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  1. AU="Cho, Hyun-Ju"
  2. AU="Jurgen Claassen"
  3. AU="Zhukovskaia, E A"
  4. AU=Yee Rebecca AU=Yee Rebecca
  5. AU="d. S. C. Borges, G."
  6. AU="van Deursen, Alexander Jam"
  7. AU="Wang, Hsiu-Hung"
  8. AU="Mehta, Kedar"
  9. AU="Nelly A. Khachatryan"
  10. AU=Albensi Benedict C.
  11. AU=McRae Simon
  12. AU="Shorubalko, Ivan"
  13. AU="Stewart, Rodney A"
  14. AU="Bakthavatsalu, Maheshwar"
  15. AU="Fussner, Steven"
  16. AU="Dolsten, Mikael"
  17. AU="Sarnyai, Zoltán"
  18. AU=Dongaonkar Ranjeet M
  19. AU="Singh, Leher"
  20. AU="Sevilla Porras, Marta"
  21. AU="Fuller, Chris K"
  22. AU="Vandeloo, Judith"
  23. AU="Meyers, Amanda"
  24. AU="Jiménez-Bambague, Eliana M"
  25. AU="Turner, J C"
  26. AU="Moore, C J" AU="Moore, C J"
  27. AU="Leresche, Téa"
  28. AU=Astrom Siv AU=Astrom Siv
  29. AU="Di Meglio, Florent"
  30. AU=Simon H U
  31. AU=Croucher P I
  32. AU="Jasti, Madhu"

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  1. Artikel ; Online: Zero lock-in implementation by phase wrapping/unwrapping in a ring laser gyroscope.

    Lee, Jae-Cheul / Cho, Hyun-Ju / Yang, Ho-Soon

    Applied optics

    2022  Band 60, Heft 34, Seite(n) 10529–10538

    Abstract: The main factors that limit the performance of ring laser gyroscopes include random walk, quantization noise, and bias stability. The first two factors determine the alignment time for navigation systems, and the bias stability error can result in long- ... ...

    Abstract The main factors that limit the performance of ring laser gyroscopes include random walk, quantization noise, and bias stability. The first two factors determine the alignment time for navigation systems, and the bias stability error can result in long-term accuracy. We show that a phase wrapping/unwrapping algorithm, which has been widely used in interferometry fields, can be utilized to remove lock-in and quantization errors by implementing a zero-lock-in ring laser gyroscope. Furthermore, the performance of the ring laser gyroscope with no mechanical dither is described, and mirror dithering, instead of mechanical dithering, is proposed.
    Sprache Englisch
    Erscheinungsdatum 2022-02-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.438461
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: A Study on the Advancement of Spatial Maps and the Improvement of the Legal System as a Key Tool for Sustainable National Landscape Planning: Case Study of South Korea

    Cho, Hyun-Ju / Kim, Jin-Hyo / Lee, Eun Jae

    Land. 2023 May 11, v. 12, no. 5

    2023  

    Abstract: For sustainable, national landscape-planning, this study focused on land cover changes, landscape analysis methods from various perspectives on the landscape, legal system analysis related to landscape planning, and analysis of a basic spatial map for ... ...

    Abstract For sustainable, national landscape-planning, this study focused on land cover changes, landscape analysis methods from various perspectives on the landscape, legal system analysis related to landscape planning, and analysis of a basic spatial map for landscape planning. First of all, in Korea the focus is on the aesthetic aspect of the landscape, while foreign countries look at the landscape from multiple perspectives and tried to solve the problem of landscape damage on this basis. Next, looking at the changes in land cover, it was found that the urbanized area increased significantly, but the area of agricultural land and wetlands decreased significantly due to development plans. In addition, looking at the contents of the landscape plan in terms of the legal system, the legal system of the Republic of Korea included a multifunctional aspect of the landscape, but the contents were only at the level of policy suggestions. Finally, through a review of a basic spatial map for landscape planning, it was found that among various basic spatial maps, the biotope map is highly likely to be used when establishing national landscape plans. The results of this study are meaningful in that they have not only established the concept of landscape in terms of multifunctionality but also established improvement measures in terms of legal and institutional aspects and the basic spatial map.
    Schlagwörter aesthetics ; agricultural land ; biotopes ; case studies ; issues and policy ; land cover ; landscapes ; urbanization ; South Korea
    Sprache Englisch
    Erscheinungsverlauf 2023-0511
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel ; Online
    ZDB-ID 2682955-1
    ISSN 2073-445X
    ISSN 2073-445X
    DOI 10.3390/land12051044
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel: A review on the impacts of nanomaterials on neuromodulation and neurological dysfunction using a zebrafish animal model.

