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  1. Book ; Online: Beyond Antimicrobials: Non-Traditional Approaches to Combating Multidrug-Resistant Bacteria

    Kirienko, Natalia V. / Rahme, Laurence / Cho, You-Hee

    2019  

    Keywords Science: general issues ; Infectious & contagious diseases ; Drug discovery ; Infectious Disease ; Anti-Virulence ; Anti-Infectives ; Host-Microbe Interactions
    Size 1 electronic resource (281 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230836
    ISBN 9782889632565 ; 2889632563
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Autolysis of

    Choi, Shin-Yae / Chung, In-Young / Bae, Hee-Won / Cho, You-Hee

    Journal of microbiology and biotechnology

    2024  Volume 34, Issue 4, Page(s) 795–803

    Abstract: Microorganisms usually coexist as a multifaceted polymicrobial community in the natural habitats and at mucosal sites of the human body. Two opportunistic human pathogens, ...

    Abstract Microorganisms usually coexist as a multifaceted polymicrobial community in the natural habitats and at mucosal sites of the human body. Two opportunistic human pathogens,
    MeSH term(s) Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/metabolism ; Pseudomonas aeruginosa/physiology ; Pseudomonas aeruginosa/drug effects ; Quorum Sensing ; Staphylococcus aureus/genetics ; Staphylococcus aureus/physiology ; Staphylococcus aureus/drug effects ; Iron/metabolism ; Mutation ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Humans ; Bacteriolysis ; Microbial Interactions ; DNA Transposable Elements
    Chemical Substances Iron (E1UOL152H7) ; Bacterial Proteins ; DNA Transposable Elements
    Language English
    Publishing date 2024-02-02
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2412195-2
    ISSN 1738-8872 ; 1738-8872
    ISSN (online) 1738-8872
    ISSN 1738-8872
    DOI 10.4014/jmb.2312.12028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An outer membrane determinant for RNA phage genome entry in

    Bae, Hee-Won / Choi, Shin-Yae / Cho, You-Hee

    iScience

    2023  Volume 27, Issue 1, Page(s) 108675

    Abstract: Host range of a phage is determined at the various life cycle stages during phage infection. We reported the limited phage-receptor interaction between the RNA phage, PP7 and its ... ...

    Abstract Host range of a phage is determined at the various life cycle stages during phage infection. We reported the limited phage-receptor interaction between the RNA phage, PP7 and its host
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.108675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Use of Cas9 Targeting and Red Recombination for Designer Phage Engineering.

    Choi, Shin-Yae / Romero-Calle, Danitza Xiomara / Cho, Han-Gyu / Bae, Hee-Won / Cho, You-Hee

    Journal of microbiology (Seoul, Korea)

    2024  Volume 62, Issue 1, Page(s) 1–10

    Abstract: Bacteriophages (phages) are natural antibiotics and biological nanoparticles, whose application is significantly boosted by recent advances of synthetic biology tools. Designer phages are synthetic phages created by genome engineering in a way to ... ...

    Abstract Bacteriophages (phages) are natural antibiotics and biological nanoparticles, whose application is significantly boosted by recent advances of synthetic biology tools. Designer phages are synthetic phages created by genome engineering in a way to increase the benefits or decrease the drawbacks of natural phages. Here we report the development of a straightforward genome engineering method to efficiently obtain engineered phages in a model bacterial pathogen, Pseudomonas aeruginosa. This was achieved by eliminating the wild type phages based on the Streptococcus pyogenes Cas9 (SpCas9) and facilitating the recombinant generation based on the Red recombination system of the coliphage λ (λRed). The producer (PD) cells of P. aeruginosa strain PAO1 was created by miniTn7-based chromosomal integration of the genes for SpCas9 and λRed under an inducible promoter. To validate the efficiency of the recombinant generation, we created the fluorescent phages from a temperate phage MP29. A plasmid bearing the single guide RNA (sgRNA) gene for selectively targeting the wild type gp35 gene and the editing template for tagging the Gp35 with superfolder green fluorescent protein (sfGFP) was introduced into the PD cells by electroporation. We found that the targeting efficiency was affected by the position and number of sgRNA. The fluorescent phage particles were efficiently recovered from the culture of the PD cells expressing dual sgRNA molecules. This protocol can be used to create designer phages in P. aeruginosa for both application and research purposes.
    MeSH term(s) Bacteriophages/genetics ; RNA, Guide, CRISPR-Cas Systems ; CRISPR-Cas Systems ; Plasmids/genetics ; Recombination, Genetic
    Chemical Substances RNA, Guide, CRISPR-Cas Systems
    Language English
    Publishing date 2024-02-01
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2012399-1
    ISSN 1976-3794 ; 1225-8873
    ISSN (online) 1976-3794
    ISSN 1225-8873
    DOI 10.1007/s12275-024-00107-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5211: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Pyocyanin and 1-Hydroxyphenazine Promote Anaerobic Killing of Pseudomonas aeruginosa via Single-Electron Transfer with Ferrous Iron.

