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  1. Article ; Online: Phase separation driven by interchangeable properties in the intrinsically disordered regions of protein paralogs.

    Chiu, Shih-Hui / Ho, Wen-Lin / Sun, Yung-Chen / Kuo, Jean-Cheng / Huang, Jie-Rong

    Communications biology

    2022  Volume 5, Issue 1, Page(s) 400

    Abstract: Paralogs, arising from gene duplications, increase the functional diversity of proteins. Protein functions in paralog families have been extensively studied, but little is known about the roles that intrinsically disordered regions (IDRs) play in their ... ...

    Abstract Paralogs, arising from gene duplications, increase the functional diversity of proteins. Protein functions in paralog families have been extensively studied, but little is known about the roles that intrinsically disordered regions (IDRs) play in their paralogs. Without a folded structure to restrain them, IDRs mutate more diversely along with evolution. However, how the diversity of IDRs in a paralog family affects their functions is unexplored. Using the RNA-binding protein Musashi family as an example, we applied multiple structural techniques and phylogenetic analysis to show how members in a paralog family have evolved their IDRs to different physicochemical properties but converge to the same function. In this example, the lower prion-like tendency of Musashi-1's IDRs, rather than Musashi-2's, is compensated by its higher α-helical propensity to assist their assembly. Our work suggests that, no matter how diverse they become, IDRs could evolve different traits to a converged function, such as liquid-liquid phase separation.
    MeSH term(s) Humans ; Phylogeny ; Proteins/metabolism
    Chemical Substances Proteins
    Language English
    Publishing date 2022-04-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-022-03354-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Carbapenem resistant Enterobacteriaceae carrying New Delhi metallo-β-lactamase gene (NDM-1) in Taiwan.

    Wang, Shiow-Jen / Chiu, Shih-Hui / Lin, Ying-Chun / Tsai, Yun-Chi / Mu, Jung-Jung

    Diagnostic microbiology and infectious disease

    2013  Volume 76, Issue 2, Page(s) 248–249

    Abstract: The spread of New Delhi metallo-β-lactamase gene (NDM-1)-producing bacteria has become a growing concern to the medical community worldwide. In this study, we reported 4 NDM-1-positive Enterobacteriaceae isolates recovered from two Taiwanese patients ... ...

    Abstract The spread of New Delhi metallo-β-lactamase gene (NDM-1)-producing bacteria has become a growing concern to the medical community worldwide. In this study, we reported 4 NDM-1-positive Enterobacteriaceae isolates recovered from two Taiwanese patients having travel history. The β-lactamase genetic background, antimicrobial susceptibility, clonal relationships, and plasmid sizes of the NDM-1-producing Enterobacteriaceae were investigated. This report highlights the alarming introduction of NDM-1 gene among Enterobacteriaceae in Taiwan.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Carbapenems/pharmacology ; Drug Resistance, Multiple, Bacterial/genetics ; Enterobacteriaceae/drug effects ; Enterobacteriaceae/genetics ; Enterobacteriaceae/isolation & purification ; Humans ; Microbial Sensitivity Tests ; Plasmids ; Taiwan ; beta-Lactamases/genetics
    Chemical Substances Anti-Bacterial Agents ; Carbapenems ; beta-Lactamases (EC 3.5.2.6) ; beta-lactamase NDM-1 (EC 3.5.2.6)
    Language English
    Publishing date 2013-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2013.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1845: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article: Carbapenem resistant Enterobacteriaceae carrying New Delhi metallo-β-lactamase gene (NDM-1) in Taiwan

    Wang, Shiow-Jen / Chiu, Shih-Hui / Lin, Ying-Chun / Tsai, Yun-Chi / Mu, Jung-Jung

    Diagnostic microbiology & infectious disease. 2013 June, v. 76, no. 2

    2013  

    Abstract: The spread of New Delhi metallo-β-lactamase gene (NDM-1)-producing bacteria has become a growing concern to the medical community worldwide. In this study, we reported 4 NDM-1-positive Enterobacteriaceae isolates recovered from two Taiwanese patients ... ...