    Cho, Hyun-Ju / Lee, Wang Sik / Jeong, Jinyoung / Lee, Jeong-Soo

    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

    2022  Band 261, Seite(n) 109428

    Abstract: Nanomaterials have been widely employed from industrial to medical fields due to their small sizes and versatile characteristics. However, nanomaterials can also induce unexpected adverse effects on health. In particular, exposure of the nervous system ... ...

    Abstract Nanomaterials have been widely employed from industrial to medical fields due to their small sizes and versatile characteristics. However, nanomaterials can also induce unexpected adverse effects on health. In particular, exposure of the nervous system to nanomaterials can cause serious neurological dysfunctions and neurodegenerative diseases. A number of studies have adopted various animal models to evaluate the neurotoxic effects of nanomaterials. Among them, zebrafish has become an attractive animal model for neurotoxicological studies due to several advantages, including the well-characterized nervous system, efficient genome editing, convenient generation of transgenic lines, high-resolution in vivo imaging, and an array of behavioral assays. In this review, we summarize recent studies on the neurotoxicological effects of nanomaterials, particularly engineered nanomaterials and nanoplastics, using zebrafish and discuss key findings with advantages and limitations of the zebrafish model in neurotoxicological studies.
    Mesh-Begriff(e) Animals ; Animals, Genetically Modified ; Disease Models, Animal ; Nanostructures/toxicity ; Neurotoxicity Syndromes/etiology ; Zebrafish/genetics
    Sprache Englisch
    Erscheinungsdatum 2022-08-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 189285-x
    ISSN 1532-0456 ; 0306-4492 ; 0742-8413
    ISSN 1532-0456 ; 0306-4492 ; 0742-8413
    DOI 10.1016/j.cbpc.2022.109428
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  4. Artikel ; Online: Combined effects of microplastics and benz[a]anthracene on cardiotoxicity in zebrafish (Danio rerio) larvae: Size matters.

    Sim, Yugyeong / Cho, Hyun-Ju / Lee, Jeong-Soo / Lee, Wang Sik / Kim, Hyunjung / Jeong, Jinyoung

    Chemosphere

    2023  Band 330, Seite(n) 138723

    Abstract: The size of microplastics (MPs) plays an important role in combined toxic effects including synergistic or antagonistic effects. However, the influence of the size of MPs on the combined toxicity of contaminants remains unclear. In this study, we ... ...

    Abstract The size of microplastics (MPs) plays an important role in combined toxic effects including synergistic or antagonistic effects. However, the influence of the size of MPs on the combined toxicity of contaminants remains unclear. In this study, we employed a zebrafish model to investigate the effects of MP size on the combined toxicity of benz[a]anthracene (BaA), a representative polyaromatic hydrocarbon, using three different sizes of polystyrene MPs (PSMPs) (0.2, 1.0, and 10 μm). Treatment of all groups did not result in any mortality of the zebrafish larvae. However, small-sized PSMPs (0.2 μm) enhanced the toxic effect of BaA in larvae such as cardiac defect and disruption of vessel formation. Medium-sized PSMPs (1.0 μm) were boundary in terms of the combined toxic effect; however, large-sized PSMPs (10 μm) alleviated the cardiotoxicity of BaA, including cardiac defect, ROS levels, and cell death. The combined effects showed a correlation with the body burden of MPs and BaA in larvae according to particle size (in the order of 0.2 μm > 1.0 μm > 10 μm). The synergistic effects occurred likely because the small PSMPs facilitated the body burden of BaA, induced excessive ROS by Ahr-mediated activity, and caused cell death in the heart, resulting in increased heart defects in the larvae. In contrast, large PSMPs abated the combined toxic effect through decreased body burden, whereas medium PSMPs form a boundary in combined effects. Therefore, the combined toxic effects of MPs are dependent on their size, which plays an important role in the transport and accumulation of environmental pollutants.
    Mesh-Begriff(e) Animals ; Microplastics/toxicity ; Microplastics/metabolism ; Zebrafish/metabolism ; Plastics/toxicity ; Larva ; Cardiotoxicity ; Reactive Oxygen Species/metabolism ; Water Pollutants, Chemical/toxicity ; Water Pollutants, Chemical/metabolism ; Polystyrenes/toxicity ; Polystyrenes/metabolism ; Anthracenes/toxicity ; Anthracenes/metabolism
    Chemische Substanzen Microplastics ; Plastics ; Reactive Oxygen Species ; Water Pollutants, Chemical ; Polystyrenes ; anthracene (EH46A1TLD7) ; Anthracenes
    Sprache Englisch
    Erscheinungsdatum 2023-04-19
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2023.138723
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2540: Hefte anzeigen Standort:
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  5. Artikel ; Online: Combined effects of microplastics and benz[a]anthracene on cardiotoxicity in zebrafish (Danio rerio) larvae: Size matters

