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Article ; Online: Examining the Role of Self-Harm in the Relationship between Emergency Department Service Utilization and Trauma-Induced Homelessness among Homeless Individuals in Texas.

Choudhury, Sumaita / Choi, Sharon Lee / Lee, Yehyang / Manser, Stacey Stevens

2024 Volume 49, Issue 2, Page(s) 87–94

Abstract: Homelessness is a complex public health problem in the United States. Current or ongoing history of trauma among individuals adds to the complexity and challenges of homelessness. Our study assessed the moderating role of self-harm in the association ... ...

Abstract	Homelessness is a complex public health problem in the United States. Current or ongoing history of trauma among individuals adds to the complexity and challenges of homelessness. Our study assessed the moderating role of self-harm in the association between emergency department (ED) service utilization and trauma-induced homelessness (TIH) among adults in Texas. Homeless adults (N = 282) who completed their baseline Vulnerability Index Service Prioritization Decision Assistance Prescreen Tool survey between February 2021 and February 2022 at a Local Mental Health Authority in Texas were selected. The outcome variable, TIH, was assessed by current period of homelessness due to experiencing trauma or abuse. The main independent variable was ED utilization, while self-harm in the past year was assessed as the moderating variable. A multivariate logistic regression with a moderation analysis was conducted while adjusting for the covariates. Individuals who utilized ED services and engaged in self-harm and risky behaviors had greater odds of experiencing current period of TIH. Male respondents were less likely to experience TIH. Finally, engaging in self-harm significantly moderated the association between ED service use and TIH. This study may help inform efforts to develop tailored interventions and promote resilience-based approaches to improve health outcomes among individuals experiencing homelessness due to TIH.
MeSH term(s)	Humans ; Ill-Housed Persons/psychology ; Ill-Housed Persons/statistics & numerical data ; Male ; Texas/epidemiology ; Female ; Emergency Service, Hospital/statistics & numerical data ; Self-Injurious Behavior/epidemiology ; Self-Injurious Behavior/psychology ; Adult ; Middle Aged ; Surveys and Questionnaires ; Patient Acceptance of Health Care/statistics & numerical data ; Wounds and Injuries/psychology ; Wounds and Injuries/epidemiology
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	448861-1
ISSN	1545-6854 ; 0360-7283
ISSN (online)	1545-6854
ISSN	0360-7283
DOI	10.1093/hsw/hlae002
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Zs.A 1407: Show issues

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Article ; Online: Pelvic mapping to explore patterns of chronic pelvic pain.

Aibel, Kelli / Choi, Sharon / Moldwin, Robert

Neurourology and urodynamics

2023 Volume 42, Issue 4, Page(s) 837–844

Abstract: Purpose: Chronic pelvic pain syndromes (CPPS) are commonly encountered by urologists and urogynecologists and pose diagnostic and therapeutic challenges. Body maps have been helpful adjuncts to verbal descriptions of pain and may serve a role in ... ...

Abstract	Purpose: Chronic pelvic pain syndromes (CPPS) are commonly encountered by urologists and urogynecologists and pose diagnostic and therapeutic challenges. Body maps have been helpful adjuncts to verbal descriptions of pain and may serve a role in phenotyping what is known to be a heterogeneous patient population. The aim of this study was to assess whether patterns of pain as marked on a body map of the pelvis exist among common CPPS diagnoses. The secondary aim was to investigate the association between the total number of pain locations marked on the map and clinical indices in patients with 1 to 3 CPPS diagnoses. Materials and methods: Data was collected on patients who visited the Northwell Health Pelvic Pain Treatment Center (PPTC) from January to May 2022 and were diagnosed with at least one of four major CPPS diagnoses: interstitial cystitis/bladder pain syndrome (IC/BPS), pelvic floor myalgia (PFM), chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), and vulvodynia. Demographic data as well as survey data from pelvic pain maps, Genitourinary Pain Index (GUPI) forms, and the short form-6 of the Pain Catastrophizing Scale (PCS-6) were recorded. Descriptive statistics among CPPS groups and Pearson correlations among the number of CPPS diagnoses were computed. Results: One hundred seventy females and 125 males with CPPS were included in the study. Significant cross-over in mapping patterns was notable between IC/BPS and PFM groups, both most commonly marking "abdomen" and "genital" regions. The most distinct pattern of pain was seen in patients with CP/CPPS and in patients with vulvodynia. Among the total sample, as the mean number of pain locations marked within the pelvis increased, GUPI and PCS scores increased (p < 0.05). As the number of CPPS diagnoses increased, the strength of the relationship independently increased. Conclusions: Pelvic body mapping demonstrated that different forms of CPPS displayed different distributions of pain, but mapping was not predictive of any diagnostic group. Nevertheless, the pelvic body map proved useful in identifying precise locations of pain and may help uncover regions of pain that cannot be easily communicated. The total number of pain sites marked appeared to correlate with worse clinical features.
MeSH term(s)	Male ; Female ; Humans ; Chronic Disease ; Vulvodynia/complications ; Chronic Pain/therapy ; Pelvic Pain/diagnosis ; Cystitis, Interstitial/complications ; Pelvis
Language	English
Publishing date	2023-02-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	604904-7
ISSN	1520-6777 ; 0733-2467
ISSN (online)	1520-6777
ISSN	0733-2467
DOI	10.1002/nau.25145
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Zs.A 1828: Show issues

