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Article: Laparoscopic repair of colonoscopy-induced adult Bochdalek hernia: Case report.

Cho, Sung Hoon / Lim, Kyoung Hoon

International journal of surgery case reports

2022 Volume 99, Page(s) 107591

Abstract: Introduction: Bochdalek hernias are congenital diaphragmatic malformations caused by a failure to close the pleuroperitoneal cavity in the posterolateral area. Bochdalek hernias are very rare in adult, with congenital diaphragmatic defects being even ... ...

Abstract	Introduction: Bochdalek hernias are congenital diaphragmatic malformations caused by a failure to close the pleuroperitoneal cavity in the posterolateral area. Bochdalek hernias are very rare in adult, with congenital diaphragmatic defects being even rarer. Presentation of case: A 35-year-old man presented to our emergency room with epigastric pain after colonoscopy. The patient had no history of trauma. Plain chest X-ray revealed bowel gas patterns and haziness in the left lower lung field. Abdominal computed tomography revealed a left diaphragmatic defect in the posterolateral area, with herniation of the omentum and colon. The patient successfully underwent laparoscopic herniorrhaphy. Discussion: The diaphragm comprises fibrous tissue and muscle. Therefore, direct damage by a colonoscope is almost impossible. Normal chest X-ray as a part of a health screening was performed 9 days prior to admission, and the size of the diaphragmatic defect could be covered by the spleen; therefore, the patient was considered hernia-free for over 30 years. Conclusion: We report a rare case of delayed Bochdalek hernia that may have been induced by the difficult insertion of a colonoscopy. Although rare, this disorder should be recognized, examined and treated appropriately to avoid complications.
Language	English
Publishing date	2022-09-05
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2022.107591
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Article: Conservative treatment of blunt traumatic right renal venous pseudoaneurysm: A case report.

Cho, Sung Hoon / Lim, Kyoung Hoon

International journal of surgery case reports

2022 Volume 98, Page(s) 107572

Abstract: Introduction: Venous pseudoaneurysm is uncommon in blunt trauma patients, and renal venous pseudoaneurysm is especially rare, even though renal trauma occurs in approximately 8-10 % of abdominal trauma cases. There is controversy regarding the modality ... ...

Abstract	Introduction: Venous pseudoaneurysm is uncommon in blunt trauma patients, and renal venous pseudoaneurysm is especially rare, even though renal trauma occurs in approximately 8-10 % of abdominal trauma cases. There is controversy regarding the modality of treatment between surgery, conservative care, and radiologic intervention to manage renal venous pseudoaneurysms. We would like to share our experience treating blunt trauma patients having renal venous pseudoaneurysm with conservative care. Presentation of case: A 53-year-old female patient was transferred to our trauma center following a pedestrian accident. Contrast-enhanced abdominal computed tomography (CT) showed right renal injury (grade II) with partial infarction (approximately 30-40 %) and peri-renal hematoma confined to Gerota's fascia without extravasation, a 3 cm sized right renal venous pseudoaneurysm, and a liver laceration (grade III) with a small amount of perihepatic hemoperitoneum. Since her vital signs were stable, with no decrease in the hemoglobin level in the short-term follow-up laboratory test, we decided to treat the patient conservatively in the trauma intensive care unit without angioembolization or surgery. The patient was discharged on the 14th day after OR/IF surgery for a right distal tibiofibular fracture. On a CT scan performed 1 month after discharge, a peri-renal hematoma was no longer observed, and the renal venous pseudoaneurysm had nearly improved. Discussion: Patients with renal arterial injury with unstable vital signs require surgery or angioembolization. Even if vital signs are stable, arterial pseudoaneurysms are more likely to rupture; therefore, surgery or angioembolization is required. In contrast, venous pseudoaneurysms can be managed conservatively compared to intervention or surgery in vitally stable patients because they have a lower possibility of rupture due to relatively low pressure. Conclusion: Renal venous pseudoaneurysms are very rare. Surgery, conservative care, and radiologic intervention should be considered depending on the patient's condition. Because venous blood flow is slower than arterial blood flow, renal venous pseudoaneurysm can be treated with conservative care if there are no injuries requiring further management and if the patient's vital signs are stable.
Language	English
Publishing date	2022-08-31
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2022.107572
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Article ; Online: Risk factors of trauma-induced thrombotic microangiopathy-like syndrome: A retrospective analysis.

