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  1. Article ; Online: Crizanlizumab and sickle cell disease: When should medications have their approval status revoked?

    Jacobs, Jeremy W / Stephens, Laura D / Chooljian, David M / Sharma, Deva / Adkins, Brian D / Booth, Garrett S

    American journal of hematology

    2024  

    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27275
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    Zs.A 1251: Show issues Location:
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  2. Article ; Online: Liquid biopsies in blood donors: Issues in implementing cell-free DNA cancer screening tests in the blood donor population.

    Jacobs, Jeremy W / Guarente, Juliana / Chooljian, David M / Booth, Garrett S / Adkins, Brian D

    American journal of hematology

    2022  Volume 97, Issue 12, Page(s) E454–E456

    Abstract: Issues in implementing cell-free DNA cancer screening tests in blood donors. ...

    Abstract Issues in implementing cell-free DNA cancer screening tests in blood donors.
    MeSH term(s) Humans ; Blood Donors ; Early Detection of Cancer ; Cell-Free Nucleic Acids ; Liquid Biopsy ; Neoplasms/diagnosis ; Neoplasms/genetics
    Chemical Substances Cell-Free Nucleic Acids
    Language English
    Publishing date 2022-09-22
    Publishing country United States
    Document type Letter
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26727
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    Zs.A 1251: Show issues Location:
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  3. Article ; Online: Trading tissues for freedom: incentivizing stem cell and solid organ donation in the incarcerated population.

    Chooljian, David M / Jacobs, Jeremy W / Adkins, Brian D / Savani, Bipin N / Bibb, Lorin A / Booth, Garrett S

    Bone marrow transplantation

    2023  Volume 58, Issue 6, Page(s) 717–718

    MeSH term(s) Humans ; Motivation ; Tissue and Organ Procurement ; Organ Transplantation ; Freedom ; Prisoners ; Tissue Donors
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Letter
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-023-01954-0
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    Zs.A 2168: Show issues Location:
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  4. Article ; Online: When should we tell patients there may be no blood? Evaluating the 'informed' consent process.

    Booth, Garrett S / Jacobs, Jeremy W / Stephens, Laura D / Chooljian, David M / Savani, Bipin N / Gehrie, Eric A

    British journal of haematology

    2022  Volume 198, Issue 1, Page(s) e8–e10

    MeSH term(s) Humans ; Informed Consent ; Physician-Patient Relations
    Language English
    Publishing date 2022-03-22
    Publishing country England
    Document type Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18156
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  5. Article ; Online: Blood bans and COVID-19: Government attempts to influence medicine and science threaten us all.

    Jacobs, Jeremy W / Binns, Thomas C / Chooljian, David M / Adkins, Brian D / Woo, Jennifer S / Stephens, Laura D / Schlafer, T D / Savani, Bipin N / Booth, Garrett S

    American journal of clinical pathology

    2023  Volume 160, Issue 4, Page(s) 435–436

    Language English
    Publishing date 2023-07-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqad071
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    Ud II Zs.91: Show issues Location:
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  6. Article: Impact of a lung ultrasound course for rheumatology specialists (IMPACT-2).

    Gasho, Christopher J / Torralba, Karina D / Chooljian, David M / Cohen, Avi / Dinh, Vi Am

    Clinical and experimental rheumatology

    2018  Volume 37, Issue 3, Page(s) 380–384

    Abstract: Objectives: Lung ultrasound (LUS) plays an increasing role in diagnosis and monitoring of interstitial lung disease (ILD). Connective tissue disorders (CTD) frequently cause ILD, and often presents symptomatically after irreversible fibrosis has ensued. ...