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Article ; Online: Atherosclerotic renal artery stenosis and revascularization.

Choi, Sharon S

Expert review of cardiovascular therapy

2014 Volume 12, Issue 12, Page(s) 1419–1425

Abstract: Atherosclerotic renovascular disease is the most common cause of secondary hypertension. The patients with renovascular disease are at increased risk for adverse cardiac outcomes. Recent trials comparing medical therapy alone to medical therapy with ... ...

Abstract	Atherosclerotic renovascular disease is the most common cause of secondary hypertension. The patients with renovascular disease are at increased risk for adverse cardiac outcomes. Recent trials comparing medical therapy alone to medical therapy with stenting are flawed, but lay to rest any existing debate that unselected revascularization is unwarranted; however, revascularization may be appropriate in high-risk populations. Defining an appropriate population for revascularization is an area of ongoing study. Furthermore, delivery of optimal medical therapy in this population is inadequate. This review describes recent developments in renal artery revascularization.
MeSH term(s)	Animals ; Arteriosclerosis/therapy ; Humans ; Hypertension, Renovascular/therapy ; Kidney/blood supply ; Renal Artery/surgery ; Renal Artery Obstruction/therapy ; Stents
Language	English
Publishing date	2014-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2192343-7
ISSN	1744-8344 ; 1477-9072
ISSN (online)	1744-8344
ISSN	1477-9072
DOI	10.1586/14779072.2014.977258
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Article ; Online: Third-Line Overactive Bladder Therapies on TikTok: What Does the Public Learn?

Tabakin, Alexandra L / Choi, Sharon / Sandozi, Arshia / Aibel, Kelli / Weintraub, Michael A / Winkler, Harvey A / Shalom, Dara F / Tam, Justina / Lee, Wai

Urogynecology (Philadelphia, Pa.)

2023

Abstract: Importance: Millions of people rely on social media platforms, including TikTok, for health-related information. TikTok has not yet been evaluated as an information source for overactive bladder (OAB) third-line therapies.: Objectives: Our aim was to ...

Abstract	Importance: Millions of people rely on social media platforms, including TikTok, for health-related information. TikTok has not yet been evaluated as an information source for overactive bladder (OAB) third-line therapies. Objectives: Our aim was to assess TikTok videos on third-line therapies for OAB for misinformation and quality. Study design: In this cross-sectional analysis, we abstracted the top 50 TikTok videos for keywords: "Axonics," "sacral neuromodulation," "Interstim," "PTNS," "posterior tibial nerve stimulation," and "bladder Botox." Videos were scored for quality by 3 independent reviewers using the Medical Quality Video Evaluation Tool (MQ-VET). Two reviewers determined if videos contained misinformation. Results: Of 300 videos screened, 119 videos were included. Twenty-four (21%) were created by medical professionals (MPs). Medical professional videos were more frequently shared (5 vs 1, P < 0.01) but had similar views, likes, comments, and length. Although MP videos had significantly higher MQ-VET scores (43 vs 27, P < 0.01), there was no difference in the rate of misinformation between MP and non-MP videos (21% vs 18%). Twenty-two videos (18.4%) contained misinformation, which were 3 times longer (50.5 vs 15 seconds, P < 0.01) and had higher MQ-VET scores (34.5 vs 27, P = 0.03) than those without misinformation. Common themes of misinformation pertained to therapy indication, mechanism of action, and patient limitations after undergoing therapy. Conclusions: Many TikTok videos on OAB third-line therapies contain misinformation. Most of these videos were not of high quality and created by the public. Medical professionals should be aware of misinformation permeating TikTok, given its large audience, and aim to promote or offer educational material of better accuracy and quality.
Language	English
Publishing date	2023-12-20
Publishing country	United States
Document type	Journal Article
ISSN	2771-1897
ISSN (online)	2771-1897
DOI	10.1097/SPV.0000000000001431
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Article ; Online: Revascularization strategies in patients with Type 2 diabetes mellitus.