Lim, Kyoung Hoon / Park, Jinyoung / Cho, Sung Hoon

Medicine

2022 Volume 101, Issue 29, Page(s) e29315

Abstract: Patients with trauma may develop thrombocytopenia. We encountered cases wherein patients experienced symptoms resembling thrombotic microangiopathies (TMAs) following severe trauma. As the condition of these patients did not meet the diagnostic criteria ... ...

Abstract	Patients with trauma may develop thrombocytopenia. We encountered cases wherein patients experienced symptoms resembling thrombotic microangiopathies (TMAs) following severe trauma. As the condition of these patients did not meet the diagnostic criteria of thrombotic thrombocytopenic purpura and there was no mention of trauma among the several causes of TMAs, it was termed as "trauma-induced thrombotic microangiopathy-like syndrome" (t-TMAS). In this study, we aimed to analyze the risk factors that may affect the incidence of t-TMAS in patients with severe trauma. This retrospective study was conducted in the trauma intensive care unit at the Kyungpook National University Hospital between January 2018 and December 2019. The medical records of 1164 of the 1392 enrolled participants were analyzed. To assess the risk factors of t-TMAS, we analyzed age, sex, mechanism of trauma, abbreviated injury scale (AIS) score, injury severity score (ISS), hematological examination, and red blood cell volume transfused in 24 hours. Among the 1164 patients, 20 (1.7%) were diagnosed with t-TMAS. The univariate analysis revealed higher age, ISS, and myoglobin, lactate, creatine kinase-myocardial band (on admission), creatine phosphokinase, lactate dehydrogenase (LDH), and lactate (day 2) levels in the t-TMAS group than in the non-t-TMAS group. The red blood cell volume transfused in 24 hours was higher in the t-TMAS group than in the non-t-TMAS group. t-TMAS was more common in patients with injuries in the chest, abdomen, and pelvis (AIS score ≥3) than in those with head injuries (AIS score ≥3) alone. The higher the sum of AIS scores of the chest, abdomen, and pelvis injuries, the higher the incidence of t-TMAS. Multivariate analysis revealed age, ISS, and LDH level (day 2) to be independent predictors of t-TMAS. Trauma surgeons should consider the possibility of t-TMAS if thrombocytopenia persists without any evidence of bleeding, particularly among older patients with multiple severe torso injuries who have high LDH levels on day 2. Early diagnosis and treatment of t-TMAS could improve patients' prognosis.
MeSH term(s)	Humans ; Injury Severity Score ; Lactates ; Multiple Trauma/diagnosis ; Retrospective Studies ; Risk Factors ; Thrombotic Microangiopathies/epidemiology ; Thrombotic Microangiopathies/etiology
Chemical Substances	Lactates
Language	English
Publishing date	2022-07-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000029315
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Article: Cross-Sectional and Time-Dependent Analyses on Inflammatory Markers following Natural Killer Cell Activity.

Lee, Yun-Kyong / Haam, Ji-Hee / Cho, Sung-Hoon / Kim, Young-Sang

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 2

Abstract: The function of natural killer (NK) cells in inflammation has not been explored enough in large-scale population studies. The cross-sectional and time-dependent relationship between NK cell activity (NKA) and inflammatory markers was examined.: Methods! ...

Abstract	The function of natural killer (NK) cells in inflammation has not been explored enough in large-scale population studies. The cross-sectional and time-dependent relationship between NK cell activity (NKA) and inflammatory markers was examined. Methods: A total of 7031 subjects were involved in the cross-sectional analyses. Non-linear relationship between NKA and inflammatory indices was analyzed using generalized additive models. The time-dependent changes were analyzed in 1005 subjects with repeated measurement in 3-6 months. The changes in inflammatory markers were analyzed based on the changes in NKA. Results: As NKA reduces to a very low level, the white blood cell (WBC) and neutrophil counts increase sharply, and the lymphocyte count exhibits a slow decline. With increasing NKA larger than about 500 pg/mL, WBC and neutrophil-lymphocyte ratio (NLR) reduces in a mild slope. Among the subjects with repeated measurements, the follow-up NKA was increased with advancing baseline NKA levels. The subjects with a reduction in NKA indicated increment in WBC count, neutrophil count, and NLR, and decrease in lymphocyte count. Conclusions: Very low levels of NKA suggest a high inflammatory immune response. The changes in NKA may interact with the balance between neutrophils and lymphocytes.
Language	English
Publishing date	2022-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12020448
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Article ; Online: Impact of COVID-19 pandemic on interhospital transfer of patients with major trauma in Korea: a retrospective cohort study.

