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  1. Article: COVID-19-Associated Parotitis in a 10-Week-Old Male.

    Brehm, Robin / Narayanam, Lakshmi / Chon, Grace

    Cureus

    2022  Volume 14, Issue 11, Page(s) e31054

    Abstract: We describe a case of parotitis associated with coronavirus disease 2019 (COVID-19) in a young male infant. His presenting symptom at the time of diagnosis of COVID-19 was unilateral facial swelling. He then developed upper respiratory infection symptoms  ...

    Abstract We describe a case of parotitis associated with coronavirus disease 2019 (COVID-19) in a young male infant. His presenting symptom at the time of diagnosis of COVID-19 was unilateral facial swelling. He then developed upper respiratory infection symptoms and proceeded to recover over a period of about a month. Testing for other causes of parotitis was unrevealing. Other cases of COVID-19-associated parotitis have been presented in the literature, but this case is by far the youngest child noted, and is a useful reminder to pediatricians and general practitioners to consider COVID-19 as a cause of parotitis. Additionally, it sheds light on possible transmission and pathophysiology of COVID-19 in the salivary glands, as several other authors have noted.
    Language English
    Publishing date 2022-11-03
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.31054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster.

    Chon, Cristin / Chon, Grace / Matsui, Yurika / Zeng, Huiqing / Lai, Zhi-Chun / Liu, Aimin

    PloS one

    2021  Volume 16, Issue 4, Page(s) e0250188

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0245454.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0245454.].
    Language English
    Publishing date 2021-04-08
    Publishing country United States
    Document type Published Erratum
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0250188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster.

    Chon, Cristin / Chon, Grace / Matsui, Yurika / Zeng, Huiqing / Lai, Zhi-Chun / Liu, Aimin

    PloS one

    2021  Volume 16, Issue 1, Page(s) e0245454

    Abstract: Genome association studies in human and genetic studies in mouse implicated members of the transmembrane protein 132 (TMEM132) family in multiple conditions including panic disorder, hearing loss, limb and kidney malformation. However, the presence of ... ...

    Abstract Genome association studies in human and genetic studies in mouse implicated members of the transmembrane protein 132 (TMEM132) family in multiple conditions including panic disorder, hearing loss, limb and kidney malformation. However, the presence of five TMEM132 paralogs in mammalian genomes makes it extremely challenging to reveal the full requirement for these proteins in vivo. In contrast, there is only one TMEM132 homolog, detonator (dtn), in the genome of fruit fly Drosophila melanogaster, enabling straightforward research into its in vivo function. In the current study, we generate multiple loss-of-function dtn mutant fly strains through a polycistronic tRNA-gRNA approach, and show that most embryos lacking both maternal and paternal dtn fail to hatch into larvae, indicating an essential role of dtn in Drosophila reproduction.
    MeSH term(s) Animals ; Animals, Genetically Modified/genetics ; Animals, Genetically Modified/physiology ; CRISPR-Cas Systems ; Clustered Regularly Interspaced Short Palindromic Repeats ; Drosophila Proteins/genetics ; Drosophila melanogaster/genetics ; Drosophila melanogaster/physiology ; Female ; Fertility ; Gene Editing/methods ; Loss of Function Mutation ; Male ; RNA, Guide, CRISPR-Cas Systems/genetics ; RNA, Transfer/genetics ; Reproduction
    Chemical Substances Drosophila Proteins ; RNA, Guide, CRISPR-Cas Systems ; RNA, Transfer (9014-25-9)
    Language English
    Publishing date 2021-01-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0245454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Shell hardness and compressive strength of the Eastern oyster, Crassostrea virginica, and the Asian oyster, Crassostrea ariakensis.

    Lombardi, Sara A / Chon, Grace D / Lee, James Jin-Wu / Lane, Hillary A / Paynter, Kennedy T

    The Biological bulletin

    2013  Volume 225, Issue 3, Page(s) 175–183

    Abstract: The valves of oysters act as a physical barrier between tissues and the external environment, thereby protecting the oyster from environmental stress and predation. To better understand differences in shell properties and predation susceptibilities of ... ...

    Abstract The valves of oysters act as a physical barrier between tissues and the external environment, thereby protecting the oyster from environmental stress and predation. To better understand differences in shell properties and predation susceptibilities of two physiologically and morphologically similar oysters, Crassostrea virginica and Crassostrea ariakensis, we quantified and compared two mechanical properties of shells: hardness (resistance to irreversible deformation; GPa) and compressive strength (force necessary to produce a crack; N). We found no differences in the hardness values between foliated layers (innermost and outermost foliated layers), age class (C. virginica: 1, 4, 6, 9 years; C. ariakensis: 4, 6 years), or species. This suggests that the foliated layers have similar properties and are likely composed of the same material. The compressive force required to break wet and dry shells was also not different. However, the shells of both six- and nine-year-old C. virginica withstood higher compressive force than C. virginica shells aged either one or four, and the shells of C. ariakensis at both ages studied (4- and 6-years-old). Differences in ability to withstand compressive force are likely explained by differences in thickness and density between age classes and species. Further, we compared the compressive strength of differing ages of these two species to the crushing force of common oyster predators in the Chesapeake Bay. By studying the physical properties of shells, this work may contribute to a better understanding of the mechanical defenses of oysters as well as of their predation vulnerabilities.
    MeSH term(s) Animal Shells/anatomy & histology ; Animal Shells/chemistry ; Animal Shells/physiology ; Animals ; Compressive Strength ; Crassostrea/chemistry ; Crassostrea/physiology ; Hardness
    Language English
    Publishing date 2013-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1268-3
    ISSN 1939-8697 ; 0006-3185 ; 0148-9488
    ISSN (online) 1939-8697
    ISSN 0006-3185 ; 0148-9488
    DOI 10.1086/BBLv225n3p175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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