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Article: MicroRNA-765 is upregulated in myelodysplastic syndromes and induces apoptosis via PLP2 inhibition in leukemia cells.

Kang, Seong-Ho / Choi, Ji Seon

2023 Volume 58, Issue 3, Page(s) 133–137

Abstract: Background: Epigenetic studies, particularly research on microRNA (miRNA), have flourished. The abnormal expression of miRNA contributes to the development of hematologic malignancies. miR-765 has been reported to inhibit cell proliferation by ... ...

Abstract	Background: Epigenetic studies, particularly research on microRNA (miRNA), have flourished. The abnormal expression of miRNA contributes to the development of hematologic malignancies. miR-765 has been reported to inhibit cell proliferation by downregulating proteolipid protein 2 (PLP2), which causes apoptosis. We investigated miR-765 dysregulation in myelodysplastic syndromes (MDS). Methods: We compared the expression profiles of miR-765 in 65 patients with MDS and 11 controls. Cell proliferation and apoptosis assays were performed to determine the Results: We found that miR-765 levels were upregulated 10.2-fold in patients with MDS compared to controls. In refractory cytopenia with multilineage dysplasia, the percentage of patients with elevated miR-765 levels was significantly higher than in other forms of MDS. Experiments with leukemia cells revealed that transfection with a miR-765 mimic inhibited cell proliferation and induced apoptosis. RT-qPCR and western blotting demonstrated that the target of miR-765 was PLP2. Conclusion: These findings imply that upregulation of miR-765 induces apoptosis via downregulation of PLP2 and may have a role in MDS pathogenesis.
Language	English
Publishing date	2023-07-27
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2711910-5
ISSN	2288-0011 ; 2287-979X
ISSN (online)	2288-0011
ISSN	2287-979X
DOI	10.5045/br.2023.2023097
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Article ; Online: Upregulation of microRNA-597 in myelodysplastic syndromes induces apoptosis through FOSL2 inhibition.

Kang, Seong-Ho / Kim, Hong-Beum / Choi, Ji Seon

European journal of haematology

2022 Volume 109, Issue 6, Page(s) 680–685

Abstract: Introduction: Dysregulation of microRNAs (miRNAs) has been associated with the pathophysiology of myelodysplastic syndrome (MDS). Trisomy 8 is the most frequent chromosomal abnormalities in Korean patients with MDS. We investigated the dysregulation of ... ...

Abstract	Introduction: Dysregulation of microRNAs (miRNAs) has been associated with the pathophysiology of myelodysplastic syndrome (MDS). Trisomy 8 is the most frequent chromosomal abnormalities in Korean patients with MDS. We investigated the dysregulation of miR-597-5p, located on chromosome 8, which is reported to induce cell death in numerous cancers. Materials and methods: We compared the expression profiles of miR-597-5p among 65 MDS patients and 11 controls, and analyzed the in vitro effects of miR-597 on leukemic cells using an acute myeloid leukemia cell line transfected with miR-597. Results: We found that miR-597-5p levels were upregulated 4.05-fold in MDS patients compared to those in controls. In vitro study results demonstrated that transfection with a miR-597 mimic induced apoptosis through downregulation of FOS like 2 (FOSL2). Conclusion: These findings suggest that upregulation of miR-597 induces apoptosis and that miR-597 has a possible role in the pathophysiology of MDS.
MeSH term(s)	Humans ; Apoptosis ; Fos-Related Antigen-2/genetics ; Fos-Related Antigen-2/metabolism ; Leukemia, Myeloid, Acute/genetics ; MicroRNAs/genetics ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/metabolism ; Transcription Factors/genetics ; Up-Regulation
Chemical Substances	Fos-Related Antigen-2 ; FOSL2 protein, human ; MicroRNAs ; Transcription Factors ; MIRN597 microRNA, human
Language	English
Publishing date	2022-09-07
Publishing country	England
Document type	Journal Article
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/ejh.13852
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Article: Evaluation of physicochemical and textural properties of chicken breast sausages containing various combinations of salt and sodium tripolyphosphate.

Choi, Ji Seon / Chin, Koo Bok

Journal of animal science and technology

2020 Volume 62, Issue 4, Page(s) 577–586

Abstract: This study was to investigate the effect of salt alone or in combination with phosphate on physicochemical and textural properties, and chemical interactions of low-fat model sausages. pH, color, expressible moisture (EM), cooking loss (CL), proximate ... ...

