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Article ; Online: Mediator kinase subunit CDK8 phosphorylates transcription factor TCP15 during tomato pollen development.

Xu, Rui / Chong, Leelyn / Zhu, Yingfang

2024 Volume 195, Issue 1, Page(s) 865–878

Abstract: Pollen development in flowering plants has strong implications for reproductive success. Pollen DNA can be targeted to improve plant traits for yield and stress tolerance. In this study, we demonstrated that the Mediator subunit CYCLIN-DEPENDENT KINASE 8 ...

Abstract	Pollen development in flowering plants has strong implications for reproductive success. Pollen DNA can be targeted to improve plant traits for yield and stress tolerance. In this study, we demonstrated that the Mediator subunit CYCLIN-DEPENDENT KINASE 8 (CDK8) is a key modulator of pollen development in tomato (Solanum lycopersicum). SlCDK8 knockout led to significant decreases in pollen viability, fruit yield, and fruit seed number. We also found that SlCDK8 directly interacts with transcription factor TEOSINTE BRANCHED1-CYCLOIDEA-PCF15 (SlTCP15) using yeast two-hybrid screens. We subsequently showed that SlCDK8 phosphorylates Ser 187 of SlTCP15 to promote SlTCP15 stability. Phosphorylated TCP15 directly bound to the TGGGCY sequence in the promoters of DYSFUNCTIONAL TAPETUM 1 (SlDYT1) and MYB DOMAIN PROTEIN 103 (SlMYB103), which are responsible for pollen development. Consistently, disruption of SlTCP15 resembled slcdk8 tomato mutants. In sum, our work identified a new substrate of Mediator CDK8 and revealed an important regulatory role of SlCDK8 in pollen development via cooperation with SlTCP15.
MeSH term(s)	Solanum lycopersicum/genetics ; Solanum lycopersicum/growth & development ; Solanum lycopersicum/metabolism ; Pollen/growth & development ; Pollen/genetics ; Pollen/metabolism ; Plant Proteins/metabolism ; Plant Proteins/genetics ; Cyclin-Dependent Kinase 8/metabolism ; Cyclin-Dependent Kinase 8/genetics ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Phosphorylation ; Gene Expression Regulation, Plant ; Mutation/genetics
Chemical Substances	Plant Proteins ; Cyclin-Dependent Kinase 8 (EC 2.7.11.22) ; Transcription Factors
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1093/plphys/kiae079
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Article ; Online: Mass spectrometry-based proteomics for abiotic stress studies.

Chong, Leelyn / Zhu, Yingfang

Trends in plant science

2022 Volume 27, Issue 7, Page(s) 729–730

MeSH term(s)	Mass Spectrometry ; Proteome ; Proteomics ; Stress, Physiological
Chemical Substances	Proteome
Language	English
Publishing date	2022-01-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1305448-x
ISSN	1878-4372 ; 1360-1385
ISSN (online)	1878-4372
ISSN	1360-1385
DOI	10.1016/j.tplants.2021.12.013
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Article: Proarrhythmic effects of dynamic atrioventricular delay programming in a patient with cardiac resynchronization therapy and activity-induced atrioventricular node dysfunction.

Chong, Luke / Kipp, Ryan

HeartRhythm case reports

2022 Volume 8, Issue 4, Page(s) 296–300

Language	English
Publishing date	2022-02-01
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834871-0
ISSN	2214-0271
ISSN	2214-0271
DOI	10.1016/j.hrcr.2022.01.014
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Article ; Conference proceedings: Endoscopic Resection Of Colonic Lipomas: A Single Tertiary Centre Experience

Chong, L / Hebbar, S

Endoscopy

2021 Volume 53, Issue S 01

Event/congress	ESGE Days 2021, Going virtual. Staying real., 2021-03-25
Language	English
Publishing date	2021-03-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0041-1724804
Database	Thieme publisher's database

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Article ; Online: Breast feeding in infants diagnosed with phenylketonuria (PKU): a scoping review.

