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Article ; Online: Cold hypersensitivity in the hands and feet is associated with erectile dysfunction in young Taiwanese men.

Chang, Che-Jui / Fan, Yu-Hua / Chiu, Yi-Chun / Cheng, Wei-Ming

2024 Volume 14, Issue 1, Page(s) 10577

Abstract: Cold hypersensitivity in the hands and feet (CHHF) is a protective or predisposing factor for many diseases; however, the relationship between CHHF and erectile dysfunction (ED) remains unclear. We aimed to investigate associations between CHHF and ED ... ...

Abstract	Cold hypersensitivity in the hands and feet (CHHF) is a protective or predisposing factor for many diseases; however, the relationship between CHHF and erectile dysfunction (ED) remains unclear. We aimed to investigate associations between CHHF and ED among young men of Southeast Asian origin. In this cross-sectional study, sexually active Taiwanese men aged 20-40 years were enrolled via an online questionnaire comprising general demographic information, comorbidities, subjective thermal sensations of their hands and feet in the past 6 months, and their erectile function using the International Index of Erectile Function-5 (IIEF-5). Participants who reported cold sensation of hands and feet were classified to have CHHF; those with IIEF-5 score ≤ 21 were considered to have ED. Total 54.2% and 27.9% of participants had ED and CHHF, respectively. Men with CHHF were significantly younger, had lower body mass index and IIEF-5 scores (p < 0.001), and a lower prevalence of diabetes mellitus (p = 0.033) along with higher prevalence of ED, psychiatric disorders, and insomnia (p < 0.001). After adjusting for predisposing factors of ED, CHHF (odds ratio 1.410, 95% confidence interval 1.159-1.714; p = 0.001) remained an independent predictor of ED. Thus, CHHF is independently associated with ED, affecting more than a quarter of young Taiwanese men. Autonomic dysregulation and subclinical endothelial dysfunction may be common pathophysiologies of CHHF and ED.
MeSH term(s)	Humans ; Male ; Erectile Dysfunction/epidemiology ; Erectile Dysfunction/etiology ; Taiwan/epidemiology ; Adult ; Cross-Sectional Studies ; Young Adult ; Hand/physiopathology ; Foot/physiopathology ; Cryopyrin-Associated Periodic Syndromes/epidemiology ; Cryopyrin-Associated Periodic Syndromes/complications ; Surveys and Questionnaires ; Prevalence ; Cold Temperature/adverse effects ; Risk Factors
Language	English
Publishing date	2024-05-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-60260-x
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Article ; Online: Effects of early warm water sitz bath on urinary retention and pain after haemorrhoidectomy: A randomized controlled trial.

Liao, Wan-Chun / Cheng, Yu-Yi / Hsu, Chieh-Kuan / Chiu, Yi-Chun / Chiu, Hsiao-Yean / Chang, Shih-Chang / Hu, Sophia H

International journal of nursing studies

2024 Volume 154, Page(s) 104765

Abstract: Background: Haemorrhoids are a common chronic anorectal disease, and haemorrhoidectomy is the standard treatment for advanced (grade III and IV) haemorrhoids. Warm water sitz has commonly been used to stimulate urination, cleanse wounds, and decrease ... ...