Abstract	This study was to investigate the effect of salt alone or in combination with phosphate on physicochemical and textural properties, and chemical interactions of low-fat model sausages. pH, color, expressible moisture (EM), cooking loss (CL), proximate analysis, textural profile analysis and low-vacuum scanning electron microscopy were performed. As salt content increased, color tended to decrease, as did EM and CL parameters, indicating that the ability to retain moisture was improved with increased salt levels (
Language	English
Publishing date	2020-07-31
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2775231-8
ISSN	2055-0391
ISSN	2055-0391
DOI	10.5187/jast.2020.62.4.577
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Article: Structural changes of meat protein of chicken sausages with various levels of salt and phosphate and their effects on in vitro digestion

Choi, Ji Seon / Chin, Koo Bok

International journal of food science & technology. 2021 Oct., v. 56, no. 10

2021

Abstract: The objectives of this study were to evaluate protein oxidation and in vitro digestibility of chicken sausages with various salt/phosphate combinations. Hydrophobicity increased when protein was cooked and denatured (P < 0.05). Protein oxidation was ... ...

Abstract	The objectives of this study were to evaluate protein oxidation and in vitro digestibility of chicken sausages with various salt/phosphate combinations. Hydrophobicity increased when protein was cooked and denatured (P < 0.05). Protein oxidation was increased based on levels of SH, S‐S and carbonyl groups during the cooking process (P < 0.05). Sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS‐PAGE) revealed that the intensity of myosin heavy chain band was decreased while biopolymer band was denser when sausages were cooked. Sausages with 1.8% salt and 0.3% phosphate (S1P1) showed the lowest digestibility and maintained a flat and compact structure, unlike other treatments during the gastrointestinal digestive stage. SDS‐PAGE of digested chicken sausages showed that protein bands were degraded into small bands followed by gradual disappearance. In conclusion, cooking process can lead to protein denaturation and oxidation, regardless of levels of salt and phosphate added. In addition, adding salt and phosphate can significantly affect the digestibility of meat products.
Keywords	biopolymers ; chickens ; digestion ; gastrointestinal system ; hydrophobicity ; meat ; meat protein ; myosin heavy chains ; oxidation ; phosphates ; polyacrylamide gel electrophoresis ; protein denaturation ; sodium dodecyl sulfate
Language	English
Dates of publication	2021-10
Size	p. 5250-5258.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	883561-5
ISSN	0950-5423
ISSN	0950-5423
DOI	10.1111/ijfs.15181
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Article ; Online: MicroRNA-661 upregulation in myelodysplastic syndromes induces apoptosis through p53 activation and associates with decreased overall survival.

Kang, Seong-Ho / Choi, Ji-Seon

Leukemia & lymphoma

2019 Volume 60, Issue 11, Page(s) 2779–2786

Abstract: MicroRNA (miRNA) dysregulation contributes to myelodysplastic syndromes (MDS), and apoptosis is one of the pathogenic features of MDS. We investigated the dysregulation of miRNA expression and its biological significance in MDS. We compared the ... ...

Abstract	MicroRNA (miRNA) dysregulation contributes to myelodysplastic syndromes (MDS), and apoptosis is one of the pathogenic features of MDS. We investigated the dysregulation of miRNA expression and its biological significance in MDS. We compared the expression profiles of miRNAs encoded by chromosome 8 in 65 patients with MDS and 11 controls, and analyzed the
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Case-Control Studies ; Female ; Follow-Up Studies ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; MicroRNAs/genetics ; Middle Aged ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/metabolism ; Myelodysplastic Syndromes/mortality ; Myelodysplastic Syndromes/pathology ; Prognosis ; Survival Rate ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Young Adult
Chemical Substances	Biomarkers, Tumor ; MIRN661 microRNA, human ; MicroRNAs ; TP53 protein, human ; Tumor Suppressor Protein p53
Language	English
Publishing date	2019-05-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2019.1608528
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Article ; Online: Evaluation of Gelation Properties of Salt-Soluble Proteins Extracted from

Choi, Ji Seon / Kim, Geon Ho / Kim, Ha Eun / Kim, Min Jae / Chin, Koo Bok

Food science of animal resources

2023 Volume 43, Issue 6, Page(s) 1031–1043

Abstract: The purpose of this study was to investigate the functional properties of salt-soluble proteins obtained ... ...

Abstract	The purpose of this study was to investigate the functional properties of salt-soluble proteins obtained from
Language	English
Publishing date	2023-11-01
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3016289-0
ISSN	2636-0780 ; 2636-0772
ISSN (online)	2636-0780
ISSN	2636-0772
DOI	10.5851/kosfa.2023.e69
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Article ; Online: Evaluation of tongue mobility following release operation of ankyloglossia with genioglossus myotomy.

