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Book: Cumplimiento terapéutico

Chivato, Tomás

¿cómo mejorarlo? : aplicación práctica al caso del paciente con rinitis alérgica

2012

Author's details	autores, Tomás Chivato [and 3 others]
MeSH term(s)	Patient Compliance
Language	Spanish
Size	64 pages :, illustrations
Document type	Book
ISBN	9788415351009 ; 8415351003
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Efficacy of botulinum toxin type A in the management of masticatory myofascial pain: A retrospective clinical study.

de-la-Hoz, Jose L / de-Pedro, Miguel / Martín-Fontelles, Isabel / Mesa-Jimenez, Juan / Chivato, Tomás / Bagües, Ana

Journal of the American Dental Association (1939)

2021 Volume 153, Issue 7, Page(s) 683–691

Abstract: Background: Muscular pain is the main cause of disability worldwide. Myofascial pain of orofacial origin is a frequent condition, the treatment of which is not always accomplished with traditional treatment. Botulinum toxin type A (BTA) is being studied ...

Abstract	Background: Muscular pain is the main cause of disability worldwide. Myofascial pain of orofacial origin is a frequent condition, the treatment of which is not always accomplished with traditional treatment. Botulinum toxin type A (BTA) is being studied for the treatment of this type of pain with contradicting results. Thus, the objective of this study was to assess the efficacy of BTA in the therapeutic management of masticatory myofascial pain (MFP). Case description: A retrospective study of 100 patients with a diagnosis of MFP was conducted. The control group (50 patients) received conventional treatment (prescription of a muscle relaxant and craniocervical physical therapy). The BTA group (50 patients) received this same treatment and the infiltration of 100 units of BTA in the masticatory musculature. Subjective and objective pain ratings and range of mandibular movements were recorded before and after the treatment. No differences were found between groups in the baseline values. Statistically significant improvements were found in both groups compared with baseline values in all studied parameters. Moreover, BTA improved the subjective pain ratings compared with the control group. The administration of BTA added to the conventional treatment does not seem to improve objective pain ratings and functional measurements, but it improves the subjective pain ratings. Practical implications: The addition of BTA could be beneficial in the treatment of MFP in addition to conventional treatment, but further studies are needed to elucidate the mechanisms underlying this positive effect.
MeSH term(s)	Botulinum Toxins, Type A ; Humans ; Myofascial Pain Syndromes/drug therapy ; Neuromuscular Agents ; Pain ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Neuromuscular Agents ; Botulinum Toxins, Type A (EC 3.4.24.69)
Language	English
Publishing date	2021-11-08
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	220622-5
ISSN	1943-4723 ; 0002-8177 ; 1048-6364
ISSN (online)	1943-4723
ISSN	0002-8177 ; 1048-6364
DOI	10.1016/j.adaj.2021.07.020
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Article ; Online: Transcriptomics reveals a distinct metabolic profile in T cells from severe allergic asthmatic patients.

Pablo-Torres, Carmela / Garcia-Escribano, Carlota / Romeo, Martina / Gomez-Casado, Cristina / Arroyo Solera, Ricardo / Bueno-Cabrera, José Luis / Del Mar Reaño Martos, M / Iglesias-Cadarso, Alfredo / Tarín, Carlos / Agache, Ioana / Chivato, Tomás / Barber, Domingo / Escribese, María M / Izquierdo, Elena

Frontiers in allergy

2023 Volume 4, Page(s) 1129248

Abstract: The reasons behind the onset and continuation of chronic inflammation in individuals with severe allergies are still not understood. Earlier findings indicated that there is a connection between severe allergic inflammation, systemic metabolic ... ...

Abstract	The reasons behind the onset and continuation of chronic inflammation in individuals with severe allergies are still not understood. Earlier findings indicated that there is a connection between severe allergic inflammation, systemic metabolic alterations and impairment of regulatory functions. Here, we aimed to identify transcriptomic alterations in T cells associated with the degree of severity in allergic asthmatic patients. T cells were isolated from severe (
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-6101
ISSN (online)	2673-6101
DOI	10.3389/falgy.2023.1129248
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Article ; Online: Does intravenous saline infusion compromise the stability of [123I] meta-iodobenzylguanidine?

Martínez, Teresa / Chivato, Tomás / Roldán, Marta / Miñana, Elena

Nuclear medicine communications

2014 Volume 35, Issue 6, Page(s) 683–685

Abstract: To avoid adverse effects during the administration of [(123)I] meta-iodobenzylguanidine (MIBG), infusion of the drug that has been previously diluted is proposed. Stability of [(123)I] MIBG in sodium chloride solutions is studied, looking for ... ...