Cho, Sung Hoon / Nho, Woo Young / Lee, Dong Eun / Ahn, Jae Yun / Kim, Joon-Woo / Lim, Kyoung Hoon / Ryoo, Hyun Wook / Kim, Jong Kun

BMC emergency medicine

2024 Volume 24, Issue 1, Page(s) 53

Abstract: Background: Interhospital transfer (IHT) is necessary for providing ultimate care in the current emergency care system, particularly for patients with severe trauma. However, studies on IHT during the pandemic were limited. Furthermore, evidence on the ... ...

Abstract	Background: Interhospital transfer (IHT) is necessary for providing ultimate care in the current emergency care system, particularly for patients with severe trauma. However, studies on IHT during the pandemic were limited. Furthermore, evidence on the effects of the coronavirus disease 2019 (COVID-19) pandemic on IHT among patients with major trauma was lacking. Method: This retrospective cohort study was conducted in an urban trauma center (TC) of a tertiary academic affiliated hospital in Daegu, Korea. The COVID-19 period was defined as from February 1, 2020 to January 31, 2021, whereas the pre-COVID-19 period was defined as the same duration of preceding span. Clinical data collected in each period were compared. We hypothesized that the COVID-19 pandemic negatively impacted IHT. Results: A total of 2,100 individual patients were included for analysis. During the pandemic, the total number of IHTs decreased from 1,317 to 783 (- 40.5%). Patients were younger (median age, 63 [45-77] vs. 61[44-74] years, p = 0.038), and occupational injury was significantly higher during the pandemic (11.6% vs. 15.7%, p = 0.025). The trauma team activation (TTA) ratio was higher during the pandemic both on major trauma (57.3% vs. 69.6%, p = 0.006) and the total patient cohort (22.2% vs. 30.5%, p < 0.001). In the COVID-19 period, duration from incidence to the TC was longer (218 [158-480] vs. 263[180-674] minutes, p = 0.021), and secondary transfer was lower (2.5% vs. 0.0%, p = 0.025). Conclusion: We observed that the total number of IHTs to the TC was reduced during the COVID-19 pandemic. Overall, TTA was more frequent, particularly among patients with major trauma. Patients with severe injury experienced longer duration from incident to the TC and lesser secondary transfer from the TC during the COVID-19 pandemic.
MeSH term(s)	Humans ; Middle Aged ; Pandemics ; Retrospective Studies ; Patient Transfer ; COVID-19/epidemiology ; Trauma Centers ; Republic of Korea/epidemiology
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2050431-7
ISSN	1471-227X ; 1471-227X
ISSN (online)	1471-227X
ISSN	1471-227X
DOI	10.1186/s12873-024-00963-6
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Article ; Online: Performance enhancement of a diffusion-type solar still: Wettability and flowability of condensation surface

Lee, Ga-Ram / Park, Chang-Dae / Lim, Hyuneui / Cho, Sung-Hoon / Choi, Seok-Min / Lim, Byung-Ju

Renewable Energy. 2023 June, v. 209 p.277-285

2023

Abstract: Several studies have been conducted to enhance the production of solar stills. However, studies focusing on the augmentation of condensation are still insufficient compared with those focusing on production improvement by enhancing evaporation. This ... ...

Abstract	Several studies have been conducted to enhance the production of solar stills. However, studies focusing on the augmentation of condensation are still insufficient compared with those focusing on production improvement by enhancing evaporation. This study evaluates the effect of contact and sliding angles of condensation surfaces, which are criteria for determining wettability and flowability on the production of solar stills. Single-effect diffusion solar still was fabricated, and glass specimens with various wettability properties were prepared as condensation plates of the still to compare the performances. Experiments were performed by changing the condensation plates of the solar still. Meanwhile, the condensation process and droplet forms were observed as a function of wettability. The experimental results showed that the production rate increased by 45% with a decrease in the sliding angle; it also increased as the surface became superhydrophilic or superhydrophobic, but the sliding angle was a better indicator. Therefore, the material to be used for the condensation surface should be selected based on the sliding angle preferentially.
Keywords	droplets ; evaporation ; glass ; hydrophilicity ; hydrophobicity ; renewable energy sources ; solar still ; wettability ; Diffusion still ; Contact angle ; Sliding angle ; Condensation surface
Language	English
Dates of publication	2023-06
Size	p. 277-285.
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2001449-1
ISSN	1879-0682 ; 0960-1481
ISSN (online)	1879-0682
ISSN	0960-1481
DOI	10.1016/j.renene.2023.03.134
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Article: Effects of wind loads on the solar panel array of a floating photovoltaic system – Experimental study and economic analysis

