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  1. AU="Choi, Jinyong"
  2. AU="González-Mansilla, Ana"
  3. AU="Cho Kilwon"
  4. AU="Rachide Onadja, Palamanga Abdoul"
  5. AU="Bertacca, Sofia"
  6. AU="Bansal, Ayush"
  7. AU="Liao, Naikai"
  8. AU="Gomes, Lux Attiê Santos"
  9. AU="İdil Su Canıtez"
  10. AU="Baptiste Duceau"
  11. AU="Pedro Seoane-Zonjic"
  12. AU="Guthridge, Carla J"
  13. AU=Meena Netra P.
  14. AU="Boustany, Tara"

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  1. Artikel: Cytokines in Follicular Helper T Cell Biology in Physiologic and Pathologic Conditions.

    Choi, Jinyong / Crotty, Shane / Choi, Youn Soo

    Immune network

    2024  Band 24, Heft 1, Seite(n) e8

    Abstract: Follicular helper T cells (Tfh) play a crucial role in generating high-affinity antibodies (Abs) and establishing immunological memory. Cytokines, among other functional molecules produced by Tfh, are central to germinal center (GC) reactions. This ... ...

    Abstract Follicular helper T cells (Tfh) play a crucial role in generating high-affinity antibodies (Abs) and establishing immunological memory. Cytokines, among other functional molecules produced by Tfh, are central to germinal center (GC) reactions. This review focuses on the role of cytokines, including IL-21 and IL-4, in regulating B cell responses within the GC, such as differentiation, affinity maturation, and plasma cell development. Additionally, this review explores the impact of other cytokines like CXCL13, IL-10, IL-9, and IL-2 on GC responses and their potential involvement in autoimmune diseases, allergies, and cancer. This review highlights contributions of Tfh-derived cytokines to both protective immunity and immunopathology across a spectrum of diseases. A deeper understanding of Tfh cytokine biology holds promise for insights into biomedical conditions.
    Sprache Englisch
    Erscheinungsdatum 2024-02-14
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2536191-0
    ISSN 2092-6685 ; 1598-2629
    ISSN (online) 2092-6685
    ISSN 1598-2629
    DOI 10.4110/in.2024.24.e8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Single-cell and spatial sequencing application in pathology.

    Kim, Yoon-Seob / Choi, Jinyong / Lee, Sug Hyung

    Journal of pathology and translational medicine

    2023  Band 57, Heft 1, Seite(n) 43–51

    Abstract: Traditionally, diagnostic pathology uses histology representing structural alterations in a disease's cells and tissues. In many cases, however, it is supplemented by other morphology-based methods such as immunohistochemistry and fluorescent in situ ... ...

    Abstract Traditionally, diagnostic pathology uses histology representing structural alterations in a disease's cells and tissues. In many cases, however, it is supplemented by other morphology-based methods such as immunohistochemistry and fluorescent in situ hybridization. Single-cell RNA sequencing (scRNA-seq) is one of the strategies that may help tackle the heterogeneous cells in a disease, but it does not usually provide histologic information. Spatial sequencing is designed to assign cell types, subtypes, or states according to the mRNA expression on a histological section by RNA sequencing. It can provide mRNA expressions not only of diseased cells, such as cancer cells but also of stromal cells, such as immune cells, fibroblasts, and vascular cells. In this review, we studied current methods of spatial transcriptome sequencing based on their technical backgrounds, tissue preparation, and analytic procedures. With the pathology examples, useful recommendations for pathologists who are just getting started to use spatial sequencing analysis in research are provided here. In addition, leveraging spatial sequencing by integration with scRNA-seq is reviewed. With the advantages of simultaneous histologic and single-cell information, spatial sequencing may give a molecular basis for pathological diagnosis, improve our understanding of diseases, and have potential clinical applications in prognostics and diagnostic pathology.
    Sprache Englisch
    Erscheinungsdatum 2023-01-10
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article ; Review
    ZDB-ID 3022395-7
    ISSN 2383-7845 ; 2383-7837
    ISSN (online) 2383-7845
    ISSN 2383-7837
    DOI 10.4132/jptm.2022.12.12
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (T

    Choi, Jinyong / Crotty, Shane

    Trends in immunology

    2021  Band 42, Heft 4, Seite(n) 336–349

    Abstract: Follicular helper T cells ( ... ...

