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Article ; Online: Editoral commentary: Beyond the early adopter: The smartwatch ECG goes mainstream.

Cho, David J

2019 Volume 30, Issue 7, Page(s) 449–450

MeSH term(s)	Atrial Fibrillation ; Electrocardiography ; Humans
Language	English
Publishing date	2019-11-20
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1097434-9
ISSN	1873-2615 ; 1050-1738
ISSN (online)	1873-2615
ISSN	1050-1738
DOI	10.1016/j.tcm.2019.11.003
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Zs.A 3419: Show issues

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Article ; Online: Interventions for Optimization of Guideline-Directed Medical Therapy: A Systematic Review.

Tang, Amber B / Brownell, Nicholas K / Roberts, Jacob S / Haidar, Amier / Osuna-Garcia, Antonia / Cho, David J / Bokhoor, Pooya / Fonarow, Gregg C

JAMA cardiology

2024 Volume 9, Issue 4, Page(s) 397–404

Abstract: Importance: Implementation of guideline-directed medical therapy (GDMT) in real-world practice remains suboptimal. It is unclear which interventions are most effective at addressing current barriers to GDMT in patients with heart failure with reduced ... ...

Abstract	Importance: Implementation of guideline-directed medical therapy (GDMT) in real-world practice remains suboptimal. It is unclear which interventions are most effective at addressing current barriers to GDMT in patients with heart failure with reduced ejection fraction (HFrEF). Objective: To perform a systematic review to identify which types of system-level initiatives are most effective at improving GDMT use among patients with HFrEF. Evidence review: PubMed, Embase, Cochrane, CINAHL, and Web of Science databases were queried from January 2010 to November 2023 for randomized clinical trials that implemented a quality improvement intervention with GDMT use as a primary or secondary outcome. References from related review articles were also included for screening. Quality of studies and bias assessment were graded based on the Cochrane Risk of Bias tool and Oxford Centre for Evidence-Based Medicine. Findings: Twenty-eight randomized clinical trials were included with an aggregate sample size of 19 840 patients. Studies were broadly categorized as interdisciplinary interventions (n = 15), clinician education (n = 5), electronic health record initiatives (n = 6), or patient education (n = 2). Overall, interdisciplinary titration clinics were associated with significant increases in the proportion of patients on target doses of GDMT with a 10% to 60% and 2% to 53% greater proportion of patients on target doses of β-blockers and renin-angiotensin-aldosterone system inhibitors, respectively, in intervention groups compared with usual care. Other interventions, such as audits, clinician and patient education, or electronic health record alerts, were also associated with some improvements in GDMT utilization, though these findings were inconsistent across studies. Conclusions and relevance: This review summarizes interventions aimed at optimization of GDMT in clinical practice. Initiatives that used interdisciplinary teams, largely comprised of nurses and pharmacists, most consistently led to improvements in GDMT. Additional large, randomized studies are necessary to better understand other types of interventions, as well as their long-term efficacy and sustainability.
MeSH term(s)	Humans ; Heart Failure/drug therapy ; Heart Failure/diagnosis ; Stroke Volume ; Adrenergic beta-Antagonists/therapeutic use ; Ventricular Dysfunction, Left/drug therapy ; Quality Improvement
Chemical Substances	Adrenergic beta-Antagonists
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Systematic Review ; Journal Article
ISSN	2380-6591
ISSN (online)	2380-6591
DOI	10.1001/jamacardio.2023.5627
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Article ; Online: Strength and Functional Outcomes Following Achilles Tendon Reconstruction With Hamstring Tendon Autograft Augmentation.

Eble, Stephanie K / Hansen, Oliver B / Kukadia, Saanchi K / Cho, David J / Kumar, Prashanth / Papson, Andrea K / Drakos, Mark C

Foot & ankle international

2024 Volume 45, Issue 4, Page(s) 348–356

Abstract: Background: The proposed advantages of hamstring autograft reconstruction when compared to alternative procedures, such as flexor hallucis longus (FHL) transfer, V-Y lengthening, and allograft reconstruction, are improved healing and reproduction of ... ...