Kalvala, Jahnavi / Chong, Lydia / Chadborn, Neil / Ojha, Shalini

BMJ paediatrics open

2023 Volume 7, Issue 1

Abstract: Background: Phenylketonuria (PKU) is the most common inherited disease of amino acid metabolism, characterised by elevated levels of phenylalanine (Phe). There is a lack of infant feeding guidance for those with PKU. From birth to 6 months of age, ... ...

Abstract	Background: Phenylketonuria (PKU) is the most common inherited disease of amino acid metabolism, characterised by elevated levels of phenylalanine (Phe). There is a lack of infant feeding guidance for those with PKU. From birth to 6 months of age, breast feeding is the optimal nutrition for an infant and continuing breast feeding for infants with PKU is recommended by European guidelines. However, human breast milk contains Phe in varying quantities, and therefore, the effects breast feeding might have on infants with PKU needs careful consideration. Aim: To assess the effects of breast feeding (exclusive or partial) compared with low-Phe formula feeding in infants diagnosed with PKU, on blood Phe levels, growth and neurodevelopmental scores. Methods: The Cochrane Inborn Errors of Metabolism Trials Register, MEDLINE and Embase were searched (date of latest search: 9 August 2022). Studies were included if they looked at the effects of breast feeding in infants diagnosed with PKU compared with formula feeding. Predetermined outcomes included blood Phe levels, growth in the first 2 years of life and neurodevelopmental scores. Results: Seven observational studies (282 participants) met the inclusion criteria. All studies compared continuation of breast feeding with low-Phe formula versus formula feeding only. While most studies concluded that there was no difference in mean serum Phe levels in their follow-up period, two reported that breastfed infants were more likely to have a normal mean Phe level. Two studies described no difference in mean weight gain after birth, while one found that breastfed infants were more likely to have higher mean weight gain. Two studies commented that breastfed infants achieved higher developmental scores in childhood as compared with formula fed infants. Conclusion: Although there are no randomised trials, observational evidence suggests that continuation of breast feeding and supplementation with low-Phe formula is safe and may be beneficial for infants diagnosed with PKU.
MeSH term(s)	Female ; Infant ; Humans ; Breast Feeding ; Milk, Human ; Infant Formula ; Phenylketonurias ; Phenylalanine ; Weight Gain
Chemical Substances	Phenylalanine (47E5O17Y3R)
Language	English
Publishing date	2023-10-18
Publishing country	England
Document type	Review ; Journal Article
ISSN	2399-9772
ISSN (online)	2399-9772
DOI	10.1136/bmjpo-2023-002066
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Article ; Online: Mendelian randomization study shows a causal effect of asthma on epilepsy risk.

Tang, Peng / Guo, Xingzhi / Chong, Li / Li, Rui

Frontiers in immunology

2023 Volume 14, Page(s) 1071580

Abstract: Objective: The relationship between asthma and epilepsy in observational studies is controversial. The purpose of this Mendelian randomization (MR) study is to investigate whether asthma causally contributes to epilepsy susceptibility.: Methods: ... ...

Abstract	Objective: The relationship between asthma and epilepsy in observational studies is controversial. The purpose of this Mendelian randomization (MR) study is to investigate whether asthma causally contributes to epilepsy susceptibility. Methods: Independent genetic variants strongly (P<5E-08) associated with asthma were from a recent meta-analysis of genome-wide association studies on 408,442 participants. Two independent summary statistics of epilepsy obtained from the International League Against Epilepsy Consortium (ILAEC, Ncases=15,212, and Ncontrols=29,677) and FinnGen Consortium (Ncases=6,260 and Ncontrols=176,107) were used in the discovery and replication stage, respectively. Several sensitivity analyses and heterogeneity analyses were further conducted to assess the stability of the estimates. Results: Using the inverse-variance weighted approach, genetic predisposition to asthma was associated with an elevated risk of epilepsy in the discovery stage (ILAEC: odds ratio [OR]=1.112, 95% confidence intervals [CI]= 1.023-1.209, Conclusion: The present MR study suggests that asthma is associated with an increased risk of epilepsy independent of the age onset of asthma. Further studies are warranted to explain the underlying mechanisms of this association.
MeSH term(s)	Humans ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Asthma/epidemiology ; Asthma/genetics ; Causality ; Epilepsy/epidemiology ; Epilepsy/genetics
Language	English
Publishing date	2023-02-13
Publishing country	Switzerland
Document type	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1071580
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Article ; Online: Photosensitization can be an effective risk-reduction strategy against the post-baking mold spoilage of bread.

