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  1. Article: Anti-Inflammatory Effects of

    Lee, Ji Yun / Kim, Ji-Hyun / Choi, Ji Myung / Noh, Byeong Wook / Kim, Hyun Young / Cho, Eun Ju

    Foods (Basel, Switzerland)

    2024  Volume 13, Issue 7

    Abstract: Ulcerative colitis is a chronic inflammatory disease caused by abnormal immune responses in the intestinal mucosa and gut microorganisms. Unlike other mugworts, ...

    Abstract Ulcerative colitis is a chronic inflammatory disease caused by abnormal immune responses in the intestinal mucosa and gut microorganisms. Unlike other mugworts,
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods13070998
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effect of

    Choi, Ji Myung / Lee, Soo In / Cho, Eun Ju

    Journal of medicinal food

    2020  Volume 23, Issue 11, Page(s) 1155–1162

    Abstract: High-fat diet (HFD)-induced obesity is related to cognitive and memory dysfunction. Much attention was focused on functional foods as a therapeutic strategy to treat cognitive decline by obesity. In the present study, we confirmed the protective effect ... ...

    Abstract High-fat diet (HFD)-induced obesity is related to cognitive and memory dysfunction. Much attention was focused on functional foods as a therapeutic strategy to treat cognitive decline by obesity. In the present study, we confirmed the protective effect of
    MeSH term(s) Animals ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/etiology ; Diet, High-Fat/adverse effects ; Memory ; Mice ; Mice, Obese ; Plant Extracts/pharmacology ; Vigna/chemistry
    Chemical Substances Plant Extracts
    Language English
    Publishing date 2020-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1427365-2
    ISSN 1557-7600 ; 1096-620X
    ISSN (online) 1557-7600
    ISSN 1096-620X
    DOI 10.1089/jmf.2019.4644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5916: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: A Combination of Pharmacophore-Based Virtual Screening, Structure-Based Lead Optimization, and DFT Study for the Identification of

    Vuppala, Srimai / Kim, Jaeyoung / Joo, Bo-Sun / Choi, Ji-Myung / Jang, Joonkyung

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 5

    Abstract: The transcriptional regulator (TcaR) enzyme plays an important role in biofilm formation. Prevention of TcaR-DNA complex formation leads to inhibit the biofilm formation is likely to reveal therapeutic ways for the treatment of bacterial infections. To ... ...

    Abstract The transcriptional regulator (TcaR) enzyme plays an important role in biofilm formation. Prevention of TcaR-DNA complex formation leads to inhibit the biofilm formation is likely to reveal therapeutic ways for the treatment of bacterial infections. To identify the novel ligands for TcaR and to provide a new idea for drug design, two efficient drug design methods, such as pharmacophore modeling and structure-based drug design, were used for virtual screening of database and lead optimization, respectively. Gemifloxacin (FDA-approved drug) was considered to generate the pharmacophore model for virtual screening of the ZINC database, and five hits, namely ZINC77906236, ZINC09550296, ZINC77906466, ZINC09751390, and ZINC01269201, were identified as novel inhibitors of TcaR with better binding energies. Using structure-based drug design, a set of 7a-7p inhibitors of
    Language English
    Publishing date 2022-05-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15050635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycetes), Protects Aβ1-42-Induced Neurologic Damage in C6 Glial Cells.

    He, Mei Tong / Park, Chan Hum / Shin, Yu Su / Choi, Ji Myung / Cho, Eun Ju

    International journal of medicinal mushrooms

    2021  Volume 22, Issue 12, Page(s) 1203–1213

    Abstract: Alzheimer's disease (AD) shows neurological symptoms common to cognitive disorders and memory loss. Several hypotheses have suggested that the accumulation of amyloid-beta peptide (Aβ) and reduction of acetylcholine synthesis cause AD. Natural ... ...