Abstract	To avoid adverse effects during the administration of [(123)I] meta-iodobenzylguanidine (MIBG), infusion of the drug that has been previously diluted is proposed. Stability of [(123)I] MIBG in sodium chloride solutions is studied, looking for incompatibilities in the formulation. Stability was tested on the basis of the percentage of free [(123)I] iodide on solid-phase extraction. No increase in percentages of free [(123)I] iodide was found in diluted and undiluted samples over time (P>0.05). Intravenous saline infusion of [(123)I] MIBG could be a useful tool for controlling the administration rate, minimizing the side effects and lowering the exposure of the staff to ionizing radiation.
MeSH term(s)	3-Iodobenzylguanidine/chemistry ; Drug Stability ; Infusions, Intravenous ; Radiochemistry ; Sodium Chloride/administration & dosage ; Sodium Chloride/chemistry
Chemical Substances	3-Iodobenzylguanidine (35MRW7B4AD) ; Sodium Chloride (451W47IQ8X)
Language	English
Publishing date	2014-06
Publishing country	England
Document type	Journal Article
ZDB-ID	758141-5
ISSN	1473-5628 ; 0143-3636
ISSN (online)	1473-5628
ISSN	0143-3636
DOI	10.1097/MNM.0000000000000103
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Article: Understanding Systemic and Local Inflammation Induced by Nasal Polyposis: Role of the Allergic Phenotype.

Delgado-Dolset, María Isabel / Obeso, David / Sánchez-Solares, Javier / Mera-Berriatua, Leticia / Fernández, Paloma / Barbas, Coral / Fresnillo, Miguel / Chivato, Tomás / Barber, Domingo / Escribese, María M / Villaseñor, Alma

Frontiers in molecular biosciences

2021 Volume 8, Page(s) 662792

Abstract: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent symptoms associated to the development of nasal polyps. To this day, the molecular mechanisms involved are still not well defined. However, it has been suggested that a ... ...

Abstract	Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent symptoms associated to the development of nasal polyps. To this day, the molecular mechanisms involved are still not well defined. However, it has been suggested that a sustained inflammation as allergy is involved in its onset. In this exploratory study, the aim was to investigate the effect of the allergic status in the development of CRSwNP. To achieve this, we recruited 22 patients with CRSwNP and classified them in non-allergic and allergic using ImmunoCAP ISAC molecular diagnosis. Plasma samples were analyzed using liquid chromatography coupled to mass spectrometry (LC-MS). Subsequently, significant metabolites from plasma that were commercially available were then analyzed by targeted analysis in some nasal polyps. Additionally, nasal polyp and nasal mucosa samples were examined for eosinophils, neutrophils, CD3
Language	English
Publishing date	2021-05-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2021.662792
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Article ; Online: Omics technologies in allergy and asthma research: An EAACI position paper.

Radzikowska, Urszula / Baerenfaller, Katja / Cornejo-Garcia, José Antonio / Karaaslan, Cagatay / Barletta, Elena / Sarac, Basak Ezgi / Zhakparov, Damir / Villaseñor, Alma / Eguiluz-Gracia, Ibon / Mayorga, Cristobalina / Sokolowska, Milena / Barbas, Coral / Barber, Domingo / Ollert, Markus / Chivato, Tomas / Agache, Ioana / Escribese, Maria M

Allergy

2022 Volume 77, Issue 10, Page(s) 2888–2908

Abstract: Allergic diseases and asthma are heterogenous chronic inflammatory conditions with several distinct complex endotypes. Both environmental and genetic factors can influence the development and progression of allergy. Complex pathogenetic pathways observed ...

