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Article ; Online: The genome-wide association study of serum IgE levels demonstrated a shared genetic background in allergic diseases.

Lu, Hsing-Fang / Chou, Chen-Hsing / Lin, Ying-Ju / Uchiyama, Shunsuke / Terao, Chikashi / Wang, Yu-Wen / Yang, Jai-Sing / Liu, Ting-Yuan / Wong, Henry Sung-Ching / Chen, Sean Chun-Chang / Tsai, Fuu-Jen

Clinical immunology (Orlando, Fla.)

2024 Volume 260, Page(s) 109897

Abstract: Immunoglobulin E (IgE) synthessis is highly related to a variety of atopic diseases, and several genome-wide association studies (GWASs) have demonstrated the association between genes and IgE level. In this study, we conducted the largest genome-wide ... ...

Abstract	Immunoglobulin E (IgE) synthessis is highly related to a variety of atopic diseases, and several genome-wide association studies (GWASs) have demonstrated the association between genes and IgE level. In this study, we conducted the largest genome-wide association study of IgE involving a Taiwanese Han population. Eight independent variants exhibited genome-wide significance. Among them, an intronic SNP of CD28, rs1181388, and an intergenic SNP, rs1002957030, on 11q23.2 were identified as novel signals for IgE. Seven of the loci were replicated successfully in a meta-analysis using data on Japanese population. Among all the human leukocyte antigen (HLA) regions, HLA-DQA103:02 - HLA-DQB103:03 was the most significant haplotype (OR = 1.25, SE = 0.02, FDR = 1.6 × 10
MeSH term(s)	Humans ; Genome-Wide Association Study ; Hypersensitivity/genetics ; Asthma ; Polymorphism, Single Nucleotide ; Immunoglobulin E ; Genetic Predisposition to Disease
Chemical Substances	Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2024.109897
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Article ; Online: Menarche-a journey into womanhood: age at menarche and health-related outcomes in East Asians.

Chiou, Jian-Shiun / Lin, Ying-Ju / Chang, Cherry Yin-Yi / Liang, Wen-Miin / Liu, Ting-Yuan / Yang, Jai-Sing / Chou, Chen-Hsing / Lu, Hsing-Fang / Chiu, Mu-Lin / Lin, Ting-Hsu / Liao, Chiu-Chu / Huang, Shao-Mei / Chou, I-Ching / Li, Te-Mao / Huang, Peng-Yan / Chien, Tzu-Shun / Chen, Hou-Ren / Tsai, Fuu-Jen

Human reproduction (Oxford, England)

2024

Abstract: Study question: Are there associations of age at menarche (AAM) with health-related outcomes in East Asians?: Summary answer: AAM is associated with osteoporosis, Type 2 diabetes (T2D), glaucoma, and uterine fibroids, as demonstrated through ... ...