    Abstract Alzheimer's disease (AD) shows neurological symptoms common to cognitive disorders and memory loss. Several hypotheses have suggested that the accumulation of amyloid-beta peptide (Aβ) and reduction of acetylcholine synthesis cause AD. Natural ingredients, such as Cordyceps militaris, have been widely used for AD treatment. Herein, we investigated the protective role of C. militaris against neural dysfunction. First, Aβ1-42 peptide solution was incubated at 37°C for 3 days for aggregation. Next, C6 glial cells were treated with 25 μM of Aβ1-42 solution, followed by the addition of C. militaris ethanol extract (0.5, 1, 1.25, and 2.5 μg/mL); the cell viability, reactive oxygen species (ROS) production, and protein expressions were then evaluated. Reduction of viability of, and ROS generation in, Aβ1-42-treated cells were observed and compared with those in the control group. The expression levels of inducible nitric oxide synthase and cyclooxygenase-2, as well as those of phospho-p38 mitogen-activated protein kinase and phospho-c-Jun N-terminal kinase, were reduced in C. militaris-treated glial cells. Moreover, the expression of brain-derived neurotrophic factor in the C. militaris-treated cells was significantly higher than that in the control group. Thus, our findings indicate that C. militaris has the potential to protect Aβ-induced neurological damage.
    Language English
    Publishing date 2021-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2108803-2
    ISSN 1940-4344 ; 1521-9437
    ISSN (online) 1940-4344
    ISSN 1521-9437
    DOI 10.1615/IntJMedMushrooms.2020037055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7482: Show issues

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  5. Article: Effect of Vigna angularis on High-Fat Diet-Induced Memory and Cognitive Impairments

    Choi, Ji Myung / Lee, Soo In / Cho, Eun Ju

    Journal of medicinal food. 2020 Nov. 01, v. 23, no. 11

    2020  

    Abstract: High-fat diet (HFD)-induced obesity is related to cognitive and memory dysfunction. Much attention was focused on functional foods as a therapeutic strategy to treat cognitive decline by obesity. In the present study, we confirmed the protective effect ... ...

    Abstract High-fat diet (HFD)-induced obesity is related to cognitive and memory dysfunction. Much attention was focused on functional foods as a therapeutic strategy to treat cognitive decline by obesity. In the present study, we confirmed the protective effect of Vigna angularis (VA) on cognitive and memory impairment in an obese mouse model. For 16 weeks, mice were fed HFD and VA extract was administered during 4 weeks at 100 and 200 mg/kg. The cognitive abilities of HFD-induced mice were evaluated using behavioral tests. Compared with the control group, VA groups were improved spatial and recognition ability. In T-maze and novel object recognition tests, VA 100 and VA 200 groups showed increased ratios of exploration of a novel object/route compared to a familiar object/route. Moreover, VA 100 and VA 200 groups reached the platform faster than the control group in a Morris water maze test. Therefore, VA extract may protect against HFD-induced cognitive impairment and memory dysfunction. (PNU-IACUC; approval no. PNU-2019-2166).
    Keywords Vigna angularis ; cognition ; cognitive disorders ; functional foods ; high fat diet ; memory ; memory disorders ; mice ; obesity ; protective effect ; therapeutics
    Language English
    Dates of publication 2020-1101
    Size p. 1155-1162.
    Publishing place Mary Ann Liebert, Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1427365-2
    ISSN 1557-7600 ; 1096-620X
    ISSN (online) 1557-7600
    ISSN 1096-620X
    DOI 10.1089/jmf.2019.4644
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5916: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Cirsium japonicum

    Pang, Qi Qi / Kim, Ji-Hyun / Choi, Ji Myung / Song, Jia-Le / Lee, Sanghyun / Cho, Eun Ju

    BioMed research international

    2022  Volume 2022, Page(s) 4513998

    Abstract: Abnormal production and degradation of amyloid beta ( ... ...