    Abstract Follicular helper T cells (T
    Mesh-Begriff(e) Cell Differentiation ; Gene Expression Regulation ; Germinal Center ; Proto-Oncogene Proteins c-bcl-6/genetics ; Proto-Oncogene Proteins c-bcl-6/metabolism ; T Follicular Helper Cells ; T-Lymphocytes, Helper-Inducer/metabolism
    Chemische Substanzen Proto-Oncogene Proteins c-bcl-6
    Sprache Englisch
    Erscheinungsdatum 2021-03-01
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2021.02.002
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  4. Artikel ; Online: The role of cGAMP via the STING pathway in modulating germinal center responses and CD4 T cell differentiation.

    Yoon, Mijung / Choi, Yurim / Wi, Taeuk / Choi, Youn Soo / Choi, Jinyong

    Frontiers in immunology

    2024  Band 15, Seite(n) 1340001

    Abstract: Germinal center (GC) responses are essential for establishing protective, long-lasting immunity through the differentiation of GC B cells ( ... ...

    Abstract Germinal center (GC) responses are essential for establishing protective, long-lasting immunity through the differentiation of GC B cells (B
    Mesh-Begriff(e) Germinal Center/immunology ; Germinal Center/metabolism ; Animals ; Nucleotides, Cyclic/metabolism ; Nucleotides, Cyclic/immunology ; Cell Differentiation/immunology ; Membrane Proteins/metabolism ; Membrane Proteins/immunology ; Mice ; Signal Transduction ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Mice, Inbred C57BL ; Lymphocyte Activation/immunology ; Plasma Cells/immunology ; Plasma Cells/metabolism
    Chemische Substanzen Nucleotides, Cyclic ; Membrane Proteins ; cyclic guanosine monophosphate-adenosine monophosphate ; Sting1 protein, mouse
    Sprache Englisch
    Erscheinungsdatum 2024-04-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1340001
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  5. Artikel: Effect of Groove Shape on Head Loss and Filtration Performance of Disc Filters

    Lee, Sang-ik / Choi, Jin-Yong / Choi, Won

    Water. 2021 June 17, v. 13, no. 12

    2021  

    Abstract: To analyze the effect of a groove cross-sectional shape on disc filters, a head loss analysis and filtration performance test were conducted using disc filters with different groove shapes (semi-elliptical- and trapezoidal-shaped grooves). Furthermore, ... ...

    Abstract To analyze the effect of a groove cross-sectional shape on disc filters, a head loss analysis and filtration performance test were conducted using disc filters with different groove shapes (semi-elliptical- and trapezoidal-shaped grooves). Furthermore, the groove shapes were analyzed using field emission scanning electron microscopy and the relationship between flow rate and head loss was derived from the head loss test. Even if the filters were designed with the same mesh standard, the sectional areas of the grooves were different depending on the shape. Therefore, the head loss was compared under the condition that the grooves have the same sectional area by applying the relationship between head loss and sectional area, and a smaller head loss was observed in the semi-elliptical-shaped groove. Additionally, the semi-elliptical-groove-shaped disc filter was evaluated to sufficiently filter the soil particles corresponding to the 120 mesh standard. Therefore, an optimum disc filter can be designed by considering the cross-sectional shape of the disc groove to reduce energy consumption and provide stable filtration. The elliptical groove shape, which is hydraulically advantageous, is preferred for the disc filter design.
    Schlagwörter energy ; filtration ; soil ; water
    Sprache Englisch
    Erscheinungsverlauf 2021-0617
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2521238-2
    ISSN 2073-4441
    ISSN 2073-4441
    DOI 10.3390/w13121683
    Datenquelle NAL Katalog (AGRICOLA)

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  6. Artikel ; Online: Interleukin-4 downregulates transcription factor BCL6 to promote memory B cell selection in germinal centers.

    Shehata, Laila / Thouvenel, Christopher D / Hondowicz, Brian D / Pew, Lucia A / Pritchard, Gretchen Harms / Rawlings, David J / Choi, Jinyong / Pepper, Marion

    Immunity

    2024  Band 57, Heft 4, Seite(n) 843–858.e5

    Abstract: Germinal center (GC)-derived memory B cells (MBCs) are critical for humoral immunity as they differentiate into protective antibody-secreting cells during re-infection. GC formation and cellular interactions within the GC have been studied in detail, yet ...