Abstract	Background: Haemorrhoids are a common chronic anorectal disease, and haemorrhoidectomy is the standard treatment for advanced (grade III and IV) haemorrhoids. Warm water sitz has commonly been used to stimulate urination, cleanse wounds, and decrease pain. Although urinary retention and pain usually occur within the first 24 h after surgery, the warm water sitz bath is provided 24 h after haemorrhoidectomy, which might be a missed opportunity to optimize the quality and efficiency of the care provided. Objective: To investigate the effect of early warm water sitz bath on the day of haemorrhoidectomy surgery on preventing urinary retention and reducing wound pain. Design: This was a longitudinal double-blind study with a permuted block randomization design. Setting(s): This study was conducted in a surgical ward of a medical center. An average of 18 patients receiving hemorrhoid surgery in that ward every month. Participants: A total of 64 participants (32 each in the experimental and control groups) were enrolled. (The first recruitment date is January 16, 2020.) METHODS: Patients who received haemorrhoidectomy for grade III or IV haemorrhoids from January to December 2020 were enrolled. The experimental and control groups received the same conventional treatment and care before the haemorrhoidectomy. The experimental group started warm-water sitz bath 6 h after the surgery, and the control group started warm water sitz bath on post-haemorrhoidectomy day 1 as usual. Urinary retention was defined as use of Foley catheter during the hospital stay or remaining urine volume ≧ 300 ml using the bladder scan. A numerical rating scale was used to rate the pain level. Each participant was evaluated 6 times in total until hospital discharge. The data were analysed by descriptive statistics, chi-square test, and independent samples t test. Generalized estimating equations and intention to treat were used to identify changes in urinary retention and pain over time and missing data, respectively. Results: There was no significant difference in the degree of change in the number of people with urinary retention between groups. A change in the wound pain index was noted; the study group had a statistically significant lower pain score than the control group (B = -0.81, 95 % CI: -1.44 to -0.18). Conclusions: Early warm water sitz bath was a safe and effective strategy to decrease post-haemorrhoidectomy pain, but not urinary retention. Nurses could provide early warm water sitz bath for post-haemorrhoidectomy patients' comfort. Registration: ClinicalTrials.gov ID: NCT04535765.
Language	English
Publishing date	2024-03-31
Publishing country	England
Document type	Journal Article
ZDB-ID	80148-3
ISSN	1873-491X ; 0020-7489
ISSN (online)	1873-491X
ISSN	0020-7489
DOI	10.1016/j.ijnurstu.2024.104765
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Article: Correction: Hsu et al. Development of Folic Acid-Conjugated and Methylene Blue-Adsorbed Au@TNA Nanoparticles for Enhanced Photodynamic Therapy of Bladder Cancer Cells.

Hsu, Che-Wei / Cheng, Nai-Chi / Liao, Mei-Yi / Cheng, Ting-Yu / Chiu, Yi-Chun

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 15

Abstract: Within the publication of this article ... ...

Abstract	Within the publication of this article in
Language	English
Publishing date	2023-08-02
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13152233
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Article ; Online: Risk factors for gallbladder polyps observed through second-look abdominal sonography in patients with fatty liver disease.

Lin, Shu-Hsien / Wu, Kun-Ta / Chiu, Yi-Chun / Wang, Chih-Chi / Chiu, King-Wah

Medicine

2022 Volume 101, Issue 30, Page(s) e29643

Abstract: Conclusion: FLD, older age group, and alcohol consumption are major risk factors of GBP formation in Taiwanese population. The presence of GBPs might be revealed in second-look examinations of abdominal sonographies. ...

Abstract	Conclusion: FLD, older age group, and alcohol consumption are major risk factors of GBP formation in Taiwanese population. The presence of GBPs might be revealed in second-look examinations of abdominal sonographies.
MeSH term(s)	Aged ; Gallbladder Diseases/complications ; Gallbladder Neoplasms ; Gastrointestinal Neoplasms/complications ; Humans ; Liver Diseases/complications ; Polyps/diagnostic imaging ; Polyps/epidemiology ; Risk Factors
Language	English
Publishing date	2022-07-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000029643
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Article ; Online: Efficacy of intravenous hydration during extracorporeal shock wave lithotripsy in improving ureteral stone treatment success rate.

Cheng, Weiming / Chiu, Yi-Chun / Fan, Yu-Hua / Chang, Chang-Chi / Kao, Kuo-Wei

International journal of urology : official journal of the Japanese Urological Association

2022 Volume 29, Issue 6, Page(s) 548–552

Abstract: Objective: The treatment efficacy of extracorporeal shock wave lithotripsy for urolithiasis depends on several factors. We aimed to evaluate the impact of intravenous hydration during shock wave lithotripsy on stone treatment success rate in patients ... ...

Abstract	Objective: The treatment efficacy of extracorporeal shock wave lithotripsy for urolithiasis depends on several factors. We aimed to evaluate the impact of intravenous hydration during shock wave lithotripsy on stone treatment success rate in patients with ureteral stones. Methods: We retrospectively evaluated patients with ureteral stones <2 cm in diameter treated with extracorporeal shock wave lithotripsy at two sites. Patients from one of the sites received intravenous hydration with 500 mL of 0.9% NaCl. Stone treatment success status was defined as stone-free or residual ureteral stones <0.4 cm in diameter 1 month after the procedure. Predictive factors associated with treatment success were evaluated using univariate and multivariate logistic regression. Results: Overall, 146 consecutive patients with ureteral stones were included. Eighty (54.8%) patients received intravenous hydration. The overall stone treatment success rate was 66.4%. Those with intravenous hydration during the shock wave lithotripsy had significantly smaller stone size, lower serum creatinine levels, lower rate of alpha-blockers use, and higher rate of nonsteroidal anti-inflammatory drug use. Upon multivariate analysis, stone treatment success status postprocedure was significantly associated with stone size (odds ratio 4.118, 95% confidence interval 1.920-8.832, P < 0.0001) and intravenous hydration during the procedure (odds ratio 2.475, 95% confidence interval 1.176-5.208, P = 0.017). Conclusion: Besides small ureteral stone size, concomitant intravenous hydration with 500 mL of normal saline during extracorporeal shock wave lithotripsy was significantly associated with subsequent stone passage. Administering 0.9% NaCl may be a simple and effective measure to improve the treatment efficacy of extracorporeal shock wave lithotripsy.
MeSH term(s)	Humans ; Lithotripsy/adverse effects ; Lithotripsy/methods ; Retrospective Studies ; Saline Solution ; Treatment Outcome ; Ureteral Calculi/therapy
Chemical Substances	Saline Solution
Language	English
Publishing date	2022-02-26
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.14836
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Article ; Online: Renoprotective Impacts of

