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  1. Article ; Online: Extra-intestinal sodium polystyrene sulfonate crystal-induced inflammatory pseudotumour in an asymptomatic haemodialysis patient.

    Goh, Li Herng / Wong, Jiunn / Chng, Tze Wei / Chew, Min Hoe / Kee, Terence / Ho, Quan Yao

    International urology and nephrology

    2021  Volume 53, Issue 6, Page(s) 1265–1266

    MeSH term(s) Female ; Granuloma, Plasma Cell/chemically induced ; Humans ; Middle Aged ; Polystyrenes/adverse effects ; Renal Dialysis
    Chemical Substances Polystyrenes ; polystyrene sulfonic acid (70KO0R01RY)
    Language English
    Publishing date 2021-01-03
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-020-02702-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 733: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Unusual presentation of metastatic gastrointestinal stromal tumour.

    Yap, Hao-Yun / Chng, Tze-Wei / Goh, Brian K P

    ANZ journal of surgery

    2017  Volume 89, Issue 5, Page(s) E204–E205

    MeSH term(s) Biopsy, Needle ; Cysts/diagnostic imaging ; Cysts/pathology ; Diagnosis, Differential ; Follow-Up Studies ; Gastrointestinal Neoplasms ; Gastrointestinal Stromal Tumors/pathology ; Gastrointestinal Stromal Tumors/surgery ; Hepatectomy/methods ; Hepatomegaly/etiology ; Hepatomegaly/pathology ; Humans ; Immunohistochemistry ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Monitoring, Physiologic/methods ; Neoplasm Metastasis/diagnostic imaging ; Neoplasm Metastasis/pathology ; Positron Emission Tomography Computed Tomography/methods ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2017-10-18
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.14224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 180: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Abnormal lactate metabolism is linked to albuminuria and kidney injury in diabetic nephropathy.

    Azushima, Kengo / Kovalik, Jean-Paul / Yamaji, Takahiro / Ching, Jianhong / Chng, Tze Wei / Guo, Jing / Liu, Jian-Jun / Nguyen, Mien / Sakban, Rashidah Binte / George, Simi E / Tan, Puay Hoon / Lim, Su Chi / Gurley, Susan B / Coffman, Thomas M

    Kidney international

    2023  Volume 104, Issue 6, Page(s) 1135–1149

    Abstract: Diabetic nephropathy (DN) is characterized by abnormal kidney energy metabolism, but its causes and contributions to DN pathogenesis are not clear. To examine this issue, we carried out targeted metabolomics profiling in a mouse model of DN that develops ...

    Abstract Diabetic nephropathy (DN) is characterized by abnormal kidney energy metabolism, but its causes and contributions to DN pathogenesis are not clear. To examine this issue, we carried out targeted metabolomics profiling in a mouse model of DN that develops kidney disease resembling the human disorder. We found a distinct profile of increased lactate levels and impaired energy metabolism in kidneys of mice with DN, and treatment with an angiotensin-receptor blocker (ARB) reduced albuminuria, attenuated kidney pathology and corrected many metabolic abnormalities, restoring levels of lactate toward normal while increasing kidney ATP content. We also found enhanced expression of lactate dehydrogenase isoforms in DN. Expression of both the LdhA and LdhB isoforms were significantly increased in kidneys of mice, and treatment with ARB significantly reduced their expression. Single-cell sequencing studies showed specific up-regulation of LdhA in the proximal tubule, along with enhanced expression of oxidative stress pathways. There was a significant correlation between albuminuria and lactate in mice, and also in a Southeast Asian patient cohort consisting of individuals with type 2 diabetes and impaired kidney function. In the individuals with diabetes, this association was independent of ARB and angiotensin-converting enzyme inhibitor use. Furthermore, urinary lactate levels predicted the clinical outcomes of doubling of serum creatinine or development of kidney failure, and there was a significant correlation between urinary lactate levels and biomarkers of tubular injury and epithelial stress. Thus, we suggest that kidney metabolic disruptions leading to enhanced generation of lactate contribute to the pathogenesis of DN and increased urinary lactate levels may be a potential biomarker for risk of kidney disease progression.
    MeSH term(s) Humans ; Animals ; Mice ; Diabetic Nephropathies/etiology ; Lactic Acid ; Albuminuria/etiology ; Angiotensin Receptor Antagonists/pharmacology ; Angiotensin Receptor Antagonists/therapeutic use ; Diabetes Mellitus, Type 2/complications ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Kidney ; Renal Insufficiency ; Protein Isoforms
    Chemical Substances Lactic Acid (33X04XA5AT) ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Protein Isoforms
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.08.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Validation of the Singapore nomogram for outcome prediction in breast phyllodes tumours in a large patient cohort.