Abstract	Background: The proposed advantages of hamstring autograft reconstruction when compared to alternative procedures, such as flexor hallucis longus (FHL) transfer, V-Y lengthening, and allograft reconstruction, are improved healing and reproduction of normal tendon biomechanics and reduced morbidity within the foot and ankle. In this study, we examined the effect of Achilles tendon reconstruction using hamstring autografts on strength and functional outcomes. Methods: Patients who underwent Achilles repair with a hamstring autograft for insertional or midsubstance tendinopathy, delayed diagnosis of rupture, or infection after primary repair were evaluated for inclusion. Forty-six patients were identified; 12 further augmented with an FHL transfer are included in the analysis. Isokinetic testing was completed with a Biodex dynamometer under supervision of a physical therapist masked to surgical side. Pre- and postoperative Foot and Ankle Outcome Scores (FAOS, before March 2016) or Patient-Reported Outcomes Measurement Information System (PROMIS, after March 2016) surveys were collected. Results: For knee flexion, peak torque was not significantly different when comparing operative and nonoperative sides at 180 degrees/second (45.38 Nm vs 45.96 Nm; Conclusion: Achilles reconstruction with a hamstring autograft ± FHL transfer allowed patients with severe Achilles pathology to return to good subjective function, with modest deficits in calf strength compared with the uninjured side. Overall knee flexion strength did not appear impaired. These results suggest that hamstring autograft reconstruction is a viable method to treat these complex cases involving a lack of healthy tissue, allowing patients to return to symptom-free physical function and athletic activity. Level of evidence: Level IV, case series.
MeSH term(s)	Humans ; Achilles Tendon/surgery ; Hamstring Tendons/transplantation ; Male ; Female ; Adult ; Autografts ; Middle Aged ; Transplantation, Autologous ; Plastic Surgery Procedures/methods ; Muscle Strength/physiology ; Tendinopathy/surgery ; Patient Reported Outcome Measures ; Retrospective Studies ; Rupture/surgery ; Range of Motion, Articular
Language	English
Publishing date	2024-03-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1183283-6
ISSN	1944-7876 ; 1071-1007
ISSN (online)	1944-7876
ISSN	1071-1007
DOI	10.1177/10711007241227418
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Zs.A 1600: Show issues

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Article ; Online: MetAP2 inhibition reduces food intake and body weight in a ciliopathy mouse model of obesity.

Pottorf, Tana S / Fagan, Micaella P / Burkey, Bryan F / Cho, David J / Vath, James E / Tran, Pamela V

JCI insight

2020 Volume 5, Issue 2

Abstract: The ciliopathies Bardet-Biedl syndrome and Alström syndrome are genetically inherited pleiotropic disorders with hyperphagia and obesity as primary clinical features. Methionine aminopeptidase 2 inhibitors (MetAP2i) have been shown in preclinical and ... ...

Abstract	The ciliopathies Bardet-Biedl syndrome and Alström syndrome are genetically inherited pleiotropic disorders with hyperphagia and obesity as primary clinical features. Methionine aminopeptidase 2 inhibitors (MetAP2i) have been shown in preclinical and clinical studies to reduce food intake, body weight, and adiposity. Here, we investigated the effects of MetAP2i administration in a mouse model of ciliopathy produced by conditional deletion of the Thm1 gene in adulthood. Thm1 conditional knockout (cko) mice showed decreased hypothalamic proopiomelanocortin expression as well as hyperphagia, obesity, metabolic disease, and hepatic steatosis. In obese Thm1-cko mice, 2-week administration of MetAP2i reduced daily food intake and reduced body weight 17.1% from baseline (vs. 5% reduction for vehicle). This was accompanied by decreased levels of blood glucose, insulin, and leptin. Further, MetAP2i reduced gonadal adipose depots and adipocyte size and improved liver morphology. This is the first report to our knowledge of MetAP2i reducing hyperphagia and body weight and ameliorating metabolic indices in a mouse model of ciliopathy. These results support further investigation of MetAP2 inhibition as a potential therapeutic strategy for ciliary-mediated forms of obesity.
MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Blood Glucose/metabolism ; Body Weight/drug effects ; Ciliopathies/complications ; Ciliopathies/metabolism ; Disease Models, Animal ; Eating/drug effects ; Enzyme Inhibitors/pharmacology ; Fatty Liver/metabolism ; Leptin/metabolism ; Liver/metabolism ; Liver/pathology ; Male ; Methionyl Aminopeptidases/antagonists & inhibitors ; Methionyl Aminopeptidases/drug effects ; Methionyl Aminopeptidases/genetics ; Methionyl Aminopeptidases/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Obese ; Obesity/metabolism ; Transcriptome
Chemical Substances	Adaptor Proteins, Signal Transducing ; Blood Glucose ; Enzyme Inhibitors ; Leptin ; Ttc21b protein, mouse ; Metap2 protein, mouse (EC 3.4.11.18) ; Methionyl Aminopeptidases (EC 3.4.11.18)
Language	English
Publishing date	2020-01-30
Publishing country	United States
Document type	Journal Article
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.134278
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Article ; Online: Implementation of a Telemedicine Clinic in the Covid-19 Era