Choi, Seok Min / Park, Chang-Dae / Cho, Sung-Hoon / Lim, Byung-Ju

Energy. 2022 Oct. 01, v. 256

2022

Abstract: Floating photovoltaic systems have been installed around the world as solar energy is powerful renewable energy source, but they can sink or overturn depending on harsh environmental conditions. Analyzing the wind load on a solar panel array is important ...

Abstract	Floating photovoltaic systems have been installed around the world as solar energy is powerful renewable energy source, but they can sink or overturn depending on harsh environmental conditions. Analyzing the wind load on a solar panel array is important for designing an appropriate supporting structure for floating photovoltaic systems. In this study, the local pressure distributions on a solar panel array were experimentally measured and economic analysis was conducted for reduced manufacturing cost. The results showed that the first and last rows of panels had the highest drag and lift coefficients because they were the first to encounter the wind. The drag and lift coefficients gradually decreased in subsequent rows because of the sheltering effect. When the wind flowed from the side, the leftmost and rightmost columns provided a sheltering effect, which reduced the drag and lift coefficients for the center of the solar panel array by 45%–86%. From these results, the middle regions of floating bodies could be changed to the lower-cost materials which showed the 19% reduced manufacturing costs for 2.5 MW system (20 × 30). If the size of the floating PV system increases further, many floating bodies could be changed to lower-cost materials which will be more economical.
Keywords	economic analysis ; energy ; solar collectors ; solar energy ; wind
Language	English
Dates of publication	2022-1001
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2022.124649
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Article ; Online: Supplying the trip to antibody production-nutrients, signaling, and the programming of cellular metabolism in the mature B lineage.

Boothby, Mark R / Brookens, Shawna K / Raybuck, Ariel L / Cho, Sung Hoon

Cellular & molecular immunology

2021 Volume 19, Issue 3, Page(s) 352–369

Abstract: The COVID pandemic has refreshed and expanded recognition of the vital role that sustained antibody (Ab) secretion plays in our immune defenses against microbes and of the importance of vaccines that elicit Ab protection against infection. With this ... ...

Abstract	The COVID pandemic has refreshed and expanded recognition of the vital role that sustained antibody (Ab) secretion plays in our immune defenses against microbes and of the importance of vaccines that elicit Ab protection against infection. With this backdrop, it is especially timely to review aspects of the molecular programming that govern how the cells that secrete Abs arise, persist, and meet the challenge of secreting vast amounts of these glycoproteins. Whereas plasmablasts and plasma cells (PCs) are the primary sources of secreted Abs, the process leading to the existence of these cell types starts with naive B lymphocytes that proliferate and differentiate toward several potential fates. At each step, cells reside in specific microenvironments in which they not only receive signals from cytokines and other cell surface receptors but also draw on the interstitium for nutrients. Nutrients in turn influence flux through intermediary metabolism and sensor enzymes that regulate gene transcription, translation, and metabolism. This review will focus on nutrient supply and how sensor mechanisms influence distinct cellular stages that lead to PCs and their adaptations as factories dedicated to Ab secretion. Salient findings of this group and others, sometimes exhibiting differences, will be summarized with regard to the journey to a distinctive metabolic program in PCs.
MeSH term(s)	Antibody Formation ; COVID-19 ; Humans ; Immunoglobulins/metabolism ; Nutrients ; Plasma Cells ; Signal Transduction
Chemical Substances	Immunoglobulins
Language	English
Publishing date	2021-11-15
Publishing country	China
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2435097-7
ISSN	2042-0226 ; 1672-7681
ISSN (online)	2042-0226
ISSN	1672-7681
DOI	10.1038/s41423-021-00782-w
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Article: A Case-Control Study on the Changes in Natural Killer Cell Activity following Administration of Polyvalent Mechanical Bacterial Lysate in Korean Adults with Recurrent Respiratory Tract Infection.