Choi, Sharon S / Mehran, Roxana

Expert review of cardiovascular therapy

2013 Volume 11, Issue 10, Page(s) 1337–1347

Abstract: This review aims to describe new developments in coronary revascularization strategies for patients with pre-existing Type 2 diabetes mellitus (DM). Recommended strategies for revascularization have been an active area of study with recent important ... ...

Abstract	This review aims to describe new developments in coronary revascularization strategies for patients with pre-existing Type 2 diabetes mellitus (DM). Recommended strategies for revascularization have been an active area of study with recent important developments. In patients with Type 2 DM and multivessel coronary artery disease (CAD), coronary artery bypass graft (CABG) surgery is the preferred method for revascularization. Patients with DM are at increased risk for diffuse cardiovascular disease due to the proinflammatory, prothrombotic effects of chronic hyperglycemia. In patients undergoing percutaneous coronary intervention, drug-eluting stents and more potent antiplatelet agents especially in those presenting with acute coronary syndromes should be employed.
MeSH term(s)	Acute Coronary Syndrome/etiology ; Acute Coronary Syndrome/physiopathology ; Coronary Artery Bypass/methods ; Coronary Artery Disease/etiology ; Coronary Artery Disease/physiopathology ; Coronary Artery Disease/therapy ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/physiopathology ; Diabetic Cardiomyopathies/physiopathology ; Diabetic Cardiomyopathies/therapy ; Drug-Eluting Stents ; Humans ; Myocardial Revascularization/methods ; Percutaneous Coronary Intervention/methods ; Platelet Aggregation Inhibitors/therapeutic use
Chemical Substances	Platelet Aggregation Inhibitors
Keywords	covid19
Language	English
Publishing date	2013-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2192343-7
ISSN	1744-8344 ; 1477-9072
ISSN (online)	1744-8344
ISSN	1477-9072
DOI	10.1586/14779072.2013.839190
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Zs.A 6107: Show issues

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Article ; Online: The nutritional role of free sialic acid, a human milk monosaccharide, and its application as a functional food ingredient.

Röhrig, Christoph H / Choi, Sharon S H / Baldwin, Nigel

Critical reviews in food science and nutrition

2015 Volume 57, Issue 5, Page(s) 1017–1038

Abstract: N-Acetyl-d-neuraminic acid (NANA), more commonly known by its trivial name sialic acid, is an endogenous human and ubiquitous nutritional monosaccharide. As a bound sugar at the terminal positions of glycans NANA is known to play important roles in many ... ...

Abstract	N-Acetyl-d-neuraminic acid (NANA), more commonly known by its trivial name sialic acid, is an endogenous human and ubiquitous nutritional monosaccharide. As a bound sugar at the terminal positions of glycans NANA is known to play important roles in many biological events. The data that exist on the occurrence of the free monosaccharide in breast milk and nutrition, however, are less commonly discussed. In most foods of animal origin, sialic acid occurs as a mixture of NANA and N-glycolyl-d-neuraminic acid (NGNA), a hydroxylated derivative of NANA that is not found in humans. The dietary intake of NGNA has been identified as a risk factor for long-term adverse health effects. Therefore, we present summaries on the biochemistry, metabolism, bioavailability, and the data on NANA and NGNA levels that occur in diverse foods. Finally, we discuss the emerging data demonstrating that free NANA is linked to positive nutritional effects including pronounced antioxidative properties. These data and the extremely high safety profile of NANA justify dietary enrichment at levels that correspond to the dietary intake of NANA in infants through breast milk.
MeSH term(s)	Animals ; Antioxidants/analysis ; Brain/physiology ; Clinical Trials as Topic ; Cognition ; Functional Food/analysis ; Humans ; Infant ; Infant Formula/chemistry ; Milk, Human/chemistry ; Models, Animal ; Monosaccharides/chemistry ; N-Acetylneuraminic Acid/chemistry ; Prebiotics/analysis
Chemical Substances	Antioxidants ; Monosaccharides ; Prebiotics ; N-Acetylneuraminic Acid (GZP2782OP0)
Language	English
Publishing date	2015-06-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2015.1040113
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Zs.A 1459: Show issues