Abstract	Study question: Are there associations of age at menarche (AAM) with health-related outcomes in East Asians? Summary answer: AAM is associated with osteoporosis, Type 2 diabetes (T2D), glaucoma, and uterine fibroids, as demonstrated through observational studies, polygenic risk scores, genetic correlations, and Mendelian randomization (MR), with additional findings indicating a causal effect of BMI and T2D on earlier AAM. What is known already: Puberty timing is linked to adult disease risk, but research predominantly focuses on European populations, with limited studies in other groups. Study design, size, duration: We performed an AAM genome-wide association study (GWAS) with 57 890 Han Taiwanese females and examined the association between AAM and 154 disease outcomes using the Taiwanese database. Additionally, we examined genetic correlations between AAM and 113 diseases and 67 phenotypes using Japanese GWAS summary statistics. Participants/materials, setting, methods: We performed AAM GWAS and gene-based GWAS studies to obtain summary statistics and identify potential AAM-related genes. We applied phenotype, polygenic risk scores, and genetic correlation analyses of AAM to explore health-related outcomes, using multivariate regression and linkage disequilibrium score regression analyses. We also explored potential bidirectional causal relationships between AAM and related outcomes through univariable and multivariable MR analyses. Main results and the role of chance: Fifteen lead single-nucleotide polymorphisms and 24 distinct genes were associated with AAM in Taiwan. AAM was genetically associated with later menarche and menopause, greater height, increased osteoporosis risk, but lower BMI, and reduced risks of T2D, glaucoma, and uterine fibroids in East Asians. Bidirectional MR analyses indicated that higher BMI/T2D causally leads to earlier AAM. Limitations, reasons for caution: Our findings were specific to Han Taiwanese individuals, with genetic correlation analyses conducted in East Asians. Further research in other ethnic groups is necessary. Wider implications of the findings: Our study provides insights into the genetic architecture of AAM and its health-related outcomes in East Asians, highlighting causal links between BMI/T2D and earlier AAM, which may suggest potential prevention strategies for early puberty. Study funding/competing interest(s): The work was supported by China Medical University, Taiwan (CMU110-S-17, CMU110-S-24, CMU110-MF-49, CMU111-SR-158, CMU111-MF-105, CMU111-MF-21, CMU111-S-35, CMU112-SR-30, and CMU112-MF-101), the China Medical University Hospital, Taiwan (DMR-111-062, DMR-111-153, DMR-112-042, DMR-113-038, and DMR-113-103), and the Ministry of Science and Technology, Taiwan (MOST 111-2314-B-039-063-MY3, MOST 111-2314-B-039-064-MY3, MOST 111-2410-H-039-002-MY3, and NSTC 112-2813-C-039-036-B). The funders had no influence on the data collection, analyses, or conclusions of the study. No conflict of interests to declare. Trial registration number: N/A.
Language	English
Publishing date	2024-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	632776-x
ISSN	1460-2350 ; 0268-1161 ; 1477-741X
ISSN (online)	1460-2350
ISSN	0268-1161 ; 1477-741X
DOI	10.1093/humrep/deae060
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Article: Effect of Chinese herbal medicine therapy on risks of all-cause mortality, infections, parasites, and circulatory-related mortality in HIV/AIDS patients with neurological diseases.

Chiou, Jian-Shiun / Chou, Chen-Hsing / Ho, Mao-Wang / Tien, Ni / Liang, Wen-Miin / Chiu, Mu-Lin / Tsai, Fuu-Jen / Wu, Yang-Chang / Chou, I-Ching / Lu, Hsing-Fang / Lin, Ting-Hsu / Liao, Chiu-Chu / Huang, Shao-Mei / Li, Te-Mao / Lin, Ying-Ju

Frontiers in pharmacology

2023 Volume 14, Page(s) 1097862

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1097862
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Article: Association of combination antiretroviral therapy with risk of neurological diseases in patients with HIV/AIDS in Taiwan: a nested case-control study.

Chou, Chen-Hsing / Chiou, Jian-Shiun / Ho, Mao-Wang / Tien, Ni / Li, Te-Mao / Chiu, Mu-Lin / Tsai, Fuu-Jen / Wu, Yang-Chang / Chou, I-Ching / Lu, Hsing-Fang / Lin, Ting-Hsu / Liao, Chiu-Chu / Huang, Shao-Mei / Liang, Wen-Miin / Lin, Ying-Ju

Frontiers in pharmacology

2023 Volume 14, Page(s) 1110605

Abstract: Heterogeneous neurocognitive impairment remains an important issue, even in the era of combination antiretroviral therapy (cART), with an incidence ranging from 15% to 65%. Although ART drugs with higher penetration scores to the central nervous system ( ... ...

