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  1. Article ; Online: Evaluating How Physician Attitudes May Affect Practice in Fetal Cardiac Counseling.

    Martens, Anna M / Lim, Chelsey C / Kelly, Michael / Haxel, Caitlin S / Ronai, Christina / Chiu, Joanne S

    Pediatric cardiology

    2023  

    Abstract: Advances in fetal cardiac imaging over the last few decades have allowed for increased prenatal detection and detailed counseling of congenital heart disease (CHD). When CHD is detected, fetal cardiologists are faced with the challenge of providing ... ...

    Abstract Advances in fetal cardiac imaging over the last few decades have allowed for increased prenatal detection and detailed counseling of congenital heart disease (CHD). When CHD is detected, fetal cardiologists are faced with the challenge of providing nuanced prenatal counseling. Studies in other specialties have shown that differences in physician attitudes exist around termination of pregnancy and correlate with variations in the counseling provided to parents. We conducted an anonymous cross-sectional survey of fetal cardiologists in New England (n = 36) regarding attitudes toward termination of pregnancy and the counseling provided to parents with a fetal diagnosis of hypoplastic left heart syndrome. Using a screening questionnaire, there was no significant difference in the counseling provided to parents regardless of the physician's personal or professional views on termination of pregnancy, age, gender, location, type of practice, or years of experience. There were, however, differences among physicians on reasons to consider termination and their perceived professional responsibility to the fetus or mother. Further investigation on a larger geographic scale may reveal additional insights on variations in physician beliefs and whether such beliefs affect variability in counseling practices.
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-023-03210-0
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  2. Article ; Online: Diagnostic Yield of Cardiac Biomarker Testing in Predicting Cardiac Disease and Multisystem Inflammatory Syndrome in Children in the Pandemic Era.

    Kelly, Michael S / Fernandes, Neil D / Carr, Audrey V / Beaute, Jeanette I / Lahoud-Rahme, Manuella / Cummings, Brian M / Chiu, Joanne S

    Pediatric emergency care

    2022  Volume 38, Issue 10, Page(s) e1584–e1589

    Abstract: Objectives: This study aimed to assess whether elevations in cardiac biomarkers are associated with pediatric cardiac diagnoses in the era of COVID-19 and multisystem inflammatory syndrome in children (MIS-C).: Study design: This single-center ... ...

    Abstract Objectives: This study aimed to assess whether elevations in cardiac biomarkers are associated with pediatric cardiac diagnoses in the era of COVID-19 and multisystem inflammatory syndrome in children (MIS-C).
    Study design: This single-center retrospective study analyzed children with a troponin drawn in the emergency department or inpatient unit between April 21 and December 31, 2020. The primary outcome was the presence of a cardiac diagnosis or MIS-C. Relationships among demographics, complaint, cardiac diagnostics, and cardiac biomarkers were analyzed.
    Results: Four hundred eighty-six patients (mean ± SD; age 13.1 ± 7.8 years; 46.7% women) met inclusion criteria, for whom a cardiac diagnosis (excluding MIS-C) was made in 27 (5.6%) patients, with MIS-C diagnosed in 14 (2.9%) patients. The sensitivity and specificity of an elevated initial high-sensitivity troponin T (hsTropT) value (>14 ng/L) in predicting the composite outcome of a cardiac diagnosis or MIS-C were 54% and 89%, respectively. Four percent of patients with negative initial troponin values were found to have a cardiac diagnosis or MIS-C. Multivariable regression analysis demonstrated that elevated hsTropT (>14 ng/L; odds ratio [OR] [95% confidence interval]: 4.9 [1.70-14.0]) and elevated N-terminal pro B-type natriuretic peptide values (>500 pg/mL; 6.4 [2.01-20.1]) were associated with increased odds of a cardiac diagnosis or MIS-C.
    Conclusions: Children with elevated cardiac biomarkers have increased odds of a cardiac diagnosis or MIS-C and warrant workup regardless of indication for testing. Although a negative hsTropT may reassure providers, further investigation is critical in developing algorithms to reliably exclude cardiac disease.
    MeSH term(s) Adolescent ; Adult ; Biomarkers ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Testing ; Child ; Child, Preschool ; Female ; Heart Diseases/diagnosis ; Heart Diseases/epidemiology ; Humans ; Male ; Natriuretic Peptide, Brain ; Pandemics ; Retrospective Studies ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/epidemiology ; Troponin ; Troponin T ; Young Adult
    Chemical Substances Biomarkers ; Troponin ; Troponin T ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2022-08-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632588-9
    ISSN 1535-1815 ; 0749-5161
    ISSN (online) 1535-1815
    ISSN 0749-5161
    DOI 10.1097/PEC.0000000000002804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A case of right aortic arch with isolated left innominate artery and global cerebral white matter atrophy.