Abstract	Allergic diseases and asthma are heterogenous chronic inflammatory conditions with several distinct complex endotypes. Both environmental and genetic factors can influence the development and progression of allergy. Complex pathogenetic pathways observed in allergic disorders present a challenge in patient management and successful targeted treatment strategies. The increasing availability of high-throughput omics technologies, such as genomics, epigenomics, transcriptomics, proteomics, and metabolomics allows studying biochemical systems and pathophysiological processes underlying allergic responses. Additionally, omics techniques present clinical applicability by functional identification and validation of biomarkers. Therefore, finding molecules or patterns characteristic for distinct immune-inflammatory endotypes, can subsequently influence its development, progression, and treatment. There is a great potential to further increase the effectiveness of single omics approaches by integrating them with other omics, and nonomics data. Systems biology aims to simultaneously and longitudinally understand multiple layers of a complex and multifactorial disease, such as allergy, or asthma by integrating several, separated data sets and generating a complete molecular profile of the condition. With the use of sophisticated biostatistics and machine learning techniques, these approaches provide in-depth insight into individual biological systems and will allow efficient and customized healthcare approaches, called precision medicine. In this EAACI Position Paper, the Task Force "Omics technologies in allergic research" broadly reviewed current advances and applicability of omics techniques in allergic diseases and asthma research, with a focus on methodology and data analysis, aiming to provide researchers (basic and clinical) with a desk reference in the field. The potential of omics strategies in understanding disease pathophysiology and key tools to reach unmet needs in allergy precision medicine, such as successful patients' stratification, accurate disease prognosis, and prediction of treatment efficacy and successful prevention measures are highlighted.
MeSH term(s)	Asthma/diagnosis ; Asthma/genetics ; Asthma/therapy ; Biomarkers ; Genomics/methods ; Humans ; Hypersensitivity/diagnosis ; Hypersensitivity/genetics ; Hypersensitivity/therapy ; Metabolomics/methods
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-06-30
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15412
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Article ; Online: Challenges for allergy diagnosis in regions with complex pollen exposures.

Barber, Domingo / Díaz-Perales, Araceli / Villalba, Mayte / Chivato, Tomas

Current allergy and asthma reports

2015 Volume 15, Issue 2, Page(s) 496

Abstract: Over the past few decades, significant scientific progress has influenced clinical allergy practice. The biological standardization of extracts was followed by the massive identification and characterization of new allergens and their progressive use as ... ...

Abstract	Over the past few decades, significant scientific progress has influenced clinical allergy practice. The biological standardization of extracts was followed by the massive identification and characterization of new allergens and their progressive use as diagnostic tools including allergen micro arrays that facilitate the simultaneous testing of more than 100 allergen components. Specific diagnosis is the basis of allergy practice and is always aiming to select the best therapeutic or avoidance intervention. As a consequence, redundant or irrelevant information might be adding unnecessary cost and complexity to daily clinical practice. A rational use of the different diagnostic alternatives would allow a significant improvement in the diagnosis and treatment of allergic patients, especially for those residing in complex pollen exposure areas.
MeSH term(s)	Allergens/immunology ; Humans ; Hypersensitivity/diagnosis ; Hypersensitivity/immunology ; Lipid Metabolism ; Pollen/immunology
Chemical Substances	Allergens
Language	English
Publishing date	2015-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057370-4
ISSN	1534-6315 ; 1529-7322
ISSN (online)	1534-6315
ISSN	1529-7322
DOI	10.1007/s11882-014-0496-7
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Article ; Online: Quantification of the chromosomal radiation damage induced by labelling of leukocytes with [18F]FDG.

Miñana, Elena / Roldán, Marta / Chivato, Tomás / Martínez, Teresa / Fuente, Teodomiro

Nuclear medicine and biology

2015 Volume 42, Issue 9, Page(s) 720–723

Abstract: Introduction: The aim of our work is to quantify the radiation damage in lymphocytes after labelling with [18F]FDG. Comparison with gold standard [99mTc]HMPAO labelling is established. An approach to cellular dosimetry is proposed.: Methods: Mixed ... ...