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Article ; Online: Polyphosphate accelerates factor V activation by factor XIa.

Choi, Sharon H / Smith, Stephanie A / Morrissey, James H

Thrombosis and haemostasis

2014 Volume 113, Issue 3, Page(s) 599–604

Abstract: Factor Va enhances the rate of prothrombin activation by factor Xa by four to five orders of magnitude. Production of initiating levels of factor Va from its precursor, factor V, is a critical event early in haemostasis, as factor V exhibits negligible ... ...

Abstract	Factor Va enhances the rate of prothrombin activation by factor Xa by four to five orders of magnitude. Production of initiating levels of factor Va from its precursor, factor V, is a critical event early in haemostasis, as factor V exhibits negligible cofactor activity. While thrombin is the most potent physiological back-activator of factor V, the first prothrombinase complexes require a source of factor Va prior to thrombin generation. A recent study by Whelihan et al. (J Thromb Haemost 2010; 8:1532-1539) identified factor XIa as a candidate for the initial thrombin-independent activation of factor V, although this reaction was slow and required relatively high concentrations of factors V and XIa. Activated platelets secrete polyphosphate, which we previously showed to be potently procoagulant. We now report that polyphosphate greatly accelerates factor V activation by factor XIa, and that this is supported by polyphosphate polymers of the size secreted by activated human platelets. This finding provides additional evidence that factor XIa-mediated generation of factor Va may contribute to the initiation of haemostasis.
MeSH term(s)	Blood Platelets/drug effects ; Blood Platelets/enzymology ; Dose-Response Relationship, Drug ; Enzyme Activation ; Factor V/metabolism ; Factor XIa/metabolism ; Hemostasis/drug effects ; Humans ; Kinetics ; Molecular Weight ; Polyphosphates/blood ; Polyphosphates/chemistry ; Polyphosphates/pharmacology ; Protein Binding
Chemical Substances	Polyphosphates ; Factor V (9001-24-5) ; Factor XIa (EC 3.4.21.27)
Language	English
Publishing date	2014-10-23
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1160/TH14-06-0515
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Article ; Online: Impact of in-hospital major bleeding on outcomes in acute coronary syndromes.

Choi, Sharon S / Sergie, Ziad / Mehran, Roxana

Current opinion in cardiology

2012 Volume 27, Issue 6, Page(s) 669–674

Abstract: Purpose of review: To describe the hazard of in-hospital major bleeding after acute coronary syndromes.: Recent findings: Long-term complications of early bleeding can extend to over 3 years beyond the index event. Nonaccess-site bleeding accounts ... ...

Abstract	Purpose of review: To describe the hazard of in-hospital major bleeding after acute coronary syndromes. Recent findings: Long-term complications of early bleeding can extend to over 3 years beyond the index event. Nonaccess-site bleeding accounts for much of the higher risk associated with major in-hospital bleeding. Summary: Bleeding complications after percutaneous coronary intervention are a consistent and independent predictor of adverse clinical outcomes. The majority of complications associated with major bleeding are attributable to in-hospital early bleeds. Whether the link between bleeding and increased mortality is causal has not been established. Bleeding may simply be a marker of higher comorbidity. When possible, bleeding should be avoided, and strategies such as use of risk scores, bivalirudin, vascular closure devices and radial access may decrease major bleeding. In the highest-risk patients, however, bleeding avoidance strategies may not be effective.
MeSH term(s)	Acute Coronary Syndrome/complications ; Acute Coronary Syndrome/pathology ; Acute Coronary Syndrome/therapy ; Angioplasty, Balloon, Coronary/adverse effects ; Antithrombins/therapeutic use ; Hemorrhage/etiology ; Hemorrhage/mortality ; Hemorrhage/prevention & control ; Hirudins ; Hospitalization ; Humans ; Peptide Fragments/therapeutic use ; Recombinant Proteins/therapeutic use ; Risk Factors ; Treatment Outcome
Chemical Substances	Antithrombins ; Hirudins ; Peptide Fragments ; Recombinant Proteins ; bivalirudin (TN9BEX005G)
Language	English
Publishing date	2012-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645186-x
ISSN	1531-7080 ; 0268-4705
ISSN (online)	1531-7080
ISSN	0268-4705
DOI	10.1097/HCO.0b013e3283589572
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Zs.A 2556: Show issues