    Kang, Jihee / Cho, You-Hee / Lee, Yunho

    Microbiology spectrum

    2022  , Page(s) e0231222

    Abstract: Previously, it was reported that natural phenazines are able to support the anaerobic survival of Pseudomonas aeruginosa PA14 cells via electron shuttling, with electrodes poised as the terminal oxidants (Y. Wang, S. E. Kern, and D. K. Newman, J ... ...

    Abstract Previously, it was reported that natural phenazines are able to support the anaerobic survival of Pseudomonas aeruginosa PA14 cells via electron shuttling, with electrodes poised as the terminal oxidants (Y. Wang, S. E. Kern, and D. K. Newman, J Bacteriol 192:365-369, 2010, https://doi.org/10.1128/JB.01188-09). The present study shows that both pyocyanin (PYO) and 1-hydroxyphenazine (1-OHPHZ) promoted the anaerobic killing of PA14 Δ
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02312-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Iron-Induced Respiration Promotes Antibiotic Resistance in Actinomycete Bacteria.

    Choi, Joon-Sun / Seok, Yeong-Jae / Cho, You-Hee / Roe, Jung-Hye

    mBio

    2022  Volume 13, Issue 2, Page(s) e0042522

    Abstract: The bacterial response to antibiotics eliciting resistance is one of the key challenges in global health. Despite many attempts to understand intrinsic antibiotic resistance, many of the underlying mechanisms still remain elusive. In this study, we found ...

    Abstract The bacterial response to antibiotics eliciting resistance is one of the key challenges in global health. Despite many attempts to understand intrinsic antibiotic resistance, many of the underlying mechanisms still remain elusive. In this study, we found that iron supplementation promoted antibiotic resistance in Streptomyces coelicolor. Iron-promoted resistance occurred specifically against bactericidal antibiotics, irrespective of the primary target of antibiotics. Transcriptome profiling revealed that some genes in the central metabolism and respiration were upregulated under iron-replete conditions. Iron supported the growth of S. coelicolor even under anaerobic conditions. In the presence of potassium cyanide, which reduces aerobic respiration of cells, iron still promoted respiration and antibiotic resistance. This suggests the involvement of a KCN-insensitive type of respiration in the iron effect. This phenomenon was also observed in another actinobacterium, Mycobacterium smegmatis. Taken together, these findings provide insight into a bacterial resistance strategy that mitigates the activity of bactericidal antibiotics whose efficacy accompanies oxidative damage by switching the respiration mode.
    MeSH term(s) Actinobacteria/metabolism ; Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/pharmacology ; Bacteria/genetics ; Drug Resistance, Microbial ; Iron/metabolism ; Oxygen/metabolism ; Respiration ; Streptomyces coelicolor/genetics ; Streptomyces coelicolor/metabolism
    Chemical Substances Anti-Bacterial Agents ; Iron (E1UOL152H7) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00425-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A TetR family regulator of an RND efflux system that directs artemisinin resistance in

    Chung, In-Young / Choi, Shin-Yae / Bae, Hee-Won / Cho, You-Hee

    mSystems

    2023  Volume 9, Issue 1, Page(s) e0085123

    Abstract: Artemisinin (ARS) displayed bactericidal activity ... ...

    Abstract Artemisinin (ARS) displayed bactericidal activity against
    MeSH term(s) Vibrio cholerae/genetics ; Bacterial Proteins/genetics ; Anti-Bacterial Agents/pharmacology ; Biological Transport ; Artemisinins/metabolism
    Chemical Substances Bacterial Proteins ; Anti-Bacterial Agents ; Artemisinins
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5077
    ISSN (online) 2379-5077
    DOI 10.1128/msystems.00851-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Chemokine CCL6 Plays Key Role in the Inhibitory Effect of Vitamin A on Norovirus Infection.

    Lee, Heetae / Lee, Giljae / Cho, You-Hee / Song, Youngcheon / Ko, GwangPyo

    Journal of microbiology (Seoul, Korea)

    2023  Volume 61, Issue 5, Page(s) 579–587

    Abstract: Norovirus (NoV) is the most common viral cause of acute gastroenteritis worldwide. Vitamin A has demonstrated the potential to protect against gastrointestinal infections. However, the effects of vitamin A on human norovirus (HuNoV) infections remain ... ...