    Sim, Yugyeong / Cho, Hyun-Ju / Lee, Jeong-Soo / Lee, Wang Sik / Kim, Hyŏn-jŏng / Jeong, Jinyoung

    Chemosphere. 2023 July, v. 330 p.138723-

    2023  

    Abstract: The size of microplastics (MPs) plays an important role in combined toxic effects including synergistic or antagonistic effects. However, the influence of the size of MPs on the combined toxicity of contaminants remains unclear. In this study, we ... ...

    Abstract The size of microplastics (MPs) plays an important role in combined toxic effects including synergistic or antagonistic effects. However, the influence of the size of MPs on the combined toxicity of contaminants remains unclear. In this study, we employed a zebrafish model to investigate the effects of MP size on the combined toxicity of benz[a]anthracene (BaA), a representative polyaromatic hydrocarbon, using three different sizes of polystyrene MPs (PSMPs) (0.2, 1.0, and 10 μm). Treatment of all groups did not result in any mortality of the zebrafish larvae. However, small-sized PSMPs (0.2 μm) enhanced the toxic effect of BaA in larvae such as cardiac defect and disruption of vessel formation. Medium-sized PSMPs (1.0 μm) were boundary in terms of the combined toxic effect; however, large-sized PSMPs (10 μm) alleviated the cardiotoxicity of BaA, including cardiac defect, ROS levels, and cell death. The combined effects showed a correlation with the body burden of MPs and BaA in larvae according to particle size (in the order of 0.2 μm > 1.0 μm > 10 μm). The synergistic effects occurred likely because the small PSMPs facilitated the body burden of BaA, induced excessive ROS by Ahr-mediated activity, and caused cell death in the heart, resulting in increased heart defects in the larvae. In contrast, large PSMPs abated the combined toxic effect through decreased body burden, whereas medium PSMPs form a boundary in combined effects. Therefore, the combined toxic effects of MPs are dependent on their size, which plays an important role in the transport and accumulation of environmental pollutants.
    Schlagwörter Danio rerio ; anthracenes ; cardiotoxicity ; cell death ; heart ; microplastics ; models ; mortality ; particle size ; polystyrenes ; toxicity ; Benz[a]anthracene ; Combined toxicity ; Zebrafish larvae ; Ahr ; AO ; BaA ; BaP ; BHA ; BkF ; CYP1A ; EW ; MPs ; PAHs ; PE ; Phe ; PSMPs ; SH
    Sprache Englisch
    Erscheinungsverlauf 2023-07
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel ; Online
    Anmerkung Use and reproduction
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2023.138723
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  6. Artikel: A review on the impacts of nanomaterials on neuromodulation and neurological dysfunction using a zebrafish animal model

    Cho, Hyun-Ju / Lee, Wang Sik / Jeong, Jinyoung / Lee, Jeong-Soo

    Comparative biochemistry and physiology. 2022 Nov., v. 261

    2022  

    Abstract: Nanomaterials have been widely employed from industrial to medical fields due to their small sizes and versatile characteristics. However, nanomaterials can also induce unexpected adverse effects on health. In particular, exposure of the nervous system ... ...