    Binka, Edem / Sun, Lisa R / Gailloud, Philippe / Chiu, Joanne S

    Cardiology in the young

    2019  Volume 29, Issue 8, Page(s) 1107–1109

    Abstract: A right aortic arch with an isolated left innominate artery is a rare form of aortic arch anomaly. We present a case of neonatal diagnosis of this anomaly with concerning findings of global cerebral white matter atrophy at 13 months of age. ...

    Abstract A right aortic arch with an isolated left innominate artery is a rare form of aortic arch anomaly. We present a case of neonatal diagnosis of this anomaly with concerning findings of global cerebral white matter atrophy at 13 months of age.
    MeSH term(s) Aorta, Thoracic/abnormalities ; Aorta, Thoracic/diagnostic imaging ; Atrophy ; Brachiocephalic Trunk/abnormalities ; Brachiocephalic Trunk/diagnostic imaging ; Computed Tomography Angiography ; Female ; Humans ; Infant ; Infant, Newborn ; White Matter/diagnostic imaging ; White Matter/pathology
    Language English
    Publishing date 2019-07-10
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951119001537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Kawasaki Disease Features and Myocarditis in a Patient with COVID-19.

    Chiu, Joanne S / Lahoud-Rahme, Manuella / Schaffer, David / Cohen, Ari / Samuels-Kalow, Margaret

    Pediatric cardiology

    2020  Volume 41, Issue 7, Page(s) 1526–1528

    Abstract: A 10-year-old male with prolonged fever, rash, and conjunctivitis presented to the emergency department with concern for Kawasaki disease, found to have myocarditis and PCR positive for SARS-CoV-2. ...

    Abstract A 10-year-old male with prolonged fever, rash, and conjunctivitis presented to the emergency department with concern for Kawasaki disease, found to have myocarditis and PCR positive for SARS-CoV-2.
    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Cardiotonic Agents/therapeutic use ; Child ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Dopamine/therapeutic use ; Emergency Service, Hospital ; Fever ; Humans ; Male ; Mucocutaneous Lymph Node Syndrome/complications ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Mucocutaneous Lymph Node Syndrome/drug therapy ; Mucocutaneous Lymph Node Syndrome/virology ; Myocarditis/complications ; Myocarditis/diagnosis ; Myocarditis/drug therapy ; Myocarditis/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Polymerase Chain Reaction ; SARS-CoV-2
    Chemical Substances Cardiotonic Agents ; Dopamine (VTD58H1Z2X)
    Keywords covid19
    Language English
    Publishing date 2020-06-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-020-02393-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Distinguishing Features of Patients Evaluated for Multisystem Inflammatory Syndrome in Children.

    Kelly, Michael S / Fernandes, Neil D / Carr, Audrey V / Lahoud-Rahme, Manuella / Cummings, Brian M / Chiu, Joanne S

    Pediatric emergency care

    2021  Volume 37, Issue 3, Page(s) 179–184

    Abstract: Objectives: Given the significant overlap of multisystem inflammatory syndrome in children (MIS-C) with other common childhood illnesses presenting to the emergency department, extensive workup of this syndrome has become necessary. Nevertheless, little ...

    Abstract Objectives: Given the significant overlap of multisystem inflammatory syndrome in children (MIS-C) with other common childhood illnesses presenting to the emergency department, extensive workup of this syndrome has become necessary. Nevertheless, little has been published on the factors differentiating MIS-C from other conditions in the acute care setting. We investigated differences in presentation and laboratory studies between suspected versus confirmed MIS-C patients.
    Methods: This was a retrospective cohort study on patients 21 years or younger undergoing investigation for possible MIS-C at a single institution between April 21 and July 1, 2020. The primary outcome was diagnosis of MIS-C or an alternative final diagnosis. Clinical features and laboratory findings from initial presentation were collected and analyzed.
    Results: A total of 106 patients (median, 4 years; 55.7% male) were included, of whom 17 (16%) of 106 met the criteria for MIS-C. Multisystem inflammatory syndrome in children patients were significantly more likely to report a coronavirus disease 2019 exposure (odds ratio (OR), 13.17 [3.87-44.9]), have gastrointestinal symptoms (OR, 3.81 [1.02-14.19]), and have a significantly higher odds of having abnormal laboratory values including high-sensitivity troponin T (OR, 13 [4.0-42.2]), N-terminal B-type natriuretic peptide (OR, 8.4 [2.3-30.1]), D-dimer (OR, 13 [1.6-103]), and ferritin (OR, 7.8 [2.2-27.2]). There were also differences between groups in inflammatory markers: C-reactive protein (median, 134.45 mg/L vs 12.6 mg/L; P < 0.05) and procalcitonin (1.71 ng/mL vs 0.14 ng/mL; P < 0.001).
    Conclusions: Higher elevations in key laboratory studies may help to distinguish between MIS-C patients and non-MIS-C patients presenting to the emergency department.
    MeSH term(s) Adolescent ; COVID-19/epidemiology ; Child ; Child, Preschool ; Critical Care/methods ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Pandemics ; Prognosis ; Retrospective Studies ; Systemic Inflammatory Response Syndrome/epidemiology ; Young Adult
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632588-9
    ISSN 1535-1815 ; 0749-5161
    ISSN (online) 1535-1815
    ISSN 0749-5161
    DOI 10.1097/PEC.0000000000002344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2083: Show issues Location:
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  6. Article ; Online: Multisystem Inflammatory Syndrome in Children: Cardiac Biomarker Profiles and Echocardiographic Findings in the Acute and Recovery Phases.