Abstract	Heterogeneous neurocognitive impairment remains an important issue, even in the era of combination antiretroviral therapy (cART), with an incidence ranging from 15% to 65%. Although ART drugs with higher penetration scores to the central nervous system (CNS) show better HIV replication control in the CNS, the association between CNS penetration effectiveness (CPE) scores and neurocognitive impairment remains inconclusive. To explore whether ART exposure is associated with the risk of neurological diseases among patients with HIV/AIDS, this study in Taiwan involved 2,571 patients with neurological diseases and 10,284 matched, randomly selected patients without neurological diseases between 2010 and 2017. A conditional logistic regression model was used in this study. The parameters for ART exposure included ART usage, timing of exposure, cumulative defined daily dose (DDD), adherence, and cumulative CPE score. Incident cases of neurological diseases, including CNS infections, cognitive disorders, vasculopathy, and peripheral neuropathy, were obtained from the National Health Insurance Research Database in Taiwan. Odds ratios (ORs) for the risk of neurological diseases were conducted using a multivariate conditional logistic regression model. Patients with a history of past exposure (OR: 1.68, 95% confidence interval [CI]:1.22-2.32), low cumulative DDDs (< 2,500) (OR: 1.28, 95% CI: 1.15-1.42), low adherence (0 < adherence (ADH) ≤ 0.8) (OR: 1.46, 95% CI: 1.30-1.64), or high cumulative CPE scores (>14) (OR: 1.34, 95% CI: 1.14-1.57) had a high risk of neurological diseases. When stratified by classes of ART drugs, patients with low cumulative DDDs or low adherence had a high risk of neurological diseases, including NRTIs, PIs, NNRTIs, INSTIs, and multi-drug tablets. Subgroup analyses also suggested that patients with low cumulative DDDs or low adherence had a high risk of neurological diseases when they had high cumulative CPE scores. Patients with high cumulative DDDs or medication adherence were protected against neurological diseases only when they had low cumulative CPE scores (≤ 14). Patients may be at risk for neurological diseases when they have low cumulative DDDs, low adherence, or usage with high cumulative CPE scores. Continuous usage and low cumulative CPE scores of ART drugs may benefit neurocognitive health in patients with HIV/AIDS.
Language	English
Publishing date	2023-06-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1110605
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Article ; Online: Your height affects your health: genetic determinants and health-related outcomes in Taiwan.

Chiou, Jian-Shiun / Cheng, Chi-Fung / Liang, Wen-Miin / Chou, Chen-Hsing / Wang, Chung-Hsing / Lin, Wei-De / Chiu, Mu-Lin / Cheng, Wei-Chung / Lin, Cheng-Wen / Lin, Ting-Hsu / Liao, Chiu-Chu / Huang, Shao-Mei / Tsai, Chang-Hai / Lin, Ying-Ju / Tsai, Fuu-Jen

BMC medicine

2022 Volume 20, Issue 1, Page(s) 250

Abstract: Background: Height is an important anthropometric measurement and is associated with many health-related outcomes. Genome-wide association studies (GWASs) have identified hundreds of genetic loci associated with height, mainly in individuals of European ...

Abstract	Background: Height is an important anthropometric measurement and is associated with many health-related outcomes. Genome-wide association studies (GWASs) have identified hundreds of genetic loci associated with height, mainly in individuals of European ancestry. Methods: We performed genome-wide association analyses and replicated previously reported GWAS-determined single nucleotide polymorphisms (SNPs) in the Taiwanese Han population (Taiwan Biobank; n = 67,452). A genetic instrument composed of 251 SNPs was selected from our GWAS, based on height and replication results as the best-fit polygenic risk score (PRS), in accordance with the clumping and p-value threshold method. We also examined the association between genetically determined height (PRS Results: GWAS identified 6843 SNPs in 89 genomic regions with genome-wide significance, including 18 novel loci. These were the most strongly associated genetic loci (EFEMP1, DIS3L2, ZBTB38, LCORL, HMGA1, CS, and GDF5) previously reported to play a role in height. There was a positive association between PRS Conclusions: This study contributes to the understanding of the genetic features of height and health-related outcomes in individuals of Han Chinese ancestry in Taiwan.
MeSH term(s)	Cholesterol ; Extracellular Matrix Proteins ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Humans ; Polymorphism, Single Nucleotide/genetics ; Taiwan/epidemiology ; Waist-Hip Ratio
Chemical Substances	EFEMP1 protein, human ; Extracellular Matrix Proteins ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2022-07-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2131669-7
ISSN	1741-7015 ; 1741-7015
ISSN (online)	1741-7015
ISSN	1741-7015
DOI	10.1186/s12916-022-02450-w
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Article: Effect of Chinese Herbal Medicine Therapy on Risks of Overall, Diabetes-Related, and Cardiovascular Diseases-Related Mortalities in Taiwanese Patients With Hereditary Hemolytic Anemias.