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Article ; Online: Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation.

Morrissey, James H / Choi, Sharon H / Smith, Stephanie A

Blood

2012 Volume 119, Issue 25, Page(s) 5972–5979

Abstract: Inorganic polyphosphate is widespread in biology and exhibits striking prohemostatic, prothrombotic, and proinflammatory effects in vivo. Long-chain polyphosphate (of the size present in infectious microorganisms) is a potent, natural pathophysiologic ... ...

Abstract	Inorganic polyphosphate is widespread in biology and exhibits striking prohemostatic, prothrombotic, and proinflammatory effects in vivo. Long-chain polyphosphate (of the size present in infectious microorganisms) is a potent, natural pathophysiologic activator of the contact pathway of blood clotting. Medium-chain polyphosphate (of the size secreted from activated human platelets) accelerates factor V activation, completely abrogates the anticoagulant function of tissue factor pathway inhibitor, enhances fibrin clot structure, and greatly accelerates factor XI activation by thrombin. Polyphosphate may have utility as a hemostatic agent, whereas antagonists of polyphosphate may function as novel antithrombotic/anti-inflammatory agents. The detailed molecular mechanisms by which polyphosphate modulates blood clotting reactions remain to be elucidated.
MeSH term(s)	Animals ; Blood Coagulation/drug effects ; Blood Coagulation/physiology ; Blood Platelets/drug effects ; Blood Platelets/metabolism ; Blood Platelets/physiology ; Fibrin/metabolism ; Hemostasis/drug effects ; Humans ; Inflammation/blood ; Inflammation/etiology ; Inflammation/metabolism ; Models, Biological ; Platelet Adhesiveness/drug effects ; Platelet Adhesiveness/physiology ; Polyphosphates/chemistry ; Polyphosphates/metabolism ; Polyphosphates/pharmacology ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Thrombin/metabolism
Chemical Substances	Polyphosphates ; Fibrin (9001-31-4) ; Thrombin (EC 3.4.21.5)
Language	English
Publishing date	2012-04-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2012-03-306605
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Zs.MO 364: Show issues

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Article: Polyphosphate accelerates factor V activation by factor XIa

Choi, Sharon H. / Smith, Stephanie A. / Morrissey, James H.

Thrombosis and Haemostasis

2015 Volume 113, Issue 03, Page(s) 599–604

Abstract	Factor Va enhances the rate of prothrombin activation by factor Xa by four to five orders of magnitude. Production of initiating levels of factor Va from its precursor, factor V, is a critical event early in haemostasis, as factor V exhibits negligible cofactor activity. While thrombin is the most potent physiological back-activator of factor V, the first prothrombinase complexes require a source of factor Va prior to thrombin generation. A recent study by Whelihan et al. (J Thromb Haemost 2010; 8:1532–1539) identified factor XIa as a candidate for the initial thrombin-independent activation of factor V, although this reaction was slow and required relatively high concentrations of factors V and XIa. Activated platelets secrete polyphosphate, which we previously showed to be potently procoagulant. We now report that polyphosphate greatly accelerates factor V activation by factor XIa, and that this is supported by polyphosphate polymers of the size secreted by activated human platelets. This finding provides additional evidence that factor XIa-mediated generation of factor Va may contribute to the initiation of haemostasis.
Keywords	Polyphosphate ; factor V ; factor XI ; prothrombinase
Language	English
Publishing date	2015-05-01
Publisher	Schattauer GmbH
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1160/TH14-06-0515
Database	Thieme publisher's database

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Zs.MO 433: Show issues

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