    Kelly, Michael S / Valle, Christopher W / Fernandes, Neil D / Cummings, Brian M / Lahoud-Rahme, Manuella / Chiu, Joanne S

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

    2020  Volume 33, Issue 10, Page(s) 1288–1290

    MeSH term(s) Biomarkers ; COVID-19 ; Child ; Echocardiography ; Humans ; Systemic Inflammatory Response Syndrome
    Chemical Substances Biomarkers
    Keywords covid19
    Language English
    Publishing date 2020-08-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1035622-8
    ISSN 1097-6795 ; 0894-7317
    ISSN (online) 1097-6795
    ISSN 0894-7317
    DOI 10.1016/j.echo.2020.08.008
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  7. Article: Kawasaki Disease Features and Myocarditis in a Patient with COVID-19

    Chiu, Joanne S / Lahoud-Rahme, Manuella / Schaffer, David / Cohen, Ari / Samuels-Kalow, Margaret

    Pediatr Cardiol

    Abstract: A 10-year-old male with prolonged fever, rash, and conjunctivitis presented to the emergency department with concern for Kawasaki disease, found to have myocarditis and PCR positive for SARS-CoV-2. ...

    Abstract A 10-year-old male with prolonged fever, rash, and conjunctivitis presented to the emergency department with concern for Kawasaki disease, found to have myocarditis and PCR positive for SARS-CoV-2.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #598531
    Database COVID19

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  8. Article ; Online: Kawasaki Disease Features and Myocarditis in a Patient with COVID-19

    Chiu, Joanne S. / Lahoud-Rahme, Manuella / Schaffer, David / Cohen, Ari / Samuels-Kalow, Margaret

    Pediatric Cardiology ; ISSN 0172-0643 1432-1971

    2020  

    Keywords Pediatrics, Perinatology, and Child Health ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s00246-020-02393-0
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Double aortic arch in a newborn with congenital diaphragmatic hernia and tracheoesophageal fistula.

    Chiu, Joanne S / Glickstein, Julie / Shah, Amee

    Cardiology in the young

    2014  Volume 24, Issue 4, Page(s) 725–726

    Abstract: Congenital heart disease is associated with congenital diaphragmatic hernia, but diagnosis by echocardiography can be difficult. We present the unusual case of a patient with a double aortic arch and congenital diaphragmatic hernia diagnosed using ... ...

    Abstract Congenital heart disease is associated with congenital diaphragmatic hernia, but diagnosis by echocardiography can be difficult. We present the unusual case of a patient with a double aortic arch and congenital diaphragmatic hernia diagnosed using cardiac magnetic resonance imaging.
    MeSH term(s) Abnormalities, Multiple/diagnosis ; Aorta, Thoracic/abnormalities ; Cardiac Imaging Techniques ; Hernias, Diaphragmatic, Congenital/diagnosis ; Humans ; Infant, Newborn ; Magnetic Resonance Angiography ; Magnetic Resonance Imaging ; Tracheoesophageal Fistula/diagnosis
    Language English
    Publishing date 2014-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S104795111400064X
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  10. Article ; Online: Associations Between Maternal Sociodemographics and Hospital Mortality in Newborns With Prenatally Diagnosed Hypoplastic Left Heart Syndrome.

    Lopez, Keila N / Morris, Shaine A / Krishnan, Anita / Jacobs, Marni B / Bhat, Aarti H / Chelliah, Anjali / Chiu, Joanne S / Cuneo, Bettina F / Freire, Grace / Hornberger, Lisa K / Howley, Lisa / Husain, Nazia / Ikemba, Catherine / Kavanaugh-McHugh, Ann / Kutty, Shelby / Lee, Caroline / McBrien, Angela / Michelfelder, Erik C / Pinto, Nelangi M /
    Schwartz, Rachel / Stern, Kenan W D / Taylor, Carolyn / Thakur, Varsha / Tworetzky, Wayne / Wittlieb-Weber, Carol / Woldu, Kris / Donofrio, Mary T / Peyvandi, Shabnam

    Circulation

    2023  Volume 148, Issue 3, Page(s) 283–285

    MeSH term(s) Humans ; Infant, Newborn ; Female ; Pregnancy ; Hypoplastic Left Heart Syndrome ; Hospital Mortality ; Prenatal Diagnosis ; Echocardiography ; Heart Defects, Congenital ; Ultrasonography, Prenatal
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.123.064476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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