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Article ; Online: Huge post-traumatic diaphragmatic hernia remained asymptomatic for 14 years. A case report.

Chlapoutakis, Serafeim / Vassileiadis, Vassileios

Indian journal of thoracic and cardiovascular surgery : official organ, Association of Thoracic and Cardiovascular Surgeons of India

2018 Volume 34, Issue 4, Page(s) 502–505

Abstract: A 27-year-old male had an abdominal violation in a prison 14 years before the display of his symptoms and was misdiagnosed as massive haemothorax. The patient remained asymptomatic for 14 years and his symptoms were only a mild dyspnoea and mild ... ...

Abstract	A 27-year-old male had an abdominal violation in a prison 14 years before the display of his symptoms and was misdiagnosed as massive haemothorax. The patient remained asymptomatic for 14 years and his symptoms were only a mild dyspnoea and mild dysphagia. This patient had a huge chronic postdiaphragmatic hernia with most of the abdominal organs in the left hemithorax. A left thoracotomy was performed and a mesh was used to close the huge posttraumatic diaphragmatic hernia (diameter of 15 cm), after repositioning the abdominal organs. The left lung was completely consolidated and required dissection of multiple adhesions and high pressure manual ventilation to reexpand normally. Blunt post-traumatic diaphragmatic ruptures may be misdiagnosed and become chronic asymptomatic hernias for several years. Once they become symptomatic, they have to be treated as soon as possible as major organ injuries may be hidden.
Language	English
Publishing date	2018-03-23
Publishing country	India
Document type	Case Reports
ZDB-ID	2164386-6
ISSN	0973-7723 ; 0970-9134
ISSN (online)	0973-7723
ISSN	0970-9134
DOI	10.1007/s12055-018-0658-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: External flail chest stabilization; The simple, low-cost way.

Apostolakis, Efstratios / Papakonstantinou, Nikolaos A / Liakopoulou, Alexandra / Chlapoutakis, Serafeim

Journal of cardiovascular and thoracic research

2020 Volume 13, Issue 2, Page(s) 174–175

Abstract: Flail chest is a life-threatening clinical entity which can be complicated by respiratory insufficiency. Paradoxical motion of a part of chest wall is the basic cause to put the blame on. Consequently, stabilization of the chest wall is occasionally of ... ...

Abstract	Flail chest is a life-threatening clinical entity which can be complicated by respiratory insufficiency. Paradoxical motion of a part of chest wall is the basic cause to put the blame on. Consequently, stabilization of the chest wall is occasionally of paramount importance to achieve early extubation in a patient with post-trauma respiratory insufficiency. Hereby, a simple, low cost, harmless and effective approach of external stabilization is presented.
Language	English
Publishing date	2020-11-28
Publishing country	Iran
Document type	Case Reports
ZDB-ID	2654729-6
ISSN	2008-6830 ; 2008-5117
ISSN (online)	2008-6830
ISSN	2008-5117
DOI	10.34172/jcvtr.2020.58
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Article: Recurrent Exacerbations of Chronic Obstructive Pulmonary Disease Reveal Swyer-James-MacLeod Syndrome in a 63-year-old Patient.

Chlapoutakis, Serafeim / Garmpi, Anna / Trakas, Nikolaos / Damaskos, Christos / Georgakopoulou, Vasiliki E

Cureus

2021 Volume 13, Issue 1, Page(s) e12601

Abstract: Swyer-James-Macleod syndrome is an infrequent clinical condition characterized by unilateral hyperlucent lung as a complication following infectious bronchiolitis obliterans, typically diagnosed during childhood. However, in some patients, the diagnosis ... ...

Abstract	Swyer-James-Macleod syndrome is an infrequent clinical condition characterized by unilateral hyperlucent lung as a complication following infectious bronchiolitis obliterans, typically diagnosed during childhood. However, in some patients, the diagnosis may be confirmed in adulthood. The syndrome can be misdiagnosed with other lung disorders such as asthma, pulmonary embolism, and pneumothorax, leading to inappropriate management and worse outcome. We present a case of Swyer-James-MacLeod syndrome, diagnosed in a 63-year-old man, with frequent hospitalisations due to chronic obstructive pulmonary disease (COPD) exacerbations without a history of significant lung infection in childhood. Complications of Swyer-James-MacLeod syndrome include recurrent infections, lung abscess, pneumothorax, and pulmonary hypertension. The syndrome should always be considered in adults with recurrent respiratory infections or pulmonary hyperlucency on chest imaging to prevent a delay in correct diagnosis and improper treatment.
Language	English
Publishing date	2021-01-10
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.12601
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Article: Atypical Fibroxanthoma: An unexpected cause of hemoptysis.

