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Article ; Online: Long-lasting CRs after ibrutinib monotherapy for relapse or refractory primary CNS lymphoma (PCNSL) and primary vitreoretinal lymphoma (PVRL): Long-term results of the iLOC study by the Lymphoma Study Association (LYSA) and the French Oculo-Cerebral Lymphoma (LOC) Network (clinical trial number: NCT02542514).

Soussain, Carole / Malaise, Denis / Choquet, Sylvain / Ghesquières, Hervé / Houillier, Caroline

European journal of cancer (Oxford, England : 1990)

2023 Volume 189, Page(s) 112909

MeSH term(s)	Humans ; Retinal Neoplasms/drug therapy ; Retinal Neoplasms/pathology ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/pathology ; Vitreous Body/pathology ; Lymphoma/pathology ; Chronic Disease ; Central Nervous System Neoplasms/drug therapy ; Central Nervous System Neoplasms/pathology
Chemical Substances	ibrutinib (1X70OSD4VX)
Language	English
Publishing date	2023-06-08
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2023.04.025
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 583: Show issues

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Article ; Online: In situ off-line extracorporeal photopheresis conducted in a real-life situation at a Hemobiotherapy Department in France: A comparison of costs vs on-line procedure.

Azar, Nabih / Ouzegdouh, Maya / Choquet, Sylvain / Goncalves, Natalia / Leblond, Véronique

Journal of clinical apheresis

2021 Volume 37, Issue 1, Page(s) 25–30

Abstract: Background: The off-line extracorporeal photopheresis (ECP) procedure requires photosensitization in an external cell therapy laboratory as per the French regulatory requirement. This regulation results in higher time and costs compared with the on-line ...

Abstract	Background: The off-line extracorporeal photopheresis (ECP) procedure requires photosensitization in an external cell therapy laboratory as per the French regulatory requirement. This regulation results in higher time and costs compared with the on-line alternative performed entirely at the patient's bedside. Recently, full in situ execution of the off-line procedure has been implemented in the Pitié-Salpêtrière Hospital Hemobiotherapy Department (Paris, France). This report summarizes the center's experience regarding the organizational and costs impacts of this change compared with the on-line procedure. Material and methods: ECP was broken down into stages, and several procedures were monitored prospectively in real-life settings. The total costs associated with both procedures were the sum of the fixed costs and variable costs related to all stages of the procedures, nursing-time costs, property costs, and patient-related production loss costs. Results: Eight off-line ECP and fourteen on-line ECP procedures were monitored during five consecutive days. Procedure duration was not different (median 137.5 vs 154.0 minutes, P = .29). Times and costs associated with nursing were higher but offset by lower fixed costs of the off-line ECP. Total direct costs per procedure associated with using the off-line ECP were significantly lower than those of the on-line procedure (459.6 ± 7.1 EUR vs 953.8 ± 6.5 EUR; P = .0002). Similar results were observed when including the costs of patient production loss. Conclusions: As a competitive time procedure, the in situ off-line method proved to be cost-efficient by effectively offering similar patient treatment per year compared with the on-line procedure.
MeSH term(s)	Costs and Cost Analysis ; France ; Humans ; Photopheresis/economics ; Photopheresis/methods ; Point-of-Care Systems/economics ; Prospective Studies
Language	English
Publishing date	2021-11-02
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	604912-6
ISSN	1098-1101 ; 0733-2459
ISSN (online)	1098-1101
ISSN	0733-2459
DOI	10.1002/jca.21947
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Zs.A 1831: Show issues

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Article ; Online: Managing immunosuppressive therapy in potentially cured post-kidney transplant cancer (excluding non-melanoma skin cancer): an overview of the available evidence and guidance for shared decision-making.

Hellemans, Rachel / Pengel, Liset H M / Choquet, Sylvain / Maggiore, Umberto

Transplant international : official journal of the European Society for Organ Transplantation

2021 Volume 34, Issue 10, Page(s) 1789–1800

Abstract: Kidney transplant recipients (KTRs) have increased incidence of de novo cancers. After having undergone treatment for cancer with curative intent, reducing the overall immunosuppressive load and/or switching to an alternative drug regimen may potentially ...

