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Article ; Online: Advances of HER2 testing for women with breast cancer.

Chivukula, Mamatha

Translational breast cancer research : a journal focusing on translational research in breast cancer

2023 Volume 4, Page(s) 9

Language	English
Publishing date	2023-01-31
Publishing country	China
Document type	Editorial
ISSN	2218-6778
ISSN (online)	2218-6778
DOI	10.21037/tbcr-23-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Serous fluid: Metastatic sarcomas, melanoma, and other non-epithelial neoplasms.

Pantanowitz, Liron / Chivukula, Mamatha

CytoJournal

2022 Volume 19, Page(s) 15

Abstract: While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. ... ...

Abstract	While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. Diagnosing non-epithelial malignancies in effusion specimens based entirely upon their cytomorphologic features is difficult because these neoplasms often exhibit considerable morphological overlap and their cytomorphology can differ from the original tumor. As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. The use of ancillary studies including immunostaining, FISH, and molecular studies is thus often critical to reach a definitive diagnosis. This review article will be incorporated finally as one of the chapters in CMAS (CytoJournal Monograph/Atlas Series) #2. It is modified slightly from the chapter by the initial authors in the first edition of Diagnostic Cytopathology of Serous Fluids.
Language	English
Publishing date	2022-03-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2158838-7
ISSN	1742-6413 ; 0974-5963
ISSN (online)	1742-6413
ISSN	0974-5963
DOI	10.25259/CMAS_02_10_2021
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Article: Pleomorphic lobular carcinoma in situ: A divergent entity with emerging significance.

Chivukula, Mamatha

Oncology (Williston Park, N.Y.)

2011 Volume 25, Issue 4, Page(s) 358, 360, 362

MeSH term(s)	Breast Neoplasms/pathology ; Carcinoma in Situ/pathology ; Carcinoma, Lobular/pathology ; Female ; Humans
Language	English
Publishing date	2011-04-15
Publishing country	United States
Document type	Comment ; Journal Article ; Review
ZDB-ID	1067950-9
ISSN	0890-9091
ISSN	0890-9091
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Zs.A 3168: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: HER2 testing across practices-Have we come to a consensus on the ideal method of testing? A systematic literature review.

Nassar, Aziza / Pooja, Advani / Chivukula, Mamatha

The breast journal

2020 Volume 26, Issue 6, Page(s) 1185–1188

Abstract: Human epidermal growth factor (HER2) is an oncogene that codes for HER2 protein. The gene is amplified, and protein is overexpressed in 20% of patients and carries a poor prognosis. HER2-positive tumors tend to be more aggressive and highly proliferative. ...

Abstract	Human epidermal growth factor (HER2) is an oncogene that codes for HER2 protein. The gene is amplified, and protein is overexpressed in 20% of patients and carries a poor prognosis. HER2-positive tumors tend to be more aggressive and highly proliferative. In 2006, trastuzumab, a monoclonal antibody targeting HER2, was approved for use with chemotherapy as an adjuvant treatment for women with HER2-positive breast cancer. The drug has shown improved survival rates for women with HER2-positive breast cancer. As promised for survival in HER2-positive patients continues with new research, and as novel drug approvals emerge, HER2 assessment plays a significant role in adjuvant and in metastatic setting. HER2 assays approved by the US Food and Drug administration include immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and bright field dual in situ hybridization (DISH). Accuracy of HER2 testing across laboratories has an impact on treatment as false-negative testing can deprive the patients of trastuzumab therapy. The current review will focus on the variability of HER2 testing across laboratories and the potential impact on treatment.
MeSH term(s)	Antibodies, Monoclonal, Humanized ; Biomarkers, Tumor ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Consensus ; Female ; Humans ; In Situ Hybridization, Fluorescence ; Receptor, ErbB-2/genetics ; Trastuzumab/therapeutic use
Chemical Substances	Antibodies, Monoclonal, Humanized ; Biomarkers, Tumor ; Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2020-05-12
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	1289960-4
ISSN	1524-4741 ; 1075-122X
ISSN (online)	1524-4741
ISSN	1075-122X
DOI	10.1111/tbj.13867
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Zs.A 4483: Show issues

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Article: Novel HER2 dual in situ hybridization (DISH): technique and implementation in routine laboratory testing..

Chivukula, Mamatha / Bulusu, Gautam

MLO: medical laboratory observer

2015 Volume 47, Issue 4, Page(s) 22–23

MeSH term(s)	Diagnostic Tests, Routine ; Genes, erbB-2/genetics ; Humans ; In Situ Hybridization
Language	English
Publishing date	2015-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	603205-9
ISSN	0580-7247
ISSN	0580-7247
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Zs.B 2587: Show issues

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Article ; Online: Ductal carcinoma in situ: one size does not fit all.