Chiu, Mu-Lin / Chiou, Jian-Shiun / Chen, Chao-Jung / Liang, Wen-Miin / Tsai, Fuu-Jen / Wu, Yang-Chang / Lin, Ting-Hsu / Liao, Chiu-Chu / Huang, Shao-Mei / Chou, Chen-Hsing / Lin, Cheng-Wen / Li, Te-Mao / Hsu, Yu-Lung / Lin, Ying-Ju

Frontiers in pharmacology

2022 Volume 13, Page(s) 891729

Abstract: Hereditary Hemolytic Anemias (HHAs) are a rare but heterogeneous group of erythrocytic diseases, characterized by intrinsic cellular defects due to inherited genetic mutations. We investigated the efficacy of Chinese herbal medicine (CHM) in reducing the ...

Abstract	Hereditary Hemolytic Anemias (HHAs) are a rare but heterogeneous group of erythrocytic diseases, characterized by intrinsic cellular defects due to inherited genetic mutations. We investigated the efficacy of Chinese herbal medicine (CHM) in reducing the overall, diabetes-related, and cardiovascular diseases (CVDs)-related mortalities among patients with HHAs using a nationwide population database. In total, we identified 33,278 patients with HHAs and included 9,222 non-CHM and 9,222 CHM matched pairs after matching. The Cox proportional hazards model was used to compare the risk of mortality between non-CHM and CHM users. The Kaplan-Meier method and log-rank test were used to compare the cumulative incidence mortality between non-CHM and CHM users. The CHM prescription patterns were presented by the association rules and network analyses, respectively. The CHM prescription patterns were presented by the association rules and network analyses, respectively. CHM users showed significant reduced risks for of overall (adjusted hazard ratio [aHR]: 0.67, 95% confidence interval [CI]: 0.61-0.73,
Language	English
Publishing date	2022-05-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.891729
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Article: Chinese Herbal Medicine Therapy Reduces the Risks of Overall and Anemia-Related Mortalities in Patients With Aplastic Anemia: A Nationwide Retrospective Study in Taiwan.

Chiu, Mu-Lin / Hsu, Yu-Lung / Chen, Chao-Jung / Li, Te-Mao / Chiou, Jian-Shiun / Tsai, Fuu-Jen / Lin, Ting-Hsu / Liao, Chiu-Chu / Huang, Shao-Mei / Chou, Chen-Hsing / Liang, Wen-Miin / Lin, Ying-Ju

Frontiers in pharmacology

2021 Volume 12, Page(s) 730776

Abstract: Aplastic Anemia (AA) is a rare but fatal hematologic disease that may occur at any age and especially higher in Asia. We investigated whether Chinese herbal medicine (CHM) is beneficial to AA patients as a complementary therapy using a nationwide ... ...

Abstract	Aplastic Anemia (AA) is a rare but fatal hematologic disease that may occur at any age and especially higher in Asia. We investigated whether Chinese herbal medicine (CHM) is beneficial to AA patients as a complementary therapy using a nationwide population-based database in Taiwan between 2000-2016. Patient survival was estimated by Kaplan‒Meier survival analyses and Cox proportional-hazard model. CHM-users presented lower risks of overall and anemia-related mortalities when compared to non-users. The risk of overall mortality for CHM-users in AA patients was 0.70-fold [adjusted hazard ratio (aHR): 0.70, 95% confidence interval (CI): 0.66-0.74,
Language	English
Publishing date	2021-10-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.730776
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Article: Chinese Herbal Medicine Usage Reduces Overall Mortality in HIV-Infected Patients With Osteoporosis or Fractures.