Chong, Leonard / Ghate, Vinayak / Seah, Cassandra / Zhou, Weibiao

Food microbiology

2023 Volume 117, Page(s) 104390

Abstract: Photosensitization was developed as a risk-reduction strategy against the contamination by environmental mold spores during the bread cooling phase. Two food-grade photosensitizers -chlorophyllin (CHL) and riboflavin (RBF), were used to evaluate the ... ...

Abstract	Photosensitization was developed as a risk-reduction strategy against the contamination by environmental mold spores during the bread cooling phase. Two food-grade photosensitizers -chlorophyllin (CHL) and riboflavin (RBF), were used to evaluate the effect of visible (blue) LED illumination against three common bread spoilage molds. Aided by CHL, 405 nm LEDs inactivated Rhizopus stolonifer and Penicillium expansum by 77.4 ± 3.3% and 52.1 ± 7.3% respectively in 30 min on dichloran rose bengal chloramphenicol agar. These reductions were much higher than the corresponding reductions observed with food-grade RBF and 445 nm LEDs - 22.8 ± 3.2% and 45.5 ± 5.9%, indicating that CHL-based photosensitization was more effective as an intervention than RBF-based photosensitization. When the three molds were illuminated on bread after spraying CHL and spot-inoculation, their populations were reduced by 51-58%. CHL-based photosensitization was observed to retain the texture and moisture of the bread samples, but had a statistically significant impact on their colour. The results of this study suggest that CHL-based photosensitization can be developed as a risk reduction method to prevent the spoilage of bread.
MeSH term(s)	Light ; Bread ; Fungi ; Photosensitizing Agents/pharmacology
Chemical Substances	Photosensitizing Agents
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Journal Article
ZDB-ID	50892-5
ISSN	1095-9998 ; 0740-0020
ISSN (online)	1095-9998
ISSN	0740-0020
DOI	10.1016/j.fm.2023.104390
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Article ; Online: Temporal variations and trends prediction of water quality during 2010–2019 in the middle Yangtze River, China

Chong, Lynne / Zhong, Jiwen / Sun, Zhilin / Hu, Chunhong

Environ Sci Pollut Res. 2023 Mar., v. 30, no. 11 p.28745-28758

2023

Abstract: Water quality plays an important role in river habitats. This study revealed the annual and seasonal variations and trend prediction of water quality in the middle Yangtze River after the third impoundment stage of the Three Gorges Reservoir. ... ...

Abstract	Water quality plays an important role in river habitats. This study revealed the annual and seasonal variations and trend prediction of water quality in the middle Yangtze River after the third impoundment stage of the Three Gorges Reservoir. Multivariate statistical methods including principal component analysis/factor analysis (PCA/FA), Mann–Kendall (M–K) tests, discriminant analysis (DA), rescaled range (R/S) analysis, and the Canadian Council of Ministers of the Environment Water Quality Index (CCME-WQI) were used. Herein, eight water quality constituents including pH, electrical conductivity (EC), chloride (Cl), dissolved oxygen (DO), ammonia nitrogen (NH₃N), total phosphorus (TP), water temperature (T), and permanganate index (CODmn) were monthly monitored in the Jiujiang hydrological transaction during 2010–2019. The information of eight water quality constituents, related to salinity, nutrient status, and oxidation reactions efficiency, was extracted. Water quality status remained as fair-good during 2010–2019 based on the results of CCME-WQI, with the seasonal significance ranked as T > DO > Cl > pH > EC > TP > NH₃N > CODmn. In the future decade, annual average T was predicted to continue to increase although it might decrease in the wet season. EC was predicted to continue increasing annually especially in the wet season while Cl might decrease. NH₃N and TP might maintain a significant decreasing trend in the future wet and dry seasons. DO maintained significantly increasing especially in the future dry seasons, whereas CODmn will continue to decrease annually and seasonally. The continued alkalization trend of waterbody was predicted, which is more significant in the wet season. The results provide helpful references for the ecological protection of the middle Yangtze River.
Keywords	alkalinization ; ammonium nitrogen ; chlorides ; discriminant analysis ; electrical conductivity ; factor analysis ; oxidation ; oxygen ; pH ; prediction ; principal component analysis ; rivers ; salinity ; surface water ; total phosphorus ; water quality ; water temperature ; wet season ; China ; Yangtze River
Language	English
Dates of publication	2023-03
Size	p. 28745-28758.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-23968-9
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: RE: Perceptions of Canadian radiation oncologists, radiation physicists, radiation therapists and radiation trainees about the impact of artificial intelligence in radiation oncology - National survey.

Tay, Yi Xiang / Chong, Letty

Journal of medical imaging and radiation sciences

2021 Volume 52, Issue 2, Page(s) 316–317

MeSH term(s)	Artificial Intelligence ; Canada ; Humans ; Perception ; Radiation Oncologists ; Radiation Oncology
Language	English
Publishing date	2021-02-26
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2426513-5
ISSN	1876-7982 ; 1939-8654
ISSN (online)	1876-7982
ISSN	1939-8654
DOI	10.1016/j.jmir.2021.02.001
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Article ; Online: The effect of bariatric surgery on the expression of gastrointestinal taste receptors: A systematic review.

Walmsley, Rosalind / Chong, Lynn / Hii, Michael W / Brown, Robyn M / Sumithran, Priya

Reviews in endocrine & metabolic disorders

2024 Volume 25, Issue 2, Page(s) 421–446

Abstract: Gastrointestinal nutrient sensing via taste receptors may contribute to weight loss, metabolic improvements, and a reduced preference for sweet and fatty foods following bariatric surgery. This review aimed to investigate the effect of bariatric surgery ... ...

Abstract	Gastrointestinal nutrient sensing via taste receptors may contribute to weight loss, metabolic improvements, and a reduced preference for sweet and fatty foods following bariatric surgery. This review aimed to investigate the effect of bariatric surgery on the expression of oral and post-oral gastrointestinal taste receptors and associations between taste receptor alterations and clinical outcomes of bariatric surgery. A systematic review was conducted to capture data from both human and animal studies on changes in the expression of taste receptors in oral or post-oral gastrointestinal tissue following any type of bariatric surgery. Databases searched included Medline, Embase, Emcare, APA PsychInfo, Cochrane Library, and CINAHL. Two human and 21 animal studies were included. Bariatric surgery alters the quantity of many sweet, umami, and fatty acid taste receptors in the gastrointestinal tract. Changes to the expression of sweet and amino acid receptors occur most often in intestinal segments surgically repositioned more proximally, such as the alimentary limb after gastric bypass. Conversely, changes to fatty acid receptors were observed more frequently in the colon than in the small intestine. Significant heterogeneity in the methodology of included studies limited conclusions regarding the direction of change in taste receptor expression induced by bariatric surgeries. Few studies have investigated associations between taste receptor expression and clinical outcomes of bariatric surgery. As such, future studies should look to investigate the relationship between bariatric surgery-induced changes to gut taste receptor expression and function and the impact of surgery on taste preferences, food palatability, and eating behaviour.Registration code in PROSPERO: CRD42022313992.
MeSH term(s)	Animals ; Humans ; Taste/physiology ; Bariatric Surgery ; Gastric Bypass ; Taste Buds ; Fatty Acids
Chemical Substances	Fatty Acids
Language	English
Publishing date	2024-01-11
Publishing country	Germany
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2185718-0
ISSN	1573-2606 ; 1389-9155
ISSN (online)	1573-2606
ISSN	1389-9155
DOI	10.1007/s11154-023-09865-7
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