Mantzouranis, Konstantinos / Georgakopoulou, Vasiliki Epameinondas / Chlapoutakis, Serafeim / Melemeni, Despoina / Damaskos, Christos / Garmpis, Nikolaos / Sklapani, Pagona / Trakas, Nikolaos / Tsiafaki, Xanthi

Acta medica Lituanica

2021 Volume 28, Issue 1, Page(s) 165–169

Abstract: Atypical fibroxanthoma is an infrequent, low-grade superficial cutaneous neoplasm, usually presenting as a nodule or plaque of red color. It is considered as a superficial variant of pleomorphic dermal sarcoma. Although atypical fibroxanthoma has similar ...

Abstract	Atypical fibroxanthoma is an infrequent, low-grade superficial cutaneous neoplasm, usually presenting as a nodule or plaque of red color. It is considered as a superficial variant of pleomorphic dermal sarcoma. Although atypical fibroxanthoma has similar histologic features to pleomorphic dermal sarcoma, it has less aggressive behavior. Atypical fibroxanthoma usually occurs on sun-exposed regions of the head and neck of elderly patients. Ultraviolet light, specific genetic mutations and administration of immunosuppressive agents to transplant recipients have been associated with the pathogenesis of the tumor. The prognosis is typically excellent when treated with complete excision of the primary lesion. This report describes the rare case of a 84-year-old man with hemoptysis due to metastatic cutaneous atypical fibroxanthoma.
Language	English
Publishing date	2021-04-29
Publishing country	Lithuania
Document type	Case Reports
ZDB-ID	1291937-8
ISSN	2029-4174 ; 1392-0138
ISSN (online)	2029-4174
ISSN	1392-0138
DOI	10.15388/Amed.2021.28.1.16
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Article ; Online: Role of pulmonary function testing in inflammatory bowel diseases (Review).

Georgakopoulou, Vasiliki Epameinondas / Tarantinos, Kyriakos / Papalexis, Petros / Spandidos, Demetrios A / Damaskos, Christos / Gkoufa, Aikaterini / Chlapoutakis, Serafeim / Sklapani, Pagona / Trakas, Nikolaos / Mermigkis, Dimitrios

Medicine international

2022 Volume 2, Issue 4, Page(s) 25

Abstract: Inflammatory bowel disease (IBD) is a term used to describe chronic inflammatory entities of the gastrointestinal system with an unclear etiology. Extra-intestinal manifestations beyond the involvement of the gastrointestinal tract can also occur. ... ...

Abstract	Inflammatory bowel disease (IBD) is a term used to describe chronic inflammatory entities of the gastrointestinal system with an unclear etiology. Extra-intestinal manifestations beyond the involvement of the gastrointestinal tract can also occur. Several studies have investigated the alterations of pulmonary function tests (PFTs) in patients with IBD. To the best of our knowledge, the present review article is the first to summarize all the types of PFTs that have been performed in patients with IBD. Contradictory data exist regarding the association of PFT alterations with disease activity. PFT abnormalities can develop in individuals with IBD who have no clear clinical signs or radiological evidence, suggesting that PFTs may be useful in detecting latent respiratory involvement. The most prevalent finding in the PFTs of adults and children with IBD is an impairment in the diffusing capacity for carbon monoxide, although evidence on the other tests, particularly spirometric values, and their connection with disease activity is inconsistent.
Language	English
Publishing date	2022-08-02
Publishing country	England
Document type	Journal Article ; Review
ISSN	2754-1304
ISSN (online)	2754-1304
DOI	10.3892/mi.2022.50
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Article ; Online: Uncommon and atypical meningiomas and imaging variants: A report of 7 cases.

Fotakopoulos, George / Tsolaki, Vasiliki / Aravantinou-Fatorou, Aikaterini / Georgakopoulou, Vasiliki Epameinondas / Spandidos, Demetrios A / Papalexis, Petros / Tarantinos, Kyriakos / Trakas, Nikolaos / Sklapani, Pagona / Mathioudakis, Nikolaos / Chlapoutakis, Serafeim / Lavdas, Eleftherios

Medicine international

2022 Volume 2, Issue 6, Page(s) 35

Abstract: Meningiomas constitute the most common extra-axial tumor of the central nervous system and can have a wide-ranging manifestation of imaging. There are several types of unusual depictions depicted with the magnetic resonance imaging (MRI) of meningiomas ... ...