    Chng, Tze Wei / Gudi, Mihir / Lim, Swee Ho / Li, HuiHua / Tan, Puay Hoon

    Journal of clinical pathology

    2017  

    Abstract: Aims: To validate the Singapore nomogram for outcome prediction in breast phyllodes tumours in a large cohort of Singaporean patients, as previous validation studies were conducted on small numbers of patients. We also investigate the association of ... ...

    Abstract Aims: To validate the Singapore nomogram for outcome prediction in breast phyllodes tumours in a large cohort of Singaporean patients, as previous validation studies were conducted on small numbers of patients. We also investigate the association of fibroadenomas and phyllodes tumours within a subset of our cohort.
    Methods: Histological parameters, surgical margin status and clinical follow-up data of 259 women diagnosed with phyllodes tumours were analysed. Patients with concurrent malignant or premalignant disease were excluded from the validation to minimise confounding influences. Biostatistics modelling was performed, and the concordance between predicted and observed survivals was calculated. The association between fibroadenomas and phyllodes tumours was quantified in a subset of the women.
    Results: Phyllodes tumours with higher number of mitoses, stromal overgrowth and positive surgical margins were found to be associated with greater risk of clinical recurrence. Patients with a higher nomogram score had a significantly higher risk of developing relapse. Forty out of 78 (51.3%) of the subset of phyllodes cases reviewed showed either fibroadenoma-like areas within the phyllodes tumours or concurrent fibroadenomas in the ipsilateral or contralateral breast.
    Conclusions: The Singapore nomogram is useful in predicting outcome in breast phyllodes tumours when applied to a large cohort of Singaporean women.
    Language English
    Publishing date 2017-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jclinpath-2017-204568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.139: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Validation of the Singapore nomogram for outcome prediction in breast phyllodes tumours: an Australian cohort.

    Chng, Tze Wei / Lee, Jonathan Y H / Lee, C Soon / Li, HuiHua / Tan, Min-Han / Tan, Puay Hoon

    Journal of clinical pathology

    2016  Volume 69, Issue 12, Page(s) 1124–1126

    Abstract: Aim: To validate the utility of the Singapore nomogram for outcome prediction in breast phyllodes tumours.: Methods: Histological parameters, surgical margin status and clinical follow-up data of 34 women diagnosed with phyllodes tumours were ... ...

    Abstract Aim: To validate the utility of the Singapore nomogram for outcome prediction in breast phyllodes tumours.
    Methods: Histological parameters, surgical margin status and clinical follow-up data of 34 women diagnosed with phyllodes tumours were analysed. Biostatistics modelling was performed, and the concordance between predicted and observed survivals was calculated.
    Results: Women with a high nomogram score had an increased risk of developing relapse, which was predicted using the parameters defined by the Singapore nomogram.
    Conclusions: The Singapore nomogram is useful in predicting outcome in breast phyllodes tumours when applied to an Australian cohort of 34 women.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biostatistics ; Breast/pathology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/mortality ; Breast Neoplasms/surgery ; Cohort Studies ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Neoplasm Recurrence, Local/mortality ; New South Wales/epidemiology ; Nomograms ; Phyllodes Tumor/diagnosis ; Phyllodes Tumor/mortality ; Phyllodes Tumor/surgery ; Risk ; Singapore/epidemiology ; Treatment Outcome
    Language English
    Publishing date 2016-12
    Publishing country England
    Document type Journal Article ; Validation Studies
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jclinpath-2016-203951
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.139: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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