    Abstract The spread of New Delhi metallo-β-lactamase gene (NDM-1)-producing bacteria has become a growing concern to the medical community worldwide. In this study, we reported 4 NDM-1-positive Enterobacteriaceae isolates recovered from two Taiwanese patients having travel history. The β-lactamase genetic background, antimicrobial susceptibility, clonal relationships, and plasmid sizes of the NDM-1-producing Enterobacteriaceae were investigated. This report highlights the alarming introduction of NDM-1 gene among Enterobacteriaceae in Taiwan.
    Keywords Enterobacteriaceae ; bacteria ; beta-lactamase ; carbapenems ; genes ; genetic background ; patients ; plasmids ; India ; Taiwan
    Language English
    Dates of publication 2013-06
    Size p. 248-249.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 604920-5
    ISSN 0732-8893
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2013.02.003
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1845: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: PREVALENCE AND DIVERSITY OF BARTONELLA SPECIES IN WILD SMALL MAMMALS IN ASIA.

    Kim, Kyeong Soon / Inoue, Kai / Kabeya, Hidenori / Sato, Shingo / Takada, Tomoe / Pangjai, Decha / Chiu, Shih-Hui / Fujita, Hiromi / Kawabata, Hiroki / Takada, Nobuhiro / Kariwa, Hiroaki / Maruyama, Soichi

    Journal of wildlife diseases

    2016  Volume 52, Issue 1, Page(s) 10–21

    Abstract: We collected 641 small mammals belonging to 17 species of Rodentia and four species of Soricomorpha in Japan, Korea, Russia, Taiwan, and Thailand and investigated the prevalence and genetic diversity of Bartonella species. Apodemus (field mice) and ... ...

    Abstract We collected 641 small mammals belonging to 17 species of Rodentia and four species of Soricomorpha in Japan, Korea, Russia, Taiwan, and Thailand and investigated the prevalence and genetic diversity of Bartonella species. Apodemus (field mice) and Rattus (rats) were the most-common genera captured, making up 56.0% and 23.1% of the total specimens, respectively. Bartonellae were isolated from 54.6% of the collected animals, and the prevalence varied depending on the host species and the country of origin. The isolates were identified to the species level based on gltA and rpoB sequences. Although most Bartonella species were shared by more than two host species, the distribution patterns of Bartonella species clearly differed among the four most-common host genera: Apodemus, Rattus, Myodes (voles), and Suncus (shrews). The predominant Bartonella species were Bartonella grahamii in Apodemus, Bartonella tribocorum in Rattus, B. grahamii and Bartonella taylorii in Myodes, and an unclassified Bartonella sp. in Suncus.
    MeSH term(s) Animals ; Asia/epidemiology ; Bacterial Proteins/genetics ; Bartonella/classification ; Bartonella/genetics ; Bartonella/isolation & purification ; Bartonella Infections/epidemiology ; Bartonella Infections/microbiology ; Bartonella Infections/veterinary ; DNA, Bacterial/chemistry ; DNA, Bacterial/isolation & purification ; Disease Reservoirs ; Genetic Variation ; Insectivora/microbiology ; Murinae ; Phylogeny ; Prevalence ; Rats ; Rodent Diseases/epidemiology ; Rodent Diseases/microbiology ; Rodentia
    Chemical Substances Bacterial Proteins ; DNA, Bacterial
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 410709-3
    ISSN 1943-3700 ; 0090-3558
    ISSN (online) 1943-3700
    ISSN 0090-3558
    DOI 10.7589/2015-01-015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1441: Show issues Location:
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  5. Article ; Online: The presence of Borrelia valaisiana-related genospecies in ticks and a rodent in Taiwan.

    Huang, Chun-Man / Wang, Hsi-Chieh / Lin, Ying-Chun / Chiu, Shih-Hui / Kao, Ying-Shun / Lee, Pei-Lung / Wang, Hsiu-I / Hung, Ruei-Chen / Chan, Huang-I / Wu, Ho-Sheng / Chiang, Chuen-Sheue / Mu, Jung-Jung

    Journal of microbiology (Seoul, Korea)

    2011  Volume 48, Issue 6, Page(s) 877–880

    Abstract: A field survey was conducted to investigate the presence of Borrelia burgdorferi sensu lato (s.l.) in six counties of Taiwan. Spirochetes were successfully isolated from one rodent ear sample out of 485 rodent ears and 53 live, fed tick (Ixodes ... ...