    Abstract Abnormal production and degradation of amyloid beta (A
    MeSH term(s) Alzheimer Disease/chemically induced ; Alzheimer Disease/drug therapy ; Alzheimer Disease/physiopathology ; Amyloid beta-Peptides/toxicity ; Animals ; Cirsium/chemistry ; Cognitive Dysfunction/chemically induced ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/physiopathology ; Disease Models, Animal ; Humans ; Male ; Mice ; Mice, Inbred ICR ; Peptide Fragments/toxicity ; Plant Extracts/chemistry ; Plant Extracts/pharmacology
    Chemical Substances Amyloid beta-Peptides ; Peptide Fragments ; Plant Extracts ; amyloid beta-protein (25-35)
    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2022/4513998
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Membrane-Free Stem Cells and Pyridoxal 5'-Phosphate Synergistically Enhance Cognitive Function in Alzheimer's Disease Mouse Model.

    Choi, Ji Myung / Park, Hye Sook / He, Mei Tong / Kim, Young Sil / Kim, Hyun Young / Lee, Ah Young / Cho, Eun Ju

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 3

    Abstract: Accumulation of amyloid beta (Aβ) is a major pathological hallmark of Alzheimer's disease (AD). In this study, we evaluated the protective effect of membrane-free stem cell extract (MFSCE), which is a component of adipose-tissue-derived stem cells, on ... ...

    Abstract Accumulation of amyloid beta (Aβ) is a major pathological hallmark of Alzheimer's disease (AD). In this study, we evaluated the protective effect of membrane-free stem cell extract (MFSCE), which is a component of adipose-tissue-derived stem cells, on cognitive impairment in Aβ
    Language English
    Publishing date 2022-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11030601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Membrane-Free Stem Cells and Pyridoxal 5′-Phosphate Synergistically Enhance Cognitive Function in Alzheimer’s Disease Mouse Model

    Choi, Ji Myung / Park, Hye Sook / He, Mei Tong / Kim, Young Sil / Kim, Hyun Young / Lee, Ah Young / Cho, Eun Ju

    Antioxidants. 2022 Mar. 21, v. 11, no. 3

    2022  

    Abstract: Accumulation of amyloid beta (Aβ) is a major pathological hallmark of Alzheimer’s disease (AD). In this study, we evaluated the protective effect of membrane-free stem cell extract (MFSCE), which is a component of adipose-tissue-derived stem cells, on ... ...

    Abstract Accumulation of amyloid beta (Aβ) is a major pathological hallmark of Alzheimer’s disease (AD). In this study, we evaluated the protective effect of membrane-free stem cell extract (MFSCE), which is a component of adipose-tissue-derived stem cells, on cognitive impairment in Aβ₂₅–₃₅-injected AD mice. The ICR mice were i.c.v. injected with Aβ₂₅–₃₅ and then treated with MFSCE for 14 days (i.p.). The Aβ₂₅–₃₅-injected mice showed deficits in spatial and object perception abilities, whereas treatment with MFSCE inhibited Aβ₂₅–₃₅-induced learning and memory impairment in the T-maze, novel object recognition, and Morris water maze tests. Moreover, Aβ₂₅–₃₅-induced lipid peroxidation and nitric oxide overproduction were attenuated by treatment with MFSCE. These antioxidant effects of MFSCE were related to the inhibition of the apoptotic signaling pathway. In particular, the combination treatment of MFSCE and pyridoxal 5′-phosphate (PLP) showed greater suppression of Bax and cleaved caspase-3 protein expression compared to the MFSCE- or PLP-only treatment. Furthermore, the MFSCE and PLP combination significantly downregulated the amyloidogenic-pathway-related protein expressions, such as amyloid precursor protein, presenilin 1, and presenilin 2. Therefore, the MFSCE and PLP combination may synergistically prevent Aβ₂₅–₃₅-induced neuronal apoptosis and amyloidogenesis, which contributes to cognitive improvement and has potential therapeutic implications for AD patients.
    Keywords amyloid ; antioxidants ; apoptosis ; caspase-3 ; cognition ; cognitive disorders ; lipid peroxidation ; memory disorders ; mice ; neurons ; nitric oxide ; protective effect ; protein synthesis ; pyridoxal ; stem cells ; therapeutics
    Language English
    Dates of publication 2022-0321
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11030601
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Beneficial effect of black rice (