    Abstract Norovirus (NoV) is the most common viral cause of acute gastroenteritis worldwide. Vitamin A has demonstrated the potential to protect against gastrointestinal infections. However, the effects of vitamin A on human norovirus (HuNoV) infections remain poorly understood. This study aimed to investigate how vitamin A administration affects NoV replication. We demonstrated that treatment with retinol or retinoic acid (RA) inhibited NoV replication in vitro based on their effects on HuNoV replicon-bearing cells and murine norovirus-1 (MNV-1) replication in murine cells. MNV replication in vitro showed significant transcriptomic changes, which were partially reversed by retinol treatment. RNAi knockdown of CCL6, a chemokine gene that was downregulated by MNV infection but upregulated by retinol administration, resulted in increased MNV replication in vitro. This suggested a role of CCL6 in the host response to MNV infections. Similar gene expression patterns were observed in the murine intestine after oral administration of RA and/or MNV-1.CW1. CCL6 directly decreased HuNoV replication in HG23 cells, and might indirectly regulate the immune response against NoV infection. Finally, relative replication levels of MNV-1.CW1 and MNV-1.CR6 were significantly increased in CCL6 knockout RAW 264.7 cells. This study is the first to comprehensively profile transcriptomes in response to NoV infection and vitamin A treatment in vitro, and thus may provide new insights into dietary prophylaxis and NoV infections.
    MeSH term(s) Animals ; Humans ; Mice ; Caliciviridae Infections/drug therapy ; Chemokines/pharmacology ; RAW 264.7 Cells ; Tretinoin ; Virus Replication ; Vitamin A/pharmacology
    Chemical Substances Chemokines ; Tretinoin (5688UTC01R) ; Vitamin A (11103-57-4) ; Ccl6 protein, mouse (139568-96-0)
    Language English
    Publishing date 2023-05-26
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2012399-1
    ISSN 1976-3794 ; 1225-8873
    ISSN (online) 1976-3794
    ISSN 1225-8873
    DOI 10.1007/s12275-023-00047-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5211: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Molecular microbiology in antibacterial research.

    Cho, You-Hee

    Journal of microbiology (Seoul, Korea)

    2014  Volume 52, Issue 3, Page(s) 185–187

    Abstract: The special issue of Journal of Microbiology contains six reviews dealing with cutting edge research achievements in the fields of molecular microbiology focusing on antibacterial research. In a more specific sense, this special issue helps outline the ... ...

    Abstract The special issue of Journal of Microbiology contains six reviews dealing with cutting edge research achievements in the fields of molecular microbiology focusing on antibacterial research. In a more specific sense, this special issue helps outline the progress of 21(st)-century basic molecular microbiology that can encompass related disciplines regarding a variety of interactions involving bacteria during bacterial pathogenesis and their control: sociomicrobiology (interaction between bacteria), immunology (interaction between bacteria and their hosts), and bacteriophage (phage) virology (interaction between bacteria and their parasites). Recent advancements have rapidly been made in our understanding of the real situation regarding polymicrobial interactions during bacterial infection and in non-mammalian host infection models to uncover the molecular mechanisms of host-bacteria interactions, which will complement our growing knowledge about immune responses toward bacterial and environmental elicitors. Moreover, much attention has recently been paid to phages and phage products as potential antibacterial therapeutics in the era of antibiotic resistance. Below, I summarize the individual contributions in these distinct categories.
    MeSH term(s) Bacteria/pathogenicity ; Bacteria/virology ; Bacterial Physiological Phenomena ; Bacteriophages/physiology ; Host-Parasite Interactions ; Host-Pathogen Interactions ; Microbial Interactions
    Language English
    Publishing date 2014-03-02
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2012399-1
    ISSN 1976-3794 ; 1225-8873
    ISSN (online) 1976-3794
    ISSN 1225-8873
    DOI 10.1007/s12275-014-4088-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5211: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: An iron-chelating sulfonamide identified from

    Yoo, Yeon-Ji / Chung, In-Young / Jalde, Shivakumar S / Choi, Hyun-Kyung / Cho, You-Hee

    Virulence

    2022  Volume 13, Issue 1, Page(s) 833–843

    Abstract: We exploited bacterial infection assays using the fruit ... ...

    Abstract We exploited bacterial infection assays using the fruit fly
    MeSH term(s) Animals ; Drosophila ; Drosophila melanogaster ; Iron ; Iron Chelating Agents/pharmacology ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/genetics ; Sulfonamides
    Chemical Substances Iron Chelating Agents ; Sulfonamides ; Iron (E1UOL152H7)
    Language English
    Publishing date 2022-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2022.2069325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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