Chiang, Kuang-Hsing / Chiu, Yi-Chun / Yar, Noi / Chen, Yu-Chun / Cheng, Chia-Hui / Liu, Yi-Chien / Chang, Chia-Yu / Chuu, Jiunn-Jye

International journal of molecular sciences

2023 Volume 24, Issue 5

Abstract: Diabetes nephropathy (DN) is one of the most common causes of end stage renal disease (ESRD) globally. Medication options to stop or slow the progression of chronic renal disease (CKD) are limited, and patients with DN remain at a high risk of developing ...

Abstract	Diabetes nephropathy (DN) is one of the most common causes of end stage renal disease (ESRD) globally. Medication options to stop or slow the progression of chronic renal disease (CKD) are limited, and patients with DN remain at a high risk of developing renal failure.
MeSH term(s)	Mice ; Animals ; Diabetic Nephropathies/metabolism ; Streptozocin/pharmacology ; Kidney/metabolism ; Nephrectomy/adverse effects ; Diabetes Mellitus/metabolism
Chemical Substances	Streptozocin (5W494URQ81) ; ethyl acetate (76845O8NMZ)
Language	English
Publishing date	2023-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24054443
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Article: FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma.

Huang, Yung-Cheng / Chiu, Nan-Tsing / Lu, Hung-I / Chiu, Yi-Chun / Hsu, Chien-Chin / Wang, Yu-Ming / Li, Shau-Hsuan

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 19

Abstract: This study aimed to compare the diagnostic performances of endoscopic ultrasound (EUS) and FDG PET/CT in the preoperative T-staging of esophageal squamous cell carcinoma (ESCC) and determine whether their innovative coordination achieves better ... ...

Abstract	This study aimed to compare the diagnostic performances of endoscopic ultrasound (EUS) and FDG PET/CT in the preoperative T-staging of esophageal squamous cell carcinoma (ESCC) and determine whether their innovative coordination achieves better prediction. In total, 100 patients diagnosed with ESCC, 57 without (CRT
Language	English
Publishing date	2023-09-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13193083
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Article: The association between trajectory of serum cholesterol, statin dosage, and the risk of recurrent biliary stone diseases.

Sou, Fai-Meng / Hsu, Chien-Ning / Chiu, Yi-Chun / Wu, Cheng-Kun / Lu, Lung-Sheng / Kuo, Chung-Mou / Chiu, Shao-Ming / Chuah, Seng-Kee / Yang, Yao-Hsu / Liang, Chih-Ming

Journal of the Formosan Medical Association = Taiwan yi zhi

2024

Abstract: Background: Statins may reduce the risk of recurrent gallstone disease by decreasing bile cholesterol saturation and pathogenicity. However, limited studies have investigated this issue. This study aimed to assess whether statin doses and serum ... ...