Choi, Ji Seon / Park, Ji Hwan / Kim, Min Cheol / Lim, Jin Soo / Shim, Hyung-Sup

Medicine

2022 Volume 101, Issue 32, Page(s) e29648

Abstract: Ankyloglossia is a congenital anomaly characterized by a short lingual frenulum and severe form needs release surgery. Our goal in this study was to confirm the long-term safety and efficacy of Z-plasty with genioglossus myotomy compared with traditional ...

Abstract	Ankyloglossia is a congenital anomaly characterized by a short lingual frenulum and severe form needs release surgery. Our goal in this study was to confirm the long-term safety and efficacy of Z-plasty with genioglossus myotomy compared with traditional Z-plasty alone and to develop a proper measurement tool to validate the postoperative results of release operations for ankyloglossia. Patients were divided in 2 groups, release with Z-plasty only group (group 1) and Z-plasty combined with genioglossus myotomy group (group 2) In group 2, the release of central longitudinal fiber of genioglossus muscle was added in the conventional Z-plasty operative procedure. To analyze the results of the surgery, we developed an objective assessment tool which is the direct length from the innermost point of the floor of mouth to the tip of the tongue, preoperatively and postoperatively, which is called "functional tongue length." A total of 101 patients with ankyloglossia ranging in age from 36 months to 8 years underwent release operation. Although there was no significant difference in terms of postoperative measurements between groups in Kotlow class II, group 2 patients in Class III and IV showed greater postoperative functional tongue length. Also, there was no significant complication requiring secondary surgery. Our study demonstrated that adding genioglossus myotomy to a simple Z-plasty is a safe and effective method for improving the tongue mobility required to make lingual sounds, especially in moderate to severe form of ankyloglossia, along with suggestion of a new measurement tool, which can objectively assess tongue mobility with possibility for universal utilization in ankyloglossia release operation.
MeSH term(s)	Ankyloglossia/surgery ; Humans ; Lingual Frenum/abnormalities ; Lingual Frenum/surgery ; Myotomy ; Tongue/surgery ; Tongue Diseases
Language	English
Publishing date	2022-08-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000029648
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Article ; Online: Resurfacing of lower extremities: Versatility of thigh flap as pedicle extension graft with consecutive thoracodorsal artery perforator-based flap.

Choi, Ji Seon / Seo, Hyun Joon / Park, Ji Ah / Kim, Youn Hwan / Shim, Hyung-Sup

Microsurgery

2022 Volume 42, Issue 8, Page(s) 783–792

Abstract: Background: For successful microsurgical reconstruction using free tissue transfer, healthy recipient vessels must be obtained from outside the zone of injury. Securing an appropriate length pedicle length is also essential, and various techniques for ... ...

Abstract	Background: For successful microsurgical reconstruction using free tissue transfer, healthy recipient vessels must be obtained from outside the zone of injury. Securing an appropriate length pedicle length is also essential, and various techniques for lengthening a vascular pedicle have been developed. Herein, we present our experience using the descending branch (DB) of the lateral circumflex femoral vessels (LCFVs) with a thigh flap as an extender graft for consecutive second flap. Methods: We reconstructed the complex and vessel-depleted defects of nine patients. The mean age was 47.6 years. The defects were located in the lower leg in four patients, in the perineum in two patients and in the forearm in three patients. The two patients who suffered from Fournier's gangrene underwent a pedicled anteromedial thigh (pAMT) flap with the DB of the LCFVs and seven patients, five who suffered high-energy trauma and two who had scar contracture, underwent a free anterolateral thigh (ALT) flap with the distal run-off DB of the LCFVs. In all patients, second consecutive free latissimus dorsi or thoracodorsal artery perforator flaps were prepared and the thoracodorsal vessels of the second flap were anastomosed to the distal DB of the LCFVs. Results: The total length of the thigh flap pedicles measured from both ends of the DB of the LCFVs varied from 15 to 20 cm, which was sufficient for use as a vascular conduit. Of the 18 flaps, 17 survived completely without any complications and 1 pAMT flap showed partial necrosis, which was covered with a perineal perforator-based island flap. The mean follow-up period was 16.7 months. Unfortunately, one patient, who suffered a total amputation below the knee and had replantation surgery, underwent amputation due to venous congestion in the distal leg. However, the previous two flaps survived and were used for coverage of the stump. Conclusions: Using a thigh flap as a vascular extender graft for second flap may be an alternative option in vessel-depleted reconstructions.
MeSH term(s)	Male ; Humans ; Middle Aged ; Perforator Flap/blood supply ; Thigh/surgery ; Reconstructive Surgical Procedures/methods ; Soft Tissue Injuries/surgery ; Lower Extremity/surgery ; Femoral Artery/surgery ; Treatment Outcome
Language	English
Publishing date	2022-09-10
Publishing country	United States
Document type	Case Reports
ZDB-ID	605524-2
ISSN	1098-2752 ; 0738-1085
ISSN (online)	1098-2752
ISSN	0738-1085
DOI	10.1002/micr.30958
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Article ; Online: Strategy for resurfacing complex extremity defect with chimeric, linked flaps: A review with a 10-year experience at major trauma center.