Chivukula, Mamatha / Ahrendt, Gretchen

Women's health (London, England)

2010 Volume 6, Issue 5, Page(s) 669–672

Language	English
Publishing date	2010-09
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	2274503-8
ISSN	1745-5065 ; 1745-5057
ISSN (online)	1745-5065
ISSN	1745-5057
DOI	10.2217/whe.10.59
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Zs.A 6629: Show issues

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Article ; Online: ASC-H in Pap test- definitive categorization of cytomorphological spectrum

Chivukula Mamatha / Shidham Vinod B

CytoJournal, Vol 3, Iss 1, p

2006 Volume 14

Abstract: Abstract Objective The American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines for management of ASC-H is colposcopic examination followed by biopsy. HPV testing (HPVT) is recommended after a negative biopsy result. More definitive ... ...

Abstract	Abstract Objective The American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines for management of ASC-H is colposcopic examination followed by biopsy. HPV testing (HPVT) is recommended after a negative biopsy result. More definitive interpretation of ASC-H could prevent discomfort and minimize the cost. The purpose of this study was to evaluate association of various cytomorphological patterns of ASC-H with various clinical scenarios. Methods We reviewed SurePath™ (TriPath Imaging, Inc. Burlington, NC, USA) cervical smears interpreted as ASC-H in 161 women (mean age, 37 {15 to 78} years), over 24 months (2002 to 2003). HPVT (Digene, Hybrid Capture ® II HPV test, Digene Corporation, Gaithersburg, MD, USA) was performed in 20% of cases (33/161) and biopsy results were available in 54 cases (19 with and 35 without HPVT). Results HPVT was positive in 64% (21/33) cases, and negative in 36% (12/33) cases. In the follow-up biopsies of 71% (15/21) of cases with positive HPVT, 27% showed HPV changes or CIN1, 27% showed CIN2-3, and 46% were negative for epithelial abnormality. Follow-up biopsies from cases with negative HPVT (33%, 4/12 cases), 8% showed CIN1 and 25% were negative for any epithelial abnormality. Six cytomorphological patterns of ASC-H correlated with different clinical categories in relation to HPVT and biopsy results. 35% (19 out of 54 ASC-H cases in which biopsy results were available) could be interpreted definitively as HSIL by cytopathology, 11% (6/54) cases as LSIL with cyanophilic atypical parakeratotic pattern, and 31% (17/54) cases as reactive, with HPV status. The interpretation had to be continued as ASC-H in 22% (12/54) cases. Conclusion ASC-H demonstrated a spectrum of cytomorphological patterns. Some of these patterns in liquid-based cervical smears may be more specifically interpreted as LSIL, HSIL, or benign if HPV status is known.
Keywords	Cytology ; QH573-671 ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Cytology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
Subject code	610
Language	English
Publishing date	2006-05-01T00:00:00Z
Publisher	Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: ASC-H in Pap test- definitive categorization of cytomorphological spectrum

Shidham Vinod / Chivukula Mamatha

CytoJournal, Vol 3, Iss 1, p

2006 Volume 14

Abstract	Abstract Objective The American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines for management of ASC-H is colposcopic examination followed by biopsy. HPV testing (HPVT) is recommended after a negative biopsy result. More definitive interpretation of ASC-H could prevent discomfort and minimize the cost. The purpose of this study was to evaluate association of various cytomorphological patterns of ASC-H with various clinical scenarios. Methods We reviewed SurePath™ (TriPath Imaging, Inc. Burlington, NC, USA) cervical smears interpreted as ASC-H in 161 women (mean age, 37 {15 to 78} years), over 24 months (2002 to 2003). HPVT (Digene, Hybrid Capture ® II HPV test, Digene Corporation, Gaithersburg, MD, USA) was performed in 20% of cases (33/161) and biopsy results were available in 54 cases (19 with and 35 without HPVT). Results HPVT was positive in 64% (21/33) cases, and negative in 36% (12/33) cases. In the follow-up biopsies of 71% (15/21) of cases with positive HPVT, 27% showed HPV changes or CIN1, 27% showed CIN2-3, and 46% were negative for epithelial abnormality. Follow-up biopsies from cases with negative HPVT (33%, 4/12 cases), 8% showed CIN1 and 25% were negative for any epithelial abnormality. Six cytomorphological patterns of ASC-H correlated with different clinical categories in relation to HPVT and biopsy results. 35% (19 out of 54 ASC-H cases in which biopsy results were available) could be interpreted definitively as HSIL by cytopathology, 11% (6/54) cases as LSIL with cyanophilic atypical parakeratotic pattern, and 31% (17/54) cases as reactive, with HPV status. The interpretation had to be continued as ASC-H in 22% (12/54) cases. Conclusion ASC-H demonstrated a spectrum of cytomorphological patterns. Some of these patterns in liquid-based cervical smears may be more specifically interpreted as LSIL, HSIL, or benign if HPV status is known.
Keywords	Cytology ; QH573-671 ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Cytology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
Subject code	501
Language	English
Publishing date	2006-01-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Is PAX2 a reliable marker in differentiating diffuse malignant mesotheliomas of peritoneum from serous carcinomas of müllerian origin?