Abstract	Meningiomas constitute the most common extra-axial tumor of the central nervous system and can have a wide-ranging manifestation of imaging. There are several types of unusual depictions depicted with the magnetic resonance imaging (MRI) of meningiomas that have been established thus far. It is thus crucial for the reporting radiologist or neurosurgeon to have an in-depth knowledge of their variable manifestations in order to be able to differentiate these neoplasms from the numerous tumors that can mimic their appearance. Meningioma is frequently challenging to diagnose when imaging variants are present. Nevertheless, a number of unusual histological variants have imaging or clinical features which are related to typical meningiomas and, in numerous cases, these require specific surgical management. The present study describes 7 cases of meningiomas, which were either simple atypical, unusual gigantic extracranial intracranial parasagittal, or not visible meningiomas. These uncommon and atypical imaging variants of meningiomas are described herein in an aim to underline their various potential presentations.
Language	English
Publishing date	2022-11-15
Publishing country	England
Document type	Case Reports
ISSN	2754-1304
ISSN (online)	2754-1304
DOI	10.3892/mi.2022.60
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Article ; Online: COVID-19-associated pneumonia in Swyer-James-MacLeod syndrome: A case report.

Bitsani, Aikaterini / Garmpi, Anna / Avramopoulos, Pantelis / Spandidos, Demetrios A / Fotakopoulos, George / Papalexis, Petros / Tarantinos, Kyriakos / Chlapoutakis, Serafeim / Sklapani, Pagona / Trakas, Nikolaos / Georgakopoulou, Vasiliki Epameinondas

Medicine international

2022 Volume 2, Issue 5, Page(s) 28

Abstract: Coronavirus disease 2019 (COVID-19) exerts differential effects on various individuals. The majority of infected individuals experience mild-to-moderate disease and usually recover, without requiring hospitalization. It has been reported that those who ... ...

Abstract	Coronavirus disease 2019 (COVID-19) exerts differential effects on various individuals. The majority of infected individuals experience mild-to-moderate disease and usually recover, without requiring hospitalization. It has been reported that those who have underlying chronic diseases are more susceptible to infection and may thus develop significantly more serious illness. As a result, COVID-19 may aggravate pre-existing respiratory illnesses, such as interstitial lung disease, chronic obstructive pulmonary disease and asthma. Swyer-James-MacLeod syndrome is an uncommon clinical condition marked by post-infectious infantile bronchiolitis obliterans. Traditionally, the diagnosis is made in infancy following an investigation for reoccurring respiratory infections, although in rare cases, the diagnosis is made in adulthood. The present study describes the case of a 45-year-old patient with Swyer-James-MacLeod syndrome hospitalized due to COVID-19, which is the first one to be reported. To the best of our knowledge, there are currently no data available on the effects of COVID-19 in these individuals, stheir optimal therapy, or the impact of COVID-19 vaccination on their clinical course. Thus, it is hoped that the present study sheds some light into this condition.
Language	English
Publishing date	2022-09-06
Publishing country	England
Document type	Case Reports
ISSN	2754-1304
ISSN (online)	2754-1304
DOI	10.3892/mi.2022.53
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Article ; Online: COVID-19-associated acute appendicitis in adults. A report of five cases and a review of the literature.

Georgakopoulou, Vasiliki Epameinondas / Gkoufa, Aikaterini / Damaskos, Christos / Papalexis, Petros / Pierrakou, Aikaterini / Makrodimitri, Sotiria / Sypsa, Georgia / Apostolou, Apostolos / Asimakopoulou, Stavroula / Chlapoutakis, Serafeim / Sklapani, Pagona / Trakas, Nikolaos / Spandidos, Demetrios A

Experimental and therapeutic medicine

2022 Volume 24, Issue 1, Page(s) 482

Abstract: The novel coronavirus has negatively affected patients and healthcare systems globally. Individuals with coronavirus disease 2019 (COVID-19) experience a wide range of respiratory symptoms, from mild flu-like symptoms to severe and potentially fatal ... ...

Abstract	The novel coronavirus has negatively affected patients and healthcare systems globally. Individuals with coronavirus disease 2019 (COVID-19) experience a wide range of respiratory symptoms, from mild flu-like symptoms to severe and potentially fatal pneumonia. Some patients report gastrointestinal symptoms, such as nausea, vomiting and abdominal pain in addition to the respiratory symptoms or as a separate presentation. Even though abdominal pain syndrome indicates acute appendicitis, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection should be considered as a possible diagnosis during this pandemic. However, there have been reports of a few cases of acute abdominal pain revealing acute appendicitis associated with SARS-CoV-2 infection. Appendectomy is challenging in COVID-19-infected patients with acute appendicitis as it includes high surgical risks for the patients, as well as hazards for healthcare professionals who are exposed to SARS-CoV-2. The present study reports five cases of adult patients with COVID-19 with simultaneous acute appendicitis. In addition, the present study aims to provide the framework for the diagnosis and management of adult patients with COVID-19 with acute appendicitis.
Language	English
Publishing date	2022-06-01
Publishing country	Greece
Document type	Case Reports
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2022.11409
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Article ; Online: Characteristics and outcomes of cancer patients who develop pulmonary embolism: A cross-sectional study.