    Abstract Nanomaterials have been widely employed from industrial to medical fields due to their small sizes and versatile characteristics. However, nanomaterials can also induce unexpected adverse effects on health. In particular, exposure of the nervous system to nanomaterials can cause serious neurological dysfunctions and neurodegenerative diseases. A number of studies have adopted various animal models to evaluate the neurotoxic effects of nanomaterials. Among them, zebrafish has become an attractive animal model for neurotoxicological studies due to several advantages, including the well-characterized nervous system, efficient genome editing, convenient generation of transgenic lines, high-resolution in vivo imaging, and an array of behavioral assays. In this review, we summarize recent studies on the neurotoxicological effects of nanomaterials, particularly engineered nanomaterials and nanoplastics, using zebrafish and discuss key findings with advantages and limitations of the zebrafish model in neurotoxicological studies.
    Schlagwörter Danio rerio ; animal models ; animals ; genetically modified organisms ; genome ; nanoplastics ; nervous system ; neurotoxicity ; physiology
    Sprache Englisch
    Erscheinungsverlauf 2022-11
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 189285-x
    ISSN 0306-4492 ; 0742-8413 ; 1532-0456
    ISSN 0306-4492 ; 0742-8413 ; 1532-0456
    DOI 10.1016/j.cbpc.2022.109428
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel ; Online: Genetic Approaches Using Zebrafish to Study the Microbiota-Gut-Brain Axis in Neurological Disorders.

    Lee, Jae-Geun / Cho, Hyun-Ju / Jeong, Yun-Mi / Lee, Jeong-Soo

    Cells

    2021  Band 10, Heft 3

    Abstract: The microbiota-gut-brain axis (MGBA) is a bidirectional signaling pathway mediating the interaction of the microbiota, the intestine, and the central nervous system. While the MGBA plays a pivotal role in normal development and physiology of the nervous ... ...

    Abstract The microbiota-gut-brain axis (MGBA) is a bidirectional signaling pathway mediating the interaction of the microbiota, the intestine, and the central nervous system. While the MGBA plays a pivotal role in normal development and physiology of the nervous and gastrointestinal system of the host, its dysfunction has been strongly implicated in neurological disorders, where intestinal dysbiosis and derived metabolites cause barrier permeability defects and elicit local inflammation of the gastrointestinal tract, concomitant with increased pro-inflammatory cytokines, mobilization and infiltration of immune cells into the brain, and the dysregulated activation of the vagus nerve, culminating in neuroinflammation and neuronal dysfunction of the brain and behavioral abnormalities. In this topical review, we summarize recent findings in human and animal models regarding the roles of the MGBA in physiological and neuropathological conditions, and discuss the molecular, genetic, and neurobehavioral characteristics of zebrafish as an animal model to study the MGBA. The exploitation of zebrafish as an amenable genetic model combined with in vivo imaging capabilities and gnotobiotic approaches at the whole organism level may reveal novel mechanistic insights into microbiota-gut-brain interactions, especially in the context of neurological disorders such as autism spectrum disorder and Alzheimer's disease.
    Mesh-Begriff(e) Animals ; Gastrointestinal Microbiome/genetics ; Nervous System Diseases/genetics ; Zebrafish
    Sprache Englisch
    Erscheinungsdatum 2021-03-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10030566
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: NOS2 and

    Switzer, Christopher H / Cho, Hyun-Ju / Eykyn, Thomas R / Lavender, Paul / Eaton, Philip

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Band 119, Heft 21, Seite(n) e2200022119

    Abstract: Inducible nitric oxide synthase (NOS2) produces high local concentrations of nitric oxide (NO), and its expression is associated with inflammation, cellular stress signals, and cellular transformation. Additionally, NOS2 expression results in aggressive ... ...