Abstract	Introduction: The aim of our work is to quantify the radiation damage in lymphocytes after labelling with [18F]FDG. Comparison with gold standard [99mTc]HMPAO labelling is established. An approach to cellular dosimetry is proposed. Methods: Mixed leukocytes were separated from fresh venous blood and labelled with [18F]FDG and [99mTc]HMPAO following published guidelines. Cytokinesis-block micronucleus (CBMN) assay was performed for both sets of experiments. Tests for quality control of labelling described in guidelines were followed. Cellular dosimetry was calculated according to MIRD. Results: MN scored after labelling with 37 MBq of [18F]FDG were 956 ± 172 and 347 ± 26 for [99mTc]HMPAO (p < 0.05). Absorbed dose in cell nucleus was of 0.23 Gy for [18F]FDG and 0.08 Gy for [99mTc]HMPAO labelling. The CBMN assay after labelling with ~290 MBq of [18F]FDG showed radiation induced inhibition of proliferation capacity of the lymphocytes, confirmed by proliferation study. Conclusions: [18F]FDG labelling of mixed leukocytes causes severe radiation damage to the cell, higher than with [99mTc]HMPAO in accordance with the absorbed dose. Labelling of mixed leukocytes for clinical purpose induces high cytotoxicity reflected in the loss of proliferation capacity in lymphocytes this statement allows us to consider a low oncogenic risk however the association between MN formation in the PBL and subsequent risk of cancer is not well established. Advances in knowledge: This is the first work about radiation damage with [18F]FDG labelled cells. We focused on [18F]FDG labelling of leukocytes due to the growing number of research and review articles about this technique. Implications for patient care: The possibility of an increased risk of lymphoid malignancies associated with the administration of radiolabelled lymphocytes is a very controversial subject. Studies on radiation damage on new labelling procedures as the one exposed in this work must be considered.
MeSH term(s)	Adult ; Aged ; Biological Assay/methods ; Cells, Cultured ; Chromosome Aberrations/radiation effects ; Dose-Response Relationship, Radiation ; Female ; Fluorodeoxyglucose F18 ; Humans ; Isotope Labeling/methods ; Leukocytes/diagnostic imaging ; Leukocytes/physiology ; Leukocytes/radiation effects ; Male ; Micronucleus Tests/methods ; Middle Aged ; Positron-Emission Tomography/methods ; Radiation Dosage ; Radiometry/methods ; Radiopharmaceuticals
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2015-05-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1138098-6
ISSN	1872-9614 ; 0883-2897 ; 0969-8051
ISSN (online)	1872-9614
ISSN	0883-2897 ; 0969-8051
DOI	10.1016/j.nucmedbio.2015.05.002
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Article: Alternative Anaphylactic Routes: The Potential Role of Macrophages.

Escribese, María M / Rosace, Domenico / Chivato, Tomas / Fernández, Tahia D / Corbí, Angel L / Barber, Domingo

Frontiers in immunology

2017 Volume 8, Page(s) 515

Abstract: Anaphylaxis is an acute, life-threatening, multisystem syndrome resulting from the sudden release of mediators from effector cells. There are two potential pathways for anaphylaxis. The first one, IgE-dependent anaphylaxis, is induced by antigen (Ag) ... ...

Abstract	Anaphylaxis is an acute, life-threatening, multisystem syndrome resulting from the sudden release of mediators from effector cells. There are two potential pathways for anaphylaxis. The first one, IgE-dependent anaphylaxis, is induced by antigen (Ag) cross-linking of Ag-specific IgE bound to the high-affinity IgE receptor (FcεRI) on mast cells and basophils. The second one, IgG-dependent anaphylaxis is induced by Ag cross-linking of Ag-specific IgG bound to IgG receptors (FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, and FcγRIIIA) on macrophages, neutrophils, and basophils. Macrophages exhibit a huge functional plasticity and are capable of exerting their scavenging, bactericidal, and regulatory functions under a wide variety of tissue conditions. Herein, we will review their potential role in the triggering and development of anaphylaxis. Thereby, macrophages, among other immune cells, play a role in both anaphylactic pathways (1) by responding to anaphylactic mediators secreted by mast cells after specific IgE cross-linking or (2) by acting as effector cells in the anaphylactic response mediated by IgG. In this review, we will go over the cellular and molecular mechanisms that take place in the above-mentioned anaphylactic pathways and will discuss the clinical implications in human allergic reactions.
Language	English
Publishing date	2017
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2017.00515
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Article ; Online: Mentoring as the cornerstone of continued education in Allergy and Clinical Immunology: 10th anniversary of the EAACI mentorship program.

Giovannini, Mattia / Beken, Burcin / Agache, Ioana / Akdis, Cezmi A / Carvalho, Daniela / Chivato, Tomas / Comberiati, Pasquale / De Las Vecillas, Leticia / Eguiluz-Gracia, Ibon / Heffler, Enrico / Jutel, Marek / Eyice Karabacak, Deniz / Kolkhir, Pavel / Moya, Beatriz / Ollert, Markus / O'Neil, Serena / Santos, Alexandra F / Schwarze, Jurgen / Skevaki, Chrysanthi /

Sokolowska, Milena / Tsilochristou, Olympia / van Wijk, Roy Gerth / Del Giacco, Stefano / Riggioni, Carmen

Allergy

2023 Volume 79, Issue 1, Page(s) 7–11

MeSH term(s)	Humans ; Mentoring ; Mentors ; Anniversaries and Special Events ; Hypersensitivity/therapy
Language	English
Publishing date	2023-09-18
Publishing country	Denmark
Document type	Editorial
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15878
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