Chlapoutakis, Serafeim / Georgakopoulou, Vasiliki Epameinondas / Trakas, Nikolaos / Kouvelos, Georgios / Papalexis, Petros / Damaskos, Christos / Sklapani, Pagona / Grivas, Anastasios / Gouveris, Panagiotis / Tryfonopoulos, Dimitrios / Tzovaras, Alexandros / Ardavanis-Loukeris, Gerasimos / Grouzi, Elissavet / Spandidos, Demetrios A / Matsagkas, Miltiadis

Oncology letters

2022 Volume 23, Issue 5, Page(s) 168

Abstract: Pulmonary embolism (PE), along with deep vein thrombosis, are collectively known as venous thromboembolism (VTE). Predisposing factors for PE include post-operative conditions, pregnancy, cancer and an advanced age; of note, a number of genetic mutations ...

Abstract	Pulmonary embolism (PE), along with deep vein thrombosis, are collectively known as venous thromboembolism (VTE). Predisposing factors for PE include post-operative conditions, pregnancy, cancer and an advanced age; of note, a number of genetic mutations have been found to be associated with an increased risk of PE. The association between cancer and VTE is well-established, and cancer patients present a higher risk of a thrombotic event compared to the general population. In addition, PE is a significant cause of morbidity and mortality among cancer patients. The aim of the present study was to illustrate the clinical characteristics, laboratory findings, radiology features and outcomes of cancer patients who developed PE, collected from an anticancer hospital. For this purpose, adult cancer patients diagnosed with PE by imaging with computed tomography pulmonary angiography were enrolled. The following data were recorded: Demographics, comorbidities, type of cancer, time interval between cancer diagnosis and PE occurrence, the type of therapy received and the presence of metastases, clinical signs and symptoms, predisposing factors for PE development, laboratory data, radiological findings, electrocardiography findings, and the type of therapy received for PE and outcomes in a follow-up period of 6 months. In total, 60 cancer patients were enrolled. The majority of the cancer patients were males. The most common type of cancer observed was lung cancer. The majority of cases of PE occurred within the first year from the time of cancer diagnosis, while the majority of patients had already developed metastases. In addition, the majority of cancer patients had received chemotherapy over the past month, while they were not receiving anticoagulants and had central obstruction. A large proportion of patients had asymptomatic PE. The in-hospital mortality rate was 13.3% and no relapse or mortality were observed during the follow-up period. The present study demonstrates that elevated levels of lactic acid and an increased platelet count, as well as low serum levels of carcinoembryonic antigen, albumin and D-dimer, may be potential biomarkers for asymptomatic PE among cancer patients.
Language	English
Publishing date	2022-04-04
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2022.13288
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Article ; Online: Simultaneous pathological findings in biopsy specimens of patients with surgically resected lung carcinoids and their role in survival.

Georgakopoulou, Vasiliki Epameinondas / Zygouris, Eleftherios / Papalexis, Petros / Gkoufa, Aikaterini / Damaskos, Christos / Pierrakou, Aikaterini / Mantzouranis, Konstantinos / Chlapoutakis, Serafeim / Aravantinou-Fatorou, Aikaterini / Sklapani, Pagona / Trakas, Nikolaos / Janinis, Jim / Dahabreh, Jubrail / Spandidos, Demetrios A

Oncology letters

2022 Volume 24, Issue 3, Page(s) 313

Abstract: Pulmonary carcinoid tumors are rare, low-grade malignant tumors that constitute 1-2% of all lung tumors. The present study aimed to describe the simultaneous pathological findings in biopsy specimens of patients with surgically resected lung carcinoids ... ...

Abstract	Pulmonary carcinoid tumors are rare, low-grade malignant tumors that constitute 1-2% of all lung tumors. The present study aimed to describe the simultaneous pathological findings in biopsy specimens of patients with surgically resected lung carcinoids and determine their association with survival rates. For this purpose, 108 patients with resected carcinoid lung tumors were followed-up for 96 months and analyzed for simultaneous pathological findings in biopsy specimens. Among these, simultaneous pathological findings were found in 82 patients. The association between these findings and patient survival rates was evaluated. Atelectasis was a simultaneous finding in 52.4% of the patients, desquamative interstitial pneumonia (DIP) in 13.4%, emphysema in 24.4% and bronchiectasis in 9.8%. The survival rate was 100% for the patients with atelectasis, 81.8% for the patients with DIP, 90% for the patients with emphysema and 75% for the patients with bronchiectasis (P<0.05). According to the univariate analysis, the type of carcinoid was associated with patient survival with better survival rates for patients with typical carcinoids, while age, sex, stage and simultaneous pathological findings were not associated with patient survival. On the whole, there was a statistically significant difference in the survival rates of patients with resected lung carcinoids with different simultaneous pathological findings. However, further studies are warranted to assess the role of these findings in the survival of these patients.
Language	English
Publishing date	2022-07-15
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2022.13433
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