Ho, Mao-Wang / Li, Te-Mao / Li, Ju-Pi / Chiou, Jian-Shiun / Chiu, Mu-Lin / Chen, Chao-Jung / Cheng, Chi-Fung / Tsai, Fuu-Jen / Wu, Yang-Chang / Lin, Ting-Hsu / Liao, Chiu-Chu / Huang, Shao-Mei / Lin, Yu-Ning / Chou, Chen-Hsing / Liang, Wen-Miin / Lin, Ying-Ju

Frontiers in pharmacology

2021 Volume 12, Page(s) 593434

Abstract: The survival of patients with HIV has greatly improved, due to Anti-Retroviral Therapy (ART). However, long-term HIV survivors often develop serious bone abnormalities, possibly due to the interplay of osteoblasts, osteoclasts, HIV ad ART. We evaluated ... ...

Abstract	The survival of patients with HIV has greatly improved, due to Anti-Retroviral Therapy (ART). However, long-term HIV survivors often develop serious bone abnormalities, possibly due to the interplay of osteoblasts, osteoclasts, HIV ad ART. We evaluated in a nation-wide study in Taiwan the effect of Chinese herbal medicine (CHM) on overall mortality in HIV patients with osteoporosis or fractures. Enrollment period was between 1998 and 2011. Patients with osteoporosis or fractures before the HIV infection, and those with less than 14 days CHM use, were excluded. This left 498 patients, 160 CHM users, 338 without CHM. Univariate Kaplan-Meier and multivariate Cox regression analysis were used to compare the overall mortality in these 2 groups. Due to the nature of Chinese medicine, CHMs inevitably varied. We therefore also used rule mining and network analysis to determine which major CHM clusters were prescribed to the patients. CHM users had a much Lower mortality (hazard ratio (HR) = 0.43, 95% confidence interval (CI): 0.24-0.77,
Language	English
Publishing date	2021-04-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.593434
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Article ; Online: Protective effects and network analysis of natural compounds obtained from Radix dipsaci, Eucommiae cortex, and Rhizoma drynariae against RANKL-induced osteoclastogenesis in vitro.

Cheng, Chi-Fung / Chien-Fu Lin, Jeff / Tsai, Fuu-Jen / Chen, Chao-Jung / Chiou, Jian-Shiun / Chou, Chen-Hsing / Li, Te-Mao / Lin, Ting-Hsu / Liao, Chiu-Chu / Huang, Shao-Mei / Li, Ju-Pi / Lin, Jung-Chun / Lin, Chih-Chien / Ban, Bo / Liang, Wen-Miin / Lin, Ying-Ju

Journal of ethnopharmacology

2019 Volume 244, Page(s) 112074

Abstract: Ethnopharmacological relevance: Osteoporosis is one of the most common bone diseases; it is characterized by bone loss and is a risk factor for hip fracture. Chinese herbal medicines (CHMs) and their related natural compounds have been used for treating ...