Khalil, Suzan / Moore, Melissa A. / Cho, David J. / Nsair, Ali / Rodriguez, Sandra J. / Kamath, Megan

Journal of Cardiac Failure

2020 Volume 26, Issue 10, Page(s) S72

Keywords	Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	1281194-4
ISSN	1532-8414 ; 1071-9164
ISSN (online)	1532-8414
ISSN	1071-9164
DOI	10.1016/j.cardfail.2020.09.210
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Zs.A 4340: Show issues

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Article ; Online: Digital Health and the Care of the Patient With Arrhythmia: What Every Electrophysiologist Needs to Know.

Tarakji, Khaldoun G / Silva, Jennifer / Chen, Lin Y / Turakhia, Mintu P / Perez, Marco / Attia, Zachi I / Passman, Rod / Boissy, Adrienne / Cho, David J / Majmudar, Maulik / Mehta, Neil / Wan, Elaine Y / Chung, Mina

Circulation. Arrhythmia and electrophysiology

2020 Volume 13, Issue 11, Page(s) e007953

Abstract: The field of cardiac electrophysiology has been on the cutting edge of advanced digital technologies for many years. More recently, medical device development through traditional clinical trials has been supplemented by direct to consumer products with ... ...

Abstract	The field of cardiac electrophysiology has been on the cutting edge of advanced digital technologies for many years. More recently, medical device development through traditional clinical trials has been supplemented by direct to consumer products with advancement of wearables and health care apps. The rapid growth of innovation along with the mega-data generated has created challenges and opportunities. This review summarizes the regulatory landscape, applications to clinical practice, opportunities for virtual clinical trials, the use of artificial intelligence to streamline and interpret data, and integration into the electronic medical records and medical practice. Preparation of the new generation of physicians, guidance and promotion by professional societies, and advancement of research in the interpretation and application of big data and the impact of digital technologies on health outcomes will help to advance the adoption and the future of digital health care.
MeSH term(s)	Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/physiopathology ; Arrhythmias, Cardiac/therapy ; Artificial Intelligence ; Attitude of Health Personnel ; Attitude to Computers ; Clinical Trials as Topic ; Diffusion of Innovation ; Electrophysiologic Techniques, Cardiac/instrumentation ; Health Knowledge, Attitudes, Practice ; Humans ; Mobile Applications ; Patient Participation ; Predictive Value of Tests ; Prognosis ; Remote Sensing Technology ; Smartphone ; Telemedicine/instrumentation ; Wearable Electronic Devices
Language	English
Publishing date	2020-10-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2426129-4
ISSN	1941-3084 ; 1941-3149
ISSN (online)	1941-3084
ISSN	1941-3149
DOI	10.1161/CIRCEP.120.007953
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Zs.A 6667: Show issues

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Article ; Online: Nonlinear responses in optical metamaterials: theory and experiment.

Tang, Shiwei / Cho, David J / Xu, Hao / Wu, Wei / Shen, Y Ron / Zhou, Lei

Optics express

2011 Volume 19, Issue 19, Page(s) 18283–18293

Abstract: We employed both theoretical calculations and experiments to study the nonlinear responses in optical metamaterials. The spectra of second-harmonic generations measured on a fishnet metamaterial are in quantitative agreements with calculations based on ... ...

Abstract	We employed both theoretical calculations and experiments to study the nonlinear responses in optical metamaterials. The spectra of second-harmonic generations measured on a fishnet metamaterial are in quantitative agreements with calculations based on full-wave numerical simulations combined with field integrations, both exhibiting ~80 times enhancements at the magnetic resonance frequency. Our calculations explained several interesting features observed experimentally, and suggested an optimal metamaterial structure to yield the strongest nonlinear signals.
Language	English
Publishing date	2011-09-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.19.018283
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Article ; Online: Ultrafast modulation of optical metamaterials.