Abstract	Kidney transplant recipients (KTRs) have increased incidence of de novo cancers. After having undergone treatment for cancer with curative intent, reducing the overall immunosuppressive load and/or switching to an alternative drug regimen may potentially be of great benefit to avoid cancer recurrence, but should be balanced against the risks of rejection and/or severe adverse events. The TLJ (Transplant Learning Journey) project is an initiative from the European Society for Organ Transplantation (ESOT). This article reports a systematic literature search undertaken by TLJ Workstream 3 to answer the questions: (1) Should we decrease the overall anti-rejection therapy in potentially cured post-kidney transplant cancer (excluding non-melanoma skin cancer)? (2) Should we switch to mammalian target of rapamycin inhibitors (mTORi) in potentially cured post-kidney transplant cancer (excluding non-melanoma skin cancer)? The literature search revealed insufficient solid data on which to base recommendations, so this review additionally presents an extensive overview of the indirect evidence on the benefits versus risks of alterations in immunosuppressive medication. We hope this summary will help transplant physicians advise KTRs on how best to continue with anti-rejection therapy after receiving cancer treatment with curative intent, and aid shared decision-making, ensuring that patient preferences are taken into account.
MeSH term(s)	Graft Rejection ; Humans ; Immunosuppression ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation ; Neoplasm Recurrence, Local ; Skin Neoplasms/drug therapy
Chemical Substances	Immunosuppressive Agents
Language	English
Publishing date	2021-06-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.1111/tri.13952
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Zs.A 2358: Show issues

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Article ; Online: Fatigue visual analogue scale score correlates with quality of life in cancer patients receiving epoetin alfa (Sandoz) for chemotherapy-induced anaemia: The CIROCO study.

Desramé, Jerome / Baize, Nathalie / Anota, Amélie / Laribi, Kamel / Stefani, Laetitia / Hjiej, Salim / Nabirotchkina, Ekatérina / Zelek, Laurent / Choquet, Sylvain

Cancer treatment and research communications

2023 Volume 37, Page(s) 100781

Abstract: Purpose: Available tools to measure fatigue and health-related quality of life (HRQoL) in cancer patients are often difficult to use in clinical practice. The fatigue visual analogue scale (VAS) provides a simple method to assess fatigue. This study ... ...

Abstract	Purpose: Available tools to measure fatigue and health-related quality of life (HRQoL) in cancer patients are often difficult to use in clinical practice. The fatigue visual analogue scale (VAS) provides a simple method to assess fatigue. This study evaluated the correlation between HRQoL and fatigue perceived by cancer patients undergoing chemotherapy. Methods: This was a non-interventional prospective study of adult cancer patients in France presenting with chemotherapy-induced anaemia (CIA) treated with epoetin alfa (Sandoz). Data were collected using an electronic case report form at study inclusion (T0), after 2-3 chemotherapy cycles (T1) and after 4-6 cycles (T2). Results: The study included 982 patients from September 2015 to October 2017. Overall, there was a negative correlation between fatigue VAS and HRQoL. The overall haemoglobin (Hb) change between T0 and T2 was +17.8 % (± 18.1 %). Fatigue assessed by both patients and physicians showed a clinically significant improvement during the study. Global HRQoL also increased. Conclusion: Treatment of CIA with epoetin alfa (Sandoz) improved Hb levels, fatigue, and HRQoL, with a correlation observed between fatigue VAS score and HRQoL. Fatigue VAS could act as a simple alternative to more complex methods to measure HRQoL; however, further analyses are required to confirm this association.
MeSH term(s)	Adult ; Humans ; Epoetin Alfa/therapeutic use ; Erythropoietin/therapeutic use ; Erythropoietin/adverse effects ; Quality of Life ; Prospective Studies ; Visual Analog Scale ; Hematinics/therapeutic use ; Hematinics/adverse effects ; Antineoplastic Agents/adverse effects ; Treatment Outcome ; Anemia/chemically induced ; Neoplasms/complications ; Neoplasms/drug therapy ; Neoplasms/chemically induced ; Fatigue/chemically induced
Chemical Substances	Epoetin Alfa (64FS3BFH5W) ; Erythropoietin (11096-26-7) ; Hematinics ; Antineoplastic Agents
Language	English
Publishing date	2023-11-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2468-2942
ISSN (online)	2468-2942
DOI	10.1016/j.ctarc.2023.100781
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Article ; Online: Interim FDG-PET improves treatment failure prediction in primary central nervous system Lymphoma: a LOC network prospective multicentric study.

Rozenblum, Laura / Houillier, Caroline / Baptiste, Amandine / Soussain, Carole / Edeline, Véronique / Naggara, Philippe / Soret, Marine / Causse-Lemercier, Valérie / Willems, Lise / Choquet, Sylvain / Ursu, Renata / Galanaud, Damien / Belin, Lisa / Hoang-Xuan, Khê / Kas, Aurélie

Neuro-oncology

2024

Abstract: Purpose: The purpose of our study was to assess the predictive and prognostic role of 2-18F-fluoro-2-deoxy-D-glucose (FDG) PET/MRI during high-dose methotrexate-based chemotherapy (HD-MBC) in de novo primary central nervous system lymphoma (PCNSL) ... ...

Abstract	Purpose: The purpose of our study was to assess the predictive and prognostic role of 2-18F-fluoro-2-deoxy-D-glucose (FDG) PET/MRI during high-dose methotrexate-based chemotherapy (HD-MBC) in de novo primary central nervous system lymphoma (PCNSL) patients aged 60 and above. Methods: This prospective multicentric ancillary study included 65 immunocompetents patients who received induction HD-MBC as part of the BLOCAGE01 phase III trial. FDG-PET/MRI were acquired at baseline, post two cycles (PET/MRI2), and post-treatment (PET/MRI3). FDG-PET response was dichotomized, with "positive" indicating persistent tumor uptake higher than the contralateral mirroring brain region. Performances of FDG-PET and International PCNSL Collaborative Group criteria in predicting induction response, progression-free survival (PFS), and overall survival (OS) were compared. Results: Of 48 PET2 scans performed, nine were positive and aligned with a partial response (PR) on MRI2. Among these, eight (89%) progressed by the end of the induction phase. In contrast, 35/39 (90%) of PET2-negative patients achieved complete response (CR). Among the 18 discordant responses at interim (PETCR/MRIPR), 83% ultimately achieved CR. 87% of the PET2-negative patients were disease-free at 6 months versus 11% of the PET2-positive patients (p<0.001). The MRI2 response did not significantly differentiate patients based on their PFS, regardless of whether they were in CR or PR. Both PET2 and MRI2 independently predicted OS in multivariate analysis, with PET2 showing stronger association. Conclusion: Our study highlights the potential of interim FDG-PET for early management of PCNSL patients. Response-driven treatment based on PET2 may guide future clinical trials.
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2028601-6
ISSN	1523-5866 ; 1522-8517
ISSN (online)	1523-5866
ISSN	1522-8517
DOI	10.1093/neuonc/noae029
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Zs.A 5307: Show issues

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Article ; Online: Syndromes lymphoprolifératifs chroniques chez la personne âgée: du diagnostic à la prise en charge.

Choquet, Sylvain

Bulletin du cancer

2008 Volume 95 FMC Onco, Page(s) F74–8

Abstract: Chronic lymphoproliferative disorders represent a group of malignant lymphoid diseases of whom chronic lymphoid leukaemia (CLL) is the more frequent. They are incurable diseases of indolent evolution. Diagnosis is usually made on blood puncture when ... ...

Title translation	Chronic lymphoproliferative disease in the elderly.
Abstract	Chronic lymphoproliferative disorders represent a group of malignant lymphoid diseases of whom chronic lymphoid leukaemia (CLL) is the more frequent. They are incurable diseases of indolent evolution. Diagnosis is usually made on blood puncture when circulating malignant lymphocytes are present. Explorations are limited to CT-scan, and, for CLL, karyotype. Bone marrow biopsy must be avoided, as possible. Treatment indications will be limited to really evolved cases. The aim of treatment must be the quality of life. Adapted treatment are available for the majority of patients, with limited toxicity and prolonged efficacy.
MeSH term(s)	Aged ; Aged, 80 and over ; Antineoplastic Agents/therapeutic use ; Chronic Disease ; Humans ; Incidence ; Lymphoproliferative Disorders/diagnosis ; Lymphoproliferative Disorders/epidemiology ; Lymphoproliferative Disorders/therapy ; United States/epidemiology
Chemical Substances	Antineoplastic Agents
Language	French
Publishing date	2008-05-28
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1684/bdc.2007.0534
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Article ; Online: Successful treatment with adapted high dose methotrexate in a hemodialysis patient with primary central nervous system lymphoma: 100mg/m

Solignac, Justine / Farnault, Laure / Robert, Thomas / Fanciullino, Raphaelle / Choquet, Sylvain / Brunet, Philippe / Venton, Geoffroy / Bobot, Mickaël

Nefrologia

2022 Volume 42, Issue 2, Page(s) 130–134

Abstract: High dose methotrexate (HD-MTX) based chemoimmunotherapy is a central part of the standard approach to treatment of primary central nervous system lymphoma (PCNSL). Renal dysfunction leads to delayed MTX complete elimination and critical MTX ... ...

Abstract	High dose methotrexate (HD-MTX) based chemoimmunotherapy is a central part of the standard approach to treatment of primary central nervous system lymphoma (PCNSL). Renal dysfunction leads to delayed MTX complete elimination and critical MTX concentration. Despite the recommendations, hemodialysis status should not exclude HD-MTX. We report the case of a 64 years old woman on chronic hemodialysis with PCNSL successfully treated with HD-MTX-based chemoimmunotherapy with an adjusted dose of 100mg/m
MeSH term(s)	Central Nervous System/pathology ; Central Nervous System Neoplasms/complications ; Central Nervous System Neoplasms/drug therapy ; Central Nervous System Neoplasms/pathology ; Female ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Lymphoma/complications ; Lymphoma/drug therapy ; Lymphoma/pathology ; Methotrexate/therapeutic use ; Middle Aged ; Renal Dialysis
Chemical Substances	Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2022-04-30
Publishing country	Spain
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefroe.2022.02.007
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Article: Role of Positron Emission Tomography in Primary Central Nervous System Lymphoma.

Rozenblum, Laura / Houillier, Caroline / Soussain, Carole / Bertaux, Marc / Choquet, Sylvain / Galanaud, Damien / Hoang-Xuan, Khê / Kas, Aurélie

Cancers

2022 Volume 14, Issue 17

Abstract: The incidence of primary central nervous system lymphoma has increased over the past two decades in immunocompetent patients and the prognosis remains poor. A diagnosis and complete evaluation of the patient is needed without delay, but histologic ... ...

Abstract	The incidence of primary central nervous system lymphoma has increased over the past two decades in immunocompetent patients and the prognosis remains poor. A diagnosis and complete evaluation of the patient is needed without delay, but histologic evaluation is not always available and PCNSL can mimic a variety of brain lesions on MRI. In this article, we review the potential role of
Language	English
Publishing date	2022-08-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14174071
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Article ; Online: Prevalence of IGLV3-21R110 among familial CLL: a retrospective study of 45 cases.

Armand, Marine / Verrier, Patricia / Theves, Floriane / Bravetti, Clotilde / Le Garff-Tavernier, Magali / Choquet, Sylvain / Davi, Frédéric

Blood advances

2022 Volume 6, Issue 12, Page(s) 3632–3635

MeSH term(s)	Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Prevalence ; Retrospective Studies
Language	English
Publishing date	2022-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2021006658
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Zs.A 7153: Show issues

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Article ; Online: Circulating tumor cells in Waldenström macroglobulinemia.

Boccon-Gibod, Clémentine / Sourdeau, Elise / Morel, Pierre / Chapiro, Elise / Nguyen-Khac, Florence / Bravetti, Clotilde / Davi, Frédéric / Morel, Véronique / Gauthier, Nicolas / Grenier, Adrien / Boussen, Inès / Choquet, Sylvain / Leblond, Véronique / Le Garff-Tavernier, Magali / Baron, Marine / Roos-Weil, Damien

Leukemia

2024 Volume 38, Issue 4, Page(s) 903–907

MeSH term(s)	Humans ; Waldenstrom Macroglobulinemia/pathology ; Neoplastic Cells, Circulating ; Mutation ; Cell Proliferation
Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/s41375-024-02156-3
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