    Abstract A field survey was conducted to investigate the presence of Borrelia burgdorferi sensu lato (s.l.) in six counties of Taiwan. Spirochetes were successfully isolated from one rodent ear sample out of 485 rodent ears and 53 live, fed tick (Ixodes granulatus) samples. The spirochetes were confirmed to be B. burgdorferi s.l. by real-time PCR. In addition, 23 of 113 tick samples were tested positive for Borrelia DNA according to real-time PCR. The Borrelia isolate from the rodent and the 23 Borrelia DNA samples from the ticks were identified as B. valaisiana-related genospecies by phylogenetic analysis based on flagellin gene sequences. These findings suggest that the Borrelia valaisiana-related strains are maintained in a zoonotic cycle between tick vectors and reservoir hosts in Taiwan.
    MeSH term(s) Animals ; Borrelia burgdorferi Group/classification ; Borrelia burgdorferi Group/genetics ; Borrelia burgdorferi Group/isolation & purification ; Cluster Analysis ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; Flagellin/genetics ; Ixodes/microbiology ; Molecular Sequence Data ; Phylogeny ; Polymerase Chain Reaction ; Rodentia/microbiology ; Sequence Analysis, DNA ; Sequence Homology ; Taiwan
    Chemical Substances DNA, Bacterial ; Flagellin (12777-81-0)
    Language English
    Publishing date 2011-01-09
    Publishing country Korea (South)
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2012399-1
    ISSN 1976-3794 ; 1225-8873
    ISSN (online) 1976-3794
    ISSN 1225-8873
    DOI 10.1007/s12275-010-0331-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5211: Show issues Location:
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  6. Article: The Presence of Borrelia valaisiana-Related Genospecies in Ticks and a Rodent in Taiwan

    Huang, Chun-Man, Centers for Disease Control, Taipei, Taiwan / Wang, Hsi-Chieh, Centers for Disease Control, Taipei, Taiwan / Lin, Ying-Chun, Centers for Disease Control, Taipei, Taiwan / Chiu, Shih-Hui, Centers for Disease Control, Taipei, Taiwan / Kao, Ying-Shun, Centers for Disease Control, Taipei, Taiwan / Lee, Pei-Lung, Centers for Disease Control, Taipei, Taiwan / Wang, Hsiu-I, Centers for Disease Control, Taipei, Taiwan / Hung, Ruei-Chen, Centers for Disease Control, Taipei, Taiwan / Chan, Huang-I, Centers for Disease Control, Taipei, Taiwan / Wu, Ho-Sheng, Centers for Disease Control, Taipei, Taiwan / Chiang, Chuen-Sheue, Centers for Disease Control, Taipei, Taiwan / Mu, Jung-Jung, Centers for Disease Control, Taipei, Taiwan

    The Journal of Microbiology

    (Dec 2010)  Volume v. 48, Issue (6), Page(s) p. 877–880

    Abstract: A field survey was conducted to investigate the presence of Borrelia burgdorferi sensu lato (s.l.) in six counties of Taiwan. Spirochetes were successfully isolated from one rodent ear sample out of 485 rodent ears and 53 live, fed tick (Ixodes ... ...

    Abstract A field survey was conducted to investigate the presence of Borrelia burgdorferi sensu lato (s.l.) in six counties of Taiwan. Spirochetes were successfully isolated from one rodent ear sample out of 485 rodent ears and 53 live, fed tick (Ixodes granulatus) samples. The spirochetes were confirmed to be B. burgdorferi s.l. by real-time PCR. In addition, 23 of 113 tick samples were tested positive for Borrelia DNA according to real-time PCR. The Borrelia isolate from the rodent and the 23 Borrelia DNA samples from the ticks were identified as B. valaisiana-related genospecies by phylogenetic analysis based on flagellin gene sequences. These findings suggest that the Borrelia valaisiana-related strains are maintained in a zoonotic cycle between tick vectors and reservoir hosts in Taiwan.
    Keywords RODENTS ; RONGEUR ; ROEDORES
    Language English
    Document type Article
    ISSN 1225-8873
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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