Abstract	Ethnopharmacological relevance: Osteoporosis is one of the most common bone diseases; it is characterized by bone loss and is a risk factor for hip fracture. Chinese herbal medicines (CHMs) and their related natural compounds have been used for treating many diseases, including bone diseases, since ancient times in China and are regarded as a cost-effective complementary therapy. Aim of the study: The goal of this study was to investigate the osteoprotective mechanisms of these three Chinese herbs and their related natural compounds. The effects of CHMs and related natural compounds on RANKL-induced osteoclastogenesis in vitro were investigated. Materials and methods: A network pharmacology method was applied to study CHM-related natural compounds and their osteoporosis targets. In addition, their effect on RANKL-induced osteoclastogenesis in RAW264.7 cells was also investigated in vitro. Results: Radix dipsaci, Eucommiae cortex, and Rhizoma drynariae exhibited protective effects against mortality in hip fracture patients. Furthermore, these three herbs inhibited RANKL-induced TRAP activities and reduced the expression of bone resorption-related genes in RAW264.7 cells. Network analysis of natural compound (ingredient)-target interactions identified 11 natural compounds. Signal pathway analyses suggested that these compounds may target cytokine-cytokine receptor interactions, including RANKL-induced osteoclastogenesis. Five novel natural compounds exhibited reduced RANKL-induced TRAP activities and bone resorption-related gene expression. Conclusion: The clinically used CHMs, Radix dipsaci, Eucommiae cortex, and Rhizoma drynariae, and natural compounds obtained from them may suppress RANKL-induced osteoclastogenesis in vitro.
MeSH term(s)	Animals ; Dipsacaceae ; Eucommiaceae ; Humans ; Mice ; Osteoclasts/drug effects ; Osteogenesis/drug effects ; Phytochemicals/pharmacology ; Plant Extracts/pharmacology ; Plant Roots ; Polypodiaceae ; RANK Ligand ; RAW 264.7 Cells ; Signal Transduction/drug effects
Chemical Substances	Phytochemicals ; Plant Extracts ; RANK Ligand
Language	English
Publishing date	2019-07-07
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2019.112074
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Article ; Online: Protective effects and network analysis of natural compounds obtained from Radix dipsaci, Eucommiae cortex, and Rhizoma drynariae against RANKL-induced osteoclastogenesis in vitro

Cheng, Chi-Fung / Chien-Fu Lin, Jeff / Tsai, Fuu-Jen / Chen, Chao-Jung / Chiou, Jian-Shiun / Chou, Chen-Hsing / Li, Demao / Lin, Ting-Hsu / Liao, Chiu-Chu / Huang, Shao-Mei / Li, Ju-Pi / Lin, Jung-Chun / Lin, Zhijian / Ban, Bo / Liang, Wen-Miin / Lin, Ying-Ju

Journal of ethnopharmacology. 2019 Nov. 15, v. 244 p.112074-

2019

Abstract: Osteoporosis is one of the most common bone diseases; it is characterized by bone loss and is a risk factor for hip fracture. Chinese herbal medicines (CHMs) and their related natural compounds have been used for treating many diseases, including bone ... ...

Abstract	Osteoporosis is one of the most common bone diseases; it is characterized by bone loss and is a risk factor for hip fracture. Chinese herbal medicines (CHMs) and their related natural compounds have been used for treating many diseases, including bone diseases, since ancient times in China and are regarded as a cost-effective complementary therapy.The goal of this study was to investigate the osteoprotective mechanisms of these three Chinese herbs and their related natural compounds. The effects of CHMs and related natural compounds on RANKL-induced osteoclastogenesis in vitro were investigated.A network pharmacology method was applied to study CHM-related natural compounds and their osteoporosis targets. In addition, their effect on RANKL-induced osteoclastogenesis in RAW264.7 cells was also investigated in vitro.Radix dipsaci, Eucommiae cortex, and Rhizoma drynariae exhibited protective effects against mortality in hip fracture patients. Furthermore, these three herbs inhibited RANKL-induced TRAP activities and reduced the expression of bone resorption-related genes in RAW264.7 cells. Network analysis of natural compound (ingredient)-target interactions identified 11 natural compounds. Signal pathway analyses suggested that these compounds may target cytokine-cytokine receptor interactions, including RANKL-induced osteoclastogenesis. Five novel natural compounds exhibited reduced RANKL-induced TRAP activities and bone resorption-related gene expression.The clinically used CHMs, Radix dipsaci, Eucommiae cortex, and Rhizoma drynariae, and natural compounds obtained from them may suppress RANKL-induced osteoclastogenesis in vitro.
Keywords	bone resorption ; cortex ; cost effectiveness ; genes ; herbal medicines ; herbs ; hip fractures ; ingredients ; mortality ; osteoporosis ; patients ; pharmacology ; protective effect ; rhizomes ; risk factors ; signal transduction ; traditional medicine ; China ; Hip fracture ; Osteoporosis ; Chinese herbal medicine ; Natural compound ; Osteoclastogenesis
Language	English
Dates of publication	2019-1115
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2019.112074
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