Lee, Yun Kyong / Haam, Ji-Hee / Suh, Eunkyung / Cho, Sung Hoon / Kim, Young-Sang

Journal of clinical medicine

2022 Volume 11, Issue 11

Abstract: Polyvalent mechanical bacterial lysate (PMBL) is used for the treatment and prevention of recurrent respiratory tract infections. Although PMBL is an immunostimulant, it remains unknown whether treatment with PMBL influences natural killer cell activity ( ...

Abstract	Polyvalent mechanical bacterial lysate (PMBL) is used for the treatment and prevention of recurrent respiratory tract infections. Although PMBL is an immunostimulant, it remains unknown whether treatment with PMBL influences natural killer cell activity (NKA). Hence, this case-control study compared the changes in IFN-γ levels (surrogate index for NKA) following PMBL treatment or time passing between the PMBL-treated group and controls. The treatment group included adults who had a PMBL prescription for three months against recurrent respiratory tract infection from an outpatient clinic, while the control group had healthy adults visiting the health promotion center for periodic health check-ups. The control group (N = 506) showed no change in IFN-γ levels, while the treatment group (N = 301) showed a significant increase in mean from 462.8 to 749.3 pg/mL after PMBL treatment. In the subgroup with IFN-γ <500 pg/mL, IFN-γ levels significantly increased in both groups. However, the change in the treatment group (287 ± 822 pg/mL) was greater than that in the control group (58 ± 809 pg/mL), and the interaction between the visit and case/control was significant (p = 0.030) in a generalized estimating equation model. In conclusion, NKA increased in the subjects with recurrent respiratory tract infections with PMBL treatment.
Language	English
Publishing date	2022-05-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11113014
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Article ; Online: AMPKα1 in B Cells Dampens Primary Antibody Responses yet Promotes Mitochondrial Homeostasis and Persistence of B Cell Memory.

Brookens, Shawna K / Cho, Sung Hoon / Basso, Paulo J / Boothby, Mark R

Journal of immunology (Baltimore, Md. : 1950)

2020 Volume 205, Issue 11, Page(s) 3011–3022

Abstract: Emerging evidence indicates that metabolic programs regulate B cell activation and Ab responses. However, the metabolic mediators that support the durability of the memory B cell and long-lived plasma cell populations are not fully elucidated. Adenosine ... ...

Abstract	Emerging evidence indicates that metabolic programs regulate B cell activation and Ab responses. However, the metabolic mediators that support the durability of the memory B cell and long-lived plasma cell populations are not fully elucidated. Adenosine monophosphate-activated protein kinase (AMPK) is an evolutionary conserved serine/threonine kinase that integrates cellular energy status and nutrient availability to intracellular signaling and metabolic pathways. In this study, we use genetic mouse models to show that loss of ΑMPKα1 in B cells led to a weakened recall Ab response associated with a decline in the population of memory-phenotype B cells. AMPKα1-deficient memory B lymphocytes exhibited aberrant mitochondrial activity, decreased mitophagy, and increased lipid peroxidation. Moreover, loss of AMPKα1 in B lymphoblasts was associated with decreased mitochondrial spare respiratory capacity. Of note, AMPKα1 in B cells was dispensable for stability of the bone marrow-resident, long-lived plasma cell population, yet absence of this kinase led to increased rates of Ig production and elevated serum Ab concentrations elicited by primary immunization. Collectively, our findings fit a model in which AMPKα1 in B cells supports recall function of the memory B cell compartment by promoting mitochondrial homeostasis and longevity but restrains rates of Ig production.
MeSH term(s)	AMP-Activated Protein Kinases/immunology ; Animals ; Antibodies/immunology ; Antibody Formation/immunology ; B-Lymphocytes/immunology ; Bone Marrow/immunology ; Female ; Homeostasis/immunology ; Immunization/methods ; Immunoglobulins/immunology ; Immunologic Memory/immunology ; Lipid Peroxidation/immunology ; Male ; Mice ; Mitochondria/immunology ; Plasma Cells/immunology ; Protein Serine-Threonine Kinases/immunology ; Signal Transduction/immunology
Chemical Substances	Antibodies ; Immunoglobulins ; AMPK alpha1 subunit, mouse (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2020-11-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1901474
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