Article ; Online: Negatywna regulacja sygnalizacji receptorów Toll-podobnych.
Postepy higieny i medycyny doswiadczalnej (Online)
2013 Volume 67, Page(s) 339–350
Abstract: The mechanism of innate immunity is based on the pattern recognition receptors (PRR) that recognize molecular patterns associated with pathogens (PAMPs). Among PRR receptors Toll-like receptors (TLR) are distinguished. As a result of contact with ... ...
| Title translation | Negative regulation of Toll-like receptor signalling. |
|---|---|
| Abstract | The mechanism of innate immunity is based on the pattern recognition receptors (PRR) that recognize molecular patterns associated with pathogens (PAMPs). Among PRR receptors Toll-like receptors (TLR) are distinguished. As a result of contact with pathogens, TLRs activate specific intracellular signaling pathways. It happens through proteins such as adaptor molecules, e.g. MyD88, TIRAP, TRIF, TRAM, and IPS-1, which participate in the cascade activation of kinases (IKK, MAP, RIP-1, TBK-1) as well as transcription factors (NF-κB, AP-1) and regulatory factor (IRF3). The result of this activation is the production of active proinflammatory cytokines, chemokines, interferons and enzymes. The PRR pathways are controlled by extra- and intracellular molecules to prevent overexpression of PRR. They include soluble receptors (sTLR), transmembrane proteins (ST2, SIGIRR, RP105, TRAIL-R) and intracellular inhibitors (SOCS-1, SOCS-3, sMyD88, TOLLIP, IRAK-M, SARM, A20, β-arrestin, CYLD, SHP). These molecules maintain the balance between activation and inhibition and ensure balancing of the beneficial and adverse effects of antigen recognition. |
| MeSH term(s) | Antigen Presentation/immunology ; Cytokines/immunology ; Humans ; Immunity, Innate/immunology ; Interferon Regulatory Factor-3/metabolism ; Intracellular Signaling Peptides and Proteins ; NF-kappa B/metabolism ; Receptors, Pattern Recognition/immunology ; Signal Transduction/immunology ; Suppressor of Cytokine Signaling Proteins/immunology ; Toll-Like Receptors/immunology ; Transcription Factor AP-1/metabolism ; Transcription Factors/immunology |
| Chemical Substances | Cytokines ; IRF3 protein, human ; Interferon Regulatory Factor-3 ; Intracellular Signaling Peptides and Proteins ; NF-kappa B ; Receptors, Pattern Recognition ; Suppressor of Cytokine Signaling Proteins ; TOLLIP protein, human ; Toll-Like Receptors ; Transcription Factor AP-1 ; Transcription Factors |
| Language | Polish |
| Publishing date | 2013-04-25 |
| Publishing country | Poland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 418865-2 |
| ISSN | 1732-2693 ; 0032-5449 |
| ISSN (online) | 1732-2693 |
| ISSN | 0032-5449 |
| DOI | 10.5604/17322693.1046538 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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