    Abstract Objectives: Lung ultrasound (LUS) plays an increasing role in diagnosis and monitoring of interstitial lung disease (ILD). Connective tissue disorders (CTD) frequently cause ILD, and often presents symptomatically after irreversible fibrosis has ensued. As point-of-care musculoskeletal ultrasound (US) is commonly utilised by rheumatologists, translating this US expertise towards LUS places the rheumatologist in a position to screen for ILD. However, a standardised curriculum for the rheumatology community is lacking. The aim of this study is to determine the effectiveness of a formalised lung US training course for rheumatologists.
    Methods: Four rheumatology fellows and four board-certified rheumatologists participated in a 4-hour training session. Pre-course, post-course and 6-month follow-up surveys evaluated perceptions towards previous US experience, training, clinical utility and attitudes toward lung US. Didactics explained the protocols utilised in ILD evaluation. Evaluation of knowledge in US physiology, lung anatomy, artifact and pathology recognition were done through written exams before, after training, and at 6 months and through a practical exam using live models and simulation.
    Results: Temporally there was overall improvement in written test scores. Improvement was noted in overall practical skill score following training course (17.4% vs. 92.9%, p<0.001), in written test scores 49.3% vs. 72.5% p<0.001), and pathology identification (26.5% vs. 79.6%, p<0.001). Six-month follow assessments were similar to post-test results revealing similar written scores (70.6%) and practical scores (89.7%).
    Conclusions: This formalised lung ultrasound training course was effective in improving skills and knowledge of rheumatology specialists.
    MeSH term(s) Curriculum ; Humans ; Lung/diagnostic imaging ; Lung Diseases, Interstitial/diagnosis ; Rheumatology/education ; Specialization ; Ultrasonography/methods
    Language English
    Publishing date 2018-08-29
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
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    Zs.A 2002: Show issues Location:
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  7. Article: Emerging Roles of Clinical Ethicists.

    Farroni, Jeffrey S / Tumilty, Emily / Mukherjee, Debjani / McCammon, Susan / Chooljian, David M / Eves, Margot M

    The Journal of clinical ethics

    2019  Volume 30, Issue 3, Page(s) 262–269

    Abstract: Debates regarding clinical ethicists' scope of practice are not novel and will continue to evolve. Rapid changes in healthcare delivery, outcomes, and expectations have necessitated flexibility in clinical ethicists' roles whereby hospital-based clinical ...

    Abstract Debates regarding clinical ethicists' scope of practice are not novel and will continue to evolve. Rapid changes in healthcare delivery, outcomes, and expectations have necessitated flexibility in clinical ethicists' roles whereby hospital-based clinical ethicists are expected to be woven into the institutional fabric in a way that did not exist in more traditional relationships. In this article we discuss three emerging roles: the ethicist embedded in the interdisciplinary team, the ethicist with an expanded educational mandate, and the ethicist as a therapeutic presence in the patient care space. Such expanded capacities offer more robust, positive contributions to institutional culture, stakeholders' relationships, and patient-centered care.
    MeSH term(s) Delivery of Health Care ; Ethicists ; Hospitals ; Humans ; Patient-Centered Care/ethics
    Language English
    Publishing date 2019-09-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1122655-9
    ISSN 1046-7890
    ISSN 1046-7890
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    Zs.A 3456: Show issues Location:
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  8. Article ; Online: Strategies to Assess the Effect of Continuous Positive Airway Pressure on Long-Term Clinically Important Outcomes among Patients with Symptomatic Obstructive Sleep Apnea: An Official American Thoracic Society Workshop Report.

    Donovan, Lucas M / Hoyos, Camilla M / Kimoff, R John / Morrell, Mary J / Bosch, Nicholas A / Chooljian, David M / McEvoy, R Doug / Sawyer, Amy M / Wagner, Todd H / Al-Lamee, Rasha R / Bishop, David / Carno, Margaret A / Epstein, Matt / Hanson, Mark / Ip, Mary S M / Létourneau, Marie / Pamidi, Sushmita / Patel, Sanjay R / Pépin, Jean-Louis /
    Punjabi, Naresh M / Redline, Susan / Thornton, J Daryl / Patil, Susheel P

    Annals of the American Thoracic Society

    2023  Volume 20, Issue 7, Page(s) 931–943

    Abstract: Continuous positive airway pressure (CPAP) is the first-line treatment for obstructive sleep apnea (OSA). Although CPAP improves symptoms (e.g., daytime sleepiness), there is a lack of high-quality evidence that CPAP prevents many long-term outcomes, ... ...