    Abstract Germinal center (GC)-derived memory B cells (MBCs) are critical for humoral immunity as they differentiate into protective antibody-secreting cells during re-infection. GC formation and cellular interactions within the GC have been studied in detail, yet the exact signals that allow for the selection and exit of MBCs are not understood. Here, we showed that IL-4 cytokine signaling in GC B cells directly downregulated the transcription factor BCL6 via negative autoregulation to release cells from the GC program and to promote MBC formation. This selection event required additional survival cues and could therefore result in either GC exit or death. We demonstrate that both increasing IL-4 bioavailability or limiting IL-4 signaling disrupted MBC selection stringency. In this way, IL-4 control of BCL6 expression serves as a tunable switch within the GC to tightly regulate MBC selection and affinity maturation.
    Mesh-Begriff(e) B-Lymphocytes ; Germinal Center ; Interleukin-4/metabolism ; Memory B Cells ; Proto-Oncogene Proteins c-bcl-6/genetics ; Proto-Oncogene Proteins c-bcl-6/metabolism ; Transcription Factors/metabolism
    Chemische Substanzen Interleukin-4 (207137-56-2) ; Proto-Oncogene Proteins c-bcl-6 ; Transcription Factors
    Sprache Englisch
    Erscheinungsdatum 2024-03-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2024.02.018
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  7. Artikel: Effects of shift in growing season due to climate change on rice yield and crop water requirements

    Yoon, Pu Reun / Choi, Jin-Yong

    Paddy and water environment. 2020 Apr., v. 18, no. 2

    2020  

    Abstract: According to recent climate projections for South Korea, increases in temperature and precipitation will affect water use and crop production associated with paddy rice cultivation. Impacts are expected on crop growing season, crop varieties, and farming ...

    Abstract According to recent climate projections for South Korea, increases in temperature and precipitation will affect water use and crop production associated with paddy rice cultivation. Impacts are expected on crop growing season, crop varieties, and farming methods, all of which are highly vulnerable to disruption in weather conditions. Previous studies have estimated the effects on agricultural water resources according to climate change scenario, but most do not consider the growing season. In this study, changes in paddy rice yield and agricultural water requirement are estimated based on the impact of shift in growing season using a crop growth model. Future weather trends for four selected study areas in central and southern regions of South Korea were constructed using the Representative Concentration Pathway (RCP) 4.5 and 8.5 scenarios developed by the UN Intergovernmental Panel on Climate Change, and the paddy rice yields were simulated using the Crop Environment Resource Synthesis–Rice growth simulation model. Weather, soil, crop data, cultivars, and experimental data were used as model inputs. The results show a delay in the optimal transplanting date in 2100, with the date in the RCP 8.5 scenario delayed rapidly compared with the delay in RCP 4.5. In addition, paddy rice yield and growing period decrease. Consumptive water use and irrigation requirements decrease in the RCP 4.5 scenario due to increased rainfall. However, in RCP 8.5, less precipitation falls during the growing period, leading to an increase in irrigation requirements in some regions. These results are expected to be useful for paddy water management and growing season adjustment and to help establish long-term food security policies.
    Schlagwörter Oryza sativa ; climate ; climate change ; crop models ; cultivars ; farming systems ; food security ; grain yield ; growing season ; irrigation requirement ; paddies ; rain ; rice ; simulation models ; soil ; temperature ; water requirement ; water resources ; South Korea
    Sprache Englisch
    Erscheinungsverlauf 2020-04
    Umfang p. 291-307.
    Erscheinungsort Springer Singapore
    Dokumenttyp Artikel
    ZDB-ID 2168266-5
    ISSN 1611-2490
    ISSN 1611-2490
    DOI 10.1007/s10333-019-00782-7
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  8. Artikel: IL-4 downregulates BCL6 to promote memory B cell selection in germinal centers.

    Shehata, Laila / Thouvenel, Christopher D / Hondowicz, Brian D / Pew, Lucia A / Rawlings, David J / Choi, Jinyong / Pepper, Marion

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Germinal center (GC)-derived memory B cells (MBCs) are critical for humoral immunity as they differentiate into protective antibody-secreting cells during re-infection. GC formation and cellular interactions within the GC have been studied in detail, yet ...