Choi, Ji Seon / An, Jung Kwon / Park, Ji Ah / Chang, Lan Sook / Kim, Youn Hwan / Shim, Hyung-Sup

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2023 Volume 80, Page(s) 107–114

Abstract: For the reconstruction of the extensive and/or three-dimensional soft-tissue defect in upper and lower extremities, chimeric flaps composed of multiple flaps or tissues with separate vascular supplies can supply economical use of tissue and superior ... ...

Abstract	For the reconstruction of the extensive and/or three-dimensional soft-tissue defect in upper and lower extremities, chimeric flaps composed of multiple flaps or tissues with separate vascular supplies can supply economical use of tissue and superior esthetic results. Herein, we investigated the effectiveness of the thoracodorsal axis chimeric flap through the review the largest collection of long-term data. A retrospective review of all patients who received the thoracodorsal axis chimeric flap in complex three-dimensional defects of extremities between January of 2012 and December of 2021. A total of 55 type I/IP classical chimeric flaps, 19 type II/IIP anastomotic chimeric flaps, five type III perforator chimeric flaps, and seven type IV mixed chimeric flaps were analyzed. As the reconstructed area became proximal, flap dimensions increased significantly. And the optimal flap type depended on the location. The TDAp flap can provide large dimensions of skin paddle with latissimus dorsi and serratus anterior muscles with acceptable donor-site morbidities. The TDAp chimeric flaps constructed by microvascular anastomosis of two free flaps can provide large skin dimensions but also tissues with different properties. These characteristics make it possible to resurface the large and extensive defects, reconstruct the complex distal extremity defects, needing tissues with different properties, and cover the three-dimensional defect, obliterating the dead space. The thoracodorsal axis chimeric flap could be a favorable option for extensive, complex, or three-dimensional defects of the upper and lower extremities based on its reliability of the vascular system.
MeSH term(s)	Humans ; Reproducibility of Results ; Trauma Centers ; Free Tissue Flaps/blood supply ; Perforator Flap/blood supply ; Lower Extremity ; Soft Tissue Injuries/surgery
Language	English
Publishing date	2023-02-28
Publishing country	Netherlands
Document type	Review ; Journal Article
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2023.02.027
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Article: Correction of post-traumatic enophthalmos with anatomical absorbable implant and iliac bone graft.

Choi, Ji Seon / Oh, Se Young / Shim, Hyung-Sup

Archives of craniofacial surgery

2019 Volume 20, Issue 6, Page(s) 361–369

Abstract: Background: Trauma is one of the most common causes of enophthalmos, and post-traumatic enophthalmos primarily results from an increased volume of the bony orbit. We achieved good long-term results by simultaneously using an anatomical absorbable ... ...

Abstract	Background: Trauma is one of the most common causes of enophthalmos, and post-traumatic enophthalmos primarily results from an increased volume of the bony orbit. We achieved good long-term results by simultaneously using an anatomical absorbable implant and iliac bone graft to correct post-traumatic enophthalmos. Methods: From January 2012 to December 2016, we performed operations on seven patients with post-traumatic enophthalmos. In all seven cases, reduction surgery for the initial trauma was performed at our hospital. Hertel exophthalmometry, clinical photography, three-dimensional computed tomography (3D-CT), and orbital volume measurements using software to calculate the specific volume captured on 3D-CT (ITK-SNAP, Insight Toolkit-SNAP) were performed preoperatively and postoperatively. Results: Patients were evaluated based on exophthalmometry, clinical photographs, 3D-CT, and orbital volume measured by the ITK-SNAP program at 5 days and 1 year postoperatively, and all factors improved significantly compared with the preoperative baseline. Complications such as hematoma or extraocular muscle limitation were absent, and the corrected orbital volume was well maintained at the 1-year follow-up visit. Conclusion: We present a method to correct enophthalmos by reconstructing the orbital wall using an anatomical absorbable implant and a simultaneous autologous iliac bone graft. All cases showed satisfactory results for enophthalmos correction. We suggest this method as a good option for the correction of post-traumatic enophthalmos.
Language	English
Publishing date	2019-12-20
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2800630-6
ISSN	2287-5603 ; 2287-1152
ISSN (online)	2287-5603
ISSN	2287-1152
DOI	10.7181/acfs.2019.00451
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