = 0.56 [95% CI: 0.35-0.88]; P = 0.012) than in children without malnutrition. Severe stunting was less likely to be associated with dehydration (aOR = 0.44 [95% CI: 0.29-0.67]; P < 0.001) in contrast to SAM. Therefore, children hospitalized with diarrhea may have different clinical and laboratory manifestations depending on their nutritional status and may require differential treatment.
MeSH term(s)	Humans ; Child ; Infant ; Child, Preschool ; Dehydration/epidemiology ; Bangladesh/epidemiology ; Malnutrition/complications ; Malnutrition/epidemiology ; Diarrhea/epidemiology ; Growth Disorders/epidemiology
Language	English
Publishing date	2023-12-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.23-0409
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Article ; Online: Protection of staff and families during COVID-19 pandemic: experience from a research institute in Bangladesh.

Nuzhat, Sharika / Abdullah, Faisal / Islam, Md Ridwan / Alam, Baharul / Khan, Azharul Islam / Chisti, Mohammod Jobayer / Ahmed, Tahmeed

The Lancet regional health. Southeast Asia

2023 Volume 22, Page(s) 100344

Abstract: International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), which contains the world's largest diarrheal disease hospital, established a service centre, including testing facilities, isolation unit, out-patient department, in-patient ward, ...

Abstract	International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), which contains the world's largest diarrheal disease hospital, established a service centre, including testing facilities, isolation unit, out-patient department, in-patient ward, and intensive care unit during COVID-19 pandemic. When the management of COVID-19 was challenging nationwide, icddr,b established this facility with the goal to provide COVID-related services to the staff and their relatives amidst the pandemic. Data related to this analysis were collected from April 2020 to December 2021. 1399 patients received treatment under this facility. Among them, 351 patients were treated at the out-patient facility, 98 at the isolation, and 197 at the in-patient ward. Among the admitted patients, survival was 86.29% (n = 170/197). Among the suspected patients, 17% (n = 103/606) were COVID-positive. Setting up an immediate COVID-19 management facility during the pandemic was challenging. It can be an example of how an organisation can adapt to any emergency and act accordingly.
Language	English
Publishing date	2023-12-29
Publishing country	England
Document type	Journal Article ; Review
ISSN	2772-3682
ISSN (online)	2772-3682
DOI	10.1016/j.lansea.2023.100344
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