    Abstract Germinal center (GC)-derived memory B cells (MBCs) are critical for humoral immunity as they differentiate into protective antibody-secreting cells during re-infection. GC formation and cellular interactions within the GC have been studied in detail, yet the exact signals that allow for the selection and exit of MBCs are not understood. Here, we show that IL-4 signaling in GC B cells directly downregulates BCL6 via negative autoregulation to release cells from the GC program and promote MBC formation. This selection event requires additional survival cues and can therefore result in either GC exit or death. We demonstrate that both increasing IL-4 bioavailability or limiting IL-4 signaling disrupt MBC selection stringency. In this way, IL-4 control of BCL6 expression serves as a tunable switch within the GC to tightly regulate MBC selection and affinity maturation.
    Sprache Englisch
    Erscheinungsdatum 2023-10-04
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.01.26.525749
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Analysis of climate change impact on resource intensity and carbon emissions in protected farming systems using Water-Energy-Food-Carbon Nexus

    Yoon, Pu Reun / Lee, Sang-Hyun / Choi, Jin-Yong / Yoo, Seung-Hwan / Hur, Seung-Oh

    Resources, conservation, and recycling. 2022 Sept., v. 184

    2022  

    Abstract: As the uncertainty and importance of securing resources increase, the nexus concept is used for integrated sustainable use management planning. In particular, because protected farms are most affected by temperature change, the connection between the ... ...

    Abstract As the uncertainty and importance of securing resources increase, the nexus concept is used for integrated sustainable use management planning. In particular, because protected farms are most affected by temperature change, the connection between the heating temperature variable and resources must be analyzed. In this study, a water-energy-food-carbon nexus model that reflected the agricultural characteristics of protected farms was constructed. The crop yield, irrigation amount, and heating energy were simulated, and a sensitivity analysis was performed according to climate change scenarios and heating temperature variables. There was no significant decrease in the yield of food resources even at heating temperatures lower than 12 °C. In contrast, the growing period shortened as the heating temperature increased above 12 °C, which decreased the irrigation amount but tended to increase the heating energy. In addition, lowering the heating temperature standard from 12 °C to 8 °C (or less) is suitable for efficient resource management.
    Schlagwörter carbon ; climate change ; crop yield ; energy ; irrigation rates ; models ; resource management ; temperature ; uncertainty
    Sprache Englisch
    Erscheinungsverlauf 2022-09
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 1498716-8
    ISSN 0921-3449
    ISSN 0921-3449
    DOI 10.1016/j.resconrec.2022.106394
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel: Application of high-resolution meteorological data from NCAM-WRF to characterize agricultural drought in small-scale farmlands based on soil moisture deficit

    Hong, Minki / Lee, Sang-Hyun / Lee, Seung-Jae / Choi, Jin-Yong

    Agricultural water management. 2021 Jan. 01, v. 243

    2021  

    Abstract: We discussed the applicability of high-resolution meteorological data simulated by the NCAM-Weather Research and Forecasting (NCAM-WRF) model to investigate spatially distributed soil-moisture deficits in site-scale farmland areas. A gridded soil water ... ...

    Abstract We discussed the applicability of high-resolution meteorological data simulated by the NCAM-Weather Research and Forecasting (NCAM-WRF) model to investigate spatially distributed soil-moisture deficits in site-scale farmland areas. A gridded soil water budget model was developed to utilize the 90 m NCAM-WRF meteorological data to predict soil moisture content (SMC) at multiple depths. The applicability of the NCAM-WRF climatic variables to predict SMC was evaluated by comparing the SMC estimates with in-situ observations at the monitoring site. We used the Quantile Mapping (QM) method to correct the biases of NCAM-WRF precipitation outputs. The SMC estimates derived from the newly developed soil water budget model showed a good agreement with observations, and we proved that the bias-corrected NCAM-WRF precipitation data could improve the predictability of the temporal evolution of SMCs. For characterizing agricultural drought during the crop growing season, we presented a novel approach to estimate the magnitude, duration, and severity of agricultural drought events based on crop's critical pressure head. We mapped the distribution of SMC, soil matric potential (SMP), and drought severity at the 90-m resolution, and the results showed that applying the NCAM-WRF climatic variables to the modeling of SMC/SMP profiles can lead to drought characterization on site-scale while accounting for the spatial variability of rainfall and other climatic variables.
    Schlagwörter agricultural land ; drought ; meteorological data ; models ; rain ; soil matric potential ; soil water content ; soil water deficit ; water management
    Sprache Englisch
    Erscheinungsverlauf 2021-0101
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 751144-9
    ISSN 1873-2283 ; 0378-3774
    ISSN (online) 1873-2283
    ISSN 0378-3774
    DOI 10.1016/j.agwat.2020.106494
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