    Abstract Inducible nitric oxide synthase (NOS2) produces high local concentrations of nitric oxide (NO), and its expression is associated with inflammation, cellular stress signals, and cellular transformation. Additionally, NOS2 expression results in aggressive cancer cell phenotypes and is correlated with poor outcomes in patients with breast cancer. DNA hypomethylation, especially of noncoding repeat elements, is an early event in carcinogenesis and is a common feature of cancer cells. In addition to altered gene expression, DNA hypomethylation results in genomic instability via retrotransposon activation. Here, we show that NOS2 expression and associated NO signaling results in substantial DNA hypomethylation in human cell lines by inducing the degradation of DNA (cytosine-5)–methyltransferase 1 (DNMT1) protein. Similarly, NOS2 expression levels were correlated with decreased DNA methylation in human breast tumors. NOS2 expression and NO signaling also resulted in long interspersed noncoding element 1 (LINE-1) retrotransposon hypomethylation, expression, and DNA damage. DNMT1 degradation was mediated by an NO/p38-MAPK/lysine acetyltransferase 5–dependent mechanism. Furthermore, we show that this mechanism is required for NO-mediated epithelial transformation. Therefore, we conclude that NOS2 and NO signaling results in DNA damage and malignant cellular transformation via an epigenetic mechanism.
    Mesh-Begriff(e) DNA (Cytosine-5-)-Methyltransferase 1/genetics ; DNA (Cytosine-5-)-Methyltransferase 1/metabolism ; DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; DNA Methylation ; Humans ; Inflammation/genetics ; Nitric Oxide ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism ; Retroelements/genetics ; S-Nitrosothiols
    Chemische Substanzen Retroelements ; S-Nitrosothiols ; Nitric Oxide (31C4KY9ESH) ; NOS2 protein, human (EC 1.14.13.39) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; DNA (Cytosine-5-)-Methyltransferase 1 (EC 2.1.1.37) ; DNA (Cytosine-5-)-Methyltransferases (EC 2.1.1.37) ; DNMT1 protein, human (EC 2.1.1.37)
    Sprache Englisch
    Erscheinungsdatum 2022-05-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2200022119
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1148: Hefte anzeigen Standort:
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  9. Artikel ; Online: Correction to: Transplantation of PSA-NCAM-Positive Neural Precursors from Human Embryonic Stem Cells Promotes Functional Recovery in an Animal Model of Spinal Cord Injury.

    Kim, Do-Hun / Cho, Hyun-Ju / Park, Chul-Yong / Cho, Myung Soo / Kim, Dong-Wook

    Tissue engineering and regenerative medicine

    2022  Band 19, Heft 6, Seite(n) 1391

    Sprache Englisch
    Erscheinungsdatum 2022-10-26
    Erscheinungsland Korea (South)
    Dokumenttyp Published Erratum
    ZDB-ID 2677535-9
    ISSN 2212-5469 ; 1738-2696
    ISSN (online) 2212-5469
    ISSN 1738-2696
    DOI 10.1007/s13770-022-00493-x
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  10. Artikel ; Online: Transplantation of PSA-NCAM-Positive Neural Precursors from Human Embryonic Stem Cells Promotes Functional Recovery in an Animal Model of Spinal Cord Injury.

    Kim, Do-Hun / Cho, Hyun-Ju / Park, Chul-Yong / Cho, Myung Soo / Kim, Dong-Wook

    Tissue engineering and regenerative medicine

    2022  Band 19, Heft 6, Seite(n) 1349–1358

    Abstract: Background: Spinal cord injury (SCI) results in permanent impairment of motor and sensory functions at and below the lesion site. There is no therapeutic option to the functional recovery of SCI involving diverse injury responses of different cell types ...

    Abstract Background: Spinal cord injury (SCI) results in permanent impairment of motor and sensory functions at and below the lesion site. There is no therapeutic option to the functional recovery of SCI involving diverse injury responses of different cell types in the lesion that limit endogenous nerve regeneration. In this regard, cell replacement therapy utilizing stem cells or their derivatives has become a highly promising approach to promote locomotor recovery. For this reason, the demand for a safe and efficient multipotent cell source that can differentiate into various neural cells is increasing. In this study, we evaluated the efficacy and safety of human polysialylated-neural cell adhesion molecule (PSA-NCAM)-positive neural precursor cells (hNPCs
    Methods: One hundred thousand hNPCs
    Results: Locomotor activity improvement was estimated by the Basso-Beattie-Bresnahan locomotor rating scale. Behavioral tests revealed that the transplantation of the hNPCs
    Conclusion: Our results demonstrate that hNPCs
    Mesh-Begriff(e) Rats ; Animals ; Humans ; Neural Cell Adhesion Molecules/metabolism ; Neural Stem Cells/metabolism ; Human Embryonic Stem Cells/metabolism ; Human Embryonic Stem Cells/pathology ; Human Embryonic Stem Cells/transplantation ; Spinal Cord Injuries/therapy ; Disease Models, Animal
    Chemische Substanzen polysialyl neural cell adhesion molecule ; Neural Cell Adhesion Molecules
    Sprache Englisch
    Erscheinungsdatum 2022-08-29
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2677535-9
    ISSN 2212-5469 ; 1738-2696
    ISSN (online) 2212-5469
    ISSN 1738-2696
    DOI 10.1007/s13770-022-00483-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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