Abstract	Background: Statins may reduce the risk of recurrent gallstone disease by decreasing bile cholesterol saturation and pathogenicity. However, limited studies have investigated this issue. This study aimed to assess whether statin doses and serum cholesterol levels were associated with a decreased risk of recurrent biliary stone diseases after the first event index, with a follow-up time of 15 years. Methods: Based on the Chang Gung Research Database (CGRD) between January 1, 2001, and December 31, 2020, we enrolled 68,384 patients with the International Classification of Diseases, Ninth and Tenth Revision codes of choledocholithiasis. After exclusions, 32,696 patients were divided into non-statin (<28 cDDD, cumulative defined daily doses) (n = 27,929) and statin (≥28 cDDD) (n = 4767) user groups for analysis. Serum cholesterol trajectories were estimated using group-based trajectory modeling (n = 8410). Results: The statin users had higher Charlson Comorbidity Index (CCI) scores than the non-statin users. Time-dependent Cox regression analysis showed that statin use >365 cDDD was associated with a significantly lower risk of recurrent biliary stones (adjusted hazard ratio [aHR] = 0.28, 95% CI, 0.24-0.34; p < 00.0001), acute pancreatitis (aHR = 0.24, 95% CI, 0.17-0.32, p < 00.0001), and cholangitis (aHR = 0.28, 95% CI, 0.25-0.32, p < 00.0001). Cholecystectomy was also a protective factor for recurrent biliary stones (aHR = 0.41, 95% CI, 0.37-0.46; p < 00.0001). The higher trajectory serum cholesterol group (Group 3) had a lower risk trend for recurrent biliary stones (aHR = 0.79, p = 0.0700) and a lower risk of cholangitis (aHR = 0.79, p = 0.0071). Conclusion: This study supports the potential benefits of statin use and the role of cholecystectomy in reducing the risk of recurrent biliary stone diseases.
Language	English
Publishing date	2024-04-07
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2024.04.003
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Article ; Online: Multicenter study of the efficacy and safety of electrocautery-enhanced lumen-apposing metal stents for the internal drainage of pancreatic fluid collections.

Chung, Chen-Shuan / Kuo, Yu-Ting / Chiu, Yi-Chun / Lin, Yang-Chao / Yang, Chi-Ying / Chen, Kuan-Chih / Liao, Szu-Chia / Sun, Cheuk-Kay / Lin, Yen-Chih / Wang, Hsiu-Po

Scientific reports

2024 Volume 14, Issue 1, Page(s) 5481

Abstract: Pancreatic fluid collections (PFCs) including pancreatic pseudocyst (PP) and walled-off necrosis (WON) are complications after acute pancreatitis. We aimed to evaluate the efficacy and safety of endoscopic ultrasound (EUS)-guided lumen-apposing metal ... ...

Abstract	Pancreatic fluid collections (PFCs) including pancreatic pseudocyst (PP) and walled-off necrosis (WON) are complications after acute pancreatitis. We aimed to evaluate the efficacy and safety of endoscopic ultrasound (EUS)-guided lumen-apposing metal stent (LAMS) placement to manage PFCs. Between June 2019 and May 2023, patients with symptomatic PFCs who underwent EUS-guided electrocautery-enhanced LAMS drainage were enrolled retrospectively from eight tertiary centers in Taiwan. In total, 33 [14 (42.42%) PP and 19 (57.58%) WON] patients were enrolled. Gallstones (27.27%) and abdominal pain (72.73%) were the most common etiology and indication for drainage. The technical and clinical success rates were 100% and 96.97%, respectively, and the mean procedure time was 30.55 (± 16.17) min. Complications included one (3.03%) case of self-limited bleeding; there were no cases of mortality. Seven (21.21%) patients had recurrence. Patients with disconnected pancreatic duct syndrome (DPDS) had a higher recurrence rate than those without (71.43% vs. 38.46%, p = 0.05). After replacing LAMSs with transmural double-pigtail plastic stents (DPSs) in the DPDS patients, the DPS migration rate was higher in the patients with recurrence (100% vs. 33.33%, p = 0.04). In conclusion, drainage of symptomatic PFCs with EUS-guided electrocautery-enhanced LAMS appears to be efficient and safe. Replacing LAMSs with DPSs in DPDS patients was associated with a lower recurrence rate.
MeSH term(s)	Humans ; Acute Disease ; Drainage ; Electrocoagulation/adverse effects ; Pancreatic Diseases/surgery ; Pancreatitis ; Retrospective Studies
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53785-8
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Article: Hydrothermally Synthesized Mg-Based Spinel Nanoferrites: Phase Formation and Study on Magnetic Features and Microwave Characteristics.

Tsay, Chien-Yie / Chiu, Yi-Chun / Lei, Chien-Ming

Materials (Basel, Switzerland)

2018 Volume 11, Issue 11

Abstract: Three kinds of magnesium-based spinel nanoferrites with the chemical formulas of MgFe₂O₄ (Mg ferrite), ... ...

Abstract	Three kinds of magnesium-based spinel nanoferrites with the chemical formulas of MgFe₂O₄ (Mg ferrite), Mg
Language	English
Publishing date	2018-11-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma11112274
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