    Lee, Ah Young / Choi, Ji Myung / Lee, Young A / Shin, Seon Hwa / Cho, Eun Ju

    Experimental and therapeutic medicine

    2020  Volume 20, Issue 5, Page(s) 64

    Abstract: Alzheimer's disease (AD) is an age-dependent progressive neurodegenerative disease, resulting in memory loss and cognitive dysfunction. The accumulation of amyloid β (Aβ) has been identified as the most important risk factor for AD. Black rice (BR; ...

    Abstract Alzheimer's disease (AD) is an age-dependent progressive neurodegenerative disease, resulting in memory loss and cognitive dysfunction. The accumulation of amyloid β (Aβ) has been identified as the most important risk factor for AD. Black rice (BR;
    Language English
    Publishing date 2020-09-09
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2020.9192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Computer simulation approach to the identification of visfatin-derived angiogenic peptides.

    Choi, Ji Myung / Vuppala, Srimai / Park, Min Jung / Kim, Jaeyoung / Jegal, Myeong-Eun / Han, Yu-Seon / Kim, Yung-Jin / Jang, Joonkyung / Jeong, Min-Ho / Joo, Bo Sun

    PloS one

    2023  Volume 18, Issue 6, Page(s) e0287577

    Abstract: Angiogenesis plays an essential role in various normal physiological processes, such as embryogenesis, tissue repair, and skin regeneration. Visfatin is a 52 kDa adipokine secreted by various tissues including adipocytes. It stimulates the expression of ... ...

    Abstract Angiogenesis plays an essential role in various normal physiological processes, such as embryogenesis, tissue repair, and skin regeneration. Visfatin is a 52 kDa adipokine secreted by various tissues including adipocytes. It stimulates the expression of vascular endothelial growth factor (VEGF) and promotes angiogenesis. However, there are several issues in developing full-length visfatin as a therapeutic drug due to its high molecular weight. Therefore, the purpose of this study was to develop peptides, based on the active site of visfatin, with similar or superior angiogenic activity using computer simulation techniques.Initially, the active site domain (residues 181∼390) of visfatin was first truncated into small peptides using the overlapping technique. Subsequently, the 114 truncated small peptides were then subjected to molecular docking analysis using two docking programs (HADDOCK and GalaxyPepDock) to generate small peptides with the highest affinity for visfatin. Furthermore, molecular dynamics simulations (MD) were conducted to investigate the stability of the protein-ligand complexes by computing root mean square deviation (RSMD) and root mean square fluctuation(RMSF) plots for the visfatin-peptide complexes. Finally, peptides with the highest affinity were examined for angiogenic activities, such as cell migration, invasion, and tubule formation in human umbilical vein endothelial cells (HUVECs). Through the docking analysis of the 114 truncated peptides, we screened nine peptides with a high affinity for visfatin. Of these, we discovered two peptides (peptide-1: LEYKLHDFGY and peptide-2: EYKLHDFGYRGV) with the highest affinity for visfatin. In an in vitrostudy, these two peptides showed superior angiogenic activity compared to visfatin itself and stimulated mRNA expressions of visfatin and VEGF-A. These results show that the peptides generated by the protein-peptide docking simulation have a more efficient angiogenic activity than the original visfatin.
    MeSH term(s) Humans ; Vascular Endothelial Growth Factor A ; Angiogenic Proteins ; Nicotinamide Phosphoribosyltransferase ; Molecular Docking Simulation ; Endothelial Cells ; Molecular Dynamics Simulation
    Chemical Substances Vascular Endothelial Growth Factor A ; Angiogenic Proteins ; Nicotinamide Phosphoribosyltransferase (EC 2.4.2.12)
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0287577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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