Cho, David J / Wu, Wei / Ponizovskaya, Ekaterina / Chaturvedi, Pratik / Bratkovsky, Alexander M / Wang, Shih-Yuan / Zhang, Xiang / Wang, Feng / Shen, Y Ron

Optics express

2009 Volume 17, Issue 20, Page(s) 17652–17657

Abstract: We show by pump-probe spectroscopy that the optical response of a fishnet metamaterial can be modulated on the femtosecond time scale. The modulation dynamics is dominated by pump-induced changes in the constituting dielectric medium, but the strength of ...

Abstract	We show by pump-probe spectroscopy that the optical response of a fishnet metamaterial can be modulated on the femtosecond time scale. The modulation dynamics is dominated by pump-induced changes in the constituting dielectric medium, but the strength of modulation is dramatically enhanced through the plasmon resonance. The pump-induced spectral responses of the metamaterial provide understanding on how the resonance is modified by pump excitation. Our study suggests that metamaterials can be used as high-speed amplitude/phase modulators with terahertz-bandwidth.
MeSH term(s)	Computer Simulation ; Light ; Models, Theoretical ; Scattering, Radiation ; Surface Plasmon Resonance/methods
Language	English
Publishing date	2009-09-28
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.17.017652
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Article ; Online: Electrical control of optical plasmon resonance with graphene.

Kim, Jonghwan / Son, Hyungmok / Cho, David J / Geng, Baisong / Regan, Will / Shi, Sufei / Kim, Kwanpyo / Zettl, Alex / Shen, Yuen-Ron / Wang, Feng

Nano letters

2012 Volume 12, Issue 11, Page(s) 5598–5602

Abstract: Surface plasmon has the unique capability to concentrate light into subwavelength volume. Active plasmon devices using electrostatic gating can enable flexible control of the plasmon excitations, which has been demonstrated recently in terahertz ... ...

Abstract	Surface plasmon has the unique capability to concentrate light into subwavelength volume. Active plasmon devices using electrostatic gating can enable flexible control of the plasmon excitations, which has been demonstrated recently in terahertz plasmonic structures. Controlling plasmon resonance at optical frequencies, however, remains a significant challenge because gate-induced free electrons have very weak responses at optical frequencies. Here we achieve efficient control of near-infrared plasmon resonance in a hybrid graphene-gold nanorod system. Exploiting the uniquely strong and gate-tunable optical transitions of graphene, we are able to significantly modulate both the resonance frequency and quality factor of gold nanorod plasmon. Our analysis shows that the plasmon-graphene coupling is remarkably strong: even a single electron in graphene at the plasmonic hotspot could have an observable effect on plasmon scattering intensity. Such hybrid graphene-nanometallic structure provides a powerful way for electrical control of plasmon resonances at optical frequencies and could enable novel plasmonic sensing down to single charge transfer events.
Language	English
Publishing date	2012-10-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/nl302656d
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Article: Observation of excitons in one-dimensional metallic single-walled carbon nanotubes.

Wang, Feng / Cho, David J / Kessler, Brian / Deslippe, Jack / Schuck, P James / Louie, Steven G / Zettl, Alex / Heinz, Tony F / Shen, Y Ron

Physical review letters

2007 Volume 99, Issue 22, Page(s) 227401

Abstract: Excitons are generally believed not to exist in metals because of strong screening by free carriers. Here we demonstrate that excitonic states can in fact be produced in metallic systems of a one-dimensional character. Using metallic single-walled carbon ...

Abstract	Excitons are generally believed not to exist in metals because of strong screening by free carriers. Here we demonstrate that excitonic states can in fact be produced in metallic systems of a one-dimensional character. Using metallic single-walled carbon nanotubes as a model system, we show both experimentally and theoretically that electron-hole pairs form tightly bound excitons. The exciton binding energy of 50 meV, deduced from optical absorption spectra of individual metallic nanotubes, significantly exceeds that of excitons in most bulk semiconductors and agrees well with ab initio theoretical predictions.
Language	English
Publishing date	2007-11-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.99.227401
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