Gao, Faye F / Krasinskas, Alyssa M / Chivukula, Mamatha

Applied immunohistochemistry & molecular morphology : AIMM

2012 Volume 20, Issue 3, Page(s) 272–276

Abstract: Diffuse peritoneal malignant mesotheliomas (DPMM) are often disseminated in the peritoneal cavity as multiple nodules including localized masses in the ovaries that are clinically and histologically similar to serous adenocarcinomas of müllerian origin. ... ...

Abstract	Diffuse peritoneal malignant mesotheliomas (DPMM) are often disseminated in the peritoneal cavity as multiple nodules including localized masses in the ovaries that are clinically and histologically similar to serous adenocarcinomas of müllerian origin. It is imperative to differentiate these tumors given their diverse responses to chemotherapy and/or radiotherapy. PAX2 gene was recently demonstrated in benign epithelial cells of the female genital tract and in serous carcinomas (SC) of müllerian origin. The aim of our study was to determine if PAX2 can reliably be used in differentiating DPMM from SC. A total of 59 cases to include 25 cases of DPMM and 34 cases of SC were retrieved. All cases were stained with PAX2, Wilm tumor gene 1, calretinin and the results were compared. Our results demonstrate that PAX2 can be used reliably as a Müllerian marker in formulating an efficient panel to differentiate DPMM and SC.
MeSH term(s)	Biomarkers, Tumor/genetics ; Calbindin 2 ; Cystadenocarcinoma, Serous/diagnosis ; Cystadenocarcinoma, Serous/genetics ; Cystadenocarcinoma, Serous/pathology ; Diagnosis, Differential ; Female ; Gene Expression ; Humans ; Immunohistochemistry ; Mesothelioma/diagnosis ; Mesothelioma/genetics ; Mesothelioma/pathology ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Ovary/metabolism ; Ovary/pathology ; PAX2 Transcription Factor/genetics ; Peritoneal Neoplasms/diagnosis ; Peritoneal Neoplasms/genetics ; Peritoneal Neoplasms/pathology ; Peritoneum/metabolism ; Peritoneum/pathology ; S100 Calcium Binding Protein G/genetics ; WT1 Proteins/genetics
Chemical Substances	Biomarkers, Tumor ; CALB2 protein, human ; Calbindin 2 ; PAX2 Transcription Factor ; PAX2 protein, human ; S100 Calcium Binding Protein G ; WT1 Proteins
Language	English
Publishing date	2012-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1473273-7
ISSN	1533-4058 ; 1062-3345 ; 1541-2016
ISSN (online)	1533-4058
ISSN	1062-3345 ; 1541-2016
DOI	10.1097/PAI.0b013e3182366531
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Article ; Online: ASC-H in Pap test--definitive categorization of cytomorphological spectrum.

Chivukula, Mamatha / Shidham, Vinod B

CytoJournal

2006 Volume 3, Page(s) 14

Abstract: Objective: The American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines for management of ASC-H is colposcopic examination followed by biopsy. HPV testing (HPVT) is recommended after a negative biopsy result. More definitive ... ...

Abstract	Objective: The American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines for management of ASC-H is colposcopic examination followed by biopsy. HPV testing (HPVT) is recommended after a negative biopsy result. More definitive interpretation of ASC-H could prevent discomfort and minimize the cost. The purpose of this study was to evaluate association of various cytomorphological patterns of ASC-H with various clinical scenarios. Methods: We reviewed SurePath (TriPath Imaging, Inc. Burlington, NC, USA) cervical smears interpreted as ASC-H in 161 women (mean age, 37 {15 to 78} years), over 24 months (2002 to 2003). HPVT (Digene, Hybrid Capture II HPV test, Digene Corporation, Gaithersburg, MD, USA) was performed in 20% of cases (33/161) and biopsy results were available in 54 cases (19 with and 35 without HPVT). Results: HPVT was positive in 64% (21/33) cases, and negative in 36% (12/33) cases. In the follow-up biopsies of 71% (15/21) of cases with positive HPVT, 27% showed HPV changes or CIN1, 27% showed CIN2-3, and 46% were negative for epithelial abnormality. Follow-up biopsies from cases with negative HPVT (33%, 4/12 cases), 8% showed CIN1 and 25% were negative for any epithelial abnormality. Six cytomorphological patterns of ASC-H correlated with different clinical categories in relation to HPVT and biopsy results. 35% (19 out of 54 ASC-H cases in which biopsy results were available) could be interpreted definitively as HSIL by cytopathology, 11% (6/54) cases as LSIL with cyanophilic atypical parakeratotic pattern, and 31% (17/54) cases as reactive, with HPV status. The interpretation had to be continued as ASC-H in 22% (12/54) cases. Conclusion: ASC-H demonstrated a spectrum of cytomorphological patterns. Some of these patterns in liquid-based cervical smears may be more specifically interpreted as LSIL, HSIL, or benign if HPV status is known.
Language	English
Publishing date	2006-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2158838-7
ISSN	1742-6413 ; 1742-6413
ISSN (online)	1742-6413
ISSN	1742-6413
DOI	10.1186/1742-6413-3-14
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