    Abstract Continuous positive airway pressure (CPAP) is the first-line treatment for obstructive sleep apnea (OSA). Although CPAP improves symptoms (e.g., daytime sleepiness), there is a lack of high-quality evidence that CPAP prevents many long-term outcomes, including cognitive impairment, myocardial infarction, and stroke. Observational studies suggest that patients with symptoms may be particularly likely to experience these preventive benefits with CPAP, but ethical and practical concerns limited the participation of such patients in prior long-term randomized trials. As a result, there is uncertainty about the full benefits of CPAP, and resolving this uncertainty is a key priority for the field. This workshop assembled clinicians, researchers, ethicists, and patients to identify strategies to understand the causal effects of CPAP on long-term clinically important outcomes among patients with symptomatic OSA. Quasi-experimental designs can provide valuable information and are less time and resource intensive than trials. Under specific conditions and assumptions, quasi-experimental studies may be able to provide causal estimates of CPAP's effectiveness from generalizable observational cohorts. However, randomized trials represent the most reliable approach to understanding the causal effects of CPAP among patients with symptoms. Randomized trials of CPAP can ethically include patients with symptomatic OSA, as long as there is outcome-specific equipoise, adequate informed consent, and a plan to maximize safety while minimizing harm (e.g., monitoring for pathologic sleepiness). Furthermore, multiple strategies exist to ensure the generalizability and practicality of future randomized trials of CPAP. These strategies include reducing the burden of trial procedures, improving patient-centeredness, and engaging historically excluded and underserved populations.
    MeSH term(s) Humans ; Continuous Positive Airway Pressure ; Cognitive Dysfunction ; Informed Consent ; Myocardial Infarction ; Sleep Apnea, Obstructive/therapy
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202303-258ST
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    Zs.A 5828: Show issues Location:
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  9. Article ; Online: Emotional Support for Health Care Professionals: A Therapeutic Role for the Hospital Ethics Committee.

    Chooljian, David M / Hallenbeck, James / Ezeji-Okoye, Stephen C / Sebesta, Robert / Iqbal, Hasan / Kuschner, Ware G

    Journal of social work in end-of-life & palliative care

    2016  Volume 12, Issue 3, Page(s) 277–288

    Abstract: Hospital ethics committees (HECs) are typically charged with addressing ethical disputes, conflicts, and dilemmas that arise in the course of patient care. HECs are not widely viewed as having a therapeutic role for health care professionals who ... ...

    Abstract Hospital ethics committees (HECs) are typically charged with addressing ethical disputes, conflicts, and dilemmas that arise in the course of patient care. HECs are not widely viewed as having a therapeutic role for health care professionals who experience psychological distress or anticipatory grief in the course of discharging professional duties. A case is presented in which an ethics consultation was requested, chiefly, to secure emotional support for health care professionals who had been asked by a patient to discontinue life-sustaining treatments. As the case demonstrates, HECs may be called upon to provide emotional support and reassurance to health care professionals who willingly carry out psychologically difficult actions, even though these actions may be ethically uncontroversial. In providing this service, the HEC may not necessarily engage in its customary activity of deliberating an ethics issue and resolving a conflict but may still provide valuable assistance, as in the case presented.
    MeSH term(s) Ethics Committees, Clinical/organization & administration ; Grief ; Health Personnel/psychology ; Humans ; Male ; Middle Aged ; Quadriplegia/nursing ; Quadriplegia/psychology ; Respiration, Artificial ; Withholding Treatment
    Language English
    Publishing date 2016-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2179023-1
    ISSN 1552-4264 ; 1552-4256
    ISSN (online) 1552-4264
    ISSN 1552-4256
    DOI 10.1080/15524256.2016.1200519
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