Article ; Online: Transplant Outcomes After Exposure of Deceased Kidney Donors to Contrast Medium.
2023 Volume 108, Issue 1, Page(s) 252–260
Abstract: Background: The administration of contrast medium is associated with acute kidney injury; however, the effect of exposure of a deceased organ donor to contrast medium on kidney transplant outcomes has been poorly studied.: Methods: A retrospective ... ...
| Abstract | Background: The administration of contrast medium is associated with acute kidney injury; however, the effect of exposure of a deceased organ donor to contrast medium on kidney transplant outcomes has been poorly studied. Methods: A retrospective analysis of all deceased kidney donors between 2011 and 2021 and their corresponding recipients in the Netherlands was conducted. Multivariable analyses were performed to assess the associations between contrast medium exposure and delayed graft function (DGF)/graft survival. Linear mixed models were used to assess the differences in mean estimated glomerular filtration rate values in recipients 1 to 6 y after transplantation. Results: In total, 2177 donors and 3638 corresponding kidney graft recipients were included. Twenty-four percent of the donors (n = 520) were exposed to contrast medium, corresponding to 23% of recipients (n = 832). DGF was observed in 36% (n = 1321) and primary nonfunction in 3% (n = 122) of recipients. DGF rates for donation after brain death (DBD) and donation after circulatory death (DCD) donors showed no significant effect of contrast medium exposure ( P = 0.15 and P = 0.60 for DBD and DCD donors, respectively). In multivariable analyses, contrast medium administration was not significantly associated with a higher DGF risk (odds ratio 1.06; 95% confidence interval, 0.86-1.36; P = 0.63) nor was a significant predictor for death-censored graft failure (hazard ratio 1.01; 95% confidence interval, 0.77-1.33; P = 0.93). Linear mixed models showed no difference in mean estimated glomerular filtration rate values in recipients 1 to 6 y posttransplantation ( P = 0.78). Conclusions: This study indicates that contrast medium administration in DBD and DCD donors has no negative effect on early and long-term kidney graft function. |
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| MeSH term(s) | Humans ; Kidney Transplantation/adverse effects ; Tissue and Organ Procurement ; Retrospective Studies ; Graft Survival ; Tissue Donors ; Brain Death ; Delayed Graft Function/etiology |
| Language | English |
| Publishing date | 2023-09-06 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 208424-7 |
| ISSN | 1534-6080 ; 0041-1337 |
| ISSN (online) | 1534-6080 |
| ISSN | 0041-1337 |
| DOI | 